Aspectos Básicos y Aplicados de las Enfermedades Neuropsiquiatricas y Neurodegenerativas

Lineas de Investigación

Esta línea estudia desde aspectos biomédicos básicos de la neurotransmisión y regeneración en el Sistema Nervioso Central hasta aspectos aplicados a clínica y terapéutica. Está formado por diferentes equipos de trabajo que conforman un grupo multidisciplinar que permite el abordaje de enfermedades neuropsiquiatras y neurodegenerativas desde diferentes aproximaciones pero que convergen en el estudio de mecanismos básicos que permitirán el desarrollo de nuevas herramientas diagnósticas y terapéuticas en el tratamiento de estas enfermedades. Este grupo está avalado por años de investigación y docencia

01. Estudiar el papel de los neuropéptidos en el Sistema Nervioso Central (SNC), en áreas clave en la mediación de las funciones de comportamiento asociados con la ansiedad, depresión y el miedo

02. Analizar la interacción funcional de los sistemas opioide y dopaminérgico durante la dependencia a opiáceos en áreas relacionadas con el aprendizaje y consolidación de hábitos de conducta adictiva.

03. Profundizar en las bases moleculares y celulares implicados (como el estrés oxidativo) en la génesis de procesos neurodegenerativos como envejecimiento y Parkinson y estudiar los efectos neuroprotectores de IGF-II.

04. Diagnóstico precoz, monitorización e intervención en enfermedades neurodegenerativas y neuropsiquiátricas y mediante técnicas de evaluación autonómica y cognitiva. Aspectos básicos y aplicados.



Proyectos de Investigación

PI-0083-2019. ESTUDIO TRASLACIONAL DE LA PARTICIPACIÓN DEL FRAGMENTO N-TERMINAL 1-15 DE LA GALANINA EN LA DEPENDENCIA ALCOHOLICA: NUEVAS ESTRATEGIAS TERAPÉUTICAS Y EVALUACIÓN DE BIOMARCADORES EN ADICCIÓN.

