Lineas de Investigación

01. Estudio de las bases embrionarias de la enfermedad cardiovascular. Estudio de los mecanismos celulares y moleculares de la fisiopatología cardiovascular

02. Desarrollo embrionario cardiovascular.

03. Reparación y regeneración cardiovascular.

04. Fibrosis en el contexto de las cardiomiopatías.

05. Histopatología cardiovascular.

06. Diferenciación de progenitores cardiovasculares.

07. Patología vascular.



Proyectos de Investigación

PIER-0084-2019. Origen embrionario del Síndrome de Canal Auriculoventricular Completo-Tetralogía de Fallot (CAVC-ToF) y del Defecto de la Comunicación Interauricular (CIA): Mecanismos Celulares y Moleculares.

Consejería de Salud y Familias
. 2019

PC-0066-2017 Funciones del Gen Wt1 en el Miocardio Embrionario y Adulto de Un Modelo Animal

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS 2017

RD16/0011/0030 Red de Terapia Celular – TerCel

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Zhang, J, Gao, Y, Zhang, X, Feng, Q, Zhan, C, Song, J et al.. "Dual Signal-On" Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification. Anal Chem. 2021; :. doi: 10.1021/acs.analchem.1c00415. PubMed PMID:33960777 .
  2. Dat, ND, Nguyen, VT, Vo, TD, Bui, XT, Bui, MH, Nguyen, LSP et al.. Contamination, source attribution, and potential health risks of heavy metals in street dust of a metropolitan area in Southern Vietnam. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14246-1. PubMed PMID:33954920 .
  3. Liu, Y, Zhang, D, Ding, J, Hayat, K, Yang, X, Zhan, X et al.. A Facile Aptasensor for Instantaneous Determination of Cadmium Ions Based on Fluorescence Amplification Effect of MOPS on FAM-Labeled Aptamer. Biosensors (Basel). 2021;11 (5):. doi: 10.3390/bios11050133. PubMed PMID:33922514 .
  4. Sáez Moreno, D, Visram, Z, Mutti, M, Restrepo-Córdoba, M, Hartmann, S, Kremers, AI et al.. ε2-Phages Are Naturally Bred and Have a Vastly Improved Host Range in Staphylococcus aureus over Wild Type Phages. Pharmaceuticals (Basel). 2021;14 (4):. doi: 10.3390/ph14040325. PubMed PMID:33918287 PubMed Central PMC8065394.
  5. Yamaguchi, T, Taira, Y, Matsuo, M, Orita, M, Yamada, Y, Takamura, N et al.. LOCAL LEVELS OF RADIATION EXPOSURE DOSES DUE TO RADIOCESIUM FOR RETURNED RESIDENTS IN TOMIOKA TOWN, FUKUSHIMA PREFECTURE. Radiat Prot Dosimetry. 2021; :. doi: 10.1093/rpd/ncab049. PubMed PMID:33876245 .
  6. Liu, K, Wang, G, Ding, N, Zhang, J, Kong, J, Liu, T et al.. High-Performance Trichloroacetic Acid Sensor Based on the Intramolecular Hydrogen Bond Formation and Disruption of a Specially Designed Fluorescent o-Carborane Derivative in the Film State. ACS Appl Mater Interfaces. 2021;13 (16):19342-19350. doi: 10.1021/acsami.1c03331. PubMed PMID:33848121 .
  7. Bodor, K, Bodor, Z, Szép, A, Szép, R. Human health impact assessment and temporal distribution of trace elements in Copșa Mică- Romania. Sci Rep. 2021;11 (1):7049. doi: 10.1038/s41598-021-86488-5. PubMed PMID:33782481 PubMed Central PMC8007619.
