{"id":44329,"date":"2024-07-25T07:13:09","date_gmt":"2024-07-25T07:13:09","guid":{"rendered":"https:\/\/ibima.eu\/?p=44329"},"modified":"2025-09-30T12:59:17","modified_gmt":"2025-09-30T12:59:17","slug":"pre-bit","status":"publish","type":"post","link":"https:\/\/ibima.eu\/en\/pre-bit\/","title":{"rendered":"PRE-BIT"},"content":{"rendered":"

[et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbUnderstanding the role of B cell phenotypes as a predictor of the efficacy and prognosis of allergen immunotherapy using allergic rhinitis to house dust mite as a model\u00bb _builder_version=\u00bb4.27.0″ _module_preset=\u00bbdefault\u00bb title_level=\u00bbh2″ title_font=\u00bb||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#0C71C3″ custom_margin=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_5,2_5″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb3_5″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n

Financed by:<\/strong> European Union<\/span><\/p>\n

Programme: H2020- Call:<\/strong><\/span> HORIZON-MSCA-2022-PF-01-01 – MSCA Postdoctoral Fellowships 2022<\/a><\/p>\n

Grant agreement ID:<\/strong> 101105416<\/a><\/span><\/p>\n

Duration:<\/strong> April 2023 – July 2025<\/span><\/p>\n

Beneficiary:<\/strong> Carlos Aranda<\/span><\/p>\n

Supervisor:<\/strong> Cristobalina Mayorga Mayorga<\/span><\/p>\n

Implementation centre:<\/strong><\/span> Hospital Regional Universitario de M\u00e1laga<\/a><\/p>\n

Research group of IBIMA involved:<\/strong><\/span> Drug and Allergen Allergic Diseases<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb2_5″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_post_title title=\u00bboff\u00bb meta=\u00bboff\u00bb admin_label=\u00bbT\u00edtulo de publicaci\u00f3n\u00bb _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb title_font=\u00bbArial||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#2ea3f2″ title_font_size=\u00bb35px\u00bb background_color=\u00bbRGBA(255,255,255,0)\u00bb text_orientation=\u00bbcenter\u00bb width=\u00bb58%\u00bb module_alignment=\u00bbcenter\u00bb custom_margin=\u00bb4%||1%||false|false\u00bb title_font_size_last_edited=\u00bboff|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_post_title][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb50px||50px||true|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbABSTRACT\u00bb _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_color=\u00bb#0C71C3″ locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][et_pb_text _builder_version=\u00bb4.27.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n

Allergic rhinitis (AR) is one of the more prevalent respiratory allergic diseases, affecting 20-30% of the global population. The inflammatory process is mediated by eosinophil infiltration and IgE secreted by plasma cells. IgE is a key component in allergies, so understanding IgE production and its inhibition is important for treating these diseases. Allergen immunotherapy (AIT) is the only treatment that targets the etiology of allergic diseases. However, the efficacy of the treatment reaches 70-80% in the best scenarios (lower for food allergy), it has a high cost, and most importantly, prediction of the effectiveness of the treatment is not possible with current biomarkers.<\/span><\/p>\n

In this proposal, the candidate seeks to better understand the phenotypes of B cells, key cells implicated in allergy that are modified with AIT. The knowledge generated by this study will provide biomarkers of AIT prognosis and even predict the outcome of the therapy by analyzing the B cell compartment in patients who are candidates for AIT.<\/span><\/p>\n

Using very innovative approaches, we will analyze the B cell repertoire involved in the resolution of AR through AIT. The B cell repertoire will be analyzed in bulk before and after AIT. In addition, antigen-specific B cells will be immortalized so the antibody sequence as well as reactivity can be studied. Moreover, we will perform an ex vivo class switch assay that could potentially predict the outcome of AIT using cytokine microenvironments like those produced by the therapy and\/or the pathogenic situations. B cell switching from IgD\/M or IgG1 to IgG2\/4 appears to be a critical step in the effectiveness of AIT because IgE memory resides in the IgG compartment. We will use AR to house dust mite patients as a model, as it is one of the most prevalent allergic diseases.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb852.6px\u00bb custom_margin=\u00bb|auto|-7px|auto||\u00bb custom_padding=\u00bb26px||26px||true|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.25.0″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbCommunication Actions\u00bb _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_color=\u00bb#0C71C3″ custom_margin=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][et_pb_heading title=\u00bb\ud83c\udfa5 World Allergy Week | Interview with Dr. Carlos Aranda Clemente\u00bb _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb title_level=\u00bbh3″ title_font=\u00bb||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#0C71C3″ module_alignment=\u00bbcenter\u00bb custom_margin=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][et_pb_text _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb14px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n

