Lineas de Investigación

01. Neuroinflamación y respuesta glial en la enfermedad de Alzheimer.

02. Descifrar nuevos mecanismos (enfoques) patogénicos implicados en la enfermedad de Alzheimer que permitan un mayor éxito traslacional a la clínica humana. Identificación de biomarcadores y dianas terapéuticas.

03. Desarrollo de nuevos modelos animales de la enfermedad de Alzheimer que recapitulen mejor la patología de los pacientes. Estudios preclínicos de nuevas estrategias terapéuticas.

04. Desarrollo de modelos in vitro de la enfermedad de Alzheimer mediante el empleo de células iPSCs derivadas de pacientes. Estudios de mecanismos patogénicos y evaluación de nuevos fármacos.



Proyectos de Investigación

PI-0276-2018 Inmunidad Innata Cerebral y Periférica en la Enfermedad de Alzheimer: Disección Molecular de Nuevas Vías Patogénicas y Potencial Terapéutico

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer’s disease

Baglietto-Vargas, D; Prieto, GA; Limon, A; Forner, S; Rodriguez-Ortiz, CJ; Ikemura, K; Ager, RR; Medeiros, R; Trujillo-Estrada, L; Martini, AC; Kitazawa, M; Davila, JC; Cotman, CW; Gutierrez, A; LaFerla, FM
Aging Cell 2018


Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration

Garcia-Leon, JA; Cabrera-Socorro, A; Eggermont, K; Swijsen, A; Terryn, J; Fazal, R; Nami, F; Ordovas, L; Quiles, A; Lluis, F; Serneels, L; Wierda, K; Sierksma, A; Kreir, M; Pestana, F; Van Damme, P; De Strooper, B; Thorrez, L; Ebneth, A; Verfaillie, CM
Alzheimers & Dementia 2018


Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Horiuchi, K; Perez-Cerezales, S; Papasaikas, P; Ramos-Ibeas, P; Lopez-Cardona, AP; Laguna-Barraza, R; Balvis, NF; Pericuesta, E; Fernandez-Gonzalez, R; Planells, B; Viera, A; Suja, JA; Ross, PJ; Alen, F; Orio, L; de Fonseca, FR; Pintado, B; Valcarcel, J; Gutierrez-Adan, A
Cell Reports 2018


Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative

Navarro, V; Sanchez-Mejias, E; Jimenez, S; Munoz-Castro, C; Sanchez-Varo, R; Davila, JC; Vizuete, M; Gutierrez, A; Vitorica, J
Frontiers In Aging Neuroscience 2018


Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology

Romero-Molinar, C; Navarro, V; Sanchez-Varo, R; Jimenez, S; Fernandez-Valenzuela, JJ; Sanchez-Mico, MV; Munoz-Castro, C; Gutierrez, A; Vitorica, J; Vizuete, M
Frontiers In Cellular Neuroscience 2018


Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer’s disease

Gomez-Arboledas, A; Davila, JC; Sanchez-Mejias, E; Navarro, V; Nunez-Diaz, C; Sanchez-Varo, R; Sanchez-Mico, MV; Trujillo-Estrada, L; Fernandez-Valenzuela, JJ; Vizuete, M; Comella, JX; Galea, E; Vitorica, J; Gutierrez, A
Glia 2018


A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

Garcia-Bonilla, Maria; Garcia-Martin, Maria L; Munoz-Hernandez, M Carmen; Dominguez-Pinos, Dolores; Martinez-Leon, Maria I; Penalver, Ana; Castilla, Laura; Alonso, Francisco J; Marquez, Javier; Shumilov, Kirill; Hidalgo-Sanchez, Ramon; Gutierrez, Antonia; Paez-Gonzalez, Patricia; Jimenez, Antonio J
Journal Of Neuropathology And Experimental Neurology 2018


SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

Garcia-Leon, JA; Kumar, M; Boon, R; Chau, D; One, J; Wolfs, E; Eggermont, K; Berckmans, P; Gunhanlar, N; de Vrij, F; Lendemeijer, B; Pavie, B; Corthout, N; Kushner, SA; Davila, JC; Lambrichts, I; Hu, WS; Verfaillie, CM
Stem Cell Reports 2018

Dual roles of A beta in proliferative processes in an amyloidogenic model of Alzheimer»s disease

Baglietto-Vargas, D; Sanchez-Mejias, E; Navarro, V; Jimenez, S; Trujillo-Estrada, L; Gomez-Arboledas, A; Sanchez-Mico, M; Sanchez-Varo, R; Vizuete, M; Davila, JC; Garcia-Verdugo, JM; Vitorica, J; Gutierrez, AScientific Reports. 2017

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017

N370S-GBA1 Mutation Causes Lysosomal Cholesterol Accumulation in Parkinson»s Disease

Garcia-Sanz, P; Orgaz, L; Bueno-Gil, G; Espadas, I; Rodriguez-Traver, E; Kulisevsky, J; Gutierrez, A; Davila, JC; Gonzalez-Polo, RA; Fuentes, JM; Mir, P; Vicario, C; Moratalla, RMovement Disorders. 2017


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