Lineas de Investigación

Estudio de las bases biológicas del comportamiento y la fisiopatología de enfermedades degenerativas de gran prevalencia. Estas incluyen los trastornos adictivos (abuso de drogas), los trastornos de la alimentación (obesidad, diabetes, dislipemia), la enfermedad de Alzheimer, así como los síndromes de ansiedad y depresión, a lo largo del desarrollo y en modelos de enfermedad (comorbilidad psiquiátrica)..

01. Esteatohepatitis alcohólica y no alcohólica.

02. Programación metabólica durante el desarrollo y crecimiento (obesidad, diabetes)

03. Desarrollo de nuevas entidades químicas terapéuticas o nuevas indicaciones de fármacos existentes.

05 Evaluación farmacológica de alimentos de uso médico especial (ADUME).



Proyectos de Investigación

Papel del ácido lisofosfatídico en el alcoholismo y la cormobilidad psiquiátrica: implicaciones terapéuticas y evaluación de biomarcadores

CONSEJERÍA DE SALUD
: Proyectos de Investigación biomédica y en ciencias de la salud. Consejería de Salud 2016

Early life stress and excessive alcohol consumption in adolescents: Role of the endocannabinoid system in the vulnerability to alcoholism

INSTITUTO DE SALUD CARLOS III
Proyecto de Investigación Miguel Servet Tipo I. Instituto de Salud Carlos III. 2015

Red de Trastornos Adictivos (Red RTA)

INSTITUTO DE SALUD CARLOS III
RETICS. Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación 2013

Implicación del Sistema endocannabinoide en la vulnerabilidad al alcoholismo en adultos tras el consumo abusivo durante la adolescencia

CONSEJERÍA DE SALUD
Consejería de Salud 2013

CD17/00125 Sara Borrell 2017 Victor Echeverry Alzaty.Jefe de Grupo Fernando Rodriguez de Fonseca

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS SARA BORRELL 2017

PI-0140-2018 Estudio traslacional del papel del ácido lisofosfatídico (LPA) en los trastornos por uso de alcohol

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

FI17/00027 Contrato PFIS 2017 Laura Sanchez Marin.Jefe de Grupo: Fernando Rodriguez de Fonseca

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS PFIS: CONTRATOS PREDOCTORALES DE FORMACIÓN EN INVESTIGACIÓN EN SALUD 2017

PI-0139-2018 ESTUDIO DE LA ACTIVACIÓN DEL RECEPTOR PARA GLP1 COMO BASE DEL DESARROLLO DE TERAPIAS COMBINADAS PARA EL TRATAMIENTO DE LA ESTEATOHEPATITIS NO ALCOHÓLICA

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

CPII17/00024 Miiguel Servet Tipo II 2017 Juan Suarez Pérez

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONTRATOS MIGUEL SERVET TIPO II 2017

PI16/01374 Obesidad infantil grave de comienzo precoz al diagnóstico y tras pérdida ponderal: Fundamentos metabólicos, hormonales, genéticos, genómicos, metabolómicos y de microbiota

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

MS14/00212 Contrato Miguel Servet Tipo I Francisco Javier Pavón Morón

INSTITUTO DE SALUD CARLOS III
CONTRATOS MIGUEL SERVET TIPO I 2014

PND2018/033 Dimorfismo sexual en la expresión de sistemas de señalización inflamatorios de células blancas en pacientes con trastornos por uso de alcohol: Utilidad como biomarcadores de adicción.

MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIAL
PROYECTOS DE INVESTIGACIÓN SOBRE ADICCIONES 2018

PI16/01953 Estudio Traslacional del Sistema de Señalización de Quimioquina CX3CL1/R1 en la Adicción a Alcohol: Papel como Biomarcador Neuroinflamatorio

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

RC-0003-2018 Acción C Nicolás Monarde F.Rodríguez de Fonseca

SERVICIO ANDALUZ DE SALUD
RENOVACIÓN ACCIÓN C (PROGRAMA NICOLÁS MONARDES) DE LA CONVOCATORIA 2018

PRX18/00608 Estancias de movilidad de profesores e investigadores seniores en centros extranjeros de enseñanza superior e investigación, incluido el Programa Salvador de Madariaga 2018. Investigador: Fernando Antonio Rodríguez de Fonseca

MINISTERIO DE EDUCACIÓN Y FORMACIÓN PROFESIONAL
ESTANCIAS PROGRAMA SALVADOR DE MADARIAGA 2018

RD16/0017/0001 Red de Trastornos Adictivos

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

PND2018/044 BIOMARCADORES CIRCULANTES DE COMORBILIDAD PSIQUIÁTRICA EN EL TRASTORNO POR USO DE DROGAS: COMPARACIÓN CON BIOMARCADORES DE TRASTORNO DEPRESIVO Y TRASTORNO PSICÓTICO

MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIAL
PROYECTOS DE INVESTIGACIÓN SOBRE ADICCIONES 2018

RTC-2016-4983-1 Diseño, ingeniería y ensamblaje de línea piloto de nuevos extractos naturales solvent free y validacion in vivo de compuestos bioactivos

MINISTERIO DE ECONOMIA Y EMPRESA
AYUDAS PARA I+D+i RETOS COLABORACIÓN 2016

PI16/01698 Lípidos transmisores derivados del ácido oleico: Estudio traslacional de su papel en los trastornos por uso de alcohol

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2016

DTS16/00115 Desarrollo de nuevos conjugados de ácidos grasos para el tratamiento de las esteatohepatitis

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE DESARROLLO TECNOLÓGICO EN SALUD 2016

PSI2015-73156-JIN Incremento de la neurogénesis hipocampal adulta como estrategia terapéutica para las alteraciones conductuales inducidas por cocaína (COCANEUROGNSIS)

MINISTERIO DE ECONOMIA Y EMPRESA
PROYECTOS I+D+i PARA JÓVENES INVESTIGADORES 2015

MS14/00173 Contrato Miguel Servet Tipo I Antonia Mª Serrano Criado

INSTITUTO DE SALUD CARLOS III
CONTRATOS MIGUEL SERVET TIPO I 2014

2017i043 Consumo de alcohol durante la adolescencia: papel del sistema endocannabinoide en el desarrollo de adicción al alcohol y trastornos afectivos y de ansiedad comórbidos

MINISTERIO DE SANIDAD, CONSUMO Y BIENESTAR SOCIAL
PROYECTOS DE INVESTIGACIÓN SOBRE ADICCIONES 2017

PI17/02026 Estudio Traslacional del Papel del Sistema Endocannabinoide en la Amígdala Ampliada en la Ansiedad Asociada a la Dependencia Alcohólica

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD (FIS) 2017


Publicaciones científicas

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  • Otro

Cooperative role of the glucagon-like peptide-1 receptor and 3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats

Decara, J; Rivera, P; Arrabal, S; Vargas, A; Serrano, A; Pavon, FJ; Dieguez, C; Nogueiras, R; de Fonseca, FR; Suarez, J
Acta Physiologica 2018


Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood

Rivera, Patricia; Ramirez-Lopez, Maria T; Vargas, Antonio; Decara, Juan; Vazquez, Mariam; Arco, Rocio; Gomez de Heras, Raquel; Argente, Jesus; Rodriguez de Fonseca, Fernando; Chowen, Julie A; Suarez, Juan…Menos
Acta Physiologica (Oxford, England) 2018


Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study

Moreno, M; Decara, J; Pavon, FJ; Stouffer, DG; Edwards, S; Serrano, A; Suarez, J; Parsons, LH; de Fonseca, FR
Addiction Biology 2018


Cognitive and neurobehavioral benefits of an enriched environment on young adult mice after chronic ethanol consumption during adolescence.

Rico-Barrio I1,2, Peñasco S1,2, Puente N1,2, Ramos A1,2, Fontaine CJ3, Reguero L1,2, Giordano ME4, Buceta I1,2, Terradillos I1,2, Lekunberri L1, Mendizabal-Zubiaga J1,2, Rodríguez de Fonseca F5, Gerrikagoitia I1,2, Elezgarai I1,2, Grandes P1,2,3.
Addiction Biology


Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice.

