{"id":49381,"date":"2025-01-31T08:33:21","date_gmt":"2025-01-31T08:33:21","guid":{"rendered":"https:\/\/ibima.eu\/?p=49381"},"modified":"2025-02-10T12:37:10","modified_gmt":"2025-02-10T12:37:10","slug":"morbius","status":"publish","type":"post","link":"https:\/\/ibima.eu\/es\/morbius\/","title":{"rendered":"Morbius"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; disabled_on=\u00bboff|off|off\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(0,0,0,0.14)\u00bb background_image=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/06\/cover-photo.png\u00bb background_position=\u00bbtop_center\u00bb background_vertical_offset=\u00bb24%\u00bb background_blend=\u00bboverlay\u00bb custom_padding=\u00bb160px||20px||false|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb80px||30px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.20.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb25px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbMORBIUS  &#8211; Cure for Miniature Brittle Bones: Treatment of Osteogenesis ImpeRfecta patient-derived Bone organoids  with Innovative AAV-mediated Ultimate Gene-editing System\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb|||on|||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#002c5f\u00bb title_line_height=\u00bb1.3em\u00bb custom_margin=\u00bb10px||15px||false|false\u00bb custom_padding=\u00bb0px||0px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_5,2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb70%\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb3_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px|||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>ABSTRACT<\/strong><\/h2>\n<p style=\"text-align: justify;\">In the MORBIUS project, cutting-edge interdisciplinary expertise converges to revolutionize Osteogenesis Imperfecta (OI) research. Our ambitious MSCA-IF project aims to develop innovative bone organoids\u2014mini brittle bones\u2014using patient-derived induced stem cells. These 3D co-cultures replicate the natural processes of bone modeling and the unique pathophysiology of OI.<\/p>\n<p style=\"text-align: justify;\">As a groundbreaking proof-of-concept, these engineered mini brittle bones serve as platforms for gene therapy approaches. By employing bone-targeting AAV vectors, we aim to either overexpress beneficial genes or edit disease-causing pathogenic variants, tailored to each patient&#8217;s genetic profile.<\/p>\n<p>This initiative is a collaborative effort with leading-edge partners: IBIMA Plataforma Bionand in Spain for tissue engineering, Amsterdam UMC in The Netherlands for genetic and cell OI expertise, and UMASS in the US for bone-targeting gene therapies. We are also proud to partner with the Osteogenesis Imperfecta Federation Europe (OIFE), uniting OI organizations across Europe.<\/p>\n<p style=\"text-align: justify;\">Furthermore, we are developing an educational web app to disseminate knowledge on OI gene therapy and genetics, empowering patients and fostering their active participation in therapeutic advancements.<\/p>\n<p style=\"text-align: justify;\">The MORBIUS project is being conducted by Dr. Lidiia Zhytnik (IBIMA Plataforma Bionand), under the expert supervision of Prof. Ivan Duran (IBIMA Plataforma Bionand and The University of Malaga).<\/p>\n<p style=\"text-align: justify;\">Follow us on this exciting journey to transform OI treatment through innovation and collaboration.<\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb16px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>Participant Organisations<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2025\/01\/University-of-Massa.png\u00bb title_text=\u00bbUniversity of Massa\u00bb url=\u00bbhttps:\/\/www.umassmed.edu\/\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb87%\u00bb custom_margin=\u00bb11px||||false|false\u00bb border_radii=\u00bbon|2px|2px|2px|2px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2025\/01\/OIFE.png\u00bb title_text=\u00bbOIFE\u00bb url=\u00bbhttps:\/\/oife.org\/\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb87%\u00bb custom_margin=\u00bb20px||||false|false\u00bb border_radii=\u00bbon|2px|2px|2px|2px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb16px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb disabled_on=\u00bbon|on|on\u00bb disabled=\u00bbon\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>Know more about us<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_video src=\u00bbhttps:\/\/www.youtube.com\/watch?v=OGdf-Ie-rn4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb9px||||false|false\u00bb border_radii=\u00bbon|5px|5px|5px|5px\u00bb border_width_all=\u00bb3px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb disabled_on=\u00bbon|on|on\u00bb