Bases Moleculares de la Proliferación Celular y Enfermedades Raras

Lineas de Investigación

01. Angiogénesis y microentorno tumoral: Identificación y caracterización de moduladores de angiogénesis. Metabolismo en el microentorno tumoral.

02. Metabolismo de aminas biógenas y poliaminas en la salud y la enfermedad.

03. Bioinformática y redes: Modelos de interactomas, redes de enfermedad y de fármacos con métodos predictivos.

04. Flujos de trabajo bioinformáticos para la automatizacion de análisis genómicos. Análisis de expresión de transposones en cáncer.

05. Aplicaciones de las líneas 1-4 a las enfermedades raras.



Proyectos de Investigación

PI-0075-2017 Utilización de Datos Clínicos E In Vitro para Desarrollar Un Modelo Predictivo de la Alergenicidad de Proteínas Vegetales de la Familia Ltp Mediante Métodos Bioinformáticos de Aprendizaje Autómatico.

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2017

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model

Romero-Sanchez, LB; Mari-Beffa, M; Carrillo, P; Medina, MA; Diaz-Cuenca, A
Acta Biomaterialia 2018


TransFlow: a modular framework for assembling and assessing accurate de novo transcriptomes in non-model organisms

Seoane, P; Espigares, M; Carmona, R; Polonio, A; Quintana, J; Cretazzo, E; Bota, J; Perez-Garcia, A; Alche, JD; Gomez, L; Claros, MG
Bmc Bioinformatics 2018


Mathematical modeling of cancer metabolism

Medina, MA
Critical Reviews In Oncology Hematology 2018


Fishing anti(lymph)angiogenic drugs with zebrafish

Garcia-Caballero, M; Quesada, AR; Medina, MA; Mari-Beffa, M
Drug Discovery Today 2018


Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases

Bueno, A; Rodriguez-Lopez, R; Reyes-Palomares, A; Rojano, E; Corpas, M; Nevado, J; Lapunzina, P; Sanchez-Jimenez, F; Ranea, JAG
European Journal Of Human Genetics 2018


Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives

Lopez-Jimenez, A; Gallardo, E; Espartero, JL; Madrona, A; Quesada, AR; Medina, MA
Food & Function 2018


Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors

Cheng-Sanchez, I; Carrillo, P; Sanchez-Ruiz, A; Martinez-Poveda, B; Quesada, AR; Medina, MA; Lopez-Romero, JM; Sarabia, F
Journal Of Organic Chemistry 2018


(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells

Garcia-Vilas, JA; Martinez-Poveda, B; Quesada, AR; Medina, MA
Marine Drugs 2018


Bioinformatic Prediction of S-Nitrosylation Sites in Large Protein Datasets.

Carmona, Rosario; Claros, M; de Alche, Juan
Methods In Molecular Biology (Clifton, N.J.) 2018


In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis.

Garcia-Vilas, Javier A; Morilla, Ian; Bueno, Anibal; Martinez-Poveda, Beatriz; Medina, Miguel Angel; Ranea, Juan A G
Oncotarget 2018


Regulatory role of microRNA in mesenteric lymph nodes after &ITSalmonella&IT Typhimurium infection

Herrera-Uribe, J; Zaldivar-Lopez, S; Aguilar, C; Luque, C; Bautista, R; Carvajal, A; Claros, MG; Garrido, JJ
Veterinary Research 2018

Development of genomic tools in a widespread tropical tree, Symphonia globulifera L.f.: a new low-coverage draft genome, SNP and SSR markers

Olsson, S; Seoane-Zonjic, P; Bautista, R; Claros, MG; Gonzalez-Martinez, SC; Scotti, I; Scotti-Saintagne, C; Hardy, OJ; Heuertz, MMolecular Ecology Resources. 2017

Identification and Functional Annotation of Genes Differentially Expressed in the Reproductive Tissues of the Olive Tree (Olea europaea L.) through the Generation of Subtractive Libraries

Zafra, A; Carmona, R; Traverso, JA; Hancock, JT; Goldman, MHS; Claros, MG; Hiscock, SJ; Alche, JDFrontiers In Plant Science. 2017

Polyamine-RNA-membrane interactions: From the past to the future in biology

Acosta-Andrade, C; Artetxe, I; Lete, MG; Monasterio, BG; Ruiz-Mirazo, K; Goni, FM; Sanchez-Jimenez, FColloids And Surfaces B-Biointerfaces. 2017

Structural and Functional View of Polypharmacology

Moya-Garcia, A; Adeyelu, T; Kruger, FA; Dawson, NL; Lees, JG; Overington, JP; Orengo, C; Ranea, JAGScientific Reports. 2017

Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases

Garcia-Caballero, M; Paupert, J; Blacher, S; Van de Velde, M; Quesada, AR; Medina, MA; Noel, AJournal Of Hematology & Oncology. 2017

The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells

Garcia-Caballero, M; Martinez-Poveda, B; Medina, MA; Quesada, ARFrontiers In Pharmacology. 2017

The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects

Garcia-Vilas, JA; Pino-Angeles, A; Martinez-Poveda, B; Quesada, AR; Medina, MACancer Letters. 2017

Pleiotropic Role of Puupehenones in Biomedical Research

Martinez-Poveda, B; Quesada, AR; Medina, MAMarine Drugs. 2017

Generation of nitric oxide by olive (Olea europaea L.) pollen during in vitro germination and assessment of the S-nitroso- and nitro-proteomes by computational predictive methods

Jimenez-Quesada, MJ; Carmona, R; Lima-Cabello, E; Traverso, JA; Castro, AJ; Claros, MG; Alche, JDNitric Oxide-Biology And Chemistry. 2017

Genomic analysis of the marine fish pathogen Photobacterium damselae subsp piscicida: Insertion sequences proliferation is associated with chromosomal reorganisations and rampant gene decay

Balado, M; Benzekri, H; Labella, AM; Claros, MG; Manchado, M; Borrego, JJ; Osorio, CR; Lemos, MLInfection Genetics And Evolution. 2017

Automated identification of reference genes based on RNA-seq data

Carmona, R; Arroyo, M; Jimenez-Quesada, MJ; Seoane, P; Zafra, A; Larrosa, R; Alche, JD; Claros, MGBiomedical Engineering Online. 2017

Homocysteine pre-treatment increases redox capacity in both endothelial and tumor cells

Diaz-Santiago, E; Rodriguez-Caso, L; Cardenas, C; Serrano, JJ; Quesada, AR; Medina, MARedox Report. 2017


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