Pavón FJ1,2, Serrano A1,2, Stouffer DG1, Polis I1, Roberto M1, Cravatt BF3, Martin-Fardon R1, Rodríguez de Fonseca F2, Parsons LH1.
Addiction Biology


Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens

Pavon, FJ; Serrano, A; Sidhpura, N; Polis, I; Stouffer, D; de Fonseca, FR; Cravatt, BF; Martin-Fardon, R; Parsons, LH
Addiction Biology 2018


Increased plasma oleoylethanolamide and palmitoleoylethanolamide levels correlate with inflammatory changes in alcohol binge drinkers: the case of HMGB1 in women

Anton, M; Rodriguez-Gonzalez, A; Rodriguez-Rojo, IC; Pastor, A; Correas, A; Serrano, A; Ballesta, A; Alen, F; de Heras, RG; de la Torre, R; de Fonseca, FR; Orio, L
Addiction Biology 2018


Larry Parsons: Researcher, mentor, and friend

Frantz, K; Roberto, M; Mason, B; Koob, GF; Volkow, N; de Fonseca, FR
Addiction Biology 2018


Lysophosphatidic acid-induced increase in adult hippocampal neurogenesis facilitates the forgetting of cocaine-contextual memory.

Ladron de Guevara-Miranda, David; Moreno-Fernandez, Roman Dario; Gil-Rodriguez, Sara; Rosell-Valle, Cristina; Estivill-Torrus, Guillermo; Serrano, Antonia; Pavon, Francisco J; Rodriguez de Fonseca, Fernando; Santin, Luis J; Castilla-Ortega, Estela
Addiction Biology


Red Bull (R) energy drink increases consumption of higher concentrations of alcohol

Roldan, M; Echeverry-Alzate, V; Buhler, KM; Sanchez-Diez, IJ; Calleja-Conde, J; Olmos, P; Boehm, SL; Maldonado, R; de Fonseca, FR; Santiago, C; Gomez-Gallego, F; Gine, E; Lopez-Moreno, JA
Addiction Biology 2018


Special issue honoring the legacy of Loren H. Parsons

Roberto, M; de Fonseca, FR
Addiction Biology 2018


Young alcohol binge drinkers have elevated blood endotoxin, peripheral inflammation and low cortisol levels: neuropsychological correlations in women

Orio, L; Anton, M; Rodriguez-Rojo, IC; Correas, A; Garcia-Bueno, B; Corral, M; de Fonseca, FR; Garcia-Moreno, LM; Maestu, F; Cadaveira, F
Addiction Biology 2018


Patients with alcohol use disorder: initial results from a prospective multicenter registry in the Spanish Network on Addiction Disorders. CohRTA Study

Sanvisens, A; Zuluaga, P; Rivas, I; Rubio, G; Gual, A; Torrens, M; Short, A; Alvarez, FJ; Tor, J; Farre, M; de Fonseca, FR; Muga, R
Adicciones 2018


Inclusion of Alcoholic Associations Into a Public Treatment Programme for Alcoholism Improves Outcomes During the Treatment and Continuing Care Period: A 6-Year Experience

Rubio, G; Marin, M; Arias, F; Lopez-Trabada, JR; Iribarren, M; Alfonso, S; Prieto, R; Blanco, A; Urosa, B; Montes, V; Jurado, R; Jimenez-Arriero, MA; de Fonseca, FR
Alcohol And Alcoholism 2018


Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure

Rivera, P; Fernandez-Arjona, MD; Silva-Pena, D; Blanco, E; Vargas, A; Lopez-Avalos, MD; Grondona, JM; Serrano, A; Pavon, FJ; de Fonseca, FR; Suarez, J
Biochemical Pharmacology 2018


PPAR alpha/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models

Alen, F; Decara, J; Brunori, G; You, ZB; Buhler, KM; Lopez-Moreno, JA; Cippitelli, A; Pavon, FJ; Suarez, J; Gardner, EL; de la Torre, R; Ciccocioppo, R; Serrano, A; de Fonseca, FR
Biochemical Pharmacology 2018


Oleoylethanolamide and Palmitoylethanolamide Protect Cultured Cortical Neurons Against Hypoxia.

