Lineas de Investigación

01. Estudio de los mecanismos implicados en la generación del cáncer de piel con búsqueda específica de nuevos factores pronósticos, así como el abordaje terapeútico de las mismas.

02. Prevención del cáncer cutáneo con investigaciones en el campo de la fotoprotección

03. Análisis de la etiopatogenia de la psoriasis y su tratamiento tanto por mecanismos inmunoterapeúticos y fototerapia.



Estudios Clínicos

I1F-MC-RHBA.

Estudio multicéntrico, aleatorizado, en doble ciego y controlado con placebo, para comparar la eficacia y la seguridad de LY2439821 frente a etanercept y placebo en pacientes con psoriasis en placas de grado moderado a severo

ELI LILLY AND COMPANY
Fase: III ENSAYO CLINICO COMERCIAL

WA29330.

Estudio multicéntrico, aleatorizado, doble ciego, con doble simulación y comparador activo para evaluar la eficacia y la seguridad de rituximab en comparación con MMF en pacientes con pénfigo vulgar

F. HOFFMANN LA ROCHE LTD
Fase: III ENSAYO CLINICO COMERCIAL

CAIN457A3401.

Ensayo abierto, prospectivo, no aleatorizado, multicéntrico para evaluar el efecto de piel blanqueada en los resultados de calidad de vida relacionada con la salud a las 16 y 52 semanas en pacientes con psoriasis en placas de moderada a grave tratados con

NOVARTIS FARMACEUTICA, S.A.
Fase: IV ENSAYO CLINICO COMERCIAL

SP14019-18.

Evaluación de la solución de uso cutáneo SP14019-F-01 para el tratamiento de la dermatitis atópica. Estudio piloto. Estudio Cyclatop

SPHERIUM BIOMED S.L (ANTES JANUS DEVELOPMENT)
Fase: II ENSAYO CLINICO COMERCIAL

CAIN457A2323.

Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo, de 52 semanas de duración para demostrar la eficacia, seguridad y tolerabilidad de inyecciones subcutáneas de secukinumab con jeringas precargadas de 2 ml (300 mg) en pacientes adul

NOVARTIS FARMACEUTICA, S.A.
Fase: III ENSAYO CLINICO COMERCIAL

M-41008-41.

Estudio clínico abierto para evaluar la eficacia y la seguridad a largo plazo de dimetilfumarato en adultos con psoriasis crónica en placas moderada-grave en la práctica clínica (Estudio DIMESKIN 1)

