Lineas de Investigación
01. Patología condral, nuevas terapias en COT
02. Implante de condrocitos autólogos.
04. Optimización biomecánica de los procedimientos de COT.
05. Elongación de segmentos óseos en displasias.
06. Infección en Cirugía Ortopédica y traumatología.
Miembros del grupo
Proyectos de Investigación
EVALUACIÓN DE LA EFECTIVIDAD Y RESULTADOS EN SALUD DE UN PROTOCOLO ESTANDARIZADO DE CIRUGÍA EN RELACIÓN CON LA ACONDROPLASIAObra Social 'La Caixa'
A PHASE3, OPEN – LABEL LONG-TERM EXTENSION STUDY TO EVALUATE THE EFFICACY AND SAFETY OF BMN111 IN CHILDREN WITH ACHONDROPLASIA_111-302.BioMarin Pharmaceutical Inc
ESTUDIO CLÍNICO MULTICÉNTRICO Y MULTINACIONAL DE EVALUACIÓN SOBRE PACIENTES PEDIÁTRICOS CON ACONDROPLASIA_111-901.BioMarin Pharmaceutical Inc
A PHASE3 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE EFFICACY AND SAFETY OF BMN111 IN CHILDREN WITH ACHONDROPLASIA_111-301.BioMarin Pharmaceutical Inc
Close-looped graft suturing improves mechanical properties of interference screw fixation in ACL reconstruction.
Prado M, Martín-Castilla B, Espejo-Reina A, Serrano-Fernández JM, Pérez-Blanca A, Ezquerro F.
Knee Surg Sports Traumatol Arthrosc. 2013 Feb;21(2):476-84.
In anterior cruciate ligament reconstruction with looped soft-tissue grafts, an interference screw is frequently used for tibial fixation. This study compared three alternatives thought to improve the initial mechanical properties of direct bioabsorbable interference screw fixation: suturing the graft to close the loop, adding a supplementary staple, or increasing the oversize of the screw diameter relative to the bone tunnel from 1 to 2 mm. […]
Espejo-Reina A, Serrano-Fernández JM, Martín-Castilla B, Estades-Rubio FJ, Briggs KK, Espejo-Baena A.
Arthroscopy. 2014 Apr;30(4):492-6.
The purpose of this study was to determine the outcomes after repair of chronic bucket-handle medial meniscal tears by use of magnetic resonance imaging, clinical examination, and patient-reported outcomes. […]
Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells.
López-Ruiz E, Perán M, Cobo-Molinos J, Jiménez G, Picón M, Bustamante M, Arrebola F, Hernández-Lamas MC, Delgado-Martínez AD, Montañez E, Marchal JA.
Osteoarthritis Cartilage. 2013 Jan;21(1):246-58.
Infrapatellar fat pad of patients with osteoarthritis (OA) contains multipotent and highly clonogenic adipose-derived stem cells that can be isolated by low invasive methods. Moreover, nuclear and cytoplasmic cellular extracts have been showed to be effective in induction of cell differentiation and reprogramming. The aim of this study was to induce chondrogenic differentiation of autologous mesenchymal stem cells (MSCs) obtained from infrapatell […]
Anterior pre-tensioned external fixator for pelvic fractures and dislocations. Initial clinical series.
Queipo-de-Llano A, Lombardo-Torre M, Leiva-Gea A, Delgado-Rufino FB, Luna-González F.
Orthop Traumatol Surg Res. 2016 Dec;102(8):1103-1108.
In the treatment of unstable pelvic ring fractures, external fixators have the limitation of not adequately stabilizing the injured posterior elements. This article presents a novel and simple technique of temporary external fixation of the pelvic ring, able to produce compression of both the anterior and posterior pelvic elements. A curved flexible carbon-fiber rod is used, pre-tensioned before attachment to supra-acetabular Schanz screws. Altho […]
Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes.
Jiménez G, López-Ruiz E, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Gray PC, Izpisua Belmonte JC, Choe S, Perán M, Marchal JA.
Sci Rep. 2015 Nov 13;5:16400.