Portavella, Manuel; Rodriguez-Espinosa, Nieves; Galeano, Pablo; Blanco, Eduardo; Romero, Juan I; Holubiec, Mariana I; Rodriguez de Fonseca, Fernando; Fernandez-Espejo, Emilio
Cannabis And Cannabinoid Research 2018


Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice

Horiuchi, K; Perez-Cerezales, S; Papasaikas, P; Ramos-Ibeas, P; Lopez-Cardona, AP; Laguna-Barraza, R; Balvis, NF; Pericuesta, E; Fernandez-Gonzalez, R; Planells, B; Viera, A; Suja, JA; Ross, PJ; Alen, F; Orio, L; de Fonseca, FR; Pintado, B; Valcarcel, J; Gutierrez-Adan, A
Cell Reports 2018


Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway

Roman, MF; Sara, T; Estela, CO; Margarita, PM; Guillermo, ET; Fernando, RD; Javier, SL; Carmen, P
Current Neuropharmacology 2018


Effects of genetic deletion versus pharmacological blockade of the LPA(1) receptor on depression-like behaviour and related brain functional activity

Moreno-Fernandez, RD; Nieto-Quero, A; Gomez-Salas, FJ; Chun, J; Estivill-Torrus, G; de Fonseca, FR; Santin, LJ; Perez-Martin, M; Pedraza, C
Disease Models & Mechanisms 2018


Octadecylpropyl Sulfamide Reduces Neurodegeneration and Restores the Memory Deficits Induced by Hypoxia-Ischemia in Mice

Kossatz, E; Silva-Pena, D; Suarez, J; de Fonseca, FR; Maldonado, R; Robledo, P
Frontiers In Pharmacology 2018


Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders

Garcia-Marchena, N; de Guevara-Miranda, DL; Pedraz, M; Araos, PF; Rubio, G; Ruiz, JJ; Pavon, FJ; Serrano, A; Castilla-Ortega, E; Santin, LJ; de Fonseca, FR
Frontiers In Psychiatry 2018


Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis

Sampedro-Piquero, P; Moreno-Fernandez, RD; Manas-Padilla, MC; Gil-Rodriguez, S; Gavito, AL; Pavon, FJ; Pedraza, C; Garcia-Fernandez, M; de Guevara-Miranda, DL; Santin, LJ; Castilla-Ortega, E
Neurobiology Of Learning And Memory 2018


Systemic blockade of LPA(1/3) lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior

Sanchez-Maran, L; de Guevara-Miranda, DL; Manas-Padilla, MC; Alen, F; Moreno-Fernandez, RD; Diaz-Navarro, C; Perez-del Palacio, J; Garcia-Fernandez, M; Pedraza, C; Pavon, FJ; de Fonseca, FR; Santin, LJ; Serrano, A; Castilla-Ortega, E
Neuropharmacology 2018


Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake

Serrano, A; Pavon, FJ; Buczynski, MW; Schlosburg, J; Natividad, LA; Polis, IY; Stouffer, DG; Zorrilla, EP; Roberto, M; Cravatt, BF; Martin-Fardon, R; de Fonseca, FR; Parsons, LH
Neuropsychopharmacology 2018


Neuroplastic and cognitive impairment in substance use disorders: a therapeutic potential of cognitive stimulation.

Sampedro-Piquero, Patricia; de Guevara-Miranda, David Ladron; Pavon, Francisco J; Serrano, Antonia; Suarez, Juan; de Fonseca, Fernando Rodriguez; Santin, Luis J; Castilla-Ortega, Estela
Neuroscience And Biobehavioral Reviews 2018


Palmitoylethanolamide attenuates cocaine-induced behavioral sensitization and conditioned place preference in mice

Zambrana-Infantes, E; del Valle, CR; de Guevara-Miranda, DL; Galeano, P; Castilla-Ortega, E; De Fonseca, FR; Blanco, E; Santin, LJ
Pharmacology Biochemistry And Behavior 2018


Adult-onset hypothyroidism increases ethanol consumption.

Echeverry-Alzate, V; Buhler, K M; Calleja-Conde, J; Huertas, E; Maldonado, R; Rodriguez de Fonseca, F; Santiago, C; Gomez-Gallego, F; Santos, A; Gine, E; Lopez-Moreno, J A
Psychopharmacology 2018


Palmitoylethanolamide prevents neuroinflammation, reduces astrogliosis and preserves recognition and spatial memory following induction of neonatal anoxia-ischemia

Holubiec, MI; Romero, JI; Suarez, J; Portavella, M; Fernandez-Espejo, E; Blanco, E; Galeano, P; de Fonseca, FR
Psychopharmacology 2018


Impact of Percutaneous Coronary Revascularization of Severe Coronary Lesions on Secondary Branches.

Silva-Pena, Daniel; Garcia-Marchena, Nuria; Alen, Francisco; Araos, Pedro; Rivera, Patricia; Vargas, Antonio; Garcia-Fernandez, Maria Inmaculada; Martin-Velasco, Ana Isabel; Villanua, Maria Angeles; Castilla-Ortega, Estela; Santin, Luis; Pavon, Francisco Javier; Serrano, Antonia; Rubio, Gabriel; Rodriguez de Fonseca, Fernando; Suarez, Juan
Revista Espanola De Cardiologia (English Ed.) 2018


Inflammatory gene expression in adipose tissue according to diagnosis of anxiety and mood disorders in obese and non-obese subjects

Coin-Araguez, L; Pavon, FJ; Contreras, A; Gentile, AM; Lhamyani, S; De Diego-Otero, Y; Casado, Y; Olivera, WO; Olveira, G; Tinahones, FJ; Costillas, LP; El Bekay, R
Scientific Reports 2018


The adiponectin promoter activator NP-1 induces high levels of circulating TNF alpha and weight loss in obese (fa/fa) Zucker rats

Decara, J; Serrano, A; Pavon, FJ; Rivera, P; Arco, R; Gavito, A; Vargas, A; Navarro, JA; Tovar, R; Lopez-Gambero, AJ; Martinez, A; Suarez, J; de Fonseca, FR; Baixeras, E
Scientific Reports 2018


Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats.

Silva-Pena, Daniel; Garcia-Marchena, Nuria; Alen, Francisco; Araos, Pedro; Rivera, Patricia; Vargas, Antonio; Garcia-Fernandez, Maria Inmaculada; Martin-Velasco, Ana Isabel; Villanua, Maria Angeles; Castilla-Ortega, Estela; Santin, Luis; Pavon, Francisco Javier; Serrano, Antonia; Rubio, Gabriel; Rodriguez de Fonseca, Fernando; Suarez, Juan…Menos
Addiction Biology

A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner

Ramirez-Lopez, MT; Vazquez, M; Lomazzo, E; Hofmann, C; Blanco, RN; Alen, F; Anton, M; Decara, J; Arco, R; Orio, L; Suarez, J; Lutz, B; de Heras, RG; Bindila, L; de Fonseca, FRPlos One. 2017

A Positive Allosteric Modulator of the Serotonin 5-HT2c Receptor for Obesity

Garcia-Carceles, J; Decara, JM; Vazquez-Villa, H; Rodriguez, R; Codesido, E; Cruces, J; Brea, J; Loza, MI; Alen, F; Botta, J; McCormick, PJ; Ballesteros, JA; Benhamu, B; de Fonseca, FR; Lopez-Rodriguez, MLJournal Of Medicinal Chemistry. 2017

Acetaminophen-Induced Liver Injury Alters the Acyl Ethanolamine-Based Anti-Inflammatory Signaling System in Liver