  8. Fang, B, Zeng, H, Zhang, L, Wang, H, Liu, J, Hao, K et al.. Toxic metals in outdoor/indoor airborne PM2.5 in port city of Northern, China: Characteristics, sources, and personal exposure risk assessment. Environ Pollut. 2021;279 :116937. doi: 10.1016/j.envpol.2021.116937. PubMed PMID:33756243 .
  9. Qiao, SP, Liu, ZN, Li, HC, He, X, Pan, H, Gao, YZ et al.. Construction of a CRISPR-Biolayer Interferometry Platform for Real-Time, Sensitive, and Specific DNA Detection. Chembiochem. 2021; :. doi: 10.1002/cbic.202100054. PubMed PMID:33682991 .
  10. Siersbæk, J, Larsen, AR, Nybo, M, Christesen, HT. A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism. Front Endocrinol (Lausanne). 2020;11 :614993. doi: 10.3389/fendo.2020.614993. PubMed PMID:33679602 PubMed Central PMC7935514.
  11. Li, W, Yang, G, Terzis, A, Mukherjee, S, He, C, An, X et al.. In Situ Tracking of Wetting-Front Transient Heat Release on a Surface-Mounted Metal-Organic Framework. Adv Mater. 2021;33 (14):e2006980. doi: 10.1002/adma.202006980. PubMed PMID:33624896 .
  12. Li, HJ, Wang, QS, Han, W, Zhou, H, Li, P, Zhou, F et al.. Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478. J Struct Biol. 2021;213 (2):107710. doi: 10.1016/j.jsb.2021.107710. PubMed PMID:33610655 .
  13. Salemi, B, Sedaghat, N, Varidi, MJ, Mousavi, SM, Tabatabaei Yazdi, F. The combined impact of calcium lactate with cysteine pretreatment and perforation-mediated modified atmosphere packaging on quality preservation of fresh-cut 'Romaine' lettuce. J Food Sci. 2021;86 (3):715-723. doi: 10.1111/1750-3841.15619. PubMed PMID:33547662 .
  14. Kalita, B, Li, L, McCarty, RJ, Burke, K. Learning to Approximate Density Functionals. Acc Chem Res. 2021;54 (4):818-826. doi: 10.1021/acs.accounts.0c00742. PubMed PMID:33534553 .
  15. Wang, R, Jiao, L, Zhou, X, Guo, Z, Bian, H, Dai, H et al.. Highly fluorescent graphene quantum dots from biorefinery waste for tri-channel sensitive detection of Fe3+ ions. J Hazard Mater. 2021;412 :125096. doi: 10.1016/j.jhazmat.2021.125096. PubMed PMID:33517054 .
  16. Bajaj, S, Jain, V, Sharma, N, Tiwari, S, Saxena, R. Efficient lead preconcentration using two chemically functionalized carbon nanotubes in hyphenated flow injection-flame atomic absorption spectrometry system. J Chromatogr A. 2021;1638 :461888. doi: 10.1016/j.chroma.2021.461888. PubMed PMID:33482614 .
  17. Long, L, He, J, Yang, X. Characteristics, emission sources and health risk assessment of trace elements in size-segregated aerosols during haze and non-haze periods at Ningbo, China. Environ Geochem Health. 2021; :. doi: 10.1007/s10653-020-00757-2. PubMed PMID:33459888 .
  18. Otal, EH, Kim, ML, Dietrich, S, Takada, R, Nakaya, S, Kimura, M et al.. Open-Source Portable Device for the Determination of Fluoride in Drinking Water. ACS Sens. 2021;6 (1):259-266. doi: 10.1021/acssensors.0c02273. PubMed PMID:33415970 .
  19. Gu, G, Bolten, S, Mendes-Oliveira, G, Zhou, B, Teng, Z, Pearlstein, D et al.. Salmonella inactivation and sponge/microfiber mediated cross-contamination during papaya wash with chlorine or peracetic acid as sanitizer. Food Microbiol. 2021;95 :103677. doi: 10.1016/j.fm.2020.103677. PubMed PMID:33397611 .
