Lineas de Investigación

1. Genómica Funcional y Proteómica del Cáncer

2. Bases celulares y moleculares de la síntesis de glutamato en cerebro

3. Modelos animales transgénicos con déficits en el metabolismo de aminoácidos

4. Expresión heteróloga de proteínas humanas recombinantes con valor terapéutico y biotecnológico



Proyectos de Investigación

Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).

Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades 2019

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Matés, JM, Campos-Sandoval, JA, Santos-Jiménez, JL, Márquez, J. Dysregulation of glutaminase and glutamine synthetase in cancer. Cancer Lett. 2019;467 :29-39. doi: 10.1016/j.canlet.2019.09.011. PubMed PMID:31574293 .
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  1. Roza, C, Campos-Sandoval, JA, Gómez-García, MC, Peñalver, A, Márquez, J. Lysophosphatidic Acid and Glutamatergic Transmission. 2019;12 :138. doi: 10.3389/fnmol.2019.00138. PubMed PMID:31191247 PubMed Central PMC6546900.
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  1. Ramirez-Peña, E, Arnold, J, Shivakumar, V, Joseph, R, Vidhya Vijay, G, den Hollander, P et al.. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression. 2019;11 (10):. doi: 10.3390/cancers11101610. PubMed PMID:31652551 PubMed Central PMC6826439.
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  1. Majewska, E, Márquez, J, Albrecht, J, Szeliga, M. Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway. 2019;11 (1):. doi: 10.3390/cancers11010115. PubMed PMID:30669455 PubMed Central PMC6356507.
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  1. García-Bonilla, M, García-Martín, ML, Muñoz-Hernández, MC, Domínguez-Pinos, D, Martínez-León, MI, Peñalver, A et al.. A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus. J. Neuropathol. Exp. Neurol. 2018;77 (12):1122-1136. doi: 10.1093/jnen/nly097. PubMed PMID:30364991 .
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  1. Matés, JM, Campos-Sandoval, JA, Márquez, J. Glutaminase isoenzymes in the metabolic therapy of cancer. Biochim Biophys Acta Rev Cancer. 2018;1870 (2):158-164. doi: 10.1016/j.bbcan.2018.07.007. PubMed PMID:30053497 .
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  1. Márquez, J, Campos-Sandoval, JA, Peñalver, A, Matés, JM, Segura, JA, Blanco, E et al.. Glutamate and Brain Glutaminases in Drug Addiction. Neurochem. Res. 2017;42 (3):846-857. doi: 10.1007/s11064-016-2137-0. PubMed PMID:28012058 .
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  1. Peñalver, A, Campos-Sandoval, JA, Blanco, E, Cardona, C, Castilla, L, Martín-Rufián, M et al.. Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity. 2017;10 :278. doi: 10.3389/fnmol.2017.00278. PubMed PMID:28928633 PubMed Central PMC5591874.
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  1. Márquez, J, Alonso, FJ, Matés, JM, Segura, JA, Martín-Rufián, M, Campos-Sandoval, JA et al.. Glutamine Addiction In Gliomas. Neurochem. Res. 2017;42 (6):1735-1746. doi: 10.1007/s11064-017-2212-1. PubMed PMID:28281102 .
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  1. Shukla, SK, Purohit, V, Mehla, K, Gunda, V, Chaika, NV, Vernucci, E et al.. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017;32 (1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. PubMed PMID:28697344 PubMed Central PMC5533091.
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  1. Majewska, E, Rola, R, Barczewska, M, Marquez, J, Albrecht, J, Szeliga, M et al.. Transcription factor GATA3 expression is induced by GLS2 overexpression in a glioblastoma cell line but is GLS2-independent in patient-derived glioblastoma. J. Physiol. Pharmacol. 2017;68 (2):209-214. . PubMed PMID:28614770 .
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  1. Cardona, C, Sánchez-Mejías, E, Dávila, JC, Martín-Rufián, M, Campos-Sandoval, JA, Vitorica, J et al.. Expression of Gls and Gls2 glutaminase isoforms in astrocytes. Glia. 2015;63 (3):365-82. doi: 10.1002/glia.22758. PubMed PMID:25297978 .
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  1. Campos-Sandoval, JA, Martín-Rufián, M, Cardona, C, Lobo, C, Peñalver, A, Márquez, J et al.. Glutaminases in brain: Multiple isoforms for many purposes. Neurochem. Int. 2015;88 :1-5. doi: 10.1016/j.neuint.2015.03.006. PubMed PMID:25837287 .
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  1. Herranz, D, Ambesi-Impiombato, A, Sudderth, J, Sánchez-Martín, M, Belver, L, Tosello, V et al.. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat. Med. 2015;21 (10):1182-9. doi: 10.1038/nm.3955. PubMed PMID:26390244 PubMed Central PMC4598309.
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  1. Arrabal, S, Lucena, MA, Canduela, MJ, Ramos-Uriarte, A, Rivera, P, Serrano, A et al.. Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle. PLoS ONE. 2015;10 (12):e0145244. doi: 10.1371/journal.pone.0145244. PubMed PMID:26671069 PubMed Central PMC4682857.
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