{"id":51309,"date":"2025-04-02T08:43:42","date_gmt":"2025-04-02T08:43:42","guid":{"rendered":"https:\/\/ibima.eu\/?p=51309"},"modified":"2025-11-25T10:15:26","modified_gmt":"2025-11-25T10:15:26","slug":"investigadores-impulsan-el-desarrollo-de-microagujas-con-nanoparticulas-para-una-administracion-transdermica-de-farmacos-mas-eficaz-y-segura","status":"publish","type":"post","link":"https:\/\/ibima.eu\/es\/investigadores-impulsan-el-desarrollo-de-microagujas-con-nanoparticulas-para-una-administracion-transdermica-de-farmacos-mas-eficaz-y-segura\/","title":{"rendered":"Investigadores impulsan el desarrollo de microagujas con nanopart\u00edculas para una administraci\u00f3n transd\u00e9rmica de f\u00e1rmacos m\u00e1s eficaz y segura"},"content":{"rendered":"\n[et_pb_section fb_built=\u00bb1″ _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb50px|||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb width=\u00bb78%\u00bb max_width=\u00bb1816px\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4″ _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb min_height=\u00bb454.2px\u00bb custom_margin=\u00bb-55px|||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]

Investigadores de IBIMA Plataforma BIONAND, en colaboraci\u00f3n con la Queen’s University Belfast, han desarrollado un innovador sistema de administraci\u00f3n transd\u00e9rmica basado en microagujas solubles con nanopart\u00edculas de s\u00edlice mesoporosa. Esta tecnolog\u00eda permite una liberaci\u00f3n controlada y sostenida de f\u00e1rmacos, ofreciendo una alternativa indolora y eficaz a las inyecciones tradicionales y abriendo nuevas posibilidades en el tratamiento de diversas patolog\u00edas. <\/strong><\/p>\n

Investigadores de IBIMA Plataforma BIONAND, en colaboraci\u00f3n con la Queen’s University Belfast, han desarrollado un innovador sistema de administraci\u00f3n transd\u00e9rmica basado en parches de microagujas solubles que incorporan nanopart\u00edculas de s\u00edlice mesoporosa con poros de tama\u00f1o ajustable. Este hallazgo, publicado en la revista International Journal of Pharmaceutics<\/em>, representa un avance significativo en la liberaci\u00f3n sostenida y controlada de f\u00e1rmacos, abriendo nuevas posibilidades para la mejora de tratamientos m\u00e9dicos.<\/p>\n

Un nuevo enfoque para la administraci\u00f3n de f\u00e1rmacos<\/strong><\/p>\n

\n

Los parches de microagujas solubles son una tecnolog\u00eda emergente que permite la administraci\u00f3n de f\u00e1rmacos a trav\u00e9s de la piel sin causar dolor ni requerir agujas hipod\u00e9rmicas tradicionales. \u00abNuestro estudio demuestra que es posible integrar nanopart\u00edculas de s\u00edlice mesoporosa en estas microagujas, permitiendo una liberaci\u00f3n precisa y sostenida de los principios activos\u00bb, explica el Dr. Juan Luis Paris, investigador principal del proyecto en IBIMA Plataforma BIONAND; adem\u00e1s de integrante del grupo de investigaci\u00f3n sobre Enfermedades Al\u00e9rgicas a F\u00e1rmacos y Al\u00e9rgenos que lideran Mar\u00eda Jos\u00e9 Torres Ja\u00e9n y Cristobalina Mayorga Mayorga. \u00abEste avance podr\u00eda tener implicaciones directas en tratamientos dermatol\u00f3gicos, vacunas y administraci\u00f3n de terapias personalizadas\u00bb.<\/p>\n<\/blockquote>\n

Resultados clave del estudio<\/strong><\/p>\n

El equipo de investigaci\u00f3n desarroll\u00f3 un nuevo m\u00e9todo para la fabricaci\u00f3n de parches de microagujas solubles que contienen aproximadamente 2,3 mg de nanopart\u00edculas de s\u00edlice mesoporosa de distintos tama\u00f1os de poro. Estos parches fueron evaluados con \u00e9xito en modelos in vitro, ex vivo e in vivo:<\/p>\n

    \n
  • Se confirm\u00f3 la inserci\u00f3n efectiva de las microagujas en piel porcina neonatal y en modelos animales.<\/li>\n
  • Se demostr\u00f3 la disoluci\u00f3n de las microagujas y la liberaci\u00f3n de nanopart\u00edculas dentro de la piel.<\/li>\n
  • Se valid\u00f3 la capacidad de las nanopart\u00edculas para liberar la carga terap\u00e9utica de manera sostenida tras haber sido depositadas en la piel.<\/li>\n<\/ul>\n

