Grupo de investigación en Medicina Maternofetal, epigenética, enfermedades de la mujer y salud reproductiva

Como grupo estamos interesados en obtener el reconocimiento del instituto e integrarnos en el funcionamiento del mismo.

Lineas de Investigación

01. Exposición perinatal y desarrollo psicoevolutiivo.

02. Prematuridad, marcadores pronósticos de neurodesarrollo fetal, trastornos del ánimo en el período perinatal, gestación múltiple, patología reproductiva.

Proyectos destacados

Proyectos de Investigación

EMG20-003 Ayudas para el fortalecimiento de grupos emergentes

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

FRI-PI-COVID-2020-02 Placental injury and immune reaction transmitted to the neonates in cases of SARSCov2 infections. Study on placental and cord samples.

Ferring Pharmaceuticals A/S
. 2020


Primal Health Research Center
. 2012

Estudios Clínicos

Ensayo clínico de fase 2, multicéntrico, abierto, aleatorizado, para evaluar la inhibición de la ovulación de tres dosificaciones de levonorgestrel (LNG) en un sistema de liberación vaginal (SLV), que se libera durante 28 días de manera continua, frente a.

Fase: II Ensayo Clínico Comercial

Estudio de fase IIb/IIIa, multicéntrico, aleatorizado, de grupos paralelos, con enmascaramiento doble y controlado con placebo para evaluar la eficacia y la seguridad de AMAG-423, un fragmento ab de anticuerpos antidigoxina, en pacientes embarazadas con.

Fase: III Ensayo Clínico Comercial

Estudio de superioridad, multicéntrico, aleatorizado, doble ciego, de tres grupos paralelos en el que se evalúa la eficacia y seguridad de mifepristona (2,5 mg y 5 mg) frente a placebo en el tratamiento de la endometriosis en mujeres en edad fértil durant.

Fase: III Ensayo Clínico Comercial

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro

Comorbid anxiety and depression (CAD) at early stages of the pregnancy

González-Mesa E, Kabukcuoglu K, Blasco M, Körükcü O, Ibrahim N, González-Cazorla A, Cazorla O
A multicultural cross-sectional study J Affect Disord

Type of delivery and reading, writing, and arithmetic learning in twin births

González-Valenzuela MJ, López-Montiel D, Cazorla-Granados O, González-Mesa E
Dev Psychobiol 2020 May;62(4):484-495

Comorbid anxiety and depression (CAD) at early stages of the pregnancy. A multicultural cross-sectional study.

González-Mesa E, Kabukcuoglu K, Blasco M, Körükcü O, Ibrahim N, González-Cazorla A, Cazorla O.
J Affect Disord. 2020 Mar 29;270:85-89.

When anxiety and depression are comorbid (CAD), symptoms are more severe and the response to treatments is worse. Given the links between mood disorders and poor perinatal outcomes, CAD and its correlates deserve special clinical attention during pregnancy. The main objective of this study was to learn about the prevalence of comorbid anxiety and depression (CAD) in early stages of the pregnancy analyzing the relationship between CAD and cultural […]

Type of delivery and reading, writing, and arithmetic learning in twin births.

González-Valenzuela MJ, López-Montiel D, Cazorla-Granados O, González-Mesa E.
Dev Psychobiol. 2019 Oct 31.

This study analyses, in children born in twin births, the relationship between reading, writing and arithmetic learning, on the one hand, and type of delivery, on the other, controlling for the effect of interaction and/or confusion of third variables (maternal age at delivery, gestational age, fetal position, birthweight, 1-min Apgar score). In the planned retrospective cohort design, the exposed cohort consisted of children born by caesarean se […]

Poor sleep quality is associated with perinatal depression. A systematic review of last decade scientific literature and meta-analysis.

González-Mesa E, Cuenca-Marín C, Suarez-Arana M, Tripiana-Serrano B, Ibrahim-Díez N, Gonzalez-Cazorla A, Blasco-Alonso M.
J Perinat Med. 2019 Sep 25;47(7):689-703.