ALMIRALL S.A.
Fase: IV ENSAYO CLINICO COMERCIAL


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Dirschka, T, Ekanayake-Bohlig, S, Dominicus, R, Aschoff, R, Herrera-Ceballos, E, Botella-Estrada, R et al.. A randomized, intraindividual, non-inferiority, Phase III study comparing daylight photodynamic therapy with BF-200 ALA gel and MAL cream for the treatment of actinic keratosis. J Eur Acad Dermatol Venereol. 2019;33 (2):288-297. doi: 10.1111/jdv.15185. PubMed PMID:30022544 PubMed Central PMC6585804.
Search PubMed
  1. Valencia-Vera, E, Aguilera, J, Cobos, A, Bernabó, JL, Pérez-Valero, V, Herrera-Ceballos, E et al.. Association between seasonal serum folate levels and ultraviolet radiation. J Photochem Photobiol B. 2019;190 :66-71. doi: 10.1016/j.jphotobiol.2018.10.012. PubMed PMID:30502586 .
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  1. Aterido, A, Cañete, JD, Tornero, J, Ferrándiz, C, Pinto, JA, Gratacós, J et al.. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. Ann Rheum Dis. 2019;78 (3):. doi: 10.1136/annrheumdis-2018-214158. PubMed PMID:30552173 .
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  1. Montes-Torres, A, Aparicio, G, Rivera, R, Vilarrasa, E, Marcellán, M, Notario, J et al.. Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study. J Dermatolog Treat. 2019;30 (5):461-465. doi: 10.1080/09546634.2018.1535690. PubMed PMID:30307344 .
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  1. López Jiménez, P, Suárez Pérez, J, Herrera Acosta, E, Aguilera Arjona, J, Mendiola Fernández, MV, Bosch García, R et al.. Secukinumab versus ustekinumab for skin clearance in patients with moderate to severe psoriasis after a year of treatment: Real-world practice. Dermatol Ther. 2019;32 (4):e12937. doi: 10.1111/dth.12937. PubMed PMID:30983098 .
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  1. de la Coba, F, Aguilera, J, Korbee, N, de Gálvez, MV, Herrera-Ceballos, E, Álvarez-Gómez, F et al.. UVA and UVB Photoprotective Capabilities of Topical Formulations Containing Mycosporine-like Amino Acids (MAAs) through Different Biological Effective Protection Factors (BEPFs). Mar Drugs. 2019;17 (1):. doi: 10.3390/md17010055. PubMed PMID:30646557 PubMed Central PMC6356945.
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  1. de Gálvez, MV, Aguilera, J, Sánchez-Roldán, C, Herrera-Acosta, E, Herrera-Ceballos, E. Water-Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation. Photochem Photobiol. 2019;95 (3):874-878. doi: 10.1111/php.13049. PubMed PMID:30447157 .
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  1. Baños-Arévalo, AJ, López-Navarro, N, Gallego-Domínguez, E, Herrera, E. Acral Metastasis of the Fingers: Report of 2 Cases. Actas Dermosifiliogr (Engl Ed). 2018;109 (10):e1-e4. doi: 10.1016/j.ad.2017.03.024. PubMed PMID:29724431 .
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  1. Garcia-Doval, I, Descalzo, MA, Mason, KJ, Cohen, AD, Ormerod, AD, Gómez-García, FJ et al.. Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland. Br J Dermatol. 2018;179 (4):863-871. doi: 10.1111/bjd.16715. PubMed PMID:29723914 .
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  1. Willson-Kerns, C, Brazile, WJ. Noise Exposure and Evaluation at Tire- Changing Facilities. Ann Work Expo Health. 2021; :. doi: 10.1093/annweh/wxab031. PubMed PMID:34228059 .
  2. Zou, Z, Shi, ZZ, Wu, JG, Wu, C, Zeng, QX, Zhang, YY et al.. Atomically Dispersed Co to an End-Adsorbing Molecule for Excellent Biomimetically and Prime Sensitively Detecting O2•- Released from Living Cells. Anal Chem. 2021; :. doi: 10.1021/acs.analchem.1c00483. PubMed PMID:34212722 .
  3. Khalil, S, Elnaggar, AY. Selective Membrane Sensor for Aluminum Determination in Food Products, Real Samples and Standard Alloys. Membranes (Basel). 2021;11 (7):. doi: 10.3390/membranes11070504. PubMed PMID:34209425 PubMed Central PMC8308029.
  4. Areo, OM, Njobeh, PB. Risk assessment of heavy metals in rooibos (Aspalathus linearis) tea consumed in South Africa. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14968-2. PubMed PMID:34145539 .
  5. Kapten, K, Orczyk, K, Smolewska, E. The effect of vitamin D3 and thyroid hormones on the capillaroscopy-confirmed microangiopathy in pediatric patients with a suspicion of systemic connective tissue disease-a single-center experience with Raynaud phenomenon. Rheumatol Int. 2021;41 (8):1485-1493. doi: 10.1007/s00296-021-04919-y. PubMed PMID:34132891 PubMed Central PMC8207495.
