Lineas de Investigación
1. Functional genomics and proteomics of cancer.
2.Cellular and molecular bases of glutamate synthesis in the brain.
3. Transgenic animal models with amino acid metabolism deficiency.
4. Heterologous expression of recombinant human proteins of therapeutic and biotechnological value.
Miembros del grupo
Proyectos de Investigación
Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).
Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades
2019
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Glutaminases regulate glutathione and oxidative stress in cancer
Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Márquez J
Arch Toxicol 2020 Aug;94(8):2603-2623
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer
Matés JM, Di Paola FJ, Campos-Sandoval JA, Mazurek S, Márquez J
Semin Cell Dev Biol 2020 Feb;98:34-43
Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes
Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Segura JA, Alonso FJ, Márquez J
Curr Med Chem 2020;27(32):5317-5339
Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation
López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec G, Márquez J
Sci Rep 2020 Feb 10;10(1):2259
Glutaminase isoenzymes in the metabolic therapy of cancer
Mates, JM; Campos-Sandoval, JA; Marquez, J
Biochimica Et Biophysica Acta-Reviews On Cancer 2018
A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.
Garcia-Bonilla, Maria; Garcia-Martin, Maria L; Munoz-Hernandez, M Carmen; Dominguez-Pinos, Dolores; Martinez-Leon, Maria I; Penalver, Ana; Castilla, Laura; Alonso, Francisco J; Marquez, Javier; Shumilov, Kirill; Hidalgo-Sanchez, Ramon; Gutierrez, Antonia; Paez-Gonzalez, Patricia; Jimenez, Antonio J
Journal Of Neuropathology And Experimental Neurology 2018
Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity
Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017
MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer
Shukla, SK; Purohit, V; Mehla, K; Gunda, V; Chaika, NV; Vernucci, E; King, RJ; Abrego, J; Goode, GD; Dasgupta, A; Illies, AL; Gebregiworgis, T; Dai, BB; Augustine, JJ; Murthy, D; Attri, KS; Mashadova, O; Grandgenett, PM; Powers, R; Ly, QP; Lazenby, AJ; Grem, JL; Yu, F; Mates, JM; Asara, JM; Kim, JW; Hankins, JH; Weekes, C; Hollingsworth, MA; Sarkova, NJ; Sasson, AR; Fleming, JB; Oliveto, JM; Lyssiotis, CA; Cantley, LC; Berim, L; Singh, PKCancer Cell. 2017
TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA
Majewska, E; Rola, R; Barczewska, M; Marquez, J; Albrecht, J; Szeliga, MJournal Of Physiology And Pharmacology. 2017
Glutamate and Brain Glutaminases in Drug Addiction
Marquez, J; Campos-Sandoval, JA; Penalver, A; Mates, JM; Segura, JA; Blanco, E; Alonso, FJ; de Fonseca, FRNeurochemical Research. 2017
Glutamine Addiction In Gliomas
Marquez, J; Alonso, FJ; Mates, JM; Segura, JA; Martin-Rufian, M; Campos-Sandoval, JANeurochemical Research. 2017
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