Degeneración y Regeneración del Sistema Nervioso Central

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Lineas de Investigación

01. Estudios experimentales sobre posibles terapias con células madre en el tratamiento de la hidrocefalia feto-neonatal

02. Condicionamiento de la microglía a largo plazo.



Proyectos de Investigación

Terapia celular combinada basada en el uso de células madre no embrionarias humanas para la recuperación de la pared ventricular dañada por hidrocefalia

Universidad de Málaga
. 2019

Evaluación de una innovadora terapia celular para el tratamiento de la hidrocefalia posthemorrágica basada en células madre mesenquimales e inducidas humanas

Junta de Andalucía
. 2019

PI19/00778 Testing non-embryonic based stem cells as regenerative cell sources for treating neonates with intraventricular hemorrhages that develop posthemorrhagic hydrocephalus. IP ANTONIO JESUS JIMENEZ LARA

ISCIII
. 2019

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
Endoscopic third ventriculostomy in children with chronic communicating congenital hydrocephalus: a single-center cohort retrospective analysis

Baeza-Antón L, Martínez-León MI, Ros-López B, Arráez-Sánchez MÁ Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2022 Feb;38(2):319-331

External cranial expansion as treatment of intracranial hypertension. Technical note

Selfa A, Ros B, Iglesias S, Ruiz F, Pérez A, et al. Neurosurgical review 2022 Feb;45(1):897-901

A team-based competition for undergraduate medical students to learn radiology within the virtual world Second Life

Rudolphi-Solero T, Jimenez-Zayas A, Lorenzo-Alvarez R, Domínguez-Pinos D, Ruiz-Gomez MJ, et al. Insights into imaging 2021 Jun 29;12(1):89

Conventional posterior cranial vault expansion: indications and results-review of the literature

Ros B, Iglesias S, Selfa A, Ruiz F, Arráez MÁ Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2021 Oct;37(10):3149-3175

Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Ojeda-Pérez B, Campos-Sandoval JA, García-Bonilla M, Cárdenas-García C, Páez-González P, et al. Fluids and barriers of the CNS 2021 Jul 2;18(1):30

Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation

Del Puerto A, Pose-Utrilla J, Simón-García A, López-Menéndez C, Jiménez AJ, et al. Molecular psychiatry 2021 Nov;26(11):6411-6426

Microglia activated by microbial neuraminidase contributes to ependymal cell death

Fernández-Arjona MDM, León-Rodríguez A, López-Ávalos MD, Grondona JM Fluids and barriers of the CNS 2021 Mar 23;18(1):15

Quality of life in children with hydrocephalus treated with endoscopic third ventriculostomy

Ros-Sanjuán Á, Iglesias-Moroño S, Ros-López B, Rius-Díaz F, Delgado-Babiano A, et al. Journal of neurosurgery. Pediatrics 2021 Feb 19;27(5):503-510

Quality of life in school-age children with shunt implantation due to neonatal posthemorrhagic hydrocephalus

Iglesias S, Ros B, Ros A, Selfa A, Linares J, et al. Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2021 Apr;37(4):1127-1135

Shunt Overdrainage: Reappraisal of the Syndrome and Proposal for an Integrative Model

Ros B, Iglesias S, Linares J, Cerro L, Casado J, et al. Journal of clinical medicine 2021 Aug 17;10(16):

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals

Torrillas de la Cal A, Paniagua-Torija B, Arevalo-Martin A, Faulkes CG, Jiménez AJ, et al. Cells 2021 Aug 28;10(9):

Cervical myelomeningocele with CSF leakage: a case-based review

Armas-Melián K, Iglesias S, Ros B, Martínez-León MI, Arráez MÁ Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2020 Nov;36(11):2615-2620

LPA(1) receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, et al. Neuropharmacology 2020 Mar 1;164():107896

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells

García-Bonilla M, Ojeda-Pérez B, García-Martín ML, Muñoz-Hernández MC, Vitorica J, et al. Stem cell research & therapy 2020 Mar 17;11(1):121

Neuroendoscopic biopsy: analysis of a series of 80 patients

Ros-Sanjuán Á, Ros-López B, Ibáñez-Botella G, Domínguez-Páez M, Carrasco-Brenes A, et al. Neurosurgical review 2020 Feb;43(1):249-258

Neuroendoscopic treatment of arachnoid cysts in the paediatric population. Series results for 20 patients

Linares Torres J, Ros López B, Iglesias Moroño S, Ibáñez Botella G, Ros Sanjuán Á, et al. Neurocirugia (English Edition) 2020 Jul – Aug;31(4):165-172

Neuroplasticity and Epilepsy Surgery in Brain Eloquent Areas: Case Report

Serrano-Castro PJ, Ros-López B, Fernández-Sánchez VE, García-Casares N, Muñoz-Becerra L, et al. Frontiers in neurology 2020;11():698

Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis

Suárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, et al. Psychoneuroendocrinology 2019 Dec;110():104418

Effects of the LPA(1) Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice

Tabbai S, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun J, et al. Frontiers in molecular neuroscience 2019;12():146

Microglial activation by microbial neuraminidase through TLR2 and TLR4 receptors.

Fernández-Arjona MDM, Grondona JM, Fernández-Llebrez P, López-Ávalos MD Journal of neuroinflammation 2019 Dec 2;16(1):245

Microglial Morphometric Parameters Correlate With the Expression Level of IL-1 beta, and Allow Identifying Different Activated Morphotypes

Fernández-Arjona MDM, Grondona JM, Fernández-Llebrez P, López-Ávalos MD Frontiers in cellular neuroscience 2019;13():472

RGS14414 treatment induces memory enhancement and rescues episodic memory deficits.

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Delgado G, Martín-Montañez E, et al. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):11804-11820

Suprasellar ganglioglioma presenting as a middle cerebral artery infarction

Pastor L, Iglesias S, Ros B, Weil B, Martínez-León MI, et al. Child’s nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2019 Sep;35(9):1625-1628

A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus.

García-Bonilla M, García-Martín ML, Muñoz-Hernández MC, Domínguez-Pinos D, Martínez-León MI, et al. Journal of neuropathology and experimental neurology 2018 Dec 1;77(12):1122-1136

A Simple Endoscopic Score Modified for the Upper Gastrointestinal Tract in Crohn’s Disease [UGI-SES-CD]: A Report From the ImageKids Study

Ledder O, Church P, Cytter-Kuint R, Martínez-León M, Sladek M, et al. Journal of Crohn’s & colitis 2018 Aug 29;12(9):1073-1078

Effects of genetic deletion versus pharmacological blockade of the LPA(1) receptor on depression-like behaviour and related brain functional activity

Moreno-Fernández RD, Nieto-Quero A, Gómez-Salas FJ, Chun J, Estivill-Torrús G, et al. Disease models & mechanisms 2018 Sep 10;11(9):

Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells

Cifuentes M, Baeza V, Arrabal PM, Visser R, Grondona JM, et al. Molecular neurobiology 2018 Feb;55(2):1652-1664

Pharmacological blockade of fatty acid amide hydrolase (FAAH) by URB597 improves memory and changes the phenotype of hippocampal microglia despite ethanol exposure

Rivera P, Fernández-Arjona MDM, Silva-Peña D, Blanco E, Vargas A, et al. Biochemical pharmacology 2018 Nov;157():244-257

Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA(1) Pathway

Moreno-Fernandez RD, Tabbai S, Castilla-Ortega E, Perez-Martin M, Estivill-Torrus G, et al. Current neuropharmacology 2018 Mar 5;16(3):271-283

SVCT2 Expression and Function in Reactive Astrocytes Is a Common Event in Different Brain Pathologies

Salazar K, Martínez F, Pérez-Martín M, Cifuentes M, Trigueros L, et al. Molecular neurobiology 2018 Jul;55(7):5439-5452

Uncovering inherent cellular plasticity of multiciliated ependyma leading to ventricular wall transformation and hydrocephalus.

Abdi K, Lai CH, Paez-Gonzalez P, Lay M, Pyun J, et al. Nature communications 2018 Apr 25;9(1):1655

A vesicle trafficking protein alpha SNAP regulates Paneth cell differentiation in vivo

Lechuga S, Naydenov NG, Feygin A, Jimenez AJ, Ivanov AI Biochemical and biophysical research communications 2017 May 13;486(4):951-957

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernández RD, Pérez-Martín M, Castilla-Ortega E, Rosell Del Valle C, García-Fernández MI, et al. Translational psychiatry 2017 Apr 4;7(4):e1077

Microbial neuraminidase induces a Moderate and Transient Myelin Vacuolation independent of complement system activation

Granados-Durán P, López-Ávalos MD, Cifuentes M, Pérez-Martín M, Fernández-Arjona MD, et al. Frontiers in neurology 2017;8():78

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis

Fernández-Arjona MDM, Grondona JM, Granados-Durán P, Fernández-Llebrez P, López-Ávalos MD Frontiers in cellular neuroscience 2017;11():235

Perianal Pediatric Crohn Disease Is Associated With a Distinct Phenotype and Greater Inflammatory Burden

Assa A, Amitai M, Greer ML, Castro DA, Kuint RC, et al. Journal of pediatric gastroenterology and nutrition 2017 Sep;65(3):293-298

Ventricular Zone Disruption in Human Neonates With Intraventricular Hemorrhage

McAllister JP, Guerra MM, Ruiz LC, Jimenez AJ, Dominguez-Pinos D, et al. Journal of neuropathology and experimental neurology 2017 May 1;76(5):358-375

Complement system activation contributes to the ependymal damage induced by microbial neuraminidase

Granados-Durán P, López-Ávalos MD, Hughes TR, Johnson K, Morgan BP, et al. Journal of neuroinflammation 2016 May 21;13(1):115

Environmental Enrichment, Age, and PPAR alpha Interact to Regulate Proliferation in Neurogenic Niches

Pérez-Martín M, Rivera P, Blanco E, Lorefice C, Decara J, et al. Frontiers in neuroscience 2016;10():89

Cell Junction Pathology of Neural Stem Cells Is Associated With Ventricular Zone Disruption, Hydrocephalus, and Abnormal Neurogenesis

Guerra MM, Henzi R, Ortloff A, Lichtin N, Vío K, et al. Journal of neuropathology and experimental neurology 2015 Jul;74(7):653-71

Mente ActivaA (R) improves impaired spatial memory in aging rats

López-Avalos MD, Fernández-Llebrez Zayas R, Cifuentes M, De Andrés MV, Fernández-Llebrez Del Rey P, et al. The journal of nutrition, health & aging 2015 Oct;19(8):819-27

Pharmacological Blockade of Cannabinoid CB1 Receptors in Diet-Induced Obesity Regulates Mitochondrial Dihydrolipoamide Dehydrogenase in Muscle

Arrabal S, Lucena MA, Canduela MJ, Ramos-Uriarte A, Rivera P, et al. PloS one 2015;10(12):e0145244


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