Autologous chondrocyte implantation (ACI) depends on the quality and quantity of implanted cells and is hindered by the fact that chondrocytes cultured for long periods of time undergo dedifferentiation. Here we have developed a reproducible and efficient chondrogenic protocol to redifferentiate chondrocytes isolated from osteoarthritis (OA) patients. We used morphological, histological and immunological analysis together with a RT-PCR detection […]
Intra-Articular Injections of Platelet-Rich Plasma versus Hyaluronic Acid in the Treatment of Osteoarthritic Knee Pain: A Randomized Clinical Trial in the Context of the Spanish National Health Care System.
Montañez-Heredia E, Irízar S, Huertas PJ, Otero E, Del Valle M, Prat I, Díaz-Gallardo MS, Perán M, Marchal JA, Hernandez-Lamas Mdel C.
Int J Mol Sci. 2016 Jul 2;17(7).
Intra-articular injection of platelet-rich plasma (PRP) has been established as a suitable treatment for knee osteoarthritis. Here, we present a double-blind randomized controlled clinical trial, conducted in a public Hospital of the Spanish National Health Care System, to evaluate the efficacy of injecting autologous PRP versus hyaluronic acid (HA) in knee osteoarthritis. PRP was manufactured in Malaga’s Regional Blood Center (Spain). Patients t […]
Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid.
Estades-Rubio FJ, Reyes-Martín A, Morales-Marcos V, García-Piriz M, García-Vera JJ, Perán M, Marchal JA, Montañez-Heredia E.
Int J Mol Sci. 2017 Mar 17;18(3).
Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Univer […]
Correction to: The Kidney, Liver, Index surgery and C reactive protein score is a predictor of treatment response in acute prosthetic joint infection.
Jiménez-Garrido C, Gómez-Palomo JM, Rodríguez-Delourme I, Durán-Garrido FJ, Nuño-Álvarez E, Montañez-Heredia E.
Int Orthop. 2018 Jan;42(1):39.
There is an error in the name of one of the author in the original publication. The correct name is I Rodríguez-Delourme and not Delourne. […]
Impact of TGF-β family-related growth factors on chondrogenic differentiation of adipose-derived stem cells isolated from lipoaspirates and infrapatellar fat pads of osteoarthritic patients.
López-Ruiz E, Jiménez G, Kwiatkowski W, Montañez E, Arrebola F, Carrillo E, Choe S, Marchal JA, Perán M.
Eur Cell Mater. 2018 Apr 13;35:209-224.
The success of cell-based approaches for the treatment of cartilage defects requires an optimal autologous cell source with chondrogenic differentiation ability that maintains its differentiated properties and stability following implantation. The objective of this study was to compare the chondrogenic capacity of mesenchymal stem cells (MSCs) isolated from lipoaspirates (ASCs) and the infrapatellar fat pad (IFPSCs) of osteoarthritic patients and […]
General Assembly, Prevention, Wound Management: Proceedings of International Consensus on Orthopedic Infections.
Al-Houraibi RK, Aalirezaie A, Adib F, Anoushiravani A, Bhashyam A, Binlaksar R, Blevins K, Bonanzinga T, Chih-Kuo F, Cordova M, Deirmengian GK, Fillingham Y, Frenkel T, Gomez J, Gundtoft P, Harris MA, Harris M, Heller S, Jennings JA, Jiménez-Garrido C, Karam JA, Khlopas A, Klement MR, Komnos G, Krebs V, Lachiewicz P, Miller AO, Mont MA, Montañez E, Romero CA, Schwarzkopf R, Shaffer A, Sharkey PF, Smith BM, Sodhi N, Thienpont E, Villanueva AO, Yazdi H.
J Arthroplasty. 2019 Feb;34(2S):S157-S168.
A soft 3D polyacrylate hydrogel recapitulates the cartilage niche and allows growth-factor free tissue engineering of human articular cartilage.
