Investigación Clínica en Infección VIH, Infección Endovascular y Bacteriemias

Lineas de Investigación

01. Infección por el VIH.

02. Otras infecciones de transmisión sexual.

03. Infecciones endovascular y bacteriemias

04. Infecciones osteoarticulares.



Estudios Clínicos

201636. Estudio Fase III aleatorizado, multicéntrico, de grupos paralelos, de no inferioridad, para evaluar la eficacia, seguridad y tolerabilidad del cambio de una terapia antirretroviral basada en INI, ITINN o IP a dolutegravir más rilpivirina en pacientes adul

LABORATORIOS VIIV HEALTHCARE S.L.
Fase: III ENSAYO CLINICO COMERCIAL

SYMTRI. SYMTRI Study: Ensayo clínico abierto, aleatorizado y multicéntrico para comparar la eficacia, seguridad y tolerabilidad de una pauta de tratamiento TAF/FTC/DRV/cobi vs. ABC/3TC/DTG en pacientes infectados por el VIH-1 naïve de tratamiento antirretroviral.

RED DE INVESTIGACIÓN EN SIDA
Fase: IV ENSAYO CLINICO INDEPENDIENTE

GS-US-311-1717.

Estudio de fase 3b, aleatorizado, doble ciego, con cambio de tratamiento para evaluar F/TAF, en pacientes con infección por VIH-1 y supresión virológica que reciben tratamientos que contienen ABC/3TC

GILEAD SCIENCES, INC
Fase: IIIb ENSAYO CLINICO COMERCIAL

GS-US-380-1878.

Estudio fase III, aleatorizado y abierto para evaluar la seguridad y eficacia del cambio de un régimen formado por atazanavir o darunavir reforzados más emtricitabina/tenofovir o abacavir/lamivudina a GS 9883/emtricitabina/tenofovir alafenamida en adultos

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

GS-US-380-1490.

Estudio de fase 3, aleatorizado y doble ciego para evaluar la seguridad y la eficacia de GS-9883/emtricitabina/tenofovir alefenamida en comparación con dolutegravir + emtricitabina/tenofovir alefenamida en adultos infectados por el VIH-1 sin tratamiento a

GILEAD SCIENCES, INC
Fase: III ENSAYO CLINICO COMERCIAL

204862. Estudio de fase III, aleatorizado, multicéntrico, con grupos paralelos y de ausencia de inferioridad para evaluar la eficacia, la seguridad y la tolerabilidad del cambio a dolutegravir más lamivudina en adultos infectados por el VIH 1 con supresión viroló

VIIV HEALTHCARE UK LIMITED
Fase: III ENSAYO CLINICO COMERCIAL

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Bronchiectasis in COPD and Asthma. More Than Just a Coincidence.

Gomez Ayerbe, Cristina; Santos Gonzalez, Jesus; Palacios Munoz, Rosario
Archivos De Bronconeumologia 2018


Class-modeling analysis reveals T-cell homeostasis disturbances involved in loss of immune control in elite controllers

Benito, JM; Ortiz, MC; Leon, A; Sarabia, LA; Ligos, JM; Montoya, M; Garcia, M; Ruiz-Mateos, E; Palacios, R; Cabello, A; Restrepo, C; Rodriguez, C; del Romero, J; Leal, M; Munoz-Fernandez, MA; Alcami, J; Garcia, F; Gorgolas, M; Rallon, N
Bmc Medicine 2018


Impact of Staphylococcus aureus phenotype and genotype on the clinical characteristics and outcome of infective endocarditis. A multicentre, longitudinal, prospective, observational study

Fernandez-Hidalgo, N; Ribera, A; Larrosa, MN; Viedma, E; Origuen, J; de Alarcon, A; Farinas, MC; Saez, C; Pena, C; Munez, E; Lopez, MVG; Gavalda, J; Perez-Montarelo, D; Chaves, F; Almirante, B
Clinical Microbiology And Infection 2018


Consensus document on the diagnosis and treatment of sexually transmitted diseases in adults, children and adolescents

Polo, R; Palacios, R; Andreu, A; Blanco, BJL; Blanco, JR; Camino, X; Castillo, O; Curran, A; del Romero, J; Diaz, A; Fernandez, C; Gil, L; Tome, MG; Hidalgo, C; de Munain, JL; Margall, N; Navarro, M; Otero, L; Perez-Molina, JA; Prieto, L; Munoz, E; Puerta, T; Pueyo, I; Vall, M; Vazquez, F; Viciana, P; Vinuela, MC; Barbera, MJ
Enfermedades Infecciosas Y Microbiologia Clinica 2018


Costs and cost-efficacy analysis of the 2017 GESIDA/Spanish National AIDS Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults

Rivero, A; Perez-Molina, JA; Blasco, AJ; Arribas, JR; Asensi, V; Crespo, M; Domingo, P; Iribarren, JA; Lazaro, P; Lopez-Aldeguer, J; Lozano, F; Martinez, E; Moreno, S; Palacios, R; Pineda, JA; Pulido, F; Rubio, R; Santos, J; de la Torre, J; Tuset, M; Gatell, JM
Enfermedades Infecciosas Y Microbiologia Clinica 2018


Executive summary of the GESIDA/National AIDS Plan Consensus Document on Antiretroviral Therapy in Adults Infected by the Human Immunodeficiency Virus (Updated January 2017)

Rivero, A; Polo, R; Aldeguer, JL; Lozano, F; Antela, A; Arribas, JR; Asensi, V; Berenguer, J; Blanco, JR; Casado, JL; Clotet, B; Crespo, M; Domingo, P; Duenas, C; Gatell, JM; Gomez-Sirvent, JL; Gonzalez-Garcia, J; Iribarren, JA; de Quiros, JCLB; Cortes, LFL; Losa, JE; Mallolas, J; Marino, A; Martinez, E; Miro, JM; Moreno, S; Palacios, R; Pasquau, J; Pineda, JA; Podzamczer, D; Portilla, J; Poveda, E; Pulido, F; Rubio, R; Santos, J; Moreno, JS; Sanz, JS; Tellez, MJ; de la Torre, J; Tuset, M; Molina, JAP
Enfermedades Infecciosas Y Microbiologia Clinica 2018


Symtuza (DRV/c/FTC/TAF) in the management of treatment-naive HIV-patients.

Gomez Ayerbe, Cristina; Santos Gonzalez, Jesus; Palacios Munoz, Rosario
Enfermedades Infecciosas Y Microbiologia Clinica 2018


Paritaprevir/ritonavir/ombitasvir plus dasabuvir in HIV/HCV-coinfected patients with genotype 1 in real-life practice

Pineda, JA; Rivero-Juarez, A; de los Santos, I; Collado, A; Merino, D; Morano-Amado, LE; Rios, MJ; Perez-Perez, M; Tellez, F; Palacios, R; Perez, AB; Mancebo, M; Rivero, A; Macias, J
Hiv Clinical Trials 2018


Role of APOBEC3H in the Viral Control of HIV Elite Controller Patients

Benito, JM; Hillung, J; Restrepo, C; Cuevas, JM; Leon, A; Ruiz-Mateos, E; Palacios-Munoz, R; Gorgolas, M; Sanjuan, R; Rallon, N
International Journal Of Medical Sciences 2018


The Kidney, Liver, Index surgery and C reactive protein score is a predictor of treatment response in acute prosthetic joint infection

Jimenez-Garrido, C; Gomez-Palomo, JM; Rodriguez-Delourme, I; Duran-Garrido, FJ; Nuno-Alvarez, E; Montanez-Heredia, E
International Orthopaedics 2018


Continued propagation of the CRF19_cpx variant among HIV-positive MSM patients in Spain

Perez-Parra, S; Alvarez, M; Fernandez-Caballero, JA; Perez, AB; Santos, J; Bisbal, O; Aguilera, A; Rivero, M; Garcia-Fraile, L; Garcia, F
Journal Of Antimicrobial Chemotherapy 2018


Lipid changes and tolerability in a cohort of adult HIV-infected patients who switched to rilpivirine/emtricitabine/tenofovir due to intolerance to previous combination ART: the PRO-STR study

Ocampo, A; Domingo, P; Fernandez, P; Diz, J; Barbera, JR; Sepulveda, MA; Salgado, X; Rodriguez, M; Santos, J; Yzusqui, M; Mayorga, MI; Lorenzo, JF; Bahamonde, A; Bachiller, P; Martinez, E; Rozas, N; Torres, C; Munoz, A; Casado, A; Podzamczer, D
Journal Of Antimicrobial Chemotherapy 2018


Sustained virological response to direct-acting antiviral regimens reduces the risk of hepatocellular carcinoma in HIV/HCV-coinfected patients with cirrhosis

Merchante, N; Rivero-Juarez, A; Tellez, F; Merino, D; Rios-Villegas, MJ; Villalobos, M; Omar, M; Rincon, P; Rivero, A; Perez-Perez, M; Raffo, M; Lopez-Montesinos, I; Palacios, R; Gomez-Vidal, MA; Macias, J; Pineda, JA
Journal Of Antimicrobial Chemotherapy 2018


Safety and Efficacy of Dolutegravir Plus Rilpivirine in Treatment-Experienced HIV-Infected Patients: The DORIVIR Study.

Palacios, Rosario; Mayorga, M; Gonzalez-Domenech, C M; Hidalgo-Tenorio, C; Galvez, C; Munoz-Medina, L; de la Torre, J; Lozano, A; Castano, M; Omar, M; Santos, Jesus
Journal Of The International Association Of Providers Of Aids Care 2018


Human Immunodeficiency Virus/Hepatits C Virus Coinfection in Spain: Elimination Is Feasible, but the Burden of Residual Cirrhosis Will Be Significant

Berenguer, J; Jarrin, I; Perez-Latorre, L; Hontanon, V; Vivancos, MJ; Navarro, J; Tellez, MJ; Guardiola, JM; Iribarren, JA; Rivero-Juarez, A; Marquez, M; Artero, A; Morano, L; Santos, I; Moreno, J; Farinas, MC; Galindo, MJ; Hernando, MA; Montero, M; Cifuentes, C; Domingo, P; Sanz, J; Domingez, L; Ferrero, OL; De la Fuente, B; Rodriguez, C; Reus, S; Hernandez-Quero, J; Gaspar, G; Perez-Martinez, L; Garcia, C; Force, L; Veloso, S; Losa, JE; Vilaro, J; Bernal, E; Arponen, S; Orti, AJ; Chocarro, A; Teira, R; Alonso, G; Silvarino, R; Vegas, A; Geijo, P; Bisbe, J; Esteban, H; Gonzalez-Garcia, J
Open Forum Infectious Diseases 2018


Emergence as an outbreak of the HIV-1 CRF19_cpx variant in treatment-naive patients in southern Spain

Gonzalez-Domenech, CM; Viciana, I; Delaye, L; Mayorga, ML; Palacios, R; de la Torre, J; Jarilla, F; Castano, M; del Arco, A; Clavijo, E; Santos, J
Plos One 2018

Dual Therapy With Darunavir and Ritonavir Plus Lamivudine vs Triple Therapy With Darunavir and Ritonavir Plus Tenofovir Disoproxil Fumarate and Emtricitabine or Abacavir and Lamivudine for Maintenance of Human Immunodeficiency Virus Type 1 Viral Suppression: Randomized, Open-Label, Noninferiority DUAL-GESIDA 8014-RIS-EST45 Trial

Pulido, F; Ribera, E; Lagarde, M; Perez-Valero, I; Palacios, R; Iribarren, JA; Payeras, A; Domingo, P; Sanz, J; Cervero, M; Curran, A; Rodriguez-Gomez, FJ; Tellez, MJ; Ryan, P; Barrufet, P; Knobel, H; Rivero, A; Alejos, B; Yllescas, M; Arribas, JRClinical Infectious Diseases. 2017

Liver stiffness predicts variceal bleeding in HIV/HCV-coinfected patients with compensated cirrhosis

Merchante, N; Rivero-Juarez, A; Tellez, F; Merino, D; Rios-Villegas, MJ; Ojeda-Burgos, G; Omar, M; Macias, J; Rivero, A; Perez-Perez, M; Raffo, M; Lopez-Montesinos, I; Marquez-Solero, M; Gomez-Vidal, MA; Pineda, JAAids. 2017

Prevalence and distribution of hepatitis C virus genotypes in Spain during the 2000-2015 period (the GEHEP 005 study)

Aguilera, A; Navarro, D; Rodriguez-Frias, F; Viciana, I; Martinez-Sapina, AM; Rodriguez, MJ; Martro, E; Lozano, MC; Coletta, E; Cardenoso, L; Suarez, A; Trigo, M; Rodriguez-Granjer, J; Montiel, N; de la Iglesia, A; Alados, JC; Vegas, C; Bernal, S; Fernandez-Cuenca, F; Pena, MJ; Reina, G; Garcia-Bujalance, S; Echevarria, MJ; Benitez, L; Perez-Castro, S; Ocete, D; Garcia-Arata, I; Guerrero, C; Rodriguez-Iglesias, M; Casas, P; Garcia, FJournal Of Viral Hepatitis. 2017

Simplification to dual therapy (atazanavir/ritonavir plus lamivudine) versus standard triple therapy [atazanavir/ritonavir plus two nucleos(t)ides] in virologically stable patients on antiretroviral therapy: 96 week results from an open-label, non-inferiority, randomized clinical trial (SALT study)

Perez-Molina, JA; Rubio, R; Rivero, A; Pasquau, J; Suarez-Lozano, I; Riera, M; Estebanez, M; Palacios, R; Sanz-Moreno, J; Troya, J; Marino, A; Antela, A; Navarro, J; Esteban, H; Moreno, SJournal Of Antimicrobial Chemotherapy. 2017