  20. Lu, Q, Xu, Z, Xu, X, Liu, L, Liang, L, Chen, Z et al.. Cadmium exposure as a key risk factor for residents in a world large-scale barite mining district, southwestern China. Chemosphere. 2021;269 :129387. doi: 10.1016/j.chemosphere.2020.129387. PubMed PMID:33387789 .
Search PubMed
  1. Palmquist-Gomes, P, Pérez-Pomares, JM, Guadix, JA. Cell-based therapies for the treatment of myocardial infarction: lessons from cardiac regeneration and repair mechanisms in non-human vertebrates. Heart Fail Rev. 2019;24 (1):133-142. doi: 10.1007/s10741-018-9750-8. PubMed PMID:30421074 .
Search PubMed
  1. Molina, N, Nájera, F, Guadix, JA, Perez-Pomares, JM, Vida, Y, Perez-Inestrosa, E et al.. Synthesis of Amino Terminal Clicked Dendrimers. Approaches to the Application as a Biomarker. J Org Chem. 2019;84 (16):10197-10208. doi: 10.1021/acs.joc.9b01369. PubMed PMID:31310119 .
Search PubMed
  1. Zhang, J, Gao, Y, Zhang, X, Feng, Q, Zhan, C, Song, J et al.. "Dual Signal-On" Split-Type Aptasensor for TNF-α: Integrating MQDs/ZIF-8@ZnO NR Arrays with MB-Liposome-Mediated Signal Amplification. Anal Chem. 2021; :. doi: 10.1021/acs.analchem.1c00415. PubMed PMID:33960777 .
  2. Dat, ND, Nguyen, VT, Vo, TD, Bui, XT, Bui, MH, Nguyen, LSP et al.. Contamination, source attribution, and potential health risks of heavy metals in street dust of a metropolitan area in Southern Vietnam. Environ Sci Pollut Res Int. 2021; :. doi: 10.1007/s11356-021-14246-1. PubMed PMID:33954920 .
  3. Liu, Y, Zhang, D, Ding, J, Hayat, K, Yang, X, Zhan, X et al.. A Facile Aptasensor for Instantaneous Determination of Cadmium Ions Based on Fluorescence Amplification Effect of MOPS on FAM-Labeled Aptamer. Biosensors (Basel). 2021;11 (5):. doi: 10.3390/bios11050133. PubMed PMID:33922514 .
  4. Sáez Moreno, D, Visram, Z, Mutti, M, Restrepo-Córdoba, M, Hartmann, S, Kremers, AI et al.. ε2-Phages Are Naturally Bred and Have a Vastly Improved Host Range in Staphylococcus aureus over Wild Type Phages. Pharmaceuticals (Basel). 2021;14 (4):. doi: 10.3390/ph14040325. PubMed PMID:33918287 PubMed Central PMC8065394.
  5. Yamaguchi, T, Taira, Y, Matsuo, M, Orita, M, Yamada, Y, Takamura, N et al.. LOCAL LEVELS OF RADIATION EXPOSURE DOSES DUE TO RADIOCESIUM FOR RETURNED RESIDENTS IN TOMIOKA TOWN, FUKUSHIMA PREFECTURE. Radiat Prot Dosimetry. 2021; :. doi: 10.1093/rpd/ncab049. PubMed PMID:33876245 .
  6. Liu, K, Wang, G, Ding, N, Zhang, J, Kong, J, Liu, T et al.. High-Performance Trichloroacetic Acid Sensor Based on the Intramolecular Hydrogen Bond Formation and Disruption of a Specially Designed Fluorescent o-Carborane Derivative in the Film State. ACS Appl Mater Interfaces. 2021;13 (16):19342-19350. doi: 10.1021/acsami.1c03331. PubMed PMID:33848121 .
  7. Bodor, K, Bodor, Z, Szép, A, Szép, R. Human health impact assessment and temporal distribution of trace elements in Copșa Mică- Romania. Sci Rep. 2021;11 (1):7049. doi: 10.1038/s41598-021-86488-5. PubMed PMID:33782481 PubMed Central PMC8007619.