Rivera, P; Pastor, A; Arrabal, S; Decara, J; Vargas, A; Sanchez-Marin, L; Pavon, FJ; Serrano, A; Bautista, D; Boronat, A; de la Torre, R; Baixeras, E; Lucena, MI; de Fonseca, FR; Suarez, JFrontiers In Pharmacology. 2017

Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders

Garcia-Marchena, N; Silva-Pena, D; Martin-Velasco, AI; Villanua, MA; Araos, P; Pedraz, M; Maza-Ouiroga, R; Romero-Sanchiz, P; Rubio, G; Castilla-Ortega, E; Suarez, J; de Fonseca, FR; Serrano, A; Pavon, FJPlos One. 2017

Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera, A; Gago, B; Suarez-Boomgaard, D; Yoshitake, T; Roales-Bujan, R; Valderrama-Carvajal, A; Bilbao, A; Medina-Luque, J; Diaz-Cabiale, Z; Van Craenenbroeck, K; Borroto-Escuela, DO; Kehr, J; de Fonseca, FR; Santin, L; de la Calle, A; Fuxe, KAddiction Biology. 2017

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

de Guevara-Miranda, DL; Millon, C; Rosell-Valle, C; Perez-Fernandez, M; Missiroli, M; Serrano, A; Pavon, FJ; de Fonseca, FR; Martinez-Losa, M; Alvarez-Dolado, M; Santin, LJ; Castilla-Ortega, EDisease Models & Mechanisms. 2017

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernandez, RD; Perez-Martin, M; Castilla-Ortega, E; del Valle, CR; Garcia-Fernandez, MI; Chun, J; Estivill-Torrus, G; de Fonseca, FR; Santin, LJ; Pedraza, CTranslational Psychiatry. 2017

Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat frontal cortex and depressive-like behavior induced by ethanol binge administration

Anton, M; Alen, F; de Heras, RG; Serrano, A; Pavon, FJ; Leza, JC; Garcia-Bueno, B; de Fonseca, FR; Orio, LAddiction Biology. 2017

Plasma concentrations of oleoylethanolamide and other acylethanolamides are altered in alcohol-dependent patients: effect of length of abstinence

Garcia-Marchena, N; Pavon, FJ; Pastor, A; Araos, P; Pedraz, M; Romero-Sanchiz, P; Calado, M; Suarez, J; Castilla-Ortega, E; Orio, L; Boronat, A; Torrens, M; Rubio, G; de la Torre, R; de Fonseca, FR; Serrano, AAddiction Biology. 2017

Prevalence of problematic cell phone use in an adult population in Spain as assessed by the Mobile Phone Problem Use Scale (MPPUS)

De-Sola, JA; Talledo, H; de Fonseca, FR AUTOR PETICION DE COPIAS; Rubio, GPlos One. 2017

Text mining and expert curation to develop a database on psychiatric diseases and their genes

Gutierrez-Sacristan, A; Bravo, A; Portero-Tresserra, M; Valverde, O; Armario, A; Blanco-Gandia, MC; Farre, A; Fernandez-Ibarrondo, L; Fonseca, F; Giraldo, J; Leis, A; Mane, A; Mayer, MA; Montagud-Romero, S; Nadal, R; Ortiz, J; Pavon, FJ; Perez, EJ; Rodriguez-Arias, M; Serrano, A; Torrens, M; Warnault, V; Sanz, F; Furlong, LIDatabase-The Journal Of Biological Databases And Curation. 2017

The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice

Gine, E; Echeverry-Alzate, V; Lopez-Moreno, JA; de Fonseca, FR; Perez-Castillo, A; Santos, ANeuropharmacology. 2017

The impact of cocaine on adult hippocampal neurogenesis: Potential neurobiological mechanisms and contributions to maladaptive cognition in cocaine addiction disorder.

Castilla-Ortega, Estela; Ladron de Guevara-Miranda, David; Serrano, Antonia; Pavon, Francisco J; Suarez, Juan; Rodriguez de Fonseca, Fernando; Santin, Luis JBiochemical Pharmacology. 2017

Development of a Mobile Phone addiction craving scale and its Validation in a spanish adult Population

De-Sola, J; Talledo, H; Rubio, G; de Fonseca, FRFrontiers In Psychiatry. 2017

Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation

Sanchez-Marin, L; Pavon, FJ; Decara, J; Suarez, J; Gavito, A; Castilla-Ortega, E; de Fonseca, FR; Serrano, AFrontiers In Behavioral Neuroscience. 2017

Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGF alpha) as a potential biomarker of consumption and dual diagnosis

Maza-Quiroga, R; Garcia-Marchena, N; Romero-Sanchiz, P; Barrios, V; Pedraz, M; Serrano, A; Nogueira-Arjona, R; Ruiz, JJ; Soria, M; Campos, R; Chowen, JA; Argente, J; Torrens, M; Lopez-Gallardo, M; Marco, EM; de Fonseca, FR; Pavon, FJ; Araos, PPeerj. 2017

Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats

Marco, EM; Penasco, S; Hernandez, MD; Gil, A; Borcel, E; Moya, M; Gine, E; Lopez-Moreno, JA; Guerri, C; Lopez-Gallardo, M; de Fonseca, FRFrontiers In Behavioral Neuroscience. 2017

Neuronal Damage Induced by Perinatal Asphyxia Is Attenuated by Postinjury Glutaredoxin-2 Administration

Romero, JI; Holubiec, MI; Tornatore, TL; Riviere, S; Hanschmann, EM; Kolliker-Frers, RA; Tau, J; Blanco, E; Galeano, P; de Fonseca, FR; Lillig, CH; Capani, FOxidative Medicine And Cellular Longevity. 2017

Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity

Garcia-Marchena, N; Araos, PF; Barrios, V; Sanchez-Marin, L; Chowen, JA; Pedraz, M; Castilla-Ortega, E; Romero-Sanchiz, P; Ponce, G; Gavito, AL; Decara, J; Silva, D; Torrens, M; Argente, J; Rubio, G; Serrano, A; de Fonseca, FR; Pavon, FJFrontiers In Psychiatry. 2017

Psychological Factors and Alcohol Use in Problematic Mobile Phone Use in the Spanish Population

De-Sola, J; Talledo, H; Rubio, G; de Fonseca, FRFrontiers In Psychiatry. 2017

Acylethanolamides and endocannabinoid signaling system in dorsal striatum of rats exposed to perinatal asphyxia

Holubiec, MI; Romero, JI; Blanco, E; Tornatore, TL; Suarez, J; de Fonseca, FR; Galeano, P; Capani, FNeuroscience Letters. 2017

Differences in the Rates of Drug Polyconsumption and Psychiatric Comorbidity among Patients with Cocaine Use Disorders According to the Mental Health Service

Araos, P; Vergara-Moragues, Esperanza; Gonzalez-Saiz, Francisco; Pedraz, Maria; Garcia-Marchena, Nuria; Romero-Sanchiz, Pablo; Ruiz, Juan Jesus; Campos-Cloute, Rafael; Serrano, Antonia; Pavon, Francisco Javier; Torrens, Marta; Rodriguez De Fonseca, FernandoJournal Of Psychoactive Drugs. 2017

Glutamate and Brain Glutaminases in Drug Addiction

Marquez, J; Campos-Sandoval, JA; Penalver, A; Mates, JM; Segura, JA; Blanco, E; Alonso, FJ; de Fonseca, FRNeurochemical Research. 2017

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

Millon, C; Flores-Burgess, A; Narvaez, M; Borroto-Escuela, DO; Gago, B; Santin, L; Castilla-Ortega, E; Narvaez, JA; Fuxe, K; Diaz-Cabiale, ZNeuropeptides. 2017

Psychiatric comorbidity and plasma levels of 2-acyl-glycerols in outpatient treatment alcohol users. Analysis of gender differences

Garcia-Marchena, N; Araos, P; Pavon, FJ; Ponce, G; Pedraz, M; Serrano, A; Arias, F; Romero-Sanchiz, P; Suarez, J; Pastor, A; de la Torre, R; Torrens, M; Rubio, G; de Fonseca, FRAdicciones. 2017


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