Diabetes, Obesidad y otros Factores de Riesgo Vascular. Enfermedades Autoinmunes Sistémicas

Lineas de Investigación

01. Autoimmune diseases

02. Vascular Risk Factors

03. Thromboembolic Disease

04. Geriatrics and Palliative Care



Proyectos de Investigación

IDeIBIMA_001_2018 Impacto de la modificación del estilo de vida sobre la función muscular y cognitiva de una población obesa metabólicamente sana de edad avanzada.

FUNDACION PÚBLICA ANDALUZA PARA LA INVESTIGACION DE MALAGA EN BIOMEDICINA Y SALUD
AYUDAS PARA LA FINANCIACIÓN DE PROYECTOS I+De+IBIMA 2018

PI18/00766 Población obesa metabólicamente sana de edad avanzada: Estudio –ómico (Epigenética, metabolómica, metagenómica) y su relación con contaminantes ambientales

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

MS15/00028 Contrato Miguel Servet Tipo I María Rosa Bernal López

INSTITUTO DE SALUD CARLOS III
CONTRATOS MIGUEL SERVET TIPO I 2015

PI17/00855 PREDIMED+DM:Efecto de una pérdida de peso con la dieta mediterránea hipocalórica y promoción de la actividad física en la prevención de la diabetes tipo 2 en personas con síndrome metabólico

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD (FIS) 2017

CP15/00028 Proyecto de Investigación Miguel Servet Tipo I María Rosa Bernal López: Involvement of epigenetic mechanisms and the gut microbiota in the development of insulin resistance in a pediatric metabolically healthy obese population

INSTITUTO DE SALUD CARLOS III
CONTRATOS MIGUEL SERVET TIPO I 2015

PC-0198-2017 Efecto de la Intervención en el Estilo de Vida en el Desarrollo de Nefropatía Diabética en Pacientes Con Prediabetes Sin Evidencia de Lesión Micro/macrovascular

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN COORDINADOS 2017

Estudios Clínicos

GLARGL07710. Estudio Fase IV para evaluar la eficacia y seguridad de la nueva insulina Glargina 300 u/ml (GLA-300) durante la hospitalización y la intensificación al alta en pacientes con diabetes tipo 2.

SANOFI-AVENTIS, S.A.
Fase: IV ENSAYO CLINICO COMERCIAL

GLP116174. Estudio a largo plazo, aleatorizado, doble ciego, controlado con placebo para determinar el efecto de Albiglutida, cuando se añade al tratamiento hipoglucemiante estándar, sobre eventos cardiovasculares mayores en pacientes con Diabetes Mellitus Tipo2

GLAXOSMITHKLINE, S.A.
Fase: IV ENSAYO CLINICO COMERCIAL

e-PREDICE2013. Prevención temprana de complicaciones por diabetes en personas con hiperglucemia en Europa (e-PREDICE)