  6. Lim, JS, Ha, JW. Growth temperature influences the resistance of Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium on lettuce to X-ray irradiation. Food Microbiol. 2021;99 :103825. doi: 10.1016/j.fm.2021.103825. PubMed PMID:34119110 .
  7. Lim, J, Kim, E, Shin, Y, Ryu, JH, Kim, H. Antimicrobial activity of ClO2 gas against Salmonella Enteritidis on almonds. Food Microbiol. 2021;99 :103819. doi: 10.1016/j.fm.2021.103819. PubMed PMID:34119104 .
  8. Mehmood, K, Bao, Y, Abbas, R, Saifullah,, Petropoulos, GP, Ahmad, HR et al.. Pollution characteristics and human health risk assessments of toxic metals and particle pollutants via soil and air using geoinformation in urbanized city of Pakistan. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14436-x. PubMed PMID:34110590 .
  9. Lee, HJ, Chun, KY, Oh, JH, Han, CS. Wearable Triboelectric Strain-Insensitive Pressure Sensors Based on Hierarchical Superposition Patterns. ACS Sens. 2021;6 (6):2411-2418. doi: 10.1021/acssensors.1c00640. PubMed PMID:34100591 .
  10. Liu, B, Yan, Y, Liang, H, Tang, K, Ding, CF. One-step preparation of carbonaceous spheres rich in phosphate groups via hydrothermal carbonization for effective phosphopeptides enrichment. J Chromatogr A. 2021;1651 :462285. doi: 10.1016/j.chroma.2021.462285. PubMed PMID:34090058 .
  11. Chen, ZE, Zang, XF, Zhang, H. An ethyl thioglycolate-based chemosensor: Spectrophotometric detection of Fe3+ and fluorometric detection of Hg2+ with high selectivity. Spectrochim Acta A Mol Biomol Spectrosc. 2021;260 :119955. doi: 10.1016/j.saa.2021.119955. PubMed PMID:34082353 .
  12. Akter, S, Lamminmäki, U. A 15-min non-competitive homogeneous assay for microcystin and nodularin based on time-resolved Förster resonance energy transfer (TR-FRET). Anal Bioanal Chem. 2021; :. doi: 10.1007/s00216-021-03375-8. PubMed PMID:34080035 .
  13. Lee, S, Kang, D, Kim, Y, Kim, YJ, Kim, SY. Activity-Based Exposure Levels and Cancer Risk Assessment Due to Naturally Occurring Asbestos for the Residents Near Abandoned Asbestos Mines in South Korea. Int J Environ Res Public Health. 2021;18 (10):. doi: 10.3390/ijerph18105225. PubMed PMID:34069013 PubMed Central PMC8156354.
  14. Shah, A, Tauseef, I, Ali, MB, Yameen, MA, Mezni, A, Hedfi, A et al.. In-Vitro and In-Vivo Tolerance and Therapeutic Investigations of Phyto-Fabricated Iron Oxide Nanoparticles against Selected Pathogens. Toxics. 2021;9 (5):. doi: 10.3390/toxics9050105. PubMed PMID:34066825 PubMed Central PMC8150543.
  15. Bullard, TJ, Susner, MA, Taddei, KM, Brant, JA, Haugan, TJ. Magnetic and structural properties of the solid solution CuAl2(1-x)Ga2xO4. Sci Rep. 2021;11 (1):11355. doi: 10.1038/s41598-021-89197-1. PubMed PMID:34059700 PubMed Central PMC8167108.
  16. Balamurugan, M, Shanmugam, R, Chen, TW, Chen, SM, Lou, BS, Liu, X et al.. Temperature abetted synthesis of novel magnesium stannate nanoparticles assisted for nanomolar level detection of hazardous flavonoid in biological samples. Food Chem. 2021;361 :130162. doi: 10.1016/j.foodchem.2021.130162. PubMed PMID:34051600 .
  17. Tian, LL, Han, F, Fodjo, EK, Zhai, W, Huang, XY, Kong, C et al.. An Effective and Efficient Sample Preparation Method for 2-Methyl-Isoborneol and Geosmin in Fish and Their Analysis by Gas Chromatography-Mass Spectrometry. Int J Anal Chem. 2021;2021 :9980212. doi: 10.1155/2021/9980212. PubMed PMID:34046066 PubMed Central PMC8128619.
  18. Denissen, JK, Reyneke, B, Waso, M, Khan, S, Khan, W. Human Pathogenic Bacteria Detected in Rainwater: Risk Assessment and Correlation to Microbial Source Tracking Markers and Traditional Indicators. Front Microbiol. 2021;12 :659784. doi: 10.3389/fmicb.2021.659784. PubMed PMID:34025613 PubMed Central PMC8138566.
  19. Garrison, TF, Kaminski, MA, Tawabini, B, Frontalini, F. Sediment oxygen demand and benthic foraminiferal faunas in the Arabian Gulf: A test of the method on a siliciclastic substrate. Saudi J Biol Sci. 2021;28 (5):2907-2913. doi: 10.1016/j.sjbs.2021.02.024. PubMed PMID:34025168 PubMed Central PMC8117160.
  20. Lindberg, JE, Quinn, MM, Gore, RJ, Galligan, CJ, Sama, SR, Sheikh, NN et al.. Assessment of home care aides' respiratory exposure to total volatile organic compounds and chlorine during simulated bathroom cleaning: An experimental design with conventional and "green" products. J Occup Environ Hyg. 2021;18 (6):276-287. doi: 10.1080/15459624.2021.1910280. PubMed PMID:34004120 .
