{"id":39568,"date":"2024-08-13T10:44:38","date_gmt":"2024-08-13T10:44:38","guid":{"rendered":"https:\/\/ibima.eu\/?p=39568"},"modified":"2024-08-13T10:44:41","modified_gmt":"2024-08-13T10:44:41","slug":"pro-euro-dili-registry","status":"publish","type":"post","link":"https:\/\/ibima.eu\/en\/pro-euro-dili-registry\/","title":{"rendered":"Pro-Euro-DILI Registry"},"content":{"rendered":"\n[et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbProspective European Drug-Induced Liver Injury Registry\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#0C71C3&#8243; module_alignment=\u00bbcenter\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb2_3,1_3&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb2_3&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a741fef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a741fef\" data-element_type=\"section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f9afe9b\" data-id=\"f9afe9b\" data-element_type=\"column\">\n<div class=\"elementor-widget-wrap elementor-element-populated\">\n<div class=\"elementor-element elementor-element-12113c9 elementor-widget elementor-widget-text-editor\" data-id=\"12113c9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<p><span><span style=\"color: #000000;\"><strong>Financed by<\/strong>:<\/span>\u00a0<a href=\"easl.eu\/easl\/\">The European Association for the Study of the Liver<\/a><\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Programme<\/strong>:\u00a0EASL REGISTRY RESEARCH GRANTS PROGRAMME 2014<\/span><\/p>\n<p><span style=\"color: #000000;\"><strong>Rol in the project:\u00a0<\/strong>Coordinator<\/span><\/p>\n<p><span style=\"color: #000000;\"><b>Duration:\u00a0<\/b>March 2014 to March 2016<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8c5b8e5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8c5b8e5\" data-element_type=\"section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9d2e93a\" data-id=\"9d2e93a\" data-element_type=\"column\">\n<div class=\"elementor-widget-wrap elementor-element-populated\">\n<div class=\"elementor-element elementor-element-9c84891 elementor-widget elementor-widget-text-editor\" data-id=\"9c84891\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;\">Contact:\u00a0Andrade Bellido, Ra\u00fal J.<\/span><\/p>\n<p><span><span style=\"color: #000000;\">Implementation Centre<strong>:<\/strong><\/span>\u00a0<a href=\"http:\/\/www.huvv.es\/\">Hospital Universitario Virgen de la Victoria<\/a><br \/><\/span><\/p>\n<p><span><span style=\"color: #000000;\">Research group of IBIMA involved:<\/span>\u00a0<a href=\"https:\/\/ibima.eu\/en\/project\/d-05\/\">Hepatogastroenterology, Pharmacology, and Translational Clinical Therapeutics<\/a><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_3&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_post_title title=\u00bboff\u00bb meta=\u00bboff\u00bb image_height=\u00bb1000px\u00bb image_max_height=\u00bb248px\u00bb admin_label=\u00bbT\u00edtulo de publicaci\u00f3n\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bbArial||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#2ea3f2&#8243; title_font_size=\u00bb35px\u00bb meta_text_align=\u00bbcenter\u00bb background_enable_color=\u00bboff\u00bb background_enable_image=\u00bboff\u00bb text_orientation=\u00bbcenter\u00bb width=\u00bb61%\u00bb max_width=\u00bb100%\u00bb module_alignment=\u00bbcenter\u00bb min_height=\u00bb100px\u00bb height=\u00bb100px\u00bb max_height=\u00bb100px\u00bb custom_margin=\u00bb3%||1%||false|false\u00bb hover_enabled=\u00bb0&#8243; title_font_size_last_edited=\u00bboff|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_post_title][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb-9px||-49px||false|false\u00bb custom_padding=\u00bb50px||50px||true|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbABSTRACT\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_color=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb0px||19px||false|false\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3acc1b5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3acc1b5\" data-element_type=\"section\">\n<div class=\"elementor-container elementor-column-gap-default\">\n<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f4bbc10\" data-id=\"f4bbc10\" data-element_type=\"column\">\n<div class=\"elementor-widget-wrap elementor-element-populated\">\n<div class=\"elementor-element elementor-element-89d6f88 elementor-widget elementor-widget-text-editor\" data-id=\"89d6f88\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n<div class=\"elementor-widget-container\">\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">There are no evidence-based treatments for DILI; rarity of the condition and heterogeneity of the\u00a0manifestations prevents the conception and successful completion of clinical trials. Multi-centre Pro-Euro-DILI registry will provide both the infra-structure to conduct clinical trials, and also sufficient\u00a0number of well characterised patients to evaluate the efficacy of novel anti-cholestatic agents in the\u00a0resolution of DILI.<\/span><span style=\"color: #000000;\">Aims:<\/span><\/p>\n<ul>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">To set-up a multi-national registry of patients with idiosyncratic DILI enrolled prospectively <\/span><span style=\"color: #000000;\">with in-depth phenotyping including details of drug dose, duration, concomitant medications, host <\/span><span style=\"color: #000000;\">demography, comorbidity including insulin sensitivity (homeostatic model assessment; HOMA), as <\/span><span style=\"color: #000000;\">well as course of the reaction.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">To enrol similarly well-characterised control group of people who are exposed to medications <\/span><span style=\"color: #000000;\">matched for those implicated in DILI.<\/span><\/li>\n<li style=\"text-align: justify;\"><span style=\"color: #000000;\">To collect biological samples (blood, urine, stool and liver biopsy) from patients with idiosyncratic <\/span><span style=\"color: #000000;\">DILI through the course (at onset and follow-up) of the event as well as controls.<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>[\/et_pb_text][et_pb_heading title=\u00bbPartners\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_color=\u00bb#0C71C3&#8243; custom_margin=\u00bb6px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"color: #000000;\">Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA)<\/span><\/li>\n<li><span><a href=\"http:\/\/www.nottingham.ac.uk\/medicine\/about\/divisions-and-units\/nottingham-digestive-diseases-centre\/index.aspx\">Nottingham Digestive Diseases Centre<\/a><\/span><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"<p>Financed by:\u00a0The European Association for the Study of the Liver Programme:\u00a0EASL REGISTRY RESEARCH GRANTS PROGRAMME 2014 Rol in the project:\u00a0Coordinator Duration:\u00a0March 2014 to March 2016 &nbsp; Contact:\u00a0Andrade Bellido, Ra\u00fal J. Implementation Centre:\u00a0Hospital Universitario Virgen de la Victoria Research group of IBIMA involved:\u00a0Hepatogastroenterology, Pharmacology, and Translational Clinical Therapeutics There are no evidence-based treatments for DILI; rarity [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":39571,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2191],"tags":[],"class_list":["post-39568","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyectos-de-investigacion"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Pro-Euro-DILI Registry - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibima.eu\/en\/pro-euro-dili-registry\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pro-Euro-DILI Registry - Ibima\" \/>\n<meta property=\"og:description\" content=\"Financed by:\u00a0The European Association for the Study of the Liver Programme:\u00a0EASL REGISTRY RESEARCH GRANTS PROGRAMME 2014 Rol in the project:\u00a0Coordinator Duration:\u00a0March 2014 to March 2016 &nbsp; Contact:\u00a0Andrade Bellido, Ra\u00fal J. 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