FUNDACIÓN DE INVESTIGACIÓN EN RED EN ENFERMEDADES CARDIOVASCULARES (FIRCAVA)
Fase: III ENSAYO CLINICO INDEPENDIENTE

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Zapatero-Gaviria, A, Gómez-Huelgas, R, Canora-Lebrato, J, Ena-Muñoz, J, Romero-Sánchez, M, Mendez-Bailón, M et al.. Analysis of hospitalizations by cardiovascular disease in the population with diabetes in Spain. Rev Clin Esp. 2019;219 (3):124-129. doi: 10.1016/j.rce.2018.09.012. PubMed PMID:30447849 .
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  1. Roca Villanueva, B, Beltrán Salvador, M, Gómez Huelgas, R. Change climate and health. Rev Clin Esp. ;219 (5):260-265. doi: 10.1016/j.rce.2019.01.004. PubMed PMID:30795848 .
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  1. Carretero Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, García de Lucas, D, Mateos Polo, L, Varela Aguilar, JM et al.. Combination Therapy With Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors in Older Patients With Type 2 Diabetes: A Real-World Evidence Study. Can J Diabetes. 2019;43 (3):186-192. doi: 10.1016/j.jcjd.2018.09.001. PubMed PMID:30415909 .
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  1. León Jiménez, D, Gómez Huelgas, R, Fernández Romero, AJ, López Chozas, JM, Pérez de Isla, L, Miramontes González, JP et al.. Diuretic treatment of the patient with diabetes and heart failure. Role of SGLT2 inhibitors and similarities with carbonic anhydrase inhibitors. Rev Clin Esp. 2019;219 (4):208-217. doi: 10.1016/j.rce.2018.09.021. PubMed PMID:30553441 .
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  1. Pérez-Belmonte, LM, Osuna-Sánchez, J, Millán-Gómez, M, López-Carmona, MD, Gómez-Doblas, JJ, Cobos-Palacios, L et al.. Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study. Ann Med. ;51 (3-4):252-261. doi: 10.1080/07853890.2019.1613672. PubMed PMID:31037970 .
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  1. Gomez-Huelgas, R, Ruiz-Nava, J, Santamaria-Fernandez, S, Vargas-Candela, A, Alarcon-Martin, AV, Tinahones, FJ et al.. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators Inflamm. 2019;2019 :4165260. doi: 10.1155/2019/4165260. PubMed PMID:31093012 PubMed Central PMC6481026.
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  1. Pérez, A, Ramos, A, Reales, P, Tobares, N, Gómez-Huelgas, R, en nombre del Grupo de estudio AL ALTA et al.. Indicator performance after the implementation of the Spanish Consensus Document for the control of hyperglycemia in the hospital and at discharge. Rev Clin Esp. ;219 (1):18-25. doi: 10.1016/j.rce.2018.05.010. PubMed PMID:30049416 .
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  1. Pérez-Cabeza, MI, Borrás, F, Moreno-Medinilla, EE, Bardán-Rebollar, D, Ferrer-López, I, Rodríguez-García, E et al.. Infantile sialidosis: natural history in a preterm infant with two new pathogenic mutations and new ocular findings. J AAPOS. 2019;23 (2):102-104. doi: 10.1016/j.jaapos.2018.08.008. PubMed PMID:30445145 .
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  1. Lara-Rojas, CM, Pérez-Belmonte, LM, López-Carmona, MD, Guijarro-Merino, R, Bernal-López, MR, Gómez-Huelgas, R et al.. National trends in diabetes mellitus hospitalization in Spain 1997-2010: Analysis of over 5.4 millions of admissions. Eur J Intern Med. 2019;60 :83-89. doi: 10.1016/j.ejim.2018.04.005. PubMed PMID:30100217 .
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  1. Santiago-Fernández, C, Pérez-Belmonte, LM, Millán-Gómez, M, Moreno-Santos, I, Carrasco-Chinchilla, F, Ruiz-Salas, A et al.. Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes. J Transl Med. 2019;17 (1):95. doi: 10.1186/s12967-019-1842-2. PubMed PMID:30894181 PubMed Central PMC6425581.
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  1. Zapatero-Gaviria, A, Gomez-Huelgas, R, Diez-Manglano, J, Barba-Martín, R, Carretero-Gomez, J, Maestre-Peiró, A et al.. RECALMIN. Four years of growth of the internal medicine units of the Spanish National Health System (2013-2016). Rev Clin Esp. 2019;219 (4):171-176. doi: 10.1016/j.rce.2018.11.005. PubMed PMID:30808505 .