Background Although pregnancy is frequently associated with mental states of happiness, hope and well-being, some physical and psychological changes can contribute to increased sleep disturbances and worsened sleep quality. Sleep quality has been linked to negative emotions, anxiety and depression. The main objective of this paper was to systematically review the impact of sleep during pregnancy on maternal mood, studying the association between […]

Type of Delivery, Neuropsychological Development and Intelligence in Twin Births.

González-Valenzuela MJ, González-Mesa E, Cazorla-Granados O, López-Montiel D.
Front Psychol. 2019 May 3;10:972.

Based on a retrospective cohort design with 6-year-old children born in twin births, the relationship between verbal, non-verbal, global neuropsychological development, general intelligence and type of delivery has been studied. To this end, the possible effect of third gestational, obstetric and neonatal variables, such as maternal age at delivery, fetal presentation, gestational age, newborn weight and Apgar at minute one, was controlled. The e […]

Correlates for state and trait anxiety in a multicultural sample of Turkish and Spanish women at first trimester of pregnancy.

González-Mesa E, Kabukcuoglu K, Körükcü O, Blasco M, Ibrahim N, Cazorla-Granados O, Kavas T.
J Affect Disord. 2019 Apr 15;249:1-7.

The main objective of this research was to assess the potential influence of cultural factors on the anxiety levels of a multicultural sample of Spanish and Turkish pregnant women at the beginning of the pregnancy. […]

Rev Esp Cardiol (Engl Ed). 2019 Feb;72(2):109-114.


Nutr Hosp. 2018 Jul 9;35(4):751-752.


Cultural factors influencing antenatal depression: A cross-sectional study in a cohort of Turkish and Spanish women at the beginning of the pregnancy.

González-Mesa E, Kabukcuoglu K, Körükcü O, Blasco M, Ibrahim N, Kavas T.
J Affect Disord. 2018 Oct 1;238:256-260.

Depression is the most frequent mental disorder during pregnancy, and its prevalence is at least as high as that of postnatal depression. Differences between Western and Eastern countries may exist according to cultural and educational factors. […]

Toxic elements in hair and in vitro fertilization outcomes: A prospective cohort study.

García-Fortea P, Cohen-Corcia I, Córdoba-Doña JA, Reche-Rosado A, González-Mesa E.
Reprod Toxicol. 2018 Apr;77:43-52.

We analysed the association between the concentration of four toxic elements (As, Cd, Hg and Pb) and diverse reproductive outcomes in a cohort of 194 women with fertility disorders undergoing IVF in a public hospital. Concentration in hair specimens was explored as biomarker of exposure during the three months prior to oocyte retrieval. The proportion of negative results, especially regarding pregnancy and birth outcomes, is remarkable. However, […]

Mood state at the beginning of the pregnancy and its influence on obstetric and perinatal outcomes.

González-Mesa ES, Arroyo-González ML, Ibrahim-Díez N, Cazorla-Granados O.
J Psychosom Obstet Gynaecol. 2019 Jun;40(2):106-113.

Aim: We designed this study to ascertain the prevalence of depressive disorders and anxiety at the beginning of the pregnancy, studying possible associated factors and assessing the influence of mood disorders on perinatal outcomes. Methods: A representative sample of 191 pregnant women at first trimester of their pregnancies completed a questionnaire that included the Whooley´s questions, the Spanish version of the Beck Depression Inventory (BD […]

Anxiety and attitudes towards sex in women requesting emergency contraception.

González-Mesa ES, Bueno-Cobos L, Barroso-García N, Vilches-Jiménez JC.
J Psychosom Obstet Gynaecol. 2019 Mar;40(1):75-81.