    Estos resultados respaldan la seguridad y eficacia de la tecnolog\u00eda y establecen una base para futuras aplicaciones cl\u00ednicas.<\/p>\n

    <\/p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2025\/04\/20250312-Estudio-JParis_revCOIR_DEF-scaled.jpg\u00bb title_text=\u00bbCloseup of Syringe\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4″ _module_preset=\u00bbdefault\u00bb width=\u00bb78%\u00bb max_width=\u00bb56%\u00bb min_height=\u00bb175px\u00bb custom_margin=\u00bb34px||||false|false\u00bb custom_css_free_form=\u00bb.et_post_meta_wrapper img {|| max-width: 600px;|| height: auto;|| display: block;|| margin: 0 auto;||}\u00bb border_width_all=\u00bb4px\u00bb border_color_all=\u00bb#0C71C3″ global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.25.1″ _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]

    <\/p>\n

    Implicaciones y futuro de la investigaci\u00f3n<\/strong><\/p>\n

    \u00abEste desarrollo nos acerca un paso m\u00e1s a la posibilidad de administrar tratamientos sin agujas, de forma m\u00e1s eficiente y con mayor comodidad para los pacientes\u00bb, comenta el Dr. Paris. \u00abLa posibilidad de ajustar el tama\u00f1o de los poros de las nanopart\u00edculas nos permite modular la liberaci\u00f3n de f\u00e1rmacos de diferentes tama\u00f1os, desde mol\u00e9culas peque\u00f1as hasta prote\u00ednas, lo que podr\u00eda ser crucial en enfermedades que requieren dosificaciones prolongadas o personalizadas\u00bb.<\/p>\n

    \n

    El equipo de IBIMA Plataforma BIONAND ya est\u00e1 explorando nuevas aplicaciones para estos parches de microagujas, incluyendo su potencial uso en la administraci\u00f3n de vacunas y terapias dirigidas para enfermedades cr\u00f3nicas. \u00abNuestro objetivo es continuar optimizando esta tecnolog\u00eda, a\u00fan en fases iniciales, para intentar acercarla al desarrollo de ensayos cl\u00ednicos lo antes posible\u00bb, a\u00f1ade el investigador.<\/p>\n<\/blockquote>\n

    Sobre IBIMA Plataforma BIONAND<\/strong><\/p>\n

    IBIMA Plataforma BIONAND es un instituto de investigaci\u00f3n biom\u00e9dica de referencia que impulsa el desarrollo de tecnolog\u00edas innovadoras en el \u00e1mbito de la salud. Con un fuerte compromiso con la excelencia cient\u00edfica y la traslaci\u00f3n de la investigaci\u00f3n a la pr\u00e1ctica cl\u00ednica, IBIMA trabaja en colaboraci\u00f3n con instituciones nacionales e internacionales para mejorar la calidad de vida de los pacientes.<\/p>\n

    Paris JL, Vora LK, P\u00e9rez-Moreno AM, Mart\u00edn-Astorga MDC, Naser YA, Anjani QK, Ca\u00f1as JA, Torres MJ, Mayorga C, Donnelly RF. <\/strong>Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform. Int J Pharm. 2025 Jan 25;669:125064. doi: 10.1016\/j.ijpharm.2024.125064. Epub 2024 Dec 9. PMID: 39662856; PMCID: PMC11757158.<\/strong><\/p>\n

    <\/p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

    Investigadores de IBIMA Plataforma BIONAND, en colaboraci\u00f3n con la Queen’s University Belfast, han desarrollado un innovador sistema de administraci\u00f3n transd\u00e9rmica basado en microagujas solubles con nanopart\u00edculas de s\u00edlice mesoporosa. Esta tecnolog\u00eda permite una liberaci\u00f3n controlada y sostenida de f\u00e1rmacos, ofreciendo una alternativa indolora y eficaz a las inyecciones tradicionales y abriendo nuevas posibilidades en el […]<\/p>\n","protected":false},"author":4,"featured_media":51311,"comment_status":"open","ping_status":"closed","sticky":false,"template":"noticias","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[1981],"tags":[2751,2231,2747,2745,2230,2750,2743],"class_list":["post-51309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-noticias","tag-biomedica","tag-excelencia","tag-ibima","tag-internacional","tag-investigacion","tag-microagujas","tag-nanoparticulas"],"acf":[],"yoast_head":"\nInvestigadores impulsan el desarrollo de microagujas con nanopart\u00edculas para una administraci\u00f3n transd\u00e9rmica de f\u00e1rmacos m\u00e1s eficaz y segura - 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