Lineas de Investigación

Bone marrow contribution to the heart from development to adulthood

Sampaio-Pinto V, Ruiz-Villalba A, Nascimento DS, Pérez-Pomares JM Seminars in cell & developmental biology 2021 Apr;112():16-26

Deletion of the Wilms’ Tumor Suppressor Gene in the Cardiac Troponin-T Lineage Reveals Novel Functions of WT1 in Heart Development

Díaz Del Moral S, Barrena S, Hernández-Torres F, Aránega A, Villaescusa JM, et al. Frontiers in cell and developmental biology 2021;9():683861

Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction

Garbayo E, Ruiz-Villalba A, Hernandez SC, Saludas L, Abizanda G, et al. Acta biomaterialia 2021 May;126():394-407

Extracellular Vesicle-Based Therapeutics for Heart Repair

Saludas L, Oliveira CC, Roncal C, Ruiz-Villalba A, Prósper F, et al. Nanomaterials (Basel, Switzerland) 2021 Feb 25;11(3):

Fsp1 cardiac embryonic expression delineates atrioventricular endocardial cushion, coronary venous and lymphatic valve development

Cano-Ballesteros S, Palmquist-Gomes P, Marín-Sedeño E, Guadix JA, Pérez-Pomares JM Journal of anatomy 2021 Feb;238(2):508-514

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells

Arroyo N, Villamayor L, Díaz I, Carmona R, Ramos-Rodríguez M, et al. JCI insight 2021 Dec 8;6(23):

Sporulation is dispensable for the vegetable-associated life cycle of the human pathogen Bacillus cereus

Antequera-Gómez ML, Díaz-Martínez L, Guadix JA, Sánchez-Tévar AM, Sopeña-Torres S, et al. Microbial biotechnology 2021 Jul;14(4):1550-1565

Training biochemistry students in experimental developmental biology: Induction of cardia bifida formation in the chick embryo

Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology 2021 Sep;49(5):782-788

Understanding the Adult Mammalian Heart at Single-Cell RNA-Seq Resolution

Marín-Sedeño E, de Morentin XM, Pérez-Pomares JM, Gómez-Cabrero D, Ruiz-Villalba A Frontiers in cell and developmental biology 2021;9():645276

Use and Misuse of C-q in qPCR Data Analysis and Reporting

Ruiz-Villalba A, Ruijter JM, van den Hoff MJB Life (Basel, Switzerland) 2021 May 29;11(6):

An overview of international regulatory frameworks for mesenchymal stromal cell-based medicinal products: From laboratory to patient

López-Beas J, Guadix JA, Clares B, Soriano-Ruiz JL, Zugaza JL, et al. Medicinal research reviews 2020 Jul;40(4):1315-1334

Contribution of a GATA4-Expressing Hematopoietic Progenitor Lineage to the Adult Mouse Endothelium

Carmona R, Moral SDD, Barrena S, Muñoz-Chápuli R Cells 2020 May 19;9(5):

Embryonic circulating endothelial progenitor cells

Díaz Del Moral S, Barrena S, Muñoz-Chápuli R, Carmona R Angiogenesis 2020 Nov;23(4):531-541

Epicardial cell lineages and the origin of the coronary endothelium

Carmona R, Barrena S, López Gambero AJ, Rojas A, Muñoz-Chápuli R FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5223-5239

Indolenine-Based Derivatives as Customizable Two-Photon Fluorescent Probes for pH Bioimaging in Living Cells

Benitez-Martin C, Guadix JA, Pearson JR, Najera F, Perez-Pomares JM, et al. ACS sensors 2020 Apr 24;5(4):1068-1074

Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction

Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, et al. Circulation 2020 Nov 10;142(19):1831-1847

Two genomic regions encoding exopolysaccharide production systems have complementary functions in B. cereus multicellularity and host interaction

Caro-Astorga J, Álvarez-Mena A, Hierrezuelo J, Guadix JA, Heredia-Ponce Z, et al. Scientific reports 2020 Jan 22;10(1):1000

A turn-on two-photon fluorescent probe for detecting lysosomal hydroxyl radicals in living cells

Benitez-Martin, C; Guadix, JA; Pearson, JR; Najera, F; Perez-Pomares, JM; Perez-Inestrosa, E SENSORS AND ACTUATORS B-CHEMICAL 2019

Cellular identities in an unusual presentation of cyclopia in a chick embryo

Palmquist-Gomes P, Pérez-Pomares JM, Guadix JA Journal of experimental zoology. Part B, Molecular and developmental evolution 2019 Sep;332(6):179-186