Consejería de Salud y Familias
. 2019

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes) 2018

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018 2014

Publicaciones científicas

  • Todo
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  • Otro
  1. Borroto-Escuela, DO, Narváez, M, Romero-Fernández, W, Pinton, L, Wydra, K, Filip, M et al.. Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes. Mol. Neurobiol. 2019;56 (10):7045-7055. doi: 10.1007/s12035-019-1580-8. PubMed PMID:30972626 PubMed Central PMC6728299.
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  1. Silva-Peña, D, García-Marchena, N, Alén, F, Araos, P, Rivera, P, Vargas, A et al.. Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats. Addict Biol. 2019;24 (5):1019-1033. doi: 10.1111/adb.12668. PubMed PMID:30277635 .
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  1. Merchán, A, Sánchez-Kuhn, A, Prados-Pardo, A, Gago, B, Sánchez-Santed, F, Moreno, M et al.. Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2019;93 :149-160. doi: 10.1016/j.pnpbp.2019.03.016. PubMed PMID:30940483 .
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  1. Millón, C, Flores-Burgess, A, Castilla-Ortega, E, Gago, B, García-Fernandez, M, Serrano, A et al.. Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats. Addict Biol. 2019;24 (1):76-87. doi: 10.1111/adb.12582. PubMed PMID:29210146 .
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  1. Parrado, C, Mercado-Saenz, S, Perez-Davo, A, Gilaberte, Y, Gonzalez, S, Juarranz, A et al.. Environmental Stressors on Skin Aging. Mechanistic Insights. Front Pharmacol. 2019;10 :759. doi: 10.3389/fphar.2019.00759. PubMed PMID:31354480 PubMed Central PMC6629960.
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  1. Merchán, A, Mora, S, Gago, B, Rodriguez-Ortega, E, Fernández-Teruel, A, Puga, JL et al.. Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex. Genes Brain Behav. 2019;18 (3):e12489. doi: 10.1111/gbb.12489. PubMed PMID:29877027 .
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  1. Zamarrón, A, Morel, E, Lucena, SR, Mataix, M, Pérez-Davó, A, Parrado, C et al.. Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Int J Mol Sci. 2019;20 (6):. doi: 10.3390/ijms20061356. PubMed PMID:30889822 PubMed Central PMC6471785.
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  1. Flores-Burgess, A, Millón, C, Gago, B, García-Durán, L, Cantero-García, N, Coveñas, R et al.. Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats. Neuropharmacology. 2019;155 :104-112. doi: 10.1016/j.neuropharm.2019.05.023. PubMed PMID:31128121 .
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  1. Pérez-Belmonte, LM, Osuna-Sánchez, J, Millán-Gómez, M, López-Carmona, MD, Gómez-Doblas, JJ, Cobos-Palacios, L et al.. Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study. Ann. Med. ;51 (3-4):252-261. doi: 10.1080/07853890.2019.1613672. PubMed PMID:31037970 .
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  1. López-Noriega, L, Capilla-González, V, Cobo-Vuilleumier, N, Martin-Vazquez, E, Lorenzo, PI, Martinez-Force, E et al.. Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. Aging (Albany NY). 2019;11 (18):7746-7779. doi: 10.18632/aging.102285. PubMed PMID:31518338 PubMed Central PMC6781991.
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  1. Torres-Prioris, MJ, López-Barroso, D, Paredes-Pacheco, J, Roé-Vellvé, N, Dawid-Milner, MS, Berthier, ML et al.. Language as a Threat: Multimodal Evaluation and Interventions for Overwhelming Linguistic Anxiety in Severe Aphasia. Front Psychol. 2019;10 :678. doi: 10.3389/fpsyg.2019.00678. PubMed PMID:31133908 PubMed Central PMC6517493.
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  1. García-Alberca, JM, Florido, M, Cáceres, M, Sánchez-Toro, A, Lara, JP, García-Casares, N et al.. Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer's disease. Psychogeriatrics. 2019;19 (1):46-54. doi: 10.1111/psyg.12363. PubMed PMID:30084177 .
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  1. Negrete-Díaz, JV, Shumilov, K, Real, MÁ, Medina-Luque, J, Valderrama-Carvajal, A, Flores, G et al.. Pharmacological activation of dopamine D4 receptor modulates morphine-induced changes in the expression of GAD65/67 and GABAB receptors in the basal ganglia. Neuropharmacology. 2019;152 :22-29. doi: 10.1016/j.neuropharm.2019.01.024. PubMed PMID:30682345 .
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  1. Jiménez-Urbieta, H, Gago, B, Quiroga-Varela, A, Rodríguez-Chinchilla, T, Merino-Galán, L, Oregi, A et al.. Pramipexole-induced impulsivity in mildparkinsonian rats: a model of impulse control disorders in Parkinson's disease. Neurobiol. Aging. 2019;75 :126-135. doi: 10.1016/j.neurobiolaging.2018.11.021. PubMed PMID:30572183 .
