{"id":47945,"date":"2024-07-31T11:54:18","date_gmt":"2024-07-31T11:54:18","guid":{"rendered":"https:\/\/ibima.eu\/?p=47945"},"modified":"2024-07-31T11:54:20","modified_gmt":"2024-07-31T11:54:20","slug":"development-of-sophisticated-dendrimeric-nanostructural-materials-with-potential-applications-in-drug-allergy-diagnosis-towards-immunoassays-and-cellular-tests","status":"publish","type":"post","link":"https:\/\/ibima.eu\/en\/development-of-sophisticated-dendrimeric-nanostructural-materials-with-potential-applications-in-drug-allergy-diagnosis-towards-immunoassays-and-cellular-tests\/","title":{"rendered":"Development of sophisticated dendrimeric nanostructural materials with potential applications in drug allergy diagnosis: Towards immunoassays and cellular tests"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row column_structure=\u00bb3_5,2_5&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb3_5&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.0&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<p><span style=\"color: #000000;\"><strong>Financed by<\/strong>\u00a0: European Commission<\/span><\/p>\n<p><strong><span><span style=\"color: #000000;\">Grant Agreement ID:<\/span>\u00a0\u00a0<\/span><\/strong><a href=\"https:\/\/web.archive.org\/web\/20230203225042\/https:\/\/cordis.europa.eu\/project\/id\/300230\"><span>300230<\/span><\/a><\/p>\n<p><span style=\"color: #000000;\"><strong>Program<\/strong>\u00a0: FP7-PEOPLE-2011-IEF \u2013 Marie-Curie Action: \u201cIntra-European fellowships for career development\u201d<\/span><\/p>\n<p><span style=\"color: #000000;\"><b><span class=\"\">Duration:<\/span><\/b><span class=\"\">\u00a0September 2012 to August 2015<\/span><\/span><\/p>\n<p><span style=\"color: #000000;\"><\/span><\/p>\n<p><span style=\"color: #000000;\">Beneficiary: Monta\u00f1ez Vega, Mar\u00eda Isabel<\/span><\/p>\n<p><span style=\"color: #000000;\">Supervisor: Blanca G\u00f3mez, Miguel<\/span><\/p>\n<p><span style=\"color: #000000;\">Implementation center: Regional University Hospital of Malaga<\/span><\/p>\n<p><span style=\"color: #000000;\">Research group of IBIMA involved: Drug and Allergen Allergic Diseases<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb2_5&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_post_title title=\u00bboff\u00bb meta=\u00bboff\u00bb admin_label=\u00bbT\u00edtulo de publicaci\u00f3n\u00bb _builder_version=\u00bb4.27.0&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bbArial||||||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#2ea3f2&#8243; title_font_size=\u00bb35px\u00bb background_color=\u00bbRGBA(255,255,255,0)\u00bb text_orientation=\u00bbcenter\u00bb width=\u00bb100%\u00bb module_alignment=\u00bbcenter\u00bb custom_margin=\u00bb10%||1%||false|false\u00bb hover_enabled=\u00bb0&#8243; title_font_size_last_edited=\u00bboff|desktop\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_post_title][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.27.0&#8243; _module_preset=\u00bbdefault\u00bb min_height=\u00bb305.4px\u00bb custom_margin=\u00bb-16px||||false|false\u00bb custom_padding=\u00bb50px||50px||true|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.0&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbABSTRACT\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb||||||||\u00bb title_text_color=\u00bb#0C71C3&#8243; locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][et_pb_text _builder_version=\u00bb4.27.0&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<p style=\"text-align: justify;\"><span style=\"color: #000000;\">Nowadays drug allergy is considered a major public health problem in developed countries. Its correct diagnosis is very important for the adequate prescription of drugs to avoid risks for the patient. However, the adequate diagnosis is in certain cases difficult to address. This research aims at the development of sophisticated nanostructural materials with potential applications in drug allergy diagnosis. To this, the study will first focus on the identification of drug antigenic determinants still unknown by using different drug models as those derived from diclofenac and clavulanic acid, by a synthetic strategy to the hypothesized molecules and subsequent clinical evaluation. Secondly we propose the design of dendritic molecules displaying multiple presentations of relevant drug antigenic determinants. The determinants identified in the objective above and others already known as amoxicillin, will be coupled to the periphery of dendrimers and\/or dendrons with the adequate methodology. The molecular recognition of these structures by specific IgE antibodies will be evaluated by radioimmunoassays, and performances in the structures will be carried out up to reach an optimal recognition. The final well-recognized structures will be anchored onto a solid phase with the aim of developing drug allergy diagnostic kits, to use in a routine clinical practice. Other approaches towards the study of the optimal distance in crosslink-IgE to produce the basophil activation will also be addressed in order to increase the sensitivity of this test. Biocompatible dendrimer as scaffolds, click chemistry methodologies, solid phases, organic chemical design will be used for the development of this project, with an important support of clinical evaluation and a biobank with patients sera. This methodology is expected to deliver a new tool box for the design of sophisticated nanostructural materials and versatile to the diagnosis of allergy to different drugs towards a microarray.<\/span><\/p>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Financed by\u00a0: European Commission Grant Agreement ID:\u00a0\u00a0300230 Program\u00a0: FP7-PEOPLE-2011-IEF \u2013 Marie-Curie Action: \u201cIntra-European fellowships for career development\u201d Duration:\u00a0September 2012 to August 2015 Beneficiary: Monta\u00f1ez Vega, Mar\u00eda Isabel Supervisor: Blanca G\u00f3mez, Miguel Implementation center: Regional University Hospital of Malaga Research group of IBIMA involved: Drug and Allergen Allergic DiseasesNowadays drug allergy is considered a major public [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":47948,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2193],"tags":[],"class_list":["post-47945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-recursos-humanos"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Development of sophisticated dendrimeric nanostructural materials with potential applications in drug allergy diagnosis: Towards immunoassays and cellular tests - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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