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  1. de Troya-Martín, M, de Gálvez-Aranda, MV, Rivas-Ruiz, F, Blázquez-Sánchez, N, Fernández-Morano, MT, Padilla-España, L et al.. Prevalence and predictors of sunburn among beachgoers. Photodermatol Photoimmunol Photomed. 2018;34 (2):122-129. doi: 10.1111/phpp.12354. PubMed PMID:28976044 .
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  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
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  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
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  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J Invest Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
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  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
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  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew Chem Int Ed Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
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  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
Search PubMed
  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
Search PubMed
  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J Invest Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
Search PubMed
  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
Search PubMed
  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew Chem Int Ed Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
Search PubMed
  1. de Troya-Martín, M, Padilla-España, L, Férnandez-Morano, T, Delgado-Sánchez, N, Blázquez Sánchez, N, Rivas-Ruiz, F et al.. Sun Protection Habits and Attitudes Among Healthcare Personnel in a Mediterranean Population. J Cancer Educ. 2016;31 (4):789-795. doi: 10.1007/s13187-015-0913-1. PubMed PMID:26370806 .
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  1. Dávila-Seijo, P, Dauden, E, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ et al.. Survival of classic and biological systemic drugs in psoriasis: results of the BIOBADADERM registry and critical analysis. J Eur Acad Dermatol Venereol. 2016;30 (11):1942-1950. doi: 10.1111/jdv.13682. PubMed PMID:27329511 .
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  1. Julià, A, Pinto, JA, Gratacós, J, Queiró, R, Ferrándiz, C, Fonseca, E et al.. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. Ann Rheum Dis. 2015;74 (10):1875-81. doi: 10.1136/annrheumdis-2014-207190. PubMed PMID:25990289 .
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  1. Julià, A, Ferrándiz, C, Dauden, E, Fonseca, E, Fernández-López, E, Sanchez-Carazo, JL et al.. Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis. Pharmacogenomics J. 2015;15 (4):322-5. doi: 10.1038/tpj.2014.71. PubMed PMID:25403996 .
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  1. Tejera-Vaquerizo, A, Arias-Santiago, S, Nagore, E, Martín-Cuevas, P, Orgaz-Molina, J, Traves, V et al.. Defining the dermoscopic characteristics of fast-growing cutaneous melanomas. Melanoma Res. 2015;25 (3):269-72. doi: 10.1097/CMR.0000000000000157. PubMed PMID:25919929 .
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  1. Tejera-Vaquerizo, A, Nagore, E, Puig, S, Robert, C, Saiag, P, Martín-Cuevas, P et al.. Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. Eur J Cancer. 2015;51 (13):1780-93. doi: 10.1016/j.ejca.2015.05.023. PubMed PMID:26072362 PubMed Central PMC4768477.
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  1. de Gálvez, MV, Aguilera, J, Bernabó, JL, Sánchez-Roldán, C, Herrera-Ceballos, E. Human Hair as a Natural Sun Protection Agent: A Quantitative Study. Photochem Photobiol. ;91 (4):966-70. doi: 10.1111/php.12433. PubMed PMID:25682789 .
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  1. Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha Sebastián, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5-year observational study of clinical practice: 2008-2013 results of the Biobadaderm registry. J Eur Acad Dermatol Venereol. 2015;29 (1):156-63. doi: 10.1111/jdv.12492. PubMed PMID:24684267 .
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  1. Medina, C, Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha, F, Gómez-García, FJ et al.. Safety of classic and biologic systemic therapies for the treatment of psoriasis in elderly: an observational study from national BIOBADADERM registry. J Eur Acad Dermatol Venereol. 2015;29 (5):858-64. doi: 10.1111/jdv.12688. PubMed PMID:25185962 .
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