Lineas de Investigación

01. Estudio de los mecanismos implicados en la generación del cáncer de piel con búsqueda específica de nuevos factores pronósticos, así como el abordaje terapeútico de las mismas.

02. Prevención del cáncer cutáneo con investigaciones en el campo de la fotoprotección

03. Análisis de la etiopatogenia de la psoriasis y su tratamiento tanto por mecanismos inmunoterapeúticos y fototerapia.



Estudios Clínicos

I1F-MC-RHBA.

Estudio multicéntrico, aleatorizado, en doble ciego y controlado con placebo, para comparar la eficacia y la seguridad de LY2439821 frente a etanercept y placebo en pacientes con psoriasis en placas de grado moderado a severo

ELI LILLY AND COMPANY
Fase: III ENSAYO CLINICO COMERCIAL

WA29330.

Estudio multicéntrico, aleatorizado, doble ciego, con doble simulación y comparador activo para evaluar la eficacia y la seguridad de rituximab en comparación con MMF en pacientes con pénfigo vulgar

F. HOFFMANN LA ROCHE LTD
Fase: III ENSAYO CLINICO COMERCIAL

CAIN457A3401.

Ensayo abierto, prospectivo, no aleatorizado, multicéntrico para evaluar el efecto de piel blanqueada en los resultados de calidad de vida relacionada con la salud a las 16 y 52 semanas en pacientes con psoriasis en placas de moderada a grave tratados con

NOVARTIS FARMACEUTICA, S.A.
Fase: IV ENSAYO CLINICO COMERCIAL

SP14019-18.

Evaluación de la solución de uso cutáneo SP14019-F-01 para el tratamiento de la dermatitis atópica. Estudio piloto. Estudio Cyclatop

SPHERIUM BIOMED S.L (ANTES JANUS DEVELOPMENT)
Fase: II ENSAYO CLINICO COMERCIAL

CAIN457A2323.

Estudio multicéntrico, aleatorizado, doble ciego, controlado con placebo, de 52 semanas de duración para demostrar la eficacia, seguridad y tolerabilidad de inyecciones subcutáneas de secukinumab con jeringas precargadas de 2 ml (300 mg) en pacientes adul

NOVARTIS FARMACEUTICA, S.A.
Fase: III ENSAYO CLINICO COMERCIAL

M-41008-41.

Estudio clínico abierto para evaluar la eficacia y la seguridad a largo plazo de dimetilfumarato en adultos con psoriasis crónica en placas moderada-grave en la práctica clínica (Estudio DIMESKIN 1)

