Lineas de Investigación

1. Genómica Funcional y Proteómica del Cáncer

2. Bases celulares y moleculares de la síntesis de glutamato en cerebro

3. Modelos animales transgénicos con déficits en el metabolismo de aminoácidos

4. Expresión heteróloga de proteínas humanas recombinantes con valor terapéutico y biotecnológico



Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Glutaminase isoenzymes in the metabolic therapy of cancer

Mates, JM; Campos-Sandoval, JA; Marquez, J
Biochimica Et Biophysica Acta-Reviews On Cancer 2018


A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

Garcia-Bonilla, Maria; Garcia-Martin, Maria L; Munoz-Hernandez, M Carmen; Dominguez-Pinos, Dolores; Martinez-Leon, Maria I; Penalver, Ana; Castilla, Laura; Alonso, Francisco J; Marquez, Javier; Shumilov, Kirill; Hidalgo-Sanchez, Ramon; Gutierrez, Antonia; Paez-Gonzalez, Patricia; Jimenez, Antonio J
Journal Of Neuropathology And Experimental Neurology 2018

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, SK; Purohit, V; Mehla, K; Gunda, V; Chaika, NV; Vernucci, E; King, RJ; Abrego, J; Goode, GD; Dasgupta, A; Illies, AL; Gebregiworgis, T; Dai, BB; Augustine, JJ; Murthy, D; Attri, KS; Mashadova, O; Grandgenett, PM; Powers, R; Ly, QP; Lazenby, AJ; Grem, JL; Yu, F; Mates, JM; Asara, JM; Kim, JW; Hankins, JH; Weekes, C; Hollingsworth, MA; Sarkova, NJ; Sasson, AR; Fleming, JB; Oliveto, JM; Lyssiotis, CA; Cantley, LC; Berim, L; Singh, PKCancer Cell. 2017

TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA

Majewska, E; Rola, R; Barczewska, M; Marquez, J; Albrecht, J; Szeliga, MJournal Of Physiology And Pharmacology. 2017

Glutamate and Brain Glutaminases in Drug Addiction

Marquez, J; Campos-Sandoval, JA; Penalver, A; Mates, JM; Segura, JA; Blanco, E; Alonso, FJ; de Fonseca, FRNeurochemical Research. 2017

Glutamine Addiction In Gliomas

Marquez, J; Alonso, FJ; Mates, JM; Segura, JA; Martin-Rufian, M; Campos-Sandoval, JANeurochemical Research. 2017


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