disabled=\u00bbon\u00bb][\/et_pb_video][\/et_pb_column][et_pb_column type=\u00bb2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/06\/logo.png\u00bb title_text=\u00bblogo\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb52%\u00bb custom_margin=\u00bb0px||-20px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb inline_fonts=\u00bbAlike Angular\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\">\n<h1 style=\"text-align: center;\"><span style=\"font-family: 'Alike Angular'; font-weight: normal; font-size: xx-large;\"><strong><span style=\"color: #002c5f;\">MORBIUS<\/span><\/strong><\/span><\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(3,3,10,0.09)\u00bb custom_margin=\u00bb|72px|-4px|72px|false|false\u00bb custom_padding=\u00bb||0px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><\/h2>\n<h2 style=\"text-align: center;\"><span style=\"color: #000000;\"><strong><span style=\"text-decoration: underline;\">Project Information<\/span><\/strong><\/span><\/h2>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"color: #000000;\"><strong>Program<\/strong>:<\/span> <span style=\"color: #000000;\">HORIZON-MSCA-2023-PF-01<\/span><\/li>\n<li><b><span style=\"color: #000000;\">Project Reference:<\/span><\/b><a href=\"https:\/\/cordis.europa.eu\/project\/id\/101151143\">101151143<\/a><\/li>\n<li><span style=\"color: #000000;\"><b>Duration: <\/b>January 2025 to June 2027<\/span><\/li>\n<li><span><span><span style=\"color: #000000;\">Implementation Centre:<\/span> <a href=\"https:\/\/ibima.eu\/en\/donde-estamos\/\">IBIMA Plataforma BIONAND<\/a><\/span><\/span><\/li>\n<li><span><a href=\"https:\/\/www.huvv.es\/\"><\/a><\/span><span style=\"color: #000000;\">Research group of IBIMA involved:<\/span> <a href=\"https:\/\/ibima.eu\/en\/project\/h-02\/\">Skeleton Biomedicine Laboratory<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb19px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Fellow<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2025\/01\/Liidia-Zhytnik_2.jpg\u00bb title_text=\u00bbLiidia Zhytnik_2&#8243; align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb min_height=\u00bb209.8px\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb hover_enabled=\u00bb0&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb sticky_enabled=\u00bb0&#8243;]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: medium;\">Dr. Lidiia Zhytnik<\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Supervisors<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/01\/Ivan-Duran-Histologia.png\u00bb title_text=\u00bbIv\u00e1n Dur\u00e1n &#8211; Histolog\u00eda\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb custom_margin=\u00bb||-22px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb34px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: medium;\">Dr. Iv\u00e1n Dur\u00e1n<\/span><span style=\"font-size: medium;\"><\/span><\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/07\/Fabiana2048.jpeg\u00bb title_text=\u00bbFabiana2048&#8243; align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb custom_margin=\u00bb||-22px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb34px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: medium; color: #333333;\">Dr. Fabiana Csukasi<\/span><\/p>\n<p style=\"text-align: center;\"><span style=\"font-size: medium; color: #333333;\"><\/span><\/p>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<p style=\"text-align: center;\">\n<p style=\"text-align: center;\">\n<h2 style=\"text-align: center;\">Follow our social Networks<\/h2>\n<p>[\/et_pb_text][et_pb_image disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_social_media_follow disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; 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Our ambitious MSCA-IF project aims to develop innovative bone organoids\u2014mini brittle bones\u2014using patient-derived induced stem cells. These 3D co-cultures replicate the natural processes of bone modeling and the unique pathophysiology of OI. As a groundbreaking proof-of-concept, these engineered mini brittle [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":39241,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2191,2233],"tags":[],"class_list":["post-49381","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyectos-de-investigacion","category-proyectos-de-investigacion-investigador"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Morbius - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibima.eu\/es\/morbius\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Morbius - Ibima\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT In the MORBIUS project, cutting-edge interdisciplinary expertise converges to revolutionize Osteogenesis Imperfecta (OI) research. 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