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  1. Lara, JP, Compañ, A, Vargas-Núñez, JA, Cardellach, F, Fernández-González, S, López-Muñiz, A et al.. Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition. Rev Clin Esp. 2019;219 (2):84-89. doi: 10.1016/j.rce.2018.04.015. PubMed PMID:29887248 .
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  1. Masmudi-Martín, M, Navarro-Lobato, I, López-Aranda, MF, Delgado, G, Martín-Montañez, E, Quiros-Ortega, ME et al.. RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. FASEB J. 2019;33 (11):11804-11820. doi: 10.1096/fj.201900429RR. PubMed PMID:31365833 .
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  1. Millón, C, Flores-Burgess, A, Gago, B, Alén, F, Orio, L, García-Durán, L et al.. Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system. J. Psychopharmacol. (Oxford). 2019;33 (6):737-747. doi: 10.1177/0269881119844188. PubMed PMID:31081442 .
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  1. Pérez-Belmonte, LM, Florido-Santiago, M, Osuna-Sánchez, J, Barbancho, MA, Millán-Gómez, M, Jímenez-Navarro, MF et al.. Screening Versus Brief Domain-specific Tests to Assess Long-term Postoperative Cognitive Dysfunction After Concomitant Aortic Valve Replacement and Coronary Artery Bypass Grafting. J Cardiovasc Nurs. ;34 (6):511-516. doi: 10.1097/JCN.0000000000000596. PubMed PMID:31365446 .
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  1. Martín-Montañez, E, Pavia, J, Valverde, N, Boraldi, F, Lara, E, Oliver, B et al.. The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells. Free Radic. Biol. Med. 2019;137 :116-130. doi: 10.1016/j.freeradbiomed.2019.04.022. PubMed PMID:31035004 .
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  1. Carnero-Martín de Soto, P, Tamimi-Mariño, I, Bautista-Enrique, D, Bravo-Zurita, MJ, Cáceres, AG, Tamimi, F et al.. Use of beta-blockers and risk of aseptic loosening in total hip and knee arthroplasty: a nested case - control study. J Musculoskelet Neuronal Interact. 2019;19 (1):104-111. . PubMed PMID:30839308 PubMed Central PMC6454258.
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  1. de la Cruz Cosme, C, Dawid Milner, MS, Ojeda Burgos, G, Gallardo Tur, A, Márquez Martínez, M, Segura, T et al.. Validation of a basic neurosonology laboratory for detecting cervical carotid artery stenosis. Neurologia. ;34 (6):367-375. doi: 10.1016/j.nrl.2017.01.015. PubMed PMID:28347575 .
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  1. Narváez, M, Borroto-Escuela, DO, Santín, L, Millón, C, Gago, B, Flores-Burgess, A et al.. A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats. Front Cell Neurosci. 2018;12 :119. doi: 10.3389/fncel.2018.00119. PubMed PMID:29765307 PubMed Central PMC5938606.
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  1. Borroto-Escuela, DO, Perez De La Mora, M, Manger, P, Narváez, M, Beggiato, S, Crespo-Ramírez, M et al.. Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors. Front Synaptic Neurosci. 2018;10 :20. doi: 10.3389/fnsyn.2018.00020. PubMed PMID:30042672 PubMed Central PMC6048293.
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  1. de la Cruz-Cosme, C, Dawid-Milner, MS, Ojeda-Burgos, G, Gallardo-Tur, A, Segura, T. Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018;27 (12):3425-3435. doi: 10.1016/j.jstrokecerebrovasdis.2018.08.001. PubMed PMID:30185397 .
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  1. Feltmann, K, Borroto-Escuela, DO, Rüegg, J, Pinton, L, de Oliveira Sergio, T, Narváez, M et al.. Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. Alcohol. Clin. Exp. Res. 2018;42 (2):338-351. doi: 10.1111/acer.13568. PubMed PMID:29205397 PubMed Central PMC5817245.
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  1. López-González, MV, Díaz-Casares, A, González-García, M, Peinado-Aragonés, CA, Barbancho, MA, Carrillo de Albornoz, M et al.. Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area. J. Physiol. Biochem. 2018;74 (2):325-334. doi: 10.1007/s13105-018-0623-3. PubMed PMID:29577176 .
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  1. Sánchez, ML, Mangas, A, Medina, LE, Aguilar, LA, Díaz-Cabiale, Z, Narváez, JA et al.. Immunohistochemical mapping of neurotensin in the alpaca diencephalon. Folia Histochem. Cytobiol. 2018;56 (1):49-58. doi: 10.5603/FHC.a2018.0003. PubMed PMID:29516445 .
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  1. Parrado, C, Philips, N, Gilaberte, Y, Juarranz, A, González, S. Oral Photoprotection: Effective Agents and Potential Candidates. Front Med (Lausanne). 2018;5 :188. doi: 10.3389/fmed.2018.00188. PubMed PMID:29998107 PubMed Central PMC6028556.
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  1. Delgado-Alvarado, M, Dacosta-Aguayo, R, Navalpotro-Gómez, I, Gago, B, Gorostidi, A, Jiménez-Urbieta, H et al.. Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study. Mov. Disord. 2018;33 (11):1809-1813. doi: 10.1002/mds.27518. PubMed PMID:30423201 .