Impact of universal access to hepatitis C therapy on HIV-infected patients: implementation of the Spanish national hepatitis C strategy

Rivero-Juarez, A; Lopez-Cortes, LF; Castano, M; Merino, D; Marquez, M; Mancebo, M; Cuenca-Lopez, F; Jimenez-Aguilar, P; Lopez-Montesinos, I; Lopez-Cardenas, S; Collado, A; Lopez-Ruz, MA; Omar, M; Tellez, F; Perez-Stachowski, X; Hernandez-Quero, J; Giron-Gonzalez, JA; Fernandez-Fuertes, E; Rivero, AEuropean Journal Of Clinical Microbiology & Infectious Diseases. 2017

Liver stiffness predicts the response to direct-acting antiviral-based therapy against chronic hepatitis C in cirrhotic patients

Neukam, K; Morano-Amado, LE; Rivero-Juarez, A; Macias, J; Granados, R; Romero-Palacios, A; Marquez, M; Merino, D; Ortega, E; Alados-Arboledas, JC; Cucurull, J; Omar, M; Ryan-Murua, P; Pineda, JAEuropean Journal Of Clinical Microbiology & Infectious Diseases. 2017

Pulmonary Mucormycosis at Onset of Diabetes in a Young Patient

Espildora-Hernandez, J; Perez-Lopez, C; Abarca-Costalago, M; Nuno-Alvarez, EArchivos De Bronconeumologia. 2017

Aetiology of renal failure in patients with infective endocarditis. The role of antibiotics

Sanchez, MAG; Urkola, XK; Santiago, EB; Garcia, PM; Moreno, EV; Alvarez, MCF; Cobo, RT; Pulido, JMP; Gonzalez, AD; Regueiro, DS; Morales, JR; Rodriguez-Alvarez, RJ; Miranda, IA; Loyarte, JAIMedicina Clinica. 2017

Costs and cost-efficacy analysis of the 2016 GESIDA/Spanish AIDS National Plan recommended guidelines for initial antiretroviral therapy in HIV-infected adults

Rivero, A; Perez-Molina, JA; Blasco, AJ; Arribas, JR; Crespo, M; Domingo, P; Estrada, V; Iribarren, JA; Knobel, H; Lazaro, P; Lopez-Aldeguer, J; Lozano, F; Moreno, S; Palacios, R; Pineda, JA; Pulido, F; Rubio, R; de la Torre, J; Tuset, M; Gatell, JMEnfermedades Infecciosas Y Microbiologia Clinica. 2017

Endocarditis caused by anaerobic bacteria

Kestler, M; Munoz, P; Marin, M; Goenaga, MA; Viedma, PI; de Alarcon, A; Lepe, JA; Regueiro, DS; Bravo-Ferrer, JM; Pajaron, M; Costas, C; Garcia-Lopez, MV; Hidalgo-Tenorio, C; Moreno, M; Bouza, EAnaerobe. 2017

Hepatic safety of maraviroc in HIV-1-infected patients with hepatitis C and/or B co-infection. The Maraviroc Cohort Spanish Group

Crespo, M; Navarro, J; Moreno, S; Sanz, J; Marquez, M; Zamora, J; Ocampo, A; Iribaren, JA; Rivero, A; Llibre, JMEnfermedades Infecciosas Y Microbiologia Clinica. 2017

Hepatitis C virus core antigen in the management of patients treated with new direct-acting antivirals

Arboledas, JCA; Guerrero, IP; Rodriguez, MJB; Martos, ET; Perez, AB; Leon, CC; Sanchez, JFS; Prieto, MDL; Porcuna, NC; Mochon, MDO; Macias, J; Salgado, AD; Granger, JR; Fernandez, MD; Lozano, IG; Ramirez, ER; Rivero, A; Dominguez, MDL; Viciana, I; Montemayor, JCG; Garcia, FGDiagnostic Microbiology And Infectious Disease. 2017

Infective endocarditis in patients with bicuspid aortic valve: Clinical characteristics, complications, and prognosis

Becerra-Munoz, VM; Ruiz-Morales, J; Rodriguez-Bailon, I; Sanchez-Espin, G; Lopez-Garrido, MA; Robledo-Carmona, J; Guijarro-Contreras, A; Garcia-Lopez, MV; Ivanova-Georgieva, R; Mora-Navas, L; Gomez-Doblas, JJ; de Teresa-Galvan, EEnfermedades Infecciosas Y Microbiologia Clinica. 2017

Gonococcal arthritis in human immunodeficiency virus-infected patients. Review of the literature

Corrales, GS; Navas, LM; Munoz, RP; Lopez, VG; Solero, MM; Gonzalez, JSReumatologia Clinica. 2017


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