{"id":63508,"date":"2026-10-15T12:54:23","date_gmt":"2026-10-15T12:54:23","guid":{"rendered":"https:\/\/ibima.eu\/?p=63508"},"modified":"2026-10-20T12:46:32","modified_gmt":"2026-10-20T12:46:32","slug":"triple-r-eu","status":"publish","type":"post","link":"https:\/\/ibima.eu\/en\/triple-r-eu\/","title":{"rendered":"Triple-R"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; disabled_on=\u00bboff|off|off\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(0,0,0,0.14)\u00bb background_image=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Header_1.png\u00bb background_position=\u00bbtop_center\u00bb background_vertical_offset=\u00bb24%\u00bb background_blend=\u00bboverlay\u00bb custom_padding=\u00bb160px||20px||false|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb80px||30px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.20.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb25px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbTriple-R &#8211; Identification of long non-coding RNA-based biomarkers of immunotherapy response in Triple-Negative Breast Cancer via liquid biopsy profiling\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb|||on|||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#002c5f\u00bb title_line_height=\u00bb1.3em\u00bb custom_margin=\u00bb10px||15px||false|false\u00bb custom_padding=\u00bb0px||0px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_5,2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb70%\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb3_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px|||||\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h2 style=\"text-align: center;\"><strong>ABSTRACT<\/strong><\/h2>\n<p style=\"text-align: justify;\"><span>Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor and HER2 expression. This lack of molecular targets limits treatment options and highlights the urgent need of novel therapeutic strategies. While immune checkpoint inhibitors (ICIs) targeting the PD-1\/PD-L1 axis have shown promise in early-stage TNBC, response rates remain variable and difficult to predict. Recent studies have implicated long non-coding RNAs (lncRNAs) as key regulators of immune-related pathways, suggesting their potential as modulators of immunotherapy sensitivity.<\/span><\/p>\n<p><span>The Triple-R project aims to identify and functionally characterize lncRNA-based biomarkers predictive of response to neoadjuvant immunotherapy in early TNBC. The specific objectives to achieved this are: <\/span><\/p>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"text-align: justify;\"><span>To compare lncRNA expression profiles, integrating RNA-sequencing data from tumour tissue and liquid biopsy samples \u2014including exosomes, circulating tumour cells and cell-free RNA\u2014 collected from patients undergoing treatment.<\/span><\/li>\n<li style=\"text-align: justify;\">To infer lncRNA expression from cell-free DNA fragmentomics.<\/li>\n<li style=\"text-align: justify;\">To characterize the functional role of selected lncRNAs through CRISPR-based knockdown or overexpression in selected TNBC cell lines under ICIs treatment, assessing the impact on cell proliferation and relative fitness.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<p>Furthermore, the project will benefit from an international collaboration (Peter MacCallum Cancer Centre, Australia), with complementary results from the BCT 1702-CHARIOT clinical trial that will enhance the robustness and translational relevance of the findings.<\/p>\n<p style=\"text-align: justify;\"><span>The proposal introduces innovative approaches to advance precision oncology, focusing on gene expression profiling via liquid biopsy. By identifying novel potential biomarkers and lncRNA signatures linked to immunotherapy sensitivity, it aims to improve patient stratification and enable more effective, personalized treatment strategies for TNBC.<\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px|||||\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243; custom_margin=\u00bb38px||||false|false\u00bb]<\/p>\n<div>\n<div>\n<div>\n<div>\n<div>\n<div>\n<h2 style=\"text-align: center;\"><strong><span>TRIPLE-R Graphical Abstract<\/span><\/strong><\/h2>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/et_pb_text][et_pb_text disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb16px||||false|false\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>Know more about us<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_video src=\u00bbhttps:\/\/www.youtube.com\/watch?v=OGdf-Ie-rn4&#8243; disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb9px||||false|false\u00bb border_radii=\u00bbon|5px|5px|5px|5px\u00bb border_width_all=\u00bb3px\u00bb border_color_all=\u00bb#0C71C3&#8243; disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_video][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Marie-Curie-Workflow_Paleta-colores.png\u00bb title_text=\u00bbMarie Curie Workflow_Paleta colores\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb transform_origin=\u00bb102%|66%\u00bb width=\u00bb84%\u00bb max_width=\u00bb100%\u00bb min_height=\u00bb209.8px\u00bb hover_enabled=\u00bb0&#8243; border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#FFFFFF\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][\/et_pb_column][et_pb_column type=\u00bb2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg\u00bb title_text=\u00bbTriple-R_Logo\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb40%\u00bb custom_margin=\u00bb0px||14px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(3,3,10,0.09)\u00bb custom_margin=\u00bb|72px|-4px|72px|false|false\u00bb custom_padding=\u00bb||0px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><\/h2>\n<h2 style=\"text-align: center;\"><span style=\"color: #000000;\"><strong><span style=\"text-decoration: underline;\">Project Information<\/span><\/strong><\/span><\/h2>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"color: #000000;\"><strong>Program<\/strong>:<\/span> <span style=\"color: #000000;\">HORIZON-MSCA-2025-PF-01<\/span><\/li>\n<li><b><span style=\"color: #000000;\">Project Reference:<\/span><\/b><a href=\"https:\/\/cordis.europa.eu\/project\/id\/101281769\"><span> 101281769<\/span><\/a><\/li>\n<li><span style=\"color: #000000;\"><b>Duration: <\/b>July 2026 to July 2028\u00a0<\/span><\/li>\n<li><span><a href=\"https:\/\/www.huvv.es\/\"><\/a><\/span><span style=\"color: #000000;\"><span style=\"color: #000000;\"><strong>Research group of IBIMA involved<\/strong>: <\/span><\/span><a href=\"https:\/\/ibima.eu\/en\/project\/b-01\/\">Clinical and Translational Research in Cancer<\/a>\u00a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb19px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Fellow<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/CristinaOliveira2.jpeg\u00bb title_text=\u00bbCristinaOliveira2&#8243; align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb transform_origin=\u00bb102%|66%\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb min_height=\u00bb209.8px\u00bb hover_enabled=\u00bb0&#8243; border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#8300E9&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb5px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: medium;\">Dr. Cristina Oliveira <\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb18px||0px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Supervisors<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/07\/person-icon.png\u00bb title_text=\u00bbperson-icon\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb custom_margin=\u00bb||-22px|||\u00bb hover_enabled=\u00bb0&#8243; border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#8300E9&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb20px||||false|false\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: medium;\">Dr. Javier Pascual<\/span><span style=\"font-size: medium;\"><\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.7&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\">\n<h2 style=\"text-align: center;\">Follow our social Networks<\/h2>\n<p>[\/et_pb_text][et_pb_image disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_social_media_follow disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb text_orientation=\u00bbcenter\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_social_media_follow_network social_network=\u00bbinstagram\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#ea2c59&#8243; custom_margin=\u00bb||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb follow_button=\u00bboff\u00bb url_new_window=\u00bbon\u00bb]instagram[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=\u00bbfacebook\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#3b5998&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb follow_button=\u00bboff\u00bb url_new_window=\u00bbon\u00bb]facebook[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=\u00bbtwitter\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#000000&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb follow_button=\u00bboff\u00bb url_new_window=\u00bbon\u00bb]twitter[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=\u00bblinkedin\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#007bb6&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb follow_button=\u00bboff\u00bb url_new_window=\u00bbon\u00bb]linkedin[\/et_pb_social_media_follow_network][et_pb_social_media_follow_network social_network=\u00bbyoutube\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bb#a82400&#8243; custom_margin=\u00bb|||-1px|false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb follow_button=\u00bboff\u00bb url_new_window=\u00bbon\u00bb]youtube[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ABSTRACT Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor and HER2 expression. This lack of molecular targets limits treatment options and highlights the urgent need of novel therapeutic strategies. While immune checkpoint inhibitors (ICIs) targeting the PD-1\/PD-L1 axis have shown [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":63511,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2191,2233],"tags":[],"class_list":["post-63508","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyectos-de-investigacion","category-proyectos-de-investigacion-investigador"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.7 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Triple-R - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibima.eu\/en\/triple-r-eu\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Triple-R - Ibima\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor and HER2 expression. This lack of molecular targets limits treatment options and highlights the urgent need of novel therapeutic strategies. While immune checkpoint inhibitors (ICIs) targeting the PD-1\/PD-L1 axis have shown [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibima.eu\/en\/triple-r-eu\/\" \/>\n<meta property=\"og:site_name\" content=\"Ibima\" \/>\n<meta property=\"article:published_time\" content=\"2026-10-15T12:54:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-20T12:46:32+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"992\" \/>\n\t<meta property=\"og:image:height\" content=\"1086\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Divulgaci\u00f3n\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Divulgaci\u00f3n\" \/>\n\t<meta name=\"twitter:label2\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/\"},\"author\":{\"name\":\"Divulgaci\u00f3n\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#\\\/schema\\\/person\\\/31b8becdcc53729d5a51d5b3436ce9a5\"},\"headline\":\"Triple-R\",\"datePublished\":\"2026-10-15T12:54:23+00:00\",\"dateModified\":\"2026-10-20T12:46:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/\"},\"wordCount\":1485,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Triple-R_Logo.jpg\",\"articleSection\":[\"Proyectos