To mark the start of World Allergy Week, IBIMA Plataforma BIONAND presents an interview with Dr. Carlos Aranda, Marie Sk\u0142odowska-Curie postdoctoral researcher at our institute and member of the \u201cDrug and Allergen Hypersensitivity Diseases\u201d group, led by Drs. Mar\u00eda Jos\u00e9 Torres Ja\u00e9n and Cristobalina Mayorga.<\/span><\/p>\n

With a background in inflammatory bowel disease research and immunology training in the U.S. (NYU and Mt. Sinai), Dr. Aranda now leads the EU-funded PRE-BIT<\/strong> project, aiming to better understand the role of B cells as predictors of efficacy and prognosis in allergen immunotherapy, using house dust mite allergic rhinitis as a model.<\/span><\/p>\n

Don’t miss this inspiring testimony you can find bellow<\/span><\/p>\n

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\ud83d\udd2c On September 29th 2023, Dr. Cecilia Frecha, showcased their groundbreaking research at \u2018The European Researchers\u2019 Night\u2019 in M\u00e1laga using gamification techniques to make biomedical science engaging for everyone. \ud83c\udfae<\/span><\/p>\n

Check how it was clicking on any of our social media profiles<\/span><\/p>\n

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Financed by: European Union Programme: H2020- Call: HORIZON-MSCA-2022-PF-01-01 – MSCA Postdoctoral Fellowships 2022 Grant agreement ID: 101105416 Duration: April 2023 – July 2025 Beneficiary: Carlos Aranda Supervisor: Cristobalina Mayorga Mayorga Implementation centre: Hospital Regional Universitario de M\u00e1laga Research group of IBIMA involved: Drug and Allergen Allergic DiseasesAllergic rhinitis (AR) is one of the more prevalent […]<\/p>\n","protected":false},"author":2,"featured_media":51106,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2191],"tags":[],"class_list":["post-44329","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyectos-de-investigacion"],"acf":[],"yoast_head":"\nPRE-BIT - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibima.eu\/en\/pre-bit\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRE-BIT - Ibima\" \/>\n<meta property=\"og:description\" content=\"Financed by: European Union Programme: H2020- Call: HORIZON-MSCA-2022-PF-01-01 - MSCA Postdoctoral Fellowships 2022 Grant agreement ID: 101105416 Duration: April 2023 - July 2025 Beneficiary: Carlos Aranda Supervisor: Cristobalina Mayorga Mayorga Implementation centre: Hospital Regional Universitario de M\u00e1laga Research group of IBIMA involved: Drug and Allergen Allergic DiseasesAllergic rhinitis (AR) is one of the more prevalent […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibima.eu\/en\/pre-bit\/\" \/>\n<meta property=\"og:site_name\" content=\"Ibima\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-25T07:13:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-30T12:59:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibima.eu\/wp-content\/uploads\/2024\/07\/Logo_PRE-BIT_2.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"639\" \/>\n\t<meta property=\"og:image:height\" content=\"630\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"prodriguez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"prodriguez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/\"},\"author\":{\"name\":\"prodriguez\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#\\\/schema\\\/person\\\/40b410344dd5ad2315bb651e3fbfa635\"},\"headline\":\"PRE-BIT\",\"datePublished\":\"2024-07-25T07:13:09+00:00\",\"dateModified\":\"2025-09-30T12:59:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/\"},\"wordCount\":1876,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2024\\\/07\\\/Logo_PRE-BIT_2.jpeg\",\"articleSection\":[\"Proyectos de Investigaci\u00f3n\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/\",\"url\":\"https:\\\/\\\/ibima.eu\\\/es\\\/pre-bit\\\/\",\"name\":\"PRE-BIT - 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