  8. Fang, B, Zeng, H, Zhang, L, Wang, H, Liu, J, Hao, K et al.. Toxic metals in outdoor/indoor airborne PM2.5 in port city of Northern, China: Characteristics, sources, and personal exposure risk assessment. Environ Pollut. 2021;279 :116937. doi: 10.1016/j.envpol.2021.116937. PubMed PMID:33756243 .
  9. Qiao, SP, Liu, ZN, Li, HC, He, X, Pan, H, Gao, YZ et al.. Construction of a CRISPR-Biolayer Interferometry Platform for Real-Time, Sensitive, and Specific DNA Detection. Chembiochem. 2021; :. doi: 10.1002/cbic.202100054. PubMed PMID:33682991 .
  10. Siersbæk, J, Larsen, AR, Nybo, M, Christesen, HT. A Sensitive Plasma Insulin Immunoassay to Establish the Diagnosis of Congenital Hyperinsulinism. Front Endocrinol (Lausanne). 2020;11 :614993. doi: 10.3389/fendo.2020.614993. PubMed PMID:33679602 PubMed Central PMC7935514.
  11. Li, W, Yang, G, Terzis, A, Mukherjee, S, He, C, An, X et al.. In Situ Tracking of Wetting-Front Transient Heat Release on a Surface-Mounted Metal-Organic Framework. Adv Mater. 2021;33 (14):e2006980. doi: 10.1002/adma.202006980. PubMed PMID:33624896 .
  12. Li, HJ, Wang, QS, Han, W, Zhou, H, Li, P, Zhou, F et al.. Anti-NSCLC activity in vitro of Hsp90N inhibitor KW-2478 and complex crystal structure determination of Hsp90N-KW-2478. J Struct Biol. 2021;213 (2):107710. doi: 10.1016/j.jsb.2021.107710. PubMed PMID:33610655 .
  13. Salemi, B, Sedaghat, N, Varidi, MJ, Mousavi, SM, Tabatabaei Yazdi, F. The combined impact of calcium lactate with cysteine pretreatment and perforation-mediated modified atmosphere packaging on quality preservation of fresh-cut 'Romaine' lettuce. J Food Sci. 2021;86 (3):715-723. doi: 10.1111/1750-3841.15619. PubMed PMID:33547662 .
  14. Kalita, B, Li, L, McCarty, RJ, Burke, K. Learning to Approximate Density Functionals. Acc Chem Res. 2021;54 (4):818-826. doi: 10.1021/acs.accounts.0c00742. PubMed PMID:33534553 .
  15. Wang, R, Jiao, L, Zhou, X, Guo, Z, Bian, H, Dai, H et al.. Highly fluorescent graphene quantum dots from biorefinery waste for tri-channel sensitive detection of Fe3+ ions. J Hazard Mater. 2021;412 :125096. doi: 10.1016/j.jhazmat.2021.125096. PubMed PMID:33517054 .
  16. Bajaj, S, Jain, V, Sharma, N, Tiwari, S, Saxena, R. Efficient lead preconcentration using two chemically functionalized carbon nanotubes in hyphenated flow injection-flame atomic absorption spectrometry system. J Chromatogr A. 2021;1638 :461888. doi: 10.1016/j.chroma.2021.461888. PubMed PMID:33482614 .
  17. Long, L, He, J, Yang, X. Characteristics, emission sources and health risk assessment of trace elements in size-segregated aerosols during haze and non-haze periods at Ningbo, China. Environ Geochem Health. 2021; :. doi: 10.1007/s10653-020-00757-2. PubMed PMID:33459888 .
  18. Otal, EH, Kim, ML, Dietrich, S, Takada, R, Nakaya, S, Kimura, M et al.. Open-Source Portable Device for the Determination of Fluoride in Drinking Water. ACS Sens. 2021;6 (1):259-266. doi: 10.1021/acssensors.0c02273. PubMed PMID:33415970 .