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  1. Borroto-Escuela, DO, Narváez, M, Ambrogini, P, Ferraro, L, Brito, I, Romero-Fernandez, W et al.. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules. 2018;23 (6):. doi: 10.3390/molecules23061341. PubMed PMID:29865267 PubMed Central PMC6099659.
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  1. Shumilov, K, Real, MÁ, Valderrama-Carvajal, A, Rivera, A. Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway. PLoS ONE. 2018;13 (8):e0203135. doi: 10.1371/journal.pone.0203135. PubMed PMID:30157254 PubMed Central PMC6114927.
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  1. Lucena-Serrano, C, Lucena-Serrano, A, Rivera, A, López-Romero, JM, Valpuesta, M, Díaz, A et al.. Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines. Bioorg. Chem. 2018;80 :480-491. doi: 10.1016/j.bioorg.2018.06.038. PubMed PMID:29990896 .
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  1. Sánchez-Marín, L, Ladrón de Guevara-Miranda, D, Mañas-Padilla, MC, Alén, F, Moreno-Fernández, RD, Díaz-Navarro, C et al.. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018;133 :189-201. doi: 10.1016/j.neuropharm.2018.01.033. PubMed PMID:29378212 .
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  1. Carrillo-Linares, JL, García-Fernández, MI, Morillo, MJ, Sánchez, P, Rioja, J, Barón, FJ et al.. The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study. Front Med (Lausanne). 2018;5 :86. doi: 10.3389/fmed.2018.00086. PubMed PMID:29713628 PubMed Central PMC5911498.
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  1. Sampedro-Piquero, P, Moreno-Fernández, RD, Mañas-Padilla, MC, Gil-Rodríguez, S, Gavito, AL, Pavón, FJ et al.. Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiol Learn Mem. 2018;151 :35-42. doi: 10.1016/j.nlm.2018.03.023. PubMed PMID:29608953 .
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  1. Valderrama-Carvajal, A, Irizar, H, Gago, B, Jiménez-Urbieta, H, Fuxe, K, Rodríguez-Oroz, MC et al.. Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen. Sci Rep. 2018;8 (1):7337. doi: 10.1038/s41598-018-25604-4. PubMed PMID:29743514 PubMed Central PMC5943359.
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  1. Alonso-Montejo, MM, Pradillo, MC, Moreno-Medinilla, EE, Navas-Sanchez, P, Martinez-Anton, JL. [Acute polyneuropathies in a hospital in the south of Spain: ten years' experience]. Rev Neurol. 2017;64 (11):502-508. . PubMed PMID:28555456 .
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  1. Rodriguez-Losada, N, Romero, P, Estivill-Torrús, G, Guzmán de Villoria, R, Aguirre, JA. Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos. PLoS ONE. 2017;12 (3):e0173978. doi: 10.1371/journal.pone.0173978. PubMed PMID:28334019 PubMed Central PMC5363826.
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  1. Borroto-Escuela, DO, Narváez, M, Wydra, K, Pintsuk, J, Pinton, L, Jimenez-Beristain, A et al.. Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder. Pharmacol. Biochem. Behav. 2017;155 :24-31. doi: 10.1016/j.pbb.2017.03.003. PubMed PMID:28300546 .
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  1. Alameda, MT, Morel, E, Parrado, C, González, S, Juarranz, Á. Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells. Int J Mol Sci. 2017;18 (2):. doi: 10.3390/ijms18020463. PubMed PMID:28230777 PubMed Central PMC5343996.
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  1. Borroto-Escuela, DO, DuPont, CM, Li, X, Savelli, D, Lattanzi, D, Srivastava, I et al.. Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression. Front Cell Neurosci. 2017;11 :309. doi: 10.3389/fncel.2017.00309. PubMed PMID:29066953 PubMed Central PMC5641403.
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  1. Rivera, A, Gago, B, Suárez-Boomgaard, D, Yoshitake, T, Roales-Buján, R, Valderrama-Carvajal, A et al.. Dopamine D4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction. Addict Biol. 2017;22 (5):1232-1245. doi: 10.1111/adb.12407. PubMed PMID:27212105 .
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  1. Chamorro, M, Lara, JP, Insa, I, Espadas, M, Alda-Diez, JA. [Evaluation and treatment of sleep problems in children diagnosed with attention deficit hyperactivity disorder: an update of the evidence]. Rev Neurol. 2017;64 (9):413-421. . PubMed PMID:28444684 .
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  1. Flores-Burgess, A, Millón, C, Gago, B, Narváez, M, Borroto-Escuela, DO, Mengod, G et al.. Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression. Neuropharmacology. 2017;118 :233-241. doi: 10.1016/j.neuropharm.2017.03.010. PubMed PMID:28288814 .
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  1. Martín-Montañez, E, Millon, C, Boraldi, F, Garcia-Guirado, F, Pedraza, C, Lara, E et al.. IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids. Redox Biol. 2017;13 :69-81. doi: 10.1016/j.redox.2017.05.012. PubMed PMID:28575743 PubMed Central PMC5454142.