ALMIRALL S.A.
Fase: IV ENSAYO CLINICO COMERCIAL


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Dirschka, T, Ekanayake-Bohlig, S, Dominicus, R, Aschoff, R, Herrera-Ceballos, E, Botella-Estrada, R et al.. A randomized, intraindividual, non-inferiority, Phase III study comparing daylight photodynamic therapy with BF-200 ALA gel and MAL cream for the treatment of actinic keratosis. J Eur Acad Dermatol Venereol. 2019;33 (2):288-297. doi: 10.1111/jdv.15185. PubMed PMID:30022544 PubMed Central PMC6585804.
Search PubMed
  1. Valencia-Vera, E, Aguilera, J, Cobos, A, Bernabó, JL, Pérez-Valero, V, Herrera-Ceballos, E et al.. Association between seasonal serum folate levels and ultraviolet radiation. J Photochem Photobiol B. 2019;190 :66-71. doi: 10.1016/j.jphotobiol.2018.10.012. PubMed PMID:30502586 .
Search PubMed
  1. Aterido, A, Cañete, JD, Tornero, J, Ferrándiz, C, Pinto, JA, Gratacós, J et al.. Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis. Ann Rheum Dis. 2019;78 (3):. doi: 10.1136/annrheumdis-2018-214158. PubMed PMID:30552173 .
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  1. Montes-Torres, A, Aparicio, G, Rivera, R, Vilarrasa, E, Marcellán, M, Notario, J et al.. Safety and effectiveness of conventional systemic therapy and biological drugs in patients with moderate to severe psoriasis and HIV infection: a retrospective multicenter study. J Dermatolog Treat. 2019;30 (5):461-465. doi: 10.1080/09546634.2018.1535690. PubMed PMID:30307344 .
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  1. López Jiménez, P, Suárez Pérez, J, Herrera Acosta, E, Aguilera Arjona, J, Mendiola Fernández, MV, Bosch García, R et al.. Secukinumab versus ustekinumab for skin clearance in patients with moderate to severe psoriasis after a year of treatment: Real-world practice. Dermatol Ther. 2019;32 (4):e12937. doi: 10.1111/dth.12937. PubMed PMID:30983098 .
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  1. de la Coba, F, Aguilera, J, Korbee, N, de Gálvez, MV, Herrera-Ceballos, E, Álvarez-Gómez, F et al.. UVA and UVB Photoprotective Capabilities of Topical Formulations Containing Mycosporine-like Amino Acids (MAAs) through Different Biological Effective Protection Factors (BEPFs). Mar Drugs. 2019;17 (1):. doi: 10.3390/md17010055. PubMed PMID:30646557 PubMed Central PMC6356945.
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  1. de Gálvez, MV, Aguilera, J, Sánchez-Roldán, C, Herrera-Acosta, E, Herrera-Ceballos, E. Water-Filtered Infrared Radiation Decreases the Generation of Photodermatoses Dependent on Ultraviolet and Visible Radiation. Photochem Photobiol. 2019;95 (3):874-878. doi: 10.1111/php.13049. PubMed PMID:30447157 .
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  1. Baños-Arévalo, AJ, López-Navarro, N, Gallego-Domínguez, E, Herrera, E. Acral Metastasis of the Fingers: Report of 2 Cases. Actas Dermosifiliogr. 2018;109 (10):e1-e4. doi: 10.1016/j.ad.2017.03.024. PubMed PMID:29724431 .
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  1. Garcia-Doval, I, Descalzo, MA, Mason, KJ, Cohen, AD, Ormerod, AD, Gómez-García, FJ et al.. Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland. Br J Dermatol. 2018;179 (4):863-871. doi: 10.1111/bjd.16715. PubMed PMID:29723914 .
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  1. Zhang, J, Gao, Y, Zhang, X, Feng, Q, Zhan, C, Song, J et al.. "Dual Signal-On" Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification. Anal Chem. 2021; :. doi: 10.1021/acs.analchem.1c00415. PubMed PMID:33960777 .
  2. Dat, ND, Nguyen, VT, Vo, TD, Bui, XT, Bui, MH, Nguyen, LSP et al.. Contamination, source attribution, and potential health risks of heavy metals in street dust of a metropolitan area in Southern Vietnam. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14246-1. PubMed PMID:33954920 .
  3. Liu, Y, Zhang, D, Ding, J, Hayat, K, Yang, X, Zhan, X et al.. A Facile Aptasensor for Instantaneous Determination of Cadmium Ions Based on Fluorescence Amplification Effect of MOPS on FAM-Labeled Aptamer. Biosensors (Basel). 2021;11 (5):. doi: 10.3390/bios11050133. PubMed PMID:33922514 .
  4. Sáez Moreno, D, Visram, Z, Mutti, M, Restrepo-Córdoba, M, Hartmann, S, Kremers, AI et al.. ε2-Phages Are Naturally Bred and Have a Vastly Improved Host Range in Staphylococcus aureus over Wild Type Phages. Pharmaceuticals (Basel). 2021;14 (4):. doi: 10.3390/ph14040325. PubMed PMID:33918287 PubMed Central PMC8065394.
  5. Yamaguchi, T, Taira, Y, Matsuo, M, Orita, M, Yamada, Y, Takamura, N et al.. LOCAL LEVELS OF RADIATION EXPOSURE DOSES DUE TO RADIOCESIUM FOR RETURNED RESIDENTS IN TOMIOKA TOWN, FUKUSHIMA PREFECTURE. Radiat Prot Dosimetry. 2021; :. doi: 10.1093/rpd/ncab049. PubMed PMID:33876245 .