Development of the Myocardial Interstitium

Pogontke C, Guadix JA, Ruiz-Villalba A, Pérez-Pomares JM Anatomical record (Hoboken, N.J. : 2007) 2019 Jan;302(1):58-68

Mesothelial-mesenchymal transitions in embryogenesis

Carmona R, Ariza L, Cano E, Jiménez-Navarro M, Muñoz-Chápuli R Seminars in cell & developmental biology 2019 Aug;92():37-44

Platinum-Doped Dendritic Structure as a Phosphorescent Label for Bacteria in Two-Photon Excitation Microscopy

Molina N, Cnudde M, Guadix JA, Perez-Pomares JM, Strassert CA, et al. ACS omega 2019 Aug 20;4(8):13027-13033

Principal Criteria for Evaluating the Quality, Safety and Efficacy of hMSC-Based Products in Clinical Practice: Current Approaches and Challenges

Guadix JA, López-Beas J, Clares B, Soriano-Ruiz JL, Zugaza JL, et al. Pharmaceutics 2019 Oct 24;11(11):

Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker

Molina N, Nájera F, Guadix JA, Perez-Pomares JM, Vida Y, et al. The Journal of organic chemistry 2019 Aug 16;84(16):10197-10208

The Wilms’ tumor suppressor gene regulates pancreas homeostasis and repair

Ariza L, Rojas A, Muñoz-Chápuli R, Carmona R PLoS genetics 2019 Feb;15(2):e1007971

Avian embryonic coronary arterio-venous patterning involves the contribution of different endothelial and endocardial cell populations

Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Developmental dynamics : an official publication of the American Association of Anatomists 2018 May;247(5):686-698

Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction

Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, et al. Arteriosclerosis, thrombosis, and vascular biology 2018 Sep;38(9):2160-2173

Comparative developmental biology of the cardiac inflow tract

Carmona R, Ariza L, Cañete A, Muñoz-Chápuli R Journal of molecular and cellular cardiology 2018 Mar;116():155-164

Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity

Prados B, Gómez-Apiñániz P, Papoutsi T, Luxán G, Zaffran S, et al. Cell death & disease 2018 Mar 14;9(3):399

Role of the Wilms’ Tumor Suppressor Gene Wt1 in Pancreatic Development

Ariza L, Cañete A, Rojas A, Muñoz-Chápuli R, Carmona R Developmental dynamics : an official publication of the American Association of Anatomists 2018 Jul;247(7):924-933

A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice

Cañete A, Carmona R, Ariza L, Sánchez MJ, Rojas A, et al. Haematologica 2017 Apr;102(4):647-655

A right-handed signalling pathway drives heart looping in vertebrates

Ocaña OH, Coskun H, Minguillón C, Murawala P, Tanaka EM, et al. Nature 2017 Sep 6;549(7670):86-90

Characteristics, applications and prospects of mesenchymal stem cells in cell therapy

Guadix JA, Zugaza JL, Gálvez-Martín P Medicina clinica 2017 May 10;148(9):408-414

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix JA, Orlova VV, Giacomelli E, Bellin M, Ribeiro MC, et al. Stem cell reports 2017 Dec 12;9(6):1754-1764

Reference genes for gene expression studies in the mouse heart

Ruiz-Villalba A, Mattiotti A, Gunst QD, Cano-Ballesteros S, van den Hoff MJ, et al. Scientific reports 2017 Feb 2;7(1):24

Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis

Cañete A, Cano E, Muñoz-Chápuli R, Carmona R Nutrients 2017 Feb 20;9(2):

A chick embryo cryoinjury model for the study of embryonic organ development and repair

Palmquist-Gomes P, Guadix JA, Pérez-Pomares JM Differentiation; research in biological diversity 2016 Apr-Jun;91(4-5):72-7

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

Rivera-Torres J, Calvo CJ, Llach A, Guzmán-Martínez G, Caballero R, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Nov 15;113(46):E7250-E7259

Coelomic epithelium-derived cells in visceral morphogenesis

Ariza L, Carmona R, Cañete A, Cano E, Muñoz-Chápuli R Developmental dynamics : an official publication of the American Association of Anatomists 2016 Mar;245(3):307-22

Conditional deletion of WT1 in the septum transversum mesenchyme causes congenital diaphragmatic hernia in mice

Carmona R, Cañete A, Cano E, Ariza L, Rojas A, et al. eLife 2016 Sep 19;5():

Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology-a position statement of the development, anatomy, and pathology ESC Working Group

Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, et al. Cardiovascular research 2016 Feb 1;109(2):204-16

