[et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb background_image=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2023\/04\/BANNER_2.jpg\u00bb custom_padding=\u00bb80px||80px||true|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb header_2_font=\u00bbPoppins|500|||||||\u00bb header_2_text_color=\u00bb#FFFFFF\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row column_structure=\u00bb1_2,1_2″ use_custom_gutter=\u00bbon\u00bb gutter_width=\u00bb3″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb80px||80px||true|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb|40px|||false|false\u00bb border_width_right=\u00bb1px\u00bb border_color_right=\u00bb#41a7d4″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb text_font=\u00bbPoppins||||||||\u00bb text_text_color=\u00bb#41a7d4″ text_font_size=\u00bb20px\u00bb header_font=\u00bb|600|||||||\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n
Service Description<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]The NMR service is equipped with a High resolution NMR Spectrometers: a 600 MHz, spectrometer dedicated NMR studies that are more demanding in terms of sensitivity. This system is also equipped with a high resolution magic angle spinning (HR-MAS) NMR to analyze heterogeneous samples (tissue biopsies or partially insoluble compounds).
\nApplications of NMR spectroscopy to chemistry range from structure elucidation of small molecules to studies of ligand-protein interactions. In biomedicine, the use of NMR spectroscopy has expanded from the classical metabolic studies using enriched stable isotope tracers to the more recent NMR-based metabolomics of biofluids (urine, plasma, CSF). [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb text_font=\u00bbPoppins||||||||\u00bb text_text_color=\u00bb#41a7d4″ text_font_size=\u00bb20px\u00bb header_font=\u00bb|600|||||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n
Equipment<\/p>\n
[\/et_pb_text][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n
\u2022 Bruker Avance 600 MHz NMR spectrometer<\/b><\/span><\/span><\/p>\n – Ultra ShieldTM Plus 14.1T magnet<\/span><\/span><\/p>\n – 5 mm BBFOPLUS probe, optimized for X-nuclei direct observation in a frequency range between 31P and 15N<\/span><\/span><\/p>\n – 5 mm TXI probe, optimized for higher sensitivity 1H-nuclei observation<\/span><\/span><\/p>\n – TCI CryoProbe Prodigy, uses nitrogen-cooled RF coils and preamplifiers for 1H, 2H and 13C, delivering a 2.5x 1 H sensitivity boost<\/span><\/span><\/p>\n – HR-MAS Probe<\/span><\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_divider color=\u00bb#41a7d4″ divider_style=\u00bbdotted\u00bb _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb1_2,1_2″ use_custom_gutter=\u00bbon\u00bb gutter_width=\u00bb3″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb80px||80px||true|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb|40px|||false|false\u00bb border_width_right=\u00bb1px\u00bb border_color_right=\u00bb#41a7d4″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb text_font=\u00bbPoppins||||||||\u00bb text_text_color=\u00bb#41a7d4″ text_font_size=\u00bb20px\u00bb header_font=\u00bb|600|||||||\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n Applications<\/p>\n [\/et_pb_text][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n – Metabolomic analysis of biofluids (urine, blood serum, etc.)<\/span><\/span><\/p>\n – Metabolomic analysis of intact tissue (biopsies)<\/span><\/span><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=\u00bb1_2″ _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb text_font=\u00bbPoppins||||||||\u00bb text_text_color=\u00bb#41a7d4″ text_font_size=\u00bb20px\u00bb header_font=\u00bb|600|||||||\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n Services Offered<\/p>\n [\/et_pb_text][et_pb_text _builder_version=\u00bb4.20.4″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb30px||||false|false\u00bb hover_enabled=\u00bb0″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0″]<\/p>\n \u2022 Experimental design advice and project plan consulting. Services Offered <\/span><\/span><\/p>\n \u2022 Acquisition of 1D NMR spectra at 600 MHz (1 H, 13C, 31P, etc.)<\/span><\/span><\/p>\n \u2022 Acquisition of basic 2D experiments: COSY, TOCSY, HSQC, HMBC, J-RES<\/span><\/span><\/p>\n – Nuclear Overhauser Effect experiments (NOE and ROE), Diffusion experiments (DOSY), selective excitation experiments.<\/span><\/span><\/p>\n \u2022 Acquisition of 1 H and 31P HR-MAS NMR spectra.<\/span><\/span><\/p>\n \u2022 Preparation of biofluid samples (urine, blood serum\/plasma) for high resolution NMR spectroscopy following standardized protocols.<\/span><\/span><\/p>\n \u2022 Preparation of tissue samples for HR-MAS NMR spectroscopy.<\/span><\/span><\/p>\n \u2022 Basic processing of NMR spectra.<\/span><\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Bruker Avance 600 MHz NMR spectrometerService DescriptionThe NMR service is equipped with a High resolution NMR Spectrometers: a 600 MHz, spectrometer dedicated NMR studies that are more demanding in terms of sensitivity. This system is also equipped with a high resolution magic angle spinning (HR-MAS) NMR to analyze heterogeneous samples (tissue biopsies or partially insoluble […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-12415","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\n