{"id":59867,"date":"2026-02-09T09:48:55","date_gmt":"2026-02-09T09:48:55","guid":{"rendered":"https:\/\/ibima.eu\/?p=59867"},"modified":"2026-02-09T10:19:17","modified_gmt":"2026-02-09T10:19:17","slug":"gradient","status":"publish","type":"post","link":"https:\/\/ibima.eu\/es\/gradient\/","title":{"rendered":"Gradient"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00bb1&#8243; disabled_on=\u00bboff|off|off\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(0,0,0,0.14)\u00bb background_image=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/06\/cover-photo.png\u00bb background_position=\u00bbtop_center\u00bb background_vertical_offset=\u00bb24%\u00bb background_blend=\u00bboverlay\u00bb custom_padding=\u00bb160px||20px||false|false\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb80px||30px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.20.4&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\u00bb1&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb25px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_row _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb4_4&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_heading title=\u00bbGRADIENT &#8211; Impact of gut microbiota targeted dietary intervention on obesity: A precision medicine approach\u00bb _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb title_font=\u00bb|||on|||||\u00bb title_text_align=\u00bbcenter\u00bb title_text_color=\u00bb#002c5f\u00bb title_line_height=\u00bb1.3em\u00bb custom_margin=\u00bb10px||15px||false|false\u00bb custom_padding=\u00bb0px||0px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=\u00bb3_5,2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb70%\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_column type=\u00bb3_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px|||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>ABSTRACT<\/strong><\/h2>\n<p style=\"text-align: justify;\">Obesity affects a big proportion of the global population and impairs health by increasing the risk of type 2 diabetes and heart disease. Every few years, we witness new dietary trends that promise rapid and efficient weight loss. However, hardly any information is available on the impact of these dietary interventions on the gut microbiome and host metabolism. Funded by the Marie Sk\u0142odowska-Curie Actions programme, the GRADIENT project aims to fill in knowledge gaps on the short-term and long-term impact of intermittent fasting, the KetoDiet and the classical Mediterranean diet. Results will inform better obesity treatments, improve mental and physical health, and potentially reduce surgical interventions.<\/p>\n<p style=\"text-align: justify;\">[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb custom_padding=\u00bb0px|||||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>OBJECTIVE<\/strong><\/h2>\n<p style=\"text-align: justify;\"><span>The main objective is to analyze the impact of dietary hypocaloric interventions based on their capacity to generate ketone bodies in different degrees of intensity: using Intermittent fasting, KetoDiet in comparison with the classical MedDiet, in individuals with obesity, and their influences on the gut microbiota, resistome, host metabolism, and the possible genetic and epigenetics links. We aim to contribute with the advance in the development of a precision medicine approach in obesity to decrease the prevalence of obesity and its associated comorbidities, and to evaluate the impact of dietary interventions as an alternative approach to antimicrobial resistance.<\/span><br \/><span>To achieve our goal, we will study in a randomized cross-over group of individuals with obesity: A) Analyse the effect of dietary interventions (MedDiet, intermittent fasting (IF) and KetoDiet) on the gut microbiota composition and the relationship with anthropometrics, metabolic, inflammatory and epigenetics driven factors at short term (1 month) B) Analyse the effect of dietary interventions (MedDiet, IF, KetoDiet) on the gut microbiota composition and the relationship with epigenetics factors at medium-term(3 months) C) Evaluate the impact of the gut microbiota targeted dietary interventions (MedDiet, IF and KetoDiet) at short- and medium-term on the gut resistome and relate it with the inflammatory milieu of the host.<\/span><br \/><span>Our results will help to improve the treatment of metabolic diseases associated to obesity using a precision medicine approach based on the influence of diet interventions on the gut microbiota, gut resistome, host response and environmental factors. The outcome of this project will have an impact in the health sector by improving mental health and physical health of all overweight and obese individuals, in the economy sector by reducing the need of surgical approaches to achieve weight loss, reducing the risk of development obesity-related complications and overuse of antimicrobials.<\/span><\/p>\n<p style=\"text-align: justify;\">[\/et_pb_text][et_pb_text disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb16px||||false|false\u00bb disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><strong>Know more about us<\/strong><\/h2>\n<p>[\/et_pb_text][et_pb_video src=\u00bbhttps:\/\/www.youtube.com\/watch?v=OGdf-Ie-rn4&#8243; disabled_on=\u00bbon|on|on\u00bb _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb9px||||false|false\u00bb border_radii=\u00bbon|5px|5px|5px|5px\u00bb border_width_all=\u00bb3px\u00bb border_color_all=\u00bb#0C71C3&#8243; disabled=\u00bbon\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_video][\/et_pb_column][et_pb_column type=\u00bb2_5&#8243; _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/06\/logo.png\u00bb title_text=\u00bblogo\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb max_width=\u00bb52%\u00bb custom_margin=\u00bb0px||-20px||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb inline_fonts=\u00bbAlike Angular\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h1 style=\"text-align: center;\"><span style=\"font-family: 'Alike Angular'; font-weight: normal; font-size: xx-large;\"><strong><span style=\"color: #002c5f;\">GRADIENT<\/span><\/strong><\/span><\/h1>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb background_color=\u00bbrgba(3,3,10,0.09)\u00bb custom_margin=\u00bb|72px|-4px|72px|false|false\u00bb custom_padding=\u00bb||0px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb locked=\u00bboff\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><\/h2>\n<h2 style=\"text-align: center;\"><span style=\"color: #000000;\"><strong><span style=\"text-decoration: underline;\">Project Information<\/span><\/strong><\/span><\/h2>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li><span style=\"color: #000000;\"><strong>Program<\/strong>:<\/span> <span style=\"color: #000000;\">HORIZON-MSCA-2023-PF-01<\/span><\/li>\n<li><b><span style=\"color: #000000;\">Project Reference: <\/span><\/b><a href=\"https:\/\/cordis.europa.eu\/project\/id\/101151843\"><span style=\"color: #000000;\">101151843<\/span><\/a><\/li>\n<li><span style=\"color: #000000;\"><b>Duration: <\/b>January 2026 to January 2028\u00a0<\/span><\/li>\n<li><span><span><span style=\"color: #000000;\">Implementation Centre:<\/span> <a href=\"https:\/\/ibima.eu\/en\/donde-estamos\/\">IBIMA Plataforma BIONAND<\/a><\/span><\/span><\/li>\n<li><span><a href=\"https:\/\/www.huvv.es\/\"><\/a><\/span><span style=\"color: #000000;\"><span style=\"color: #000000;\">Research group of IBIMA involved: <\/span><\/span><a href=\"https:\/\/ibima.eu\/en\/project\/a-02\/\">Obesity, Diabetes and their Comorbidities: Prevention and Treatment<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb19px||||false|false\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Fellow<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/07\/person-icon.png\u00bb title_text=\u00bbperson-icon\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb min_height=\u00bb209.8px\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||5px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\"><span style=\"font-size: medium;\">Dr. Teresita de Jesus Bello Gonzalez<\/span><\/h2>\n<p>[\/et_pb_text][et_pb_text _builder_version=\u00bb4.25.1&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb]<\/p>\n<h2 style=\"text-align: center;\">Supervisor<\/h2>\n<p>[\/et_pb_text][et_pb_image src=\u00bbhttps:\/\/ibima.eu\/wp-content\/uploads\/2024\/02\/Isabel-Moreno-Genomica-1.png\u00bb alt=\u00bbIsabel Moreno Genomica\u00bb title_text=\u00bbIsabel Moreno Genomica\u00bb align=\u00bbcenter\u00bb _builder_version=\u00bb4.27.5&#8243; _module_preset=\u00bbdefault\u00bb width=\u00bb41%\u00bb max_width=\u00bb73%\u00bb custom_margin=\u00bb||-22px|||\u00bb border_radii=\u00bbon|8px|8px|8px|8px\u00bb border_width_all=\u00bb2px\u00bb border_color_all=\u00bb#0C71C3&#8243; global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_image][et_pb_text _builder_version=\u00bb4.27.4&#8243; _module_preset=\u00bbdefault\u00bb custom_margin=\u00bb||0px|||\u00bb global_colors_info=\u00bb{}\u00bb theme_builder_area=\u00bbpost_content\u00bb][\/et_pb_text][et_pb_text _builder_version=\u00bb4.27.5&#8243; 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Every few years, we witness new dietary trends that promise rapid and efficient weight loss. However, hardly any information is available on the impact of these dietary interventions on the gut [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":39241,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[2191,2233],"tags":[],"class_list":["post-59867","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-proyectos-de-investigacion","category-proyectos-de-investigacion-investigador"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Gradient - Ibima<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibima.eu\/es\/gradient\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gradient - Ibima\" \/>\n<meta property=\"og:description\" content=\"ABSTRACT Obesity affects a big proportion of the global population and impairs health by increasing the risk of type 2 diabetes and heart disease. Every few years, we witness new dietary trends that promise rapid and efficient weight loss. However, hardly any information is available on the impact of these dietary interventions on the gut [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibima.eu\/es\/gradient\/\" \/>\n<meta property=\"og:site_name\" content=\"Ibima\" \/>\n<meta property=\"article:published_time\" content=\"2026-02-09T09:48:55+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-09T10:19:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ibima.eu\/wp-content\/uploads\/2024\/06\/logo.png\" \/>\n\t<meta property=\"og:image:width\" content=\"764\" \/>\n\t<meta property=\"og:image:height\" content=\"759\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Divulgaci\u00f3n\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"Divulgaci\u00f3n\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/gradient\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/gradient\\\/\"},\"author\":{\"name\":\"Divulgaci\u00f3n\",\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/#\\\/schema\\\/person\\\/31b8becdcc53729d5a51d5b3436ce9a5\"},\"headline\":\"Gradient\",\"datePublished\":\"2026-02-09T09:48:55+00:00\",\"dateModified\":\"2026-02-09T10:19:17+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/gradient\\\/\"},\"wordCount\":1567,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/ibima.eu\\\/es\\\/gradient\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ibima.eu\\\/wp-content\\\/uploads\\\/2024\\\/06\\\/logo.png\",\"articleSection\":[\"Proyectos de Investigaci\u00f3n\",\"Proyectos de Investigaci\u00f3n - 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