de Investigaci\u00f3n\",\"Proyectos de Investigaci\u00f3n - Investigador\"],\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/\",\"url\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/\",\"name\":\"Triple-R - Ibima\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Triple-R_Logo.jpg\",\"datePublished\":\"2026-10-15T12:54:23+00:00\",\"dateModified\":\"2026-10-20T12:46:32+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#\\\/schema\\\/person\\\/31b8becdcc53729d5a51d5b3436ce9a5\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#primaryimage\",\"url\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Triple-R_Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2026\\\/10\\\/Triple-R_Logo.jpg\",\"width\":992,\"height\":1086},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/triple-r-eu\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/ibima.eu\\\/es\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Triple-R\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#website\",\"url\":\"https:\\\/\\\/ibima.eu\\\/es\\\/\",\"name\":\"Ibima\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibima.eu\\\/es\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#\\\/schema\\\/person\\\/31b8becdcc53729d5a51d5b3436ce9a5\",\"name\":\"Divulgaci\u00f3n\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g\",\"caption\":\"Divulgaci\u00f3n\"},\"url\":\"https:\\\/\\\/ibima.eu\\\/en\\\/author\\\/divulgacioncientifica\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Triple-R - Ibima","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibima.eu\/en\/triple-r-eu\/","og_locale":"en_GB","og_type":"article","og_title":"Triple-R - Ibima","og_description":"ABSTRACT Triple-negative breast cancer (TNBC) is the most aggressive and lethal subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor and HER2 expression. This lack of molecular targets limits treatment options and highlights the urgent need of novel therapeutic strategies. While immune checkpoint inhibitors (ICIs) targeting the PD-1\/PD-L1 axis have shown [&hellip;]","og_url":"https:\/\/ibima.eu\/en\/triple-r-eu\/","og_site_name":"Ibima","article_published_time":"2026-10-15T12:54:23+00:00","article_modified_time":"2026-10-20T12:46:32+00:00","og_image":[{"width":992,"height":1086,"url":"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg","type":"image\/jpeg"}],"author":"Divulgaci\u00f3n","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Divulgaci\u00f3n","Estimated reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#article","isPartOf":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/"},"author":{"name":"Divulgaci\u00f3n","@id":"https:\/\/ibima.eu\/es\/#\/schema\/person\/31b8becdcc53729d5a51d5b3436ce9a5"},"headline":"Triple-R","datePublished":"2026-10-15T12:54:23+00:00","dateModified":"2026-10-20T12:46:32+00:00","mainEntityOfPage":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/"},"wordCount":1485,"commentCount":0,"image":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#primaryimage"},"thumbnailUrl":"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg","articleSection":["Proyectos de Investigaci\u00f3n","Proyectos de Investigaci\u00f3n - Investigador"],"inLanguage":"en-GB","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/ibima.eu\/es\/triple-r-eu\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/","url":"https:\/\/ibima.eu\/es\/triple-r-eu\/","name":"Triple-R - Ibima","isPartOf":{"@id":"https:\/\/ibima.eu\/es\/#website"},"primaryImageOfPage":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#primaryimage"},"image":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#primaryimage"},"thumbnailUrl":"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg","datePublished":"2026-10-15T12:54:23+00:00","dateModified":"2026-10-20T12:46:32+00:00","author":{"@id":"https:\/\/ibima.eu\/es\/#\/schema\/person\/31b8becdcc53729d5a51d5b3436ce9a5"},"breadcrumb":{"@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibima.eu\/es\/triple-r-eu\/"]}]},{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#primaryimage","url":"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg","contentUrl":"https:\/\/ibima.eu\/wp-content\/uploads\/2026\/10\/Triple-R_Logo.jpg","width":992,"height":1086},{"@type":"BreadcrumbList","@id":"https:\/\/ibima.eu\/es\/triple-r-eu\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/ibima.eu\/es\/"},{"@type":"ListItem","position":2,"name":"Triple-R"}]},{"@type":"WebSite","@id":"https:\/\/ibima.eu\/es\/#website","url":"https:\/\/ibima.eu\/es\/","name":"Ibima","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibima.eu\/es\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Person","@id":"https:\/\/ibima.eu\/es\/#\/schema\/person\/31b8becdcc53729d5a51d5b3436ce9a5","name":"Divulgaci\u00f3n","image":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/secure.gravatar.com\/avatar\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a96ea83ae1abdc712e138b425847bdc88b61da083b2e05603d5a5305a98cd781?s=96&d=mm&r=g","caption":"Divulgaci\u00f3n"},"url":"https:\/\/ibima.eu\/en\/author\/divulgacioncientifica\/"}]}},"_links":{"self":[{"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/posts\/63508","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/comments?post=63508"}],"version-history":[{"count":21,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/posts\/63508\/revisions"}],"predecessor-version":[{"id":63694,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/posts\/63508\/revisions\/63694"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/media\/63511"}],"wp:attachment":[{"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/media?parent=63508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/categories?post=63508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibima.eu\/en\/wp-json\/wp\/v2\/tags?post=63508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}