  6. Liu, K, Wang, G, Ding, N, Zhang, J, Kong, J, Liu, T et al.. High-Performance Trichloroacetic Acid Sensor Based on the Intramolecular Hydrogen Bond Formation and Disruption of a Specially Designed Fluorescent o-Carborane Derivative in the Film State. ACS Appl Mater Interfaces. 2021;13 (16):19342-19350. doi: 10.1021/acsami.1c03331. PubMed PMID:33848121 .
  7. Bodor, K, Bodor, Z, Szép, A, Szép, R. Human health impact assessment and temporal distribution of trace elements in Copșa Mică- Romania. Sci Rep. 2021;11 (1):7049. doi: 10.1038/s41598-021-86488-5. PubMed PMID:33782481 PubMed Central PMC8007619.
  8. Fang, B, Zeng, H, Zhang, L, Wang, H, Liu, J, Hao, K et al.. Toxic metals in outdoor/indoor airborne PM2.5 in port city of Northern, China: Characteristics, sources, and personal exposure risk assessment. Environ Pollut. 2021;279 :116937. doi: 10.1016/j.envpol.2021.116937. PubMed PMID:33756243 .
  9. Qiao, SP, Liu, ZN, Li, HC, He, X, Pan, H, Gao, YZ et al.. Construction of a CRISPR-Biolayer Interferometry Platform for Real-Time, Sensitive, and Specific DNA Detection. Chembiochem. 2021; :. doi: 10.1002/cbic.202100054. PubMed PMID:33682991 .
  10. Siersbæk, J, Larsen, AR, Nybo, M, Christesen, HT. A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism. Front Endocrinol (Lausanne). 2020;11 :614993. doi: 10.3389/fendo.2020.614993. PubMed PMID:33679602 PubMed Central PMC7935514.
  11. Li, W, Yang, G, Terzis, A, Mukherjee, S, He, C, An, X et al.. In Situ Tracking of Wetting-Front Transient Heat Release on a Surface-Mounted Metal-Organic Framework. Adv Mater. 2021;33 (14):e2006980. doi: 10.1002/adma.202006980. PubMed PMID:33624896 .
  12. Li, HJ, Wang, QS, Han, W, Zhou, H, Li, P, Zhou, F et al.. Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478. J Struct Biol. 2021;213 (2):107710. doi: 10.1016/j.jsb.2021.107710. PubMed PMID:33610655 .
  13. Salemi, B, Sedaghat, N, Varidi, MJ, Mousavi, SM, Tabatabaei Yazdi, F. The combined impact of calcium lactate with cysteine pretreatment and perforation-mediated modified atmosphere packaging on quality preservation of fresh-cut 'Romaine' lettuce. J Food Sci. 2021;86 (3):715-723. doi: 10.1111/1750-3841.15619. PubMed PMID:33547662 .
  14. Kalita, B, Li, L, McCarty, RJ, Burke, K. Learning to Approximate Density Functionals. Acc Chem Res. 2021;54 (4):818-826. doi: 10.1021/acs.accounts.0c00742. PubMed PMID:33534553 .
  15. Wang, R, Jiao, L, Zhou, X, Guo, Z, Bian, H, Dai, H et al.. Highly fluorescent graphene quantum dots from biorefinery waste for tri-channel sensitive detection of Fe3+ ions. J Hazard Mater. 2021;412 :125096. doi: 10.1016/j.jhazmat.2021.125096. PubMed PMID:33517054 .
  16. Bajaj, S, Jain, V, Sharma, N, Tiwari, S, Saxena, R. Efficient lead preconcentration using two chemically functionalized carbon nanotubes in hyphenated flow injection-flame atomic absorption spectrometry system. J Chromatogr A. 2021;1638 :461888. doi: 10.1016/j.chroma.2021.461888. PubMed PMID:33482614 .
  17. Long, L, He, J, Yang, X. Characteristics, emission sources and health risk assessment of trace elements in size-segregated aerosols during haze and non-haze periods at Ningbo, China. Environ Geochem Health. 2021; :. doi: 10.1007/s10653-020-00757-2. PubMed PMID:33459888 .
  18. Otal, EH, Kim, ML, Dietrich, S, Takada, R, Nakaya, S, Kimura, M et al.. Open-Source Portable Device for the Determination of Fluoride in Drinking Water. ACS Sens. 2021;6 (1):259-266. doi: 10.1021/acssensors.0c02273. PubMed PMID:33415970 .
  19. Gu, G, Bolten, S, Mendes-Oliveira, G, Zhou, B, Teng, Z, Pearlstein, D et al.. Salmonella inactivation and sponge/microfiber mediated cross-contamination during papaya wash with chlorine or peracetic acid as sanitizer. Food Microbiol. 2021;95 :103677. doi: 10.1016/j.fm.2020.103677. PubMed PMID:33397611 .
  20. Lu, Q, Xu, Z, Xu, X, Liu, L, Liang, L, Chen, Z et al.. Cadmium exposure as a key risk factor for residents in a world large-scale barite mining district, southwestern China. Chemosphere. 2021;269 :129387. doi: 10.1016/j.chemosphere.2020.129387. PubMed PMID:33387789 .
Search PubMed
  1. de Troya-Martín, M, de Gálvez-Aranda, MV, Rivas-Ruiz, F, Blázquez-Sánchez, N, Fernández-Morano, MT, Padilla-España, L et al.. Prevalence and predictors of sunburn among beachgoers. Photodermatol Photoimmunol Photomed. 2018;34 (2):122-129. doi: 10.1111/phpp.12354. PubMed PMID:28976044 .
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  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
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  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
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  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J Invest Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
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  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