We performed an observational descriptive study on 89 women who requested for emergency contraception (EC) at the emergency units of two hospitals, Virgen de la Victoria Hospital, and Regional University Hospital in Malaga between October 2016 and April 2017. Both hospitals are on the Andalusian Public Health System. We evaluated a group of socio-demographic variables and others related to the beliefs and the knowledge about EC and contraception […]

Neurological complications after therapy for fetal-fetal transfusion syndrome: a systematic review of the outcomes at 24 months.

Miralles-Gutiérrez A, Narbona-Arias I, González-Mesa E.
J Perinat Med. 2018 Nov 27;46(9):991-997.

The main objective of this study was to review the available scientific evidence about mid-term neurological outcomes in twins after laser therapy for twin-to-twin transfusion syndrome (TTTS). […]

Temporal trends for pregnancy length in a hospital setting of Southern Spain.

González-Mesa E, Villegas E.
J Obstet Gynaecol. 2017 Jan;37(1):38-43.

For centuries it has been considered that the due date for delivery in our species is 280 days after the onset of the last menstruation. However, in most cases this statement is not accurate. The main objective of this study was to determine the mean duration of pregnancy in our setting and whether it has experienced changes in recent years. A retrospective, population-based descriptive study was made of 102,169 deliveries assisted in Malaga Univ […]

The increasing number of multiple pregnancies in recent years has raised a particular concern about the problems associated to these pregnancies. It still remains unclear whether twin deliveries, as currently conceived, provide the same future health chances to both fetuses. In this regard, it is worth mentioning that the effects of obstetric and neonatal care beyond the perinatal period have not often been evaluated. The main objective of this r […]

Exposure to tobacco, alcohol and drugs of abuse during pregnancy. A study of prevalence among pregnant women in Malaga (Spain).

Blasco-Alonso M, González-Mesa E, Gálvez Montes M, Lozano Bravo I, Merino Galdón F, Cuenca Campos F, Marín Schiaffino G, Pérez Torres S, Herrera Peral J, Bellido Estévez I.
Adicciones. 2015 Jun 17;27(2):99-108.


High levels of alcohol consumption in pregnant women from a touristic area of Southern Spain.

González-Mesa E, Blasco-Alonso M, Gálvez Montes M, Lozano Bravo I, Merino-Galdón F, Cuenca-Campos F, Marín-Schiaffino G, Bellido-Estévez I.
J Obstet Gynaecol. 2015;35(8):821-4.

The prevalence of alcohol intake in women who become pregnant is similar to that found in the general population, especially in cases of unplanned pregnancies. Consequently, foetal exposure is high during the period of maximum vulnerability. The present study was carried out to determine the prenatal level of exposure to alcohol in Málaga, a Mediterranean region whose economy is based on the touristic sector (Costa del Sol). A cross-sectional, o […]

Exposure to synthetic oxytocin during delivery and its effect on psychomotor development.

González-Valenzuela MJ, López-Montiel D, González-Mesa ES.
Dev Psychobiol. 2015 Dec;57(8):908-20.

The main objective is to examine the influence of oxytocin administration during delivery on psychomotor development at age five years. This was a retrospective cohort study involving two groups: children of mothers exposed vs. not exposed to oxytocin during labor. Of the 7,465 newborns registered in our maternity service during 2006 we randomly selected an initial sample of 400 children. Of these, 146 children were assessed using the motor scale […]

Use of a temporary inferior vena cava filter during pregnancy in patients with thromboembolic events.

González-Mesa E, Azumendi P, Marsac A, Armenteros A, Molina N, Narbona I, Herrera J, Artero I, Rodríguez-Mesa JM.
J Obstet Gynaecol. 2015;35(8):771-6.

There are circumstances in the management of thromboembolic events during pregnancy when anticoagulant therapy is either contraindicated or not advisable, such as when pulmonary embolism (PE) or deep venous thrombosis is diagnosed close to term, given the risk of bleeding during delivery. In these cases, the thromboembolic risk can be controlled using temporary inferior vena cava filters (T-IVCFs). We present the case of a pregnant woman with thr […]

Effects of oxytocin used during delivery on development: a retrospective cohort study.