Jiménez G, Venkateswaran S, López-Ruiz E, Perán M, Pernagallo S, Díaz-Monchón JJ, Canadas RF, Antich C, Oliveira JM, Callanan A, Walllace R, Reis RL, Montañez E, Carrillo E, Bradley M, Marchal JA.
Acta Biomater. 2019 May;90:146-156.
Cartilage degeneration or damage treatment is still a challenge, but, tissue engineering strategies, which combine cell therapy strategies, which combine cell therapy and scaffolds, and have emerged as a promising new approach. In this regard, polyurethanes and polyacrylates polymers have been shown to have clinical potential to treat osteochondral injuries. Here, we have used polymer microarrays technology to screen 380 different polyurethanes a […]
Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome.
Oliva-Olivera W, Leiva Gea A, Lhamyani S, Coín-Aragüez L, Alcaide Torres J, Bernal-López MR, García-Luna PP, Morales Conde S, Fernández-Veledo S, El Bekay R, Tinahones FJ.
Endocrinology. 2015 Dec;156(12):4492-501.
Multiple studies have suggested that the reduced differentiation capacity of multipotent adipose tissue-derived mesenchymal stem cells (ASCs) in obese subjects could compromise their use in cell therapy. Our aim was to assess the osteogenic potential of omental ASCs and to examine the status of the isolated CD34(negative)-enriched fraction of omental-derived ASCs from subjects with different metabolic profiles. Omental ASCs from normal-weight sub […]
Cross-cultural selection and validation of instruments to assess patient-reported outcomes in children and adolescents with achondroplasia.
Bloemeke J, Sommer R, Witt S, Bullinger M, Nordon C, Badia FJ, González FL, Leiva-Gea A, Delgado Rufino FB, Mayoral-Cleries F, Romero-Sanchiz P, Clamagirand Saiz V, Nogueira-Arjona R, Mohnike K, Quitmann J.
Qual Life Res. 2019 May 15.
Achondroplasia, as the most common form of disproportionate short stature, potentially impacts the health-related quality of life (HRQOL) and functioning of people with this condition. Because there are no psychometrically validated patient-reported outcome (PRO) condition-specific instruments for achondroplasia, this study selected and tested available generic, disease-specific and under development questionnaires for possible use in multination […]
Espejo-Baena A, Espejo-Reina A, Espejo-Reina MJ, Martín-Castilla MB, Dalla-Rosa Nogales J, Sevillano-Pérez E.
Arthrosc Tech. 2017 May 22;6(3):e621-e626.
A technique for posterior meniscal root reinsertion is presented. With the arthroscope in the central transtendinous portal for a better view, a 5-mm transtibial tunnel is created with the aid of an anterior cruciate ligament guide open to 45°. A suture device, which consists of a long needle with an eyelet on its tip, is introduced through the tunnel with a suture thread inserted through the eyelet, while the meniscus is stabilized with a grasp […]
«Over the Top» Augmentation for Partial Anterior Cruciate Ligament Tears Using Suspension Device for Tibial Fixation.
Espejo-Baena A, Espejo-Reina A, Espejo-Reina MJ, Rosa-Nogales JD, Ruiz-Del Pino J, Martín-Castilla MB.
Arthrosc Tech. 2018 Jun 11;7(7):e731-e737.
A technique for augmentation of the partial anterior cruciate ligament is presented. The patient is positioned supine with the knee flexed 90°. After addressing intra-articular injuries, the autologous semitendinosus tendon is harvested and measured in a doubled manner; after that, the tibial tunnel is performed in the outside-in direction, of the same diameter of the doubled graft. Both ends of the graft are sutured together, after inserting it […]
Gómez-Palomo JM, Jiménez-Garrido C, Martínez-Crespo A, García-Vera JJ, Pérez-Cardeña J, Montañez-Heredia E.
JBJS Case Connect. 2019 Jul 30.
A 24-year-old female diagnosed with fibroblastic osteosarcoma of the patella underwent a total patellectomy and surgical reconstruction with a large bone-tendon allograft of the extensor mechanism and adjuvant chemotherapy. At 5 years’ postoperative, the patient has adequate disease control and excellent joint function. […]