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  1. Pérez-Belmonte, LM, Florido-Santiago, M, Osuna-Sánchez, J, Barbancho, MA, Millán-Gómez, M, Jímenez-Navarro, MF et al.. Screening Versus Brief Domain-specific Tests to Assess Long-term Postoperative Cognitive Dysfunction After Concomitant Aortic Valve Replacement and Coronary Artery Bypass Grafting. J Cardiovasc Nurs. ;34 (6):511-516. doi: 10.1097/JCN.0000000000000596. PubMed PMID:31365446 .
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  1. Julibert, A, Bibiloni, MDM, Bouzas, C, Martínez-González, MÁ, Salas-Salvadó, J, Corella, D et al.. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk. Nutrients. 2019;11 (7):. doi: 10.3390/nu11071493. PubMed PMID:31261967 PubMed Central PMC6682917.
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  1. Gómez-Huelgas, R, Lara-Rojas, CM, López-Carmona, MD, Jansen-Chaparro, S, Barba, R, Zapatero, A et al.. Trends in Diabetes-Related Potentially Preventable Hospitalizations in Adult Population in Spain, 1997⁻2015: A Nation-Wide Population-Based Study. J Clin Med. 2019;8 (4):. doi: 10.3390/jcm8040492. PubMed PMID:30978979 PubMed Central PMC6526470.
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  1. García-Alfonso, P, Cavanagh Podesta, M, Muñoz Martín, A, Blanco Codeisido, M, Calvo, A, Peligros, I et al.. Chemotherapy Plus Bevacizumab as Neoadjuvant or Conversion Treatment in Patients with Colorectal Liver Metastases. Anticancer Res. 2018;38 (5):3069-3077. doi: 10.21873/anticanres.12564. PubMed PMID:29715142 .
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  1. Ena, J, Gaviria, AZ, Romero-Sánchez, M, Carretero-Gómez, J, Carrasco-Sánchez, FJ, Segura-Heras, JV et al.. Derivation and validation model for hospital hypoglycemia. Eur J Intern Med. 2018;47 :43-48. doi: 10.1016/j.ejim.2017.08.024. PubMed PMID:28882417 .
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  1. Ena, J, Gómez-Huelgas, R, Gracia-Tello, BC, Vázquez-Rodríguez, P, Alcalá-Pedrajas, JN, Carrasco-Sánchez, FJ et al.. Derivation and validation of a predictive model for the readmission of patients with diabetes mellitus treated in internal medicine departments. Rev Clin Esp. ;218 (6):271-278. doi: 10.1016/j.rce.2018.03.010. PubMed PMID:29731294 .
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  1. Manzano-Gamero, V, Pardo-Cabello, AJ, Vargas-Hitos, JA, Zamora-Pasadas, M, Navarrete-Navarrete, N, Sabio, JM et al.. Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus: a multicenter cross-sectional study. Int J Rheum Dis. 2018;21 (11):2028-2035. doi: 10.1111/1756-185X.13117. PubMed PMID:28593703 .
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  1. Garcia de Lucas, MD, Pérez Belmonte, LM, Suárez Tembra, M, Olalla Sierra, J, Gómez Huelgas, R. Efficacy and safety of replacing sitagliptin with canagliflozin in real-world patients with type 2 diabetes uncontrolled with sitagliptin combined with metformin and/or gliclazide: The SITA-CANA Switch Study. Diabetes Metab. 2018;44 (4):373-375. doi: 10.1016/j.diabet.2018.05.005. PubMed PMID:29859992 .
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  1. Serena, C, Ceperuelo-Mallafré, V, Keiran, N, Queipo-Ortuño, MI, Bernal, R, Gomez-Huelgas, R et al.. Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota. ISME J. 2018;12 (7):1642-1657. doi: 10.1038/s41396-018-0068-2. PubMed PMID:29434314 PubMed Central PMC6018807.
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  1. Carretero-Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, De Escalante Yangüela, B, Gracia Tello, B, Pérez Belmonte, L et al.. Hydration and obesity among outpatient-based population: H2Ob study. J Investig Med. 2018;66 (4):780-783. doi: 10.1136/jim-2017-000641. PubMed PMID:29367255 .
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  1. Arévalo-Lorido, JC, Gómez, JC, Huelgas, RG, de Lucas, DG, Polo, LM, Aguilar, JMV et al.. Lowering Blood Pressure with the Combination of a Sodium-Glucose Cotransporter 2 Inhibitor and a Glucagon-like Peptide-1 Receptor Agonist in Type 2 Diabetic Patients: A Clinical Evidence. High Blood Press Cardiovasc Prev. 2018;25 (4):417-420. doi: 10.1007/s40292-018-0280-1. PubMed PMID:30251110 .
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  1. Carrasco-Sánchez, FJ, Carretero-Gómez, J, Gómez-Huelgas, R, Garcia-Ordoñez, MA, Pardo-Ortega, MV, de Escalante-Yanguela, B et al.. Stress-induced hyperglycemia on complications in non-critically elderly hospitalized patients. Rev Clin Esp. ;218 (5):223-231. doi: 10.1016/j.rce.2018.02.017. PubMed PMID:29661504 .
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  1. Gómez-Huelgas, R, Gómez Peralta, F, Rodríguez Mañas, L, Formiga, F, Puig Domingo, M, Mediavilla Bravo, JJ et al.. Treatment of type 2 diabetes mellitus in elderly patients. Rev Clin Esp. 2018;218 (2):74-88. doi: 10.1016/j.rce.2017.12.003. PubMed PMID:29366502 .
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  1. Pérez-Belmonte, LM, Gómez-Doblas, JJ, Millán-Gómez, M, López-Carmona, MD, Guijarro-Merino, R, Carrasco-Chinchilla, F et al.. Use of Linagliptin for the Management of Medicine Department Inpatients with Type 2 Diabetes in Real-World Clinical Practice (Lina-Real-World Study). J Clin Med. 2018;7 (9):. doi: 10.3390/jcm7090271. PubMed PMID:30208631 PubMed Central PMC6162816.
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  1. Jiménez-Navarro, MF, Lopez-Jimenez, F, Pérez-Belmonte, LM, Lennon, RJ, Diaz-Melean, C, Rodriguez-Escudero, JP et al.. Benefits of Cardiac Rehabilitation on Cardiovascular Outcomes in Patients With Diabetes Mellitus After Percutaneous Coronary Intervention. J Am Heart Assoc. 2017;6 (10):. doi: 10.1161/JAHA.117.006404. PubMed PMID:29021270 PubMed Central PMC5721849.
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  1. Lopez-Carmona, MD, Plaza-Seron, MC, Vargas-Candela, A, Tinahones, FJ, Gomez-Huelgas, R, Bernal-Lopez, MR et al.. CD36 overexpression: a possible etiopathogenic mechanism of atherosclerosis in patients with prediabetes and diabetes. Diabetol Metab Syndr. 2017;9 :55. doi: 10.1186/s13098-017-0253-x. PubMed PMID:28729885 PubMed Central PMC5516302.
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  1. Gómez-Huelgas, R, López-Carmona, MD. Diabetes in the elderly: primum non nocere. Rev Clin Esp. 2017;217 (9):518-519. doi: 10.1016/j.rce.2017.10.003. PubMed PMID:29122208 .
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  1. Hanefeld, M, Arteaga, JM, Leiter, LA, Marchesini, G, Nikonova, E, Shestakova, M et al.. Efficacy and safety of lixisenatide in patients with type 2 diabetes and renal impairment. Diabetes Obes Metab. 2017;19 (11):1594-1601. doi: 10.1111/dom.12986. PubMed PMID:28449324 PubMed Central PMC5655920.
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  1. Gómez-Moyano, E, Ureña-Garnica, I, Manrique-Arija, S, Perez-Belmonte, LM. Erythematous patches with keratotic annular borders on the glans penis. Cleve Clin J Med. 2017;84 (1):23-24. doi: 10.3949/ccjm.84a.15145. PubMed PMID:28084979 .
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  1. Pérez-Belmonte, LM, Moreno-Santos, I, Gómez-Doblas, JJ, García-Pinilla, JM, Morcillo-Hidalgo, L, Garrido-Sánchez, L et al.. Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure. Int J Med Sci. 2017;14 (9):891-895. doi: 10.7150/ijms.19854. PubMed PMID:28824327 PubMed Central PMC5562197.
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  1. Pérez-Belmonte, LM, Moreno-Santos, I, Cabrera-Bueno, F, Sánchez-Espín, G, Castellano, D, Such, M et al.. Expression of Sterol Regulatory Element-Binding Proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study. Int J Med Sci. 2017;14 (3):268-274. doi: 10.7150/ijms.17821. PubMed PMID:28367087 PubMed Central PMC5370289.
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  1. Carretero Gómez, J, Arévalo Lorido, JC, Gómez Huelgas, R, Sánchez Vidal, MT, Suárez Tembra, M, Varela Aguilar, JM et al.. Prevalence of obesity according to Edmonton staging in the Internal Medicine consultations. Results of the OBEMI study. Rev Clin Esp. 2017;217 (2):71-78. doi: 10.1016/j.rce.2016.11.003. PubMed PMID:27939027 .
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  1. Zapatero-Gaviria, A, Barba-Martín, R, Canora Lebrato, J, Fernández-Pérez, C, Gómez-Huelgas, R, Bernal-Sobrino, JL et al.. RECALMIN II. Eight years of hospitalisation in Internal Medicine Units (2007-2014). What has changed?. Rev Clin Esp. 2017;217 (8):446-453. doi: 10.1016/j.rce.2017.07.008. PubMed PMID:28851485 .
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  1. Zapatero-Gaviria, A, Javier Elola-Somoza, F, Casariego-Vales, E, Fernandez-Perez, C, Gomez-Huelgas, R, Bernal, JL et al.. RECALMIN: The association between management of Spanish National Health Service Internal Medical Units and health outcomes. Int J Qual Health Care. 2017;29 (4):507-511. doi: 10.1093/intqhc/mzx055. PubMed PMID:28541515 .
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  1. Gómez-Huelgas, R, Sabán-Ruiz, J, García-Román, FJ, Quintela-Fernández, N, Seguí-Ripoll, JM, Bonilla-Hernández, MV et al.. Safety and efficacy of a basal-plus regimen with insulin glargine and insulin glulisine for elderly patients with high cardiovascular risk and type 2 diabetes mellitus. Rev Clin Esp. 2017;217 (4):201-206. doi: 10.1016/j.rce.2017.02.005. PubMed PMID:28314656 .
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  1. Gómez-Huelgas, R, Artola-Menéndez, S, Menéndez-Torre, E. Analysis of the healthcare process of patients with type 2 diabetes mellitus and associated comorbidity treated in Spain's National Health System: A perspective of medical professionals. IMAGINE study. Rev Clin Esp. 2016;216 (3):113-20. doi: 10.1016/j.rce.2015.11.009. PubMed PMID:26772868 .
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  1. Martínez-Sellés, M, Gómez Huelgas, R, Abu-Assi, E, Calderón, A, Vidán, MT. [Chronic ischaemic heart disease in the elderly]. Med Clin (Barc). 2016;146 (8):372.e1-372.e10. doi: 10.1016/j.medcli.2016.01.014. PubMed PMID:26965220 .
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  1. Ena, J, Gómez-Huelgas, R, Zapatero-Gaviria, A, Vázquez-Rodriguez, P, González-Becerra, C, Romero-Sánchez, M et al.. Effect of an intervention on quality indicators for improving the treatment of hyperglycemia in patients hospitalized in noncritical areas. Rev Clin Esp. 2016;216 (7):352-360. doi: 10.1016/j.rce.2016.05.006. PubMed PMID:27318510 .
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  1. El Bekay, R, Coín-Aragüez, L, Fernández-García, D, Oliva-Olivera, W, Bernal-López, R, Clemente-Postigo, M et al.. Effects of glucagon-like peptide-1 on the differentiation and metabolism of human adipocytes. Br J Pharmacol. 2016;173 (11):1820-34. doi: 10.1111/bph.13481. PubMed PMID:26993859 PubMed Central PMC4867741.
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  1. Calvo Gómez, C, Gómez-Huelgas, R, Lima Ruiz, J, Masmiquel Comas, L, Michán Doña, A, Zapatero Gaviria, A et al.. Expert consensus on the use of liraglutide in the treatment of diabetes in internal medicine. Int J Clin Pharmacol Ther. 2016;54 (11):880-890. doi: 10.5414/CP202428. PubMed PMID:27487367 .
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  1. Ortiz-Fernández, L, Carmona, FD, Montes-Cano, MA, García-Lozano, JR, Conde-Jaldón, M, Ortego-Centeno, N et al.. Genetic Analysis with the Immunochip Platform in Behçet Disease. Identification of Residues Associated in the HLA Class I Region and New Susceptibility Loci. PLoS One. 2016;11 (8):e0161305. doi: 10.1371/journal.pone.0161305. PubMed PMID:27548383 PubMed Central PMC4993481.
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  1. Ena, J, Gómez-Huelgas, R, Sánchez-Fuentes, D, Camafort-Babkowsk, M, Formiga, F, Michán-Doña, A et al.. Management of patients with type 2 diabetes and multiple chronic conditions: A Delphi consensus of the Spanish Society of Internal Medicine. Eur J Intern Med. 2016;27 :31-6. doi: 10.1016/j.ejim.2015.10.015. PubMed PMID:26586286 .
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  1. Tulipani, S, Griffin, J, Palau-Rodriguez, M, Mora-Cubillos, X, Bernal-Lopez, RM, Tinahones, FJ et al.. Metabolomics-guided insights on bariatric surgery versus behavioral interventions for weight loss. Obesity (Silver Spring). 2016;24 (12):2451-2466. doi: 10.1002/oby.21686. PubMed PMID:27891833 .
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  1. Ortiz-Fernández, L, Montes-Cano, MA, García-Lozano, JR, Conde-Jaldón, M, Ortego-Centeno, N, González-Leon, R et al.. PTPN22 is not associated with Behçet's disease. Study spanning the complete gene region in the Spanish population and meta-analysis of the functional variant R620W. Clin Exp Rheumatol. ;34 (6 Suppl 102):S41-S45. . PubMed PMID:27050764 .
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  1. Guijarro, R, de Miguel-Diez, J, Jimenez, D, Trujillo-Santos, J, Otero, R, Barba, R et al.. Pulmonary embolism, acute coronary syndrome and ischemic stroke in the Spanish National Discharge Database. Eur J Intern Med. 2016;28 :65-9. doi: 10.1016/j.ejim.2015.10.006. PubMed PMID:26603210 .