González-Valenzuela MJ, García-Fortea P, Delgado-Ríos M, Cazorla-Granados O, Blasco-Alonso M, González-Mesa E.
J Clin Exp Neuropsychol. 2014;36(7):680-90.

The objective was to evaluate the potential influence of oxytocin administered during delivery on children’s development at the age of 5. […]

Tubal ectopic pregnancy two years after laparoscopic supracervical hysterectomy.

Villegas E, González-Mesa E, Benítez MJ, Luna S, Gómez C, Marsac A, Jiménez J.
BMC Womens Health. 2014 May 24;14:69.

Ectopic pregnancy after hysterectomy is a very rare condition, but it must be kept in mind in women with history of hysterectomy who present with abdominal pain and ecographic adnexal heterogeneous images. Since first described by Wendeler in 1895, at least 67 ectopic pregnancies (tubal, ovarian and abdominal) have been described in patients subjected to prior hysterectomy. […]

Oxytocin administered during labor and breast-feeding: a retrospective cohort study.

García-Fortea P, González-Mesa E, Blasco M, Cazorla O, Delgado-Ríos M, González-Valenzuela MJ.
J Matern Fetal Neonatal Med. 2014 Oct;27(15):1598-603.

The relationship between labor physiology and the onset of lactation leads to assess the potential correlation between oxytocin administration during labor and duration of breast-feeding. […]

Uterine rotation: a cause of intestinal obstruction.

González-Mesa E, Narbona I, Cohen I, Villegas E, Cuenca C.
Case Rep Obstet Gynecol. 2013;2013:759250.

Intestinal obstruction is an uncommon surgical emergency during pregnancy that affects seriously the prognosis of gestation. The underlying cause can be identified in the majority of cases and usually consists of adhesions secondary to previous abdominal or pelvic surgery, followed in order of frequency by intestinal volvuli. In recent years there have been no reports in which the gravid uterus has been the cause of intestinal obstruction. We rep […]

Thrombotic thrombocytopenic purpura is a type of occlusive thrombotic microangiopathy that is not specific to pregnancy but occurs with an increased frequency during it. Prognosis of thrombotic thrombocytopenic purpura greatly depends on early diagnosis and treatment. As delivery does not generally cause resolution of thrombotic thrombocytopenic purpura, pregnancy termination is not initially considered, especially under 34 weeks, although it may […]

Klippel-Trenaunay syndrome complicating pregnancy.

González-Mesa E, Blasco M, Andérica J, Herrera J.
BMJ Case Rep. 2012 Aug 1;2012.

The Klippel-Trenaunay syndrome is a rare congenital disorder that affects one or more limbs. It is characterised by cutaneous vascular nevi, venous malformations and hypertrophy of soft tissues and bone. There are very few cases reported in pregnant women, so the level of uncertainty is high when it appears during gestation. It is a disease that increases obstetric risk and can exacerbate complications, mainly thromboembolic and haemorrhagic. We […]

Temporal trends of latency period and perinatal survival after very early preterm premature rupture of fetal membranes.

González-Mesa E, Herrera JA, Urgal A, Lazarraga C, Benítez MJ, Gómez C.
Arch Gynecol Obstet. 2012 Aug;286(2):347-52.

This paper shows temporal trends of latency period and perinatal survival after preterm premature rupture of membranes at or before 28 weeks (very early PPROM). […]

Incidence and costs of multifetal pregnancies in Andalusia (2000-2010).

Mesa EG, Peral JA.
Twin Res Hum Genet. 2011 Oct;14(5):484-9.

In the past 50 years the incidence of multiple pregnancies has increased dramatically due almost exclusively to two factors: delayed childbearing and assisted reproductive techniques. In this paper we analyze the variations in the incidence of multiