Lineas de Investigación

1. Functional genomics and proteomics of cancer.

2.Cellular and molecular bases of glutamate synthesis in the brain.

3. Transgenic animal models with amino acid metabolism deficiency.

4. Heterologous expression of recombinant human proteins of therapeutic and biotechnological value.



Proyectos de Investigación

Terapia metabólica del cáncer: supresión tumoral inducida por desregulación de glutaminasa (RTI2018-096866-B-I00).

Ministerio de Ciencia, Innovación y Universidades
Ministerio de Ciencia, Innovación y Universidades 2019

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro


Glutaminases regulate glutathione and oxidative stress in cancer

Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Márquez J
Arch Toxicol 2020 Aug;94(8):2603-2623


Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer

Matés JM, Di Paola FJ, Campos-Sandoval JA, Mazurek S, Márquez J
Semin Cell Dev Biol 2020 Feb;98:34-43


Metabolic Reprogramming of Cancer by Chemicals that Target Glutaminase Isoenzymes

Matés JM, Campos-Sandoval JA, de Los Santos-Jiménez J, Segura JA, Alonso FJ, Márquez J
Curr Med Chem 2020;27(32):5317-5339


Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates with Proliferation Arrest and Differentiation

López de la Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D, Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec G, Márquez J
Sci Rep 2020 Feb 10;10(1):2259


Glutaminase isoenzymes in the metabolic therapy of cancer

Mates, JM; Campos-Sandoval, JA; Marquez, J
Biochimica Et Biophysica Acta-Reviews On Cancer 2018


A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

Garcia-Bonilla, Maria; Garcia-Martin, Maria L; Munoz-Hernandez, M Carmen; Dominguez-Pinos, Dolores; Martinez-Leon, Maria I; Penalver, Ana; Castilla, Laura; Alonso, Francisco J; Marquez, Javier; Shumilov, Kirill; Hidalgo-Sanchez, Ramon; Gutierrez, Antonia; Paez-Gonzalez, Patricia; Jimenez, Antonio J
Journal Of Neuropathology And Experimental Neurology 2018

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA(1) Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Penalver, A; Campos-Sandoval, JA; Blanco, E; Cardona, C; Castilla, L; Martin-Rufian, M; Estivill-Torrus, G; Sanchez-Varo, R; Alonso, FJ; Perez-Hernandez, M; Colado, MI; Gutierrez, A; de Fonseca, FR; Marquez, JFrontiers In Molecular Neuroscience. 2017

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, SK; Purohit, V; Mehla, K; Gunda, V; Chaika, NV; Vernucci, E; King, RJ; Abrego, J; Goode, GD; Dasgupta, A; Illies, AL; Gebregiworgis, T; Dai, BB; Augustine, JJ; Murthy, D; Attri, KS; Mashadova, O; Grandgenett, PM; Powers, R; Ly, QP; Lazenby, AJ; Grem, JL; Yu, F; Mates, JM; Asara, JM; Kim, JW; Hankins, JH; Weekes, C; Hollingsworth, MA; Sarkova, NJ; Sasson, AR; Fleming, JB; Oliveto, JM; Lyssiotis, CA; Cantley, LC; Berim, L; Singh, PKCancer Cell. 2017

TRANSCRIPTION FACTOR GATA3 EXPRESSION IS INDUCED BY GLS2 OVEREXPRESSION IN A GLIOBLASTOMA CELL LINE BUT IS GLS2-INDEPENDENT IN PATIENT-DERIVED GLIOBLASTOMA

Majewska, E; Rola, R; Barczewska, M; Marquez, J; Albrecht, J; Szeliga, MJournal Of Physiology And Pharmacology. 2017

Glutamate and Brain Glutaminases in Drug Addiction

Marquez, J; Campos-Sandoval, JA; Penalver, A; Mates, JM; Segura, JA; Blanco, E; Alonso, FJ; de Fonseca, FRNeurochemical Research. 2017

Glutamine Addiction In Gliomas

Marquez, J; Alonso, FJ; Mates, JM; Segura, JA; Martin-Rufian, M; Campos-Sandoval, JANeurochemical Research. 2017


Subscribe

Suscríbete a nuestro Newsletter y recibe en tu correo todas las últimas novedades del Instituto.
Consulta el histórico de Newsletter:

Calle Doctor Miguel Díaz Recio , 28 Málaga 29010

(+34) 951 440 260
Fax: (+34) 951 440 263