Coronary stem development in wild-type and Tbx1 null mouse hearts

Théveniau-Ruissy M, Pérez-Pomares JM, Parisot P, Baldini A, Miquerol L, et al. Developmental dynamics : an official publication of the American Association of Anatomists 2016 Apr;245(4):445-59

Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections

Cano E, Carmona R, Ruiz-Villalba A, Rojas A, Chau YY, et al. Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 19;113(3):656-61

Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population

Villa Del Campo C, Lioux G, Carmona R, Sierra R, Muñoz-Chápuli R, et al. Scientific reports 2016 Oct 18;6():35366

Interacting Resident Epicardium-Derived Fibroblasts and Recruited Bone Marrow Cells Form Myocardial Infarction Scar

Ruiz-Villalba A, Simón AM, Pogontke C, Castillo MI, Abizanda G, et al. Journal of the American College of Cardiology 2015 May 19;65(19):2057-66

The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros

Cano E, Carmona R, Velecela V, Martínez-Estrada O, Muñoz-Chápuli R Evolution & development 2015 Jul-Aug;17(4):224-30



Proyectos de Investigación

PIER-0084-2019. Origen embrionario del Síndrome de Canal Auriculoventricular Completo-Tetralogía de Fallot (CAVC-ToF) y del Defecto de la Comunicación Interauricular (CIA): Mecanismos Celulares y Moleculares.

Consejería de Salud y Familias
. 2019

PC-0066-2017 Funciones del Gen Wt1 en el Miocardio Embrionario y Adulto de Un Modelo Animal

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS 2017

RD16/0011/0030 Red de Terapia Celular – TerCel

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

Publicaciones científicas

  • Todo
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  • Otro

Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction

Herrero, D; Canon, S; Pelacho, B; Salvador-Bernaldez, M; Aguilar, S; Pogontke, C; Carmona, RM; Salvador, JM; Perez-Pomares, JM; Klein, OD; Prosper, F; Jimenez-Borreguero, LJ; Bernad, A
Arteriosclerosis Thrombosis And Vascular Biology 2018


Myocardial Bmp2 gain causes ectopic EMT and promotes cardiomyocyte proliferation and immaturity

Prados, B; Gomez-Apinaniz, P; Papoutsi, T; Luxan, G; Zaffran, S; Perez-Pomares, JM; de la Pompa, JL
Cell Death & Disease 2018


Role of the Wilms’ Tumor Suppressor Gene Wt1 in Pancreatic Development

Ariza, L; Canete, A; Rojas, A; Munoz-Chapuli, R; Carmona, R
Developmental Dynamics 2018


Comparative developmental biology of the cardiac inflow tract

Carmona, R; Ariza, L; Canete, A; Munoz-Chapuli, R
Journal Of Molecular And Cellular Cardiology 2018


Mesothelial-mesenchymal transitions in embryogenesis.

Carmona, Rita; Ariza, Laura; Cano, Elena; Jimenez-Navarro, Manuel; Munoz-Chapuli, Ramon
Seminars In Cell & Developmental Biology 2018

A population of hematopoietic stem cells derives from GATA4-expressing progenitors located in the placenta and lateral mesoderm of mice

Canete, A; Carmona, R; Ariza, L; Sanchez, MJ; Rojas, A; Munoz-Chapuli, RHaematologica. 2017

A right-handed signalling pathway drives heart looping in vertebrates

Ocana, OH; Coskun, H; Minguillon, C; Murawala, P; Tanaka, EM; Galceran, J; Munoz-Chapuli, R; Nieto, MANature. 2017

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells

Guadix, JA; Orlova, VV; Giacomelli, E; Bellin, M; Ribeiro, MC; Mummery, CL; Perez-Pomares, JM AUTOR PETICION COPIA; Passier, RStem Cell Reports. 2017

Reference genes for gene expression studies in the mouse heart

Ruiz-Villalba, A; Mattiotti, A; Gunst, QD; Cano-Ballesteros, S; van den Hoff, MJB; Ruijter, JMScientific Reports. 2017

Role of Vitamin A/Retinoic Acid in Regulation of Embryonic and Adult Hematopoiesis

Canete, A; Cano, E; Munoz-Chapuli, R; Carmona, RNutrients. 2017

Characteristics, applications and prospects of mesenchymal stem cells in cell therapy

Guadix, JA (Guadix, Juan A.)[ 1,2 ] ; Zugaza, JL (Zugaza, Jose L.)[ 3,4,5 ] ; Galvez-Martin, P (Galvez-Martin, Patricia)[ 6 ]Medicina Clinica. 2017

Expansion Microscopy: Beyond limits

Carmona, R; Canete, A; Munoz-Chapuli, REuropean Journal Of Anatomy. 2017


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