  19. Gu, G, Bolten, S, Mendes-Oliveira, G, Zhou, B, Teng, Z, Pearlstein, D et al.. Salmonella inactivation and sponge/microfiber mediated cross-contamination during papaya wash with chlorine or peracetic acid as sanitizer. Food Microbiol. 2021;95 :103677. doi: 10.1016/j.fm.2020.103677. PubMed PMID:33397611 .
  20. Lu, Q, Xu, Z, Xu, X, Liu, L, Liang, L, Chen, Z et al.. Cadmium exposure as a key risk factor for residents in a world large-scale barite mining district, southwestern China. Chemosphere. 2021;269 :129387. doi: 10.1016/j.chemosphere.2020.129387. PubMed PMID:33387789 .
Search PubMed
  1. Ariza, L, Cañete, A, Rojas, A, Muñoz-Chápuli, R, Carmona, R. Role of the Wilms' tumor suppressor gene Wt1 in pancreatic development. Dev Dyn. 2018;247 (7):924-933. doi: 10.1002/dvdy.24636. PubMed PMID:29708625 .
Search PubMed
  1. Guadix, JA, Orlova, VV, Giacomelli, E, Bellin, M, Ribeiro, MC, Mummery, CL et al.. Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells. Stem Cell Reports. 2017;9 (6):1754-1764. doi: 10.1016/j.stemcr.2017.10.023. PubMed PMID:29173898 PubMed Central PMC5785703.
Search PubMed
  1. Palmquist-Gomes, P, Guadix, JA, Pérez-Pomares, JM. A chick embryo cryoinjury model for the study of embryonic organ development and repair. Differentiation. ;91 (4-5):72-7. doi: 10.1016/j.diff.2015.10.011. PubMed PMID:26558986 .
Search PubMed
  1. Pérez-Pomares, JM, de la Pompa, JL, Franco, D, Henderson, D, Ho, SY, Houyel, L et al.. Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group. Cardiovasc Res. 2016;109 (2):204-16. doi: 10.1093/cvr/cvv251. PubMed PMID:26811390 .
Search PubMed
  1. Théveniau-Ruissy, M, Pérez-Pomares, JM, Parisot, P, Baldini, A, Miquerol, L, Kelly, RG et al.. Coronary stem development in wild-type and Tbx1 null mouse hearts. Dev Dyn. 2016;245 (4):445-59. doi: 10.1002/dvdy.24380. PubMed PMID:26708418 .
Search PubMed
  1. Cano, E, Carmona, R, Ruiz-Villalba, A, Rojas, A, Chau, YY, Wagner, KD et al.. Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections. Proc Natl Acad Sci U S A. 2016;113 (3):656-61. doi: 10.1073/pnas.1509834113. PubMed PMID:26739565 PubMed Central PMC4725486.
Search PubMed
  1. Villa Del Campo, C, Lioux, G, Carmona, R, Sierra, R, Muñoz-Chápuli, R, Clavería, C et al.. Myc overexpression enhances of epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population. Sci Rep. 2016;6 :35366. doi: 10.1038/srep35366. PubMed PMID:27752085 PubMed Central PMC5082763.
Search PubMed
  1. Ruiz-Villalba, A, Simón, AM, Pogontke, C, Castillo, MI, Abizanda, G, Pelacho, B et al.. Interacting resident epicardium-derived fibroblasts and recruited bone marrow cells form myocardial infarction scar. J Am Coll Cardiol. 2015;65 (19):2057-66. doi: 10.1016/j.jacc.2015.03.520. PubMed PMID:25975467 .
Search PubMed
  1. Cano, E, Carmona, R, Velecela, V, Martínez-Estrada, O, Muñoz-Chápuli, R. The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros. Evol Dev. ;17 (4):224-30. doi: 10.1111/ede.12130. PubMed PMID:26174098 .
Search PubMed

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