{"id":57745,"date":"2025-10-01T09:22:33","date_gmt":"2025-10-01T09:22:33","guid":{"rendered":"https:\/\/ibima.eu\/?p=57745"},"modified":"2025-10-01T10:21:27","modified_gmt":"2025-10-01T10:21:27","slug":"nutricia-eu","status":"publish","type":"post","link":"https:\/\/ibima.eu\/es\/nutricia-eu\/","title":{"rendered":"NUTRICIA"},"content":{"rendered":"

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NUTRICIA<\/span><\/h2>\n

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ABSTRACT<\/strong><\/h2>\n

The impact of peripheral insulin resistance on systemic health is well-documented and its profound effects on brain function and cognition have gained increased attention in recent years. The project will analyze the relevance of insulin-resistance (IR) and IR-associated metabolic dysbalances in the brain as key factors promoting cognitive impairment (CI) and unhealthy aging. A triple integrative approach will be implemented in the present study. First, a retrospective analysis in a large EU cohort (Rotterdam Study) will determine the weight of life style and nutritional habits (dietary fat and carbohydrates consumption) on IR-associated CI, focusing on the predictive value of metabolic plasma biomarkers, circulating neurotrophic and systemic inflammation factors and gut microbiome analysis. Second, preclinical models of diet-induced obesity resulting in both IR and CI will provide insights on the molecular mechanisms of peripheral\/brain IR, providing a comparison with the nutritional epidemiology study. Finally, a nutritional intervention in mild CI patients with dietary administration of insulin sensitizers\/modulators (D-Pinitol (or back up D-chiroinositol) administration) will evaluate the effectiveness of IR-oriented interventions along a 2 year follow-up, where clinical records and plasma evaluation will incorporate monitoring of parameters identified in both retrospective and preclinical studies. AI-based modelling will integrate all the information gathered to establish the value of preventive interventions of IR impacting on the risk of CI and dementia.<\/p>\n

The studies will focus on gender differences to provide the most accurate gender-adjusted solutions, and will be developed in tight association with patient\u2019s organizations, health stakeholders and general citizens in an open science-based design. The contribution of an EU SME specialized on the production of high quality nutritional ingredients is incorporated to guarantee a rapid translation to the market\/citizens.<\/p>\n

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<\/h2>\n

Project Information<\/span><\/strong><\/span><\/h2>\n