Bases Moleculares de la Proliferación Celular y Enfermedades Raras
Lineas de Investigación
01. Angiogénesis y microentorno tumoral: Identificación y caracterización de moduladores de angiogénesis. Metabolismo en el microentorno tumoral.
02. Metabolismo de aminas biógenas y poliaminas en la salud y la enfermedad.
03. Bioinformática y redes: Modelos de interactomas, redes de enfermedad y de fármacos con métodos predictivos.
04. Flujos de trabajo bioinformáticos para la automatizacion de análisis genómicos. Análisis de expresión de transposones en cáncer.
05. Aplicaciones de las líneas 1-4 a las enfermedades raras.
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Otro
Proyectos de Investigación
PI-0075-2017 Utilización de Datos Clínicos E In Vitro para Desarrollar Un Modelo Predictivo de la Alergenicidad de Proteínas Vegetales de la Familia Ltp Mediante Métodos Bioinformáticos de Aprendizaje Autómatico.
CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD
2017
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Copper-containing mesoporous bioactive glass promotes angiogenesis in an in vivo zebrafish model
Romero-Sanchez, LB; Mari-Beffa, M; Carrillo, P; Medina, MA; Diaz-Cuenca, A
Acta Biomaterialia 2018
TransFlow: a modular framework for assembling and assessing accurate de novo transcriptomes in non-model organisms
Seoane, P; Espigares, M; Carmona, R; Polonio, A; Quintana, J; Cretazzo, E; Bota, J; Perez-Garcia, A; Alche, JD; Gomez, L; Claros, MG
Bmc Bioinformatics 2018
Mathematical modeling of cancer metabolism
Medina, MA
Critical Reviews In Oncology Hematology 2018
Fishing anti(lymph)angiogenic drugs with zebrafish
Garcia-Caballero, M; Quesada, AR; Medina, MA; Mari-Beffa, M
Drug Discovery Today 2018
Phenotype-loci associations in networks of patients with rare disorders: application to assist in the diagnosis of novel clinical cases
Bueno, A; Rodriguez-Lopez, R; Reyes-Palomares, A; Rojano, E; Corpas, M; Nevado, J; Lapunzina, P; Sanchez-Jimenez, F; Ranea, JAG
European Journal Of Human Genetics 2018
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
Lopez-Jimenez, A; Gallardo, E; Espartero, JL; Madrona, A; Quesada, AR; Medina, MA
Food & Function 2018
What We Know and What We Need to Know about Aromatic and Cationic Biogenic Amines in the Gastrointestinal Tract
Fernandez-Reina, A; Urdiales, JL; Sanchez-Jimenez, F
Foods 2018
Exploring the Ring-Closing Metathesis for the Construction of the Solomonamide Macrocyclic Core: Identification of Bioactive Precursors
Cheng-Sanchez, I; Carrillo, P; Sanchez-Ruiz, A; Martinez-Poveda, B; Quesada, AR; Medina, MA; Lopez-Romero, JM; Sarabia, F
Journal Of Organic Chemistry 2018
(+)-Aeroplysinin-1 Modulates the Redox Balance of Endothelial Cells
Garcia-Vilas, JA; Martinez-Poveda, B; Quesada, AR; Medina, MA
Marine Drugs 2018
Bioinformatic Prediction of S-Nitrosylation Sites in Large Protein Datasets.
Carmona, Rosario; Claros, M; de Alche, Juan
Methods In Molecular Biology (Clifton, N.J.) 2018
In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis.
Garcia-Vilas, Javier A; Morilla, Ian; Bueno, Anibal; Martinez-Poveda, Beatriz; Medina, Miguel Angel; Ranea, Juan A G
Oncotarget 2018
Regulatory role of microRNA in mesenteric lymph nodes after &ITSalmonella&IT Typhimurium infection
Herrera-Uribe, J; Zaldivar-Lopez, S; Aguilar, C; Luque, C; Bautista, R; Carvajal, A; Claros, MG; Garrido, JJ
Veterinary Research 2018
Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
Garcia-Vilas, JA; Medina, MA
World Journal Of Gastroenterology 2018
Development of genomic tools in a widespread tropical tree, Symphonia globulifera L.f.: a new low-coverage draft genome, SNP and SSR markers
Olsson, S; Seoane-Zonjic, P; Bautista, R; Claros, MG; Gonzalez-Martinez, SC; Scotti, I; Scotti-Saintagne, C; Hardy, OJ; Heuertz, MMolecular Ecology Resources. 2017
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis
Garcia-Vilas, JA; Quesada, AR; Medina, MAFood Chemistry. 2017
Identification and Functional Annotation of Genes Differentially Expressed in the Reproductive Tissues of the Olive Tree (Olea europaea L.) through the Generation of Subtractive Libraries
Zafra, A; Carmona, R; Traverso, JA; Hancock, JT; Goldman, MHS; Claros, MG; Hiscock, SJ; Alche, JDFrontiers In Plant Science. 2017
Polyamine-RNA-membrane interactions: From the past to the future in biology
Acosta-Andrade, C; Artetxe, I; Lete, MG; Monasterio, BG; Ruiz-Mirazo, K; Goni, FM; Sanchez-Jimenez, FColloids And Surfaces B-Biointerfaces. 2017
Structural and Functional View of Polypharmacology
Moya-Garcia, A; Adeyelu, T; Kruger, FA; Dawson, NL; Lees, JG; Overington, JP; Orengo, C; Ranea, JAGScientific Reports. 2017
Targeting VEGFR-3/-2 signaling pathways with AD0157: a potential strategy against tumor-associated lymphangiogenesis and lymphatic metastases
Garcia-Caballero, M; Paupert, J; Blacher, S; Van de Velde, M; Quesada, AR; Medina, MA; Noel, AJournal Of Hematology & Oncology. 2017
The Natural Antiangiogenic Compound AD0157 Induces Caspase-Dependent Apoptosis in Human Myeloid Leukemia Cells
Garcia-Caballero, M; Martinez-Poveda, B; Medina, MA; Quesada, ARFrontiers In Pharmacology. 2017
The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects
Garcia-Vilas, JA; Pino-Angeles, A; Martinez-Poveda, B; Quesada, AR; Medina, MACancer Letters. 2017
Pleiotropic Role of Puupehenones in Biomedical Research
Martinez-Poveda, B; Quesada, AR; Medina, MAMarine Drugs. 2017
Generation of nitric oxide by olive (Olea europaea L.) pollen during in vitro germination and assessment of the S-nitroso- and nitro-proteomes by computational predictive methods
Jimenez-Quesada, MJ; Carmona, R; Lima-Cabello, E; Traverso, JA; Castro, AJ; Claros, MG; Alche, JDNitric Oxide-Biology And Chemistry. 2017
Genomic analysis of the marine fish pathogen Photobacterium damselae subsp piscicida: Insertion sequences proliferation is associated with chromosomal reorganisations and rampant gene decay
Balado, M; Benzekri, H; Labella, AM; Claros, MG; Manchado, M; Borrego, JJ; Osorio, CR; Lemos, MLInfection Genetics And Evolution. 2017
Automated identification of reference genes based on RNA-seq data
Carmona, R; Arroyo, M; Jimenez-Quesada, MJ; Seoane, P; Zafra, A; Larrosa, R; Alche, JD; Claros, MGBiomedical Engineering Online. 2017
Homocysteine pre-treatment increases redox capacity in both endothelial and tumor cells
Diaz-Santiago, E; Rodriguez-Caso, L; Cardenas, C; Serrano, JJ; Quesada, AR; Medina, MARedox Report. 2017
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