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  1. Ladrón de Guevara-Miranda, D, Millón, C, Rosell-Valle, C, Pérez-Fernández, M, Missiroli, M, Serrano, A et al.. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10 (3):323-336. doi: 10.1242/dmm.026682. PubMed PMID:28138095 PubMed Central PMC5374316.
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  1. Moreno-Fernández, RD, Pérez-Martín, M, Castilla-Ortega, E, Rosell Del Valle, C, García-Fernández, MI, Chun, J et al.. maLPA1-null mice as an endophenotype of anxious depression. Transl Psychiatry. 2017;7 (4):e1077. doi: 10.1038/tp.2017.24. PubMed PMID:28375206 PubMed Central PMC5416683.
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  1. Duque-Díaz, E, Díaz-Cabiale, Z, Narváez, JA, Coveñas, R. Mapping of enkephalins and adrenocorticotropic hormone in the squirrel monkey brainstem. Anat Sci Int. 2017;92 (2):275-292. doi: 10.1007/s12565-016-0333-2. PubMed PMID:26897373 .
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  1. Rodriguez-Losada, N, Aguirre, JA. The impact of graphene on neural regenerative medicine. Neural Regen Res. 2017;12 (7):1071-1072. doi: 10.4103/1673-5374.211181. PubMed PMID:28852385 PubMed Central PMC5558482.
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  1. Millón, C, Flores-Burgess, A, Narváez, M, Borroto-Escuela, DO, Gago, B, Santín, L et al.. The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours. Neuropeptides. 2017;64 :39-45. doi: 10.1016/j.npep.2017.01.004. PubMed PMID:28196617 .
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  1. Borroto-Escuela, DO, Carlsson, J, Ambrogini, P, Narváez, M, Wydra, K, Tarakanov, AO et al.. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease. Front Cell Neurosci. 2017;11 :37. doi: 10.3389/fncel.2017.00037. PubMed PMID:28270751 PubMed Central PMC5318393.
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  1. García-Basterra, I, Lahrach, I, Morillo Sánchez, MJ, Kamal-Salah, R, Ríus-Díaz, F, Dawid Milner, MS et al.. Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2016;100 (7):891-896. doi: 10.1136/bjophthalmol-2015-307526. PubMed PMID:26453640 .
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  1. Martín-Gallego, A, Andrade-Andrade, I, Dawid-Milner, MS, Domínguez-Páez, M, Romero-Moreno, L, González-García, L et al.. Autonomic dysfunction elicited by a medulla oblongata injury after fourth ventricle tumor surgery in a pediatric patient. Auton Neurosci. 2016;194 :52-7. doi: 10.1016/j.autneu.2015.12.002. PubMed PMID:26681574 .
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  1. Delgado-Alvarado, M, Gago, B, Navalpotro-Gomez, I, Jiménez-Urbieta, H, Rodriguez-Oroz, MC. Biomarkers for dementia and mild cognitive impairment in Parkinson's disease. Mov. Disord. 2016;31 (6):861-81. doi: 10.1002/mds.26662. PubMed PMID:27193487 .
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  1. Parrado, C, Mascaraque, M, Gilaberte, Y, Juarranz, A, Gonzalez, S. Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review. Int J Mol Sci. 2016;17 (7):. doi: 10.3390/ijms17071026. PubMed PMID:27367679 PubMed Central PMC4964402.
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  1. Millón, C, Flores-Burgess, A, Narváez, M, Borroto-Escuela, DO, Santín, L, Gago, B et al.. Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system. Brain Struct Funct. 2016;221 (9):4491-4504. doi: 10.1007/s00429-015-1180-y. PubMed PMID:26792005 .
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  1. Narváez, M, Borroto-Escuela, DO, Millón, C, Gago, B, Flores-Burgess, A, Santín, L et al.. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects. Brain Struct Funct. 2016;221 (8):4129-4139. doi: 10.1007/s00429-015-1153-1. PubMed PMID:26666529 .
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  1. Sánchez, ML, Díaz-Cabiale, Z, Narváez, JA, Manso, B, Salinas, P, Rivada, E et al.. Mapping of methionine-enkephalin-arg6-gly7-leu8 in the human diencephalon. Neuroscience. 2016;334 :245-258. doi: 10.1016/j.neuroscience.2016.08.010. PubMed PMID:27531857 .
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  1. Navas, P, Rodríguez-Santos, L, Bauzano-Poley, E, Lara, JP, Barbancho, MÁ. [The importance of sleep deprivation as a mechanism for activating interictal epileptiform paroxysms]. Rev Neurol. 2016;62 (7):289-95. . PubMed PMID:26988166 .
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  1. Borroto-Escuela, DO, Wydra, K, Pintsuk, J, Narvaez, M, Corrales, F, Zaniewska, M et al.. Understanding the Functional Plasticity in Neural Networks of the Basal Ganglia in Cocaine Use Disorder: A Role for Allosteric Receptor-Receptor Interactions in A2A-D2 Heteroreceptor Complexes. Neural Plast. 2016;2016 :4827268. doi: 10.1155/2016/4827268. PubMed PMID:27872762 PubMed Central PMC5107220.
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