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  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew Chem Int Ed Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
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  1. Belinchón, I, Ramos, JM, Carretero, G, Ferrándiz, C, Rivera, R, Daudén, E et al.. Adverse events associated with discontinuation of the biologics/classic systemic treatments for moderate-to-severe plaque psoriasis: data from the Spanish Biologics Registry, Biobadaderm. J Eur Acad Dermatol Venereol. 2017;31 (10):1700-1708. doi: 10.1111/jdv.14314. PubMed PMID:28485816 .
Search PubMed
  1. Pérez-Plaza, A, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Comparison of phenotype, comorbidities, therapy and adverse events between psoriatic patients with and without psoriatic arthritis. Biobadaderm registry. J Eur Acad Dermatol Venereol. 2017;31 (6):1021-1028. doi: 10.1111/jdv.14188. PubMed PMID:28252811 .
Search PubMed
  1. Dávila-Seijo, P, Dauden, E, Descalzo, MA, Carretero, G, Carrascosa, JM, Vanaclocha, F et al.. Infections in Moderate to Severe Psoriasis Patients Treated with Biological Drugs Compared to Classic Systemic Drugs: Findings from the BIOBADADERM Registry. J Invest Dermatol. 2017;137 (2):313-321. doi: 10.1016/j.jid.2016.08.034. PubMed PMID:27677836 .
Search PubMed
  1. Tejera-Vaquerizo, A, Pérez-Cabello, G, Marínez-Leborans, L, Gallego, E, Oliver-Martínez, V, Martín-Cuevas, P et al.. Is mitotic rate still useful in the management of patients with thin melanoma?. J Eur Acad Dermatol Venereol. 2017;31 (12):2025-2029. doi: 10.1111/jdv.14485. PubMed PMID:28750139 .
Search PubMed
  1. Losantos, R, Funes-Ardoiz, I, Aguilera, J, Herrera-Ceballos, E, García-Iriepa, C, Campos, PJ et al.. Rational Design and Synthesis of Efficient Sunscreens To Boost the Solar Protection Factor. Angew Chem Int Ed Engl. 2017;56 (10):2632-2635. doi: 10.1002/anie.201611627. PubMed PMID:28128519 .
Search PubMed
  1. de Troya-Martín, M, Padilla-España, L, Férnandez-Morano, T, Delgado-Sánchez, N, Blázquez Sánchez, N, Rivas-Ruiz, F et al.. Sun Protection Habits and Attitudes Among Healthcare Personnel in a Mediterranean Population. J Cancer Educ. 2016;31 (4):789-795. doi: 10.1007/s13187-015-0913-1. PubMed PMID:26370806 .
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  1. Dávila-Seijo, P, Dauden, E, Carretero, G, Ferrandiz, C, Vanaclocha, F, Gómez-García, FJ et al.. Survival of classic and biological systemic drugs in psoriasis: results of the BIOBADADERM registry and critical analysis. J Eur Acad Dermatol Venereol. 2016;30 (11):1942-1950. doi: 10.1111/jdv.13682. PubMed PMID:27329511 .
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  1. Julià, A, Ferrándiz, C, Dauden, E, Fonseca, E, Fernández-López, E, Sanchez-Carazo, JL et al.. Association of the PDE3A-SLCO1C1 locus with the response to anti-TNF agents in psoriasis. Pharmacogenomics J. 2015;15 (4):322-5. doi: 10.1038/tpj.2014.71. PubMed PMID:25403996 .
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  1. Tejera-Vaquerizo, A, Arias-Santiago, S, Nagore, E, Martín-Cuevas, P, Orgaz-Molina, J, Traves, V et al.. Defining the dermoscopic characteristics of fast-growing cutaneous melanomas. Melanoma Res. 2015;25 (3):269-72. doi: 10.1097/CMR.0000000000000157. PubMed PMID:25919929 .
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  1. Tejera-Vaquerizo, A, Nagore, E, Puig, S, Robert, C, Saiag, P, Martín-Cuevas, P et al.. Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma. Eur J Cancer. 2015;51 (13):1780-93. doi: 10.1016/j.ejca.2015.05.023. PubMed PMID:26072362 PubMed Central PMC4768477.
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  1. de Gálvez, MV, Aguilera, J, Bernabó, JL, Sánchez-Roldán, C, Herrera-Ceballos, E. Human Hair as a Natural Sun Protection Agent: A Quantitative Study. Photochem Photobiol. ;91 (4):966-70. doi: 10.1111/php.12433. PubMed PMID:25682789 .
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  1. Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha Sebastián, F, Gómez-García, FJ, Herrera-Ceballos, E et al.. Risk of adverse events in psoriasis patients receiving classic systemic drugs and biologics in a 5-year observational study of clinical practice: 2008-2013 results of the Biobadaderm registry. J Eur Acad Dermatol Venereol. 2015;29 (1):156-63. doi: 10.1111/jdv.12492. PubMed PMID:24684267 .
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  1. Medina, C, Carretero, G, Ferrandiz, C, Dauden, E, Vanaclocha, F, Gómez-García, FJ et al.. Safety of classic and biologic systemic therapies for the treatment of psoriasis in elderly: an observational study from national BIOBADADERM registry. J Eur Acad Dermatol Venereol. 2015;29 (5):858-64. doi: 10.1111/jdv.12688. PubMed PMID:25185962 .
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