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  1. Jiménez, D, de Miguel-Díez, J, Guijarro, R, Trujillo-Santos, J, Otero, R, Barba, R et al.. Trends in the Management and Outcomes of Acute Pulmonary Embolism: Analysis From the RIETE Registry. J Am Coll Cardiol. 2016;67 (2):162-170. doi: 10.1016/j.jacc.2015.10.060. PubMed PMID:26791063 .
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  1. de Miguel-Díez, J, Muñoz-Rivas, N, Jiménez-García, R, Hernández-Barrera, V, Carrasco-Garrido, P, Monreal, M et al.. Type 2 diabetes is associated with a higher incidence of hospitalization for pulmonary embolism in Spain: Analysis of hospital discharge data during 2004-2013. Respirology. 2016;21 (7):1277-84. doi: 10.1111/resp.12847. PubMed PMID:27377690 .
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  1. Rojas, CM, Borella, E, Palma, L, Ragozzino, S, De Ramón, E, Gomez-Huelgas, R et al.. Bronchiolitis obliterans organizing pneumonia in patients with autoimmune rheumatic diseases. Immunol Res. 2015;61 (1-2):97-103. doi: 10.1007/s12026-014-8607-z. PubMed PMID:25480740 .
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  1. Bernal-Lopez, MR, Peña, D, Gomez-Martin, P, Tinahones, FJ, Gomez-Huelgas, R. Cilostazol does not improve peripheral arterial disease-linked oxidative stress. Cardiovasc Ther. 2015;33 (1):15-9. doi: 10.1111/1755-5922.12100. PubMed PMID:25393963 .
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  1. Gomez-Huelgas, R, Jansen-Chaparro, S, Baca-Osorio, AJ, Mancera-Romero, J, Tinahones, FJ, Bernal-López, MR et al.. Effects of a long-term lifestyle intervention program with Mediterranean diet and exercise for the management of patients with metabolic syndrome in a primary care setting. Eur J Intern Med. 2015;26 (5):317-23. doi: 10.1016/j.ejim.2015.04.007. PubMed PMID:25907985 .
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  1. Lara-Rojas, CM, Bernal-Lopez, MR, Lopez-Carmona, MD, Gomez-Huelgas, R. Familial aortic coarctation: a rare cause of refractory hypertension in the elderly: a case report. Medicine (Baltimore). 2015;94 (4):e467. doi: 10.1097/MD.0000000000000467. PubMed PMID:25634191 PubMed Central PMC4602944.
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  1. Gómez-Huelgas, R, Azriel, S, Puig-Domingo, M, Vidal, J, de Pablos-Velasco, P. Glucagon-like peptide-1 receptor agonists as insulin add-on therapy in patients with inadequate glycemic control in type 2 diabetes mellitus: lixisenatide as a new therapeutic option. Int J Clin Pharmacol Ther. 2015;53 (3):230-40. doi: 10.5414/CP202052. PubMed PMID:25066229 .
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  1. Ena, J, Gómez-Huelgas, R, Romero-Sánchez, M, Gaviria, AZ, Calzada-Valle, A, Varela-Aguilar, JM et al.. Hyperglycemia management in patients admitted to internal medicine in Spain: A point-prevalence survey examining adequacy of glycemic control and guideline adherence. Eur J Intern Med. 2015;26 (6):392-8. doi: 10.1016/j.ejim.2015.04.020. PubMed PMID:25962558 .
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  1. Cervera, R, Serrano, R, Pons-Estel, GJ, Ceberio-Hualde, L, Shoenfeld, Y, de Ramón, E et al.. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients. Ann Rheum Dis. 2015;74 (6):1011-8. doi: 10.1136/annrheumdis-2013-204838. PubMed PMID:24464962 .
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  1. Arcelus, JI, Domènech, P, Fernández-Capitan, Mdel C, Guijarro, R, Jiménez, D, Jiménez, S et al.. Rivaroxaban in the treatment of venous thromboembolism and the prevention of recurrences: a practical approach. Clin Appl Thromb Hemost. 2015;21 (4):297-308. doi: 10.1177/1076029614561321. PubMed PMID:25504999 .
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  1. Clemente-Postigo, M, Muñoz-Garach, A, Serrano, M, Garrido-Sánchez, L, Bernal-López, MR, Fernández-García, D et al.. Serum 25-hydroxyvitamin D and adipose tissue vitamin D receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab. 2015;100 (4):E591-5. doi: 10.1210/jc.2014-3016. PubMed PMID:25706239 .
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