Cardiovascular Development and Disease
Lineas de Investigación
Bone marrow contribution to the heart from development to adulthood
Sampaio-Pinto V, Ruiz-Villalba A, Nascimento DS, Pérez-Pomares JM Seminars in cell & developmental biology 2021 Apr;112():16-26
Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development
Díaz Del Moral S, Barrena S, Hernández-Torres F, Aránega A, Villaescusa JM, et al. Frontiers in cell and developmental biology 2021;9():683861
Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction
Garbayo E, Ruiz-Villalba A, Hernandez SC, Saludas L, Abizanda G, et al. Acta biomaterialia 2021 May;126():394-407
Extracellular Vesicle-Based Therapeutics for Heart Repair
Saludas L, Oliveira CC, Roncal C, Ruiz-Villalba A, Prósper F, et al. Nanomaterials (Basel, Switzerland) 2021 Feb 25;11(3):
Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development
Cano-Ballesteros S, Palmquist-Gomes P, Marín-Sedeño E, Guadix JA, Pérez-Pomares JM Journal of anatomy 2021 Feb;238(2):508-514
GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
Arroyo N, Villamayor L, Díaz I, Carmona R, Ramos-Rodríguez M, et al. JCI insight 2021 Dec 8;6(23):
Sporulation is dispensable for the vegetable-associated life cycle of the human pathogen Bacillus cereus
Antequera-Gómez ML, Díaz-Martínez L, Guadix JA, Sánchez-Tévar AM, Sopeña-Torres S, et al. Microbial biotechnology 2021 Jul;14(4):1550-1565
Training biochemistry students in experimental developmental biology: Induction of cardia bifida formation in the chick embryo
Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2021 Sep;49(5):782-788
Understanding the Adult Mammalian Heart at Single-Cell RNA-Seq Resolution
Marín-Sedeño E, de Morentin XM, Pérez-Pomares JM, Gómez-Cabrero D, Ruiz-Villalba A Frontiers in cell and developmental biology 2021;9():645276
Use and Misuse of C-q in qPCR Data Analysis and Reporting
Ruiz-Villalba A, Ruijter JM, van den Hoff MJB Life (Basel, Switzerland) 2021 May 29;11(6):
An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient
López-Beas J, Guadix JA, Clares B, Soriano-Ruiz JL, Zugaza JL, et al. Medicinal research reviews 2020 Jul;40(4):1315-1334
Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium
Carmona R, Moral SDD, Barrena S, Muñoz-Chápuli R Cells 2020 May 19;9(5):
Embryonic circulating endothelial progenitor cells
Díaz Del Moral S, Barrena S, Muñoz-Chápuli R, Carmona R Angiogenesis 2020 Nov;23(4):531-541
Epicardial cell lineages and the origin of the coronary endothelium
Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5223-5239
Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells
Benitez-Martin C, Guadix JA, Pearson JR, Najera F, Perez-Pomares JM, et al. ACS sensors 2020 Apr 24;5(4):1068-1074
Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction
Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, et al. Circulation 2020 Nov 10;142(19):1831-1847
Two genomic regions encoding exopolysaccharide production systems have complementary functions in B. cereus multicellularity and host interaction
Caro-Astorga J, Álvarez-Mena A, Hierrezuelo J, Guadix JA, Heredia-Ponce Z, et al. Scientific reports 2020 Jan 22;10(1):1000
A turn-on two-photon fluorescent probe for detecting lysosomal hydroxyl radicals in living cells
Benitez-Martin, C; Guadix, JA; Pearson, JR; Najera, F; Perez-Pomares, JM; Perez-Inestrosa, E SENSORS AND ACTUATORS B-CHEMICAL 2019
Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates
Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Heart failure reviews 2019 Jan;24(1):133-142
Cellular identities in an unusual presentation of cyclopia in a chick embryo
Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Journal of experimental zoology. Part B, Molecular and developmental evolution 2019 Sep;332(6):179-186
Development of the Myocardial Interstitium
Pogontke C, Guadix JA, Ruiz-Villalba A, Pérez-Pomares JM Anatomical record (Hoboken, N.J. : 2007) 2019 Jan;302(1):58-68
Mesothelial-mesenchymal transitions in embryogenesis
Carmona R, Ariza L, Cano E, Jiménez-Navarro M, Muñoz-Chápuli R Seminars in cell & developmental biology 2019 Aug;92():37-44
Platinum-Doped Dendritic Structure as a Phosphorescent Label for Bacteria in Two-Photon Excitation Microscopy
Molina N, Cnudde M, Guadix JA, Perez-Pomares JM, Strassert CA, et al. ACS omega 2019 Aug 20;4(8):13027-13033
Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges
Guadix JA, López-Beas J, Clares B, Soriano-Ruiz JL, Zugaza JL, et al. Pharmaceutics 2019 Oct 24;11(11):
Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker
Molina N, Nájera F, Guadix JA, Perez-Pomares JM, Vida Y, et al. The Journal of organic chemistry 2019 Aug 16;84(16):10197-10208
The Wilms’ tumor suppressor gene regulates pancreas homeostasis and repair
Ariza L, Rojas A, Muñoz-Chápuli R, Carmona R PLoS genetics 2019 Feb;15(2):e1007971
There is more than meets the eye: Primary production of the invasive seaweed Asparagopsis taxiformis (Bonnemaisoniaceae, Rhodophyta) is provided by six cohorts with distinctive characteristics
Zanolla, M; Altamirano, M; Niell, FX; Carmona, R AQUATIC BOTANY 2019
Avian embryonic coronary arterio-venous patterning involves the contribution of different endothelial and endocardial cell populations
Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Developmental dynamics : an official publication of the American Association of Anatomists 2018 May;247(5):686-698
Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction
Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, et al. Arteriosclerosis, thrombosis, and vascular biology 2018 Sep;38(9):2160-2173
Comparative developmental biology of the cardiac inflow tract
Carmona R, Ariza L, Cañete A, Muñoz-Chápuli R Journal of molecular and cellular cardiology 2018 Mar;116():155-164
Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity
Prados B, Gómez-Apiñániz P, Papoutsi T, Luxán G, Zaffran S, et al. Cell death & disease 2018 Mar 14;9(3):399
Role of the Wilms’ Tumor Suppressor Gene Wt1 in Pancreatic Development
Ariza L, Cañete A, Rojas A, Muñoz-Chápuli R, Carmona R Developmental dynamics : an official publication of the American Association of Anatomists 2018 Jul;247(7):924-933
A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice
Cañete A, Carmona R, Ariza L, Sánchez MJ, Rojas A, et al. Haematologica 2017 Apr;102(4):647-655
A right-handed signalling pathway drives heart looping in vertebrates
Ocaña OH, Coskun H, Minguillón C, Murawala P, Tanaka EM, et al. Nature 2017 Sep 6;549(7670):86-90
Characteristics, applications and prospects of mesenchymal stem cells in cell therapy
Guadix JA, Zugaza JL, Gálvez-Martín P Medicina clinica 2017 May 10;148(9):408-414
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
Guadix JA, Orlova VV, Giacomelli E, Bellin M, Ribeiro MC, et al. Stem cell reports 2017 Dec 12;9(6):1754-1764
Reference genes for gene expression studies in the mouse heart
Ruiz-Villalba A, Mattiotti A, Gunst QD, Cano-Ballesteros S, van den Hoff MJ, et al. Scientific reports 2017 Feb 2;7(1):24
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Cañete A, Cano E, Muñoz-Chápuli R, Carmona R Nutrients 2017 Feb 20;9(2):
A chick embryo cryoinjury model for the study of embryonic organ development and repair
Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Differentiation; research in biological diversity 2016 Apr-Jun;91(4-5):72-7
Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations
Rivera-Torres J, Calvo CJ, Llach A, Guzmán-Martínez G, Caballero R, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 15;113(46):E7250-E7259
Coelomic epithelium-derived cells in visceral morphogenesis
Ariza L, Carmona R, Cañete A, Cano E, Muñoz-Chápuli R Developmental dynamics : an official publication of the American Association of Anatomists 2016 Mar;245(3):307-22
Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice
Carmona R, Cañete A, Cano E, Ariza L, Rojas A, et al. eLife 2016 Sep 19;5():
Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology-a position statement of the development, anatomy, and pathology ESC Working Group
Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, et al. Cardiovascular research 2016 Feb 1;109(2):204-16
Coronary stem development in wild-type and Tbx1 null mouse hearts
Théveniau-Ruissy M, Pérez-Pomares JM, Parisot P, Baldini A, Miquerol L, et al. Developmental dynamics : an official publication of the American Association of Anatomists 2016 Apr;245(4):445-59
Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections
Cano E, Carmona R, Ruiz-Villalba A, Rojas A, Chau YY, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 19;113(3):656-61
Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population
Villa Del Campo C, Lioux G, Carmona R, Sierra R, Muñoz-Chápuli R, et al. Scientific reports 2016 Oct 18;6():35366
Interacting Resident Epicardium-Derived Fibroblasts and Recruited Bone Marrow Cells Form Myocardial Infarction Scar
Ruiz-Villalba A, Simón AM, Pogontke C, Castillo MI, Abizanda G, et al. Journal of the American College of Cardiology 2015 May 19;65(19):2057-66
The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros
Cano E, Carmona R, Velecela V, Martínez-Estrada O, Muñoz-Chápuli R Evolution & development 2015 Jul-Aug;17(4):224-30
Miembros del grupo
- Todos
- IR
- Co-IR
- Investigador
- Tecnico Laboratorio
- Otro
Proyectos de Investigación
PIER-0084-2019. Origen embrionario del Síndrome de Canal Auriculoventricular Completo-Tetralogía de Fallot (CAVC-ToF) y del Defecto de la Comunicación Interauricular (CIA): Mecanismos Celulares y Moleculares.
Consejería de Salud y Familias
.
2019
PC-0066-2017 Funciones del Gen Wt1 en el Miocardio Embrionario y Adulto de Un Modelo Animal
CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS
2017
RD16/0011/0030 Red de Terapia Celular – TerCel
INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS)
2016
Publicaciones científicas
- Todo
- D1
- Q1
- Q2
- Otro
Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction
Herrero, D; Canon, S; Pelacho, B; Salvador-Bernaldez, M; Aguilar, S; Pogontke, C; Carmona, RM; Salvador, JM; Perez-Pomares, JM; Klein, OD; Prosper, F; Jimenez-Borreguero, LJ; Bernad, A
Arteriosclerosis Thrombosis And Vascular Biology 2018
Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity
Prados, B; Gomez-Apinaniz, P; Papoutsi, T; Luxan, G; Zaffran, S; Perez-Pomares, JM; de la Pompa, JL
Cell Death & Disease 2018
Avian embryonic coronary arterio-venous patterning involves the contribution of different endothelial and endocardial cell populations
Palmquist-Gomes, P; Guadix, JA; Perez-Pomares, JM
Developmental Dynamics 2018
Role of the Wilms’ Tumor Suppressor Gene Wt1 in Pancreatic Development
Ariza, L; Canete, A; Rojas, A; Munoz-Chapuli, R; Carmona, R
Developmental Dynamics 2018
Comparative developmental biology of the cardiac inflow tract
Carmona, R; Ariza, L; Canete, A; Munoz-Chapuli, R
Journal Of Molecular And Cellular Cardiology 2018
Mesothelial-mesenchymal transitions in embryogenesis.
Carmona, Rita; Ariza, Laura; Cano, Elena; Jimenez-Navarro, Manuel; Munoz-Chapuli, Ramon
Seminars In Cell & Developmental Biology 2018
A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice
Canete, A; Carmona, R; Ariza, L; Sanchez, MJ; Rojas, A; Munoz-Chapuli, RHaematologica. 2017
A right-handed signalling pathway drives heart looping in vertebrates
Ocana, OH; Coskun, H; Minguillon, C; Murawala, P; Tanaka, EM; Galceran, J; Munoz-Chapuli, R; Nieto, MANature. 2017
Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
Guadix, JA; Orlova, VV; Giacomelli, E; Bellin, M; Ribeiro, MC; Mummery, CL; Perez-Pomares, JM AUTOR PETICION COPIA; Passier, RStem Cell Reports. 2017
Reference genes for gene expression studies in the mouse heart
Ruiz-Villalba, A; Mattiotti, A; Gunst, QD; Cano-Ballesteros, S; van den Hoff, MJB; Ruijter, JMScientific Reports. 2017
Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis
Canete, A; Cano, E; Munoz-Chapuli, R; Carmona, RNutrients. 2017
Characteristics, applications and prospects of mesenchymal stem cells in cell therapy
Guadix, JA (Guadix, Juan A.)[ 1,2 ] ; Zugaza, JL (Zugaza, Jose L.)[ 3,4,5 ] ; Galvez-Martin, P (Galvez-Martin, Patricia)[ 6 ]Medicina Clinica. 2017
Expansion Microscopy: Beyond limits
Carmona, R; Canete, A; Munoz-Chapuli, REuropean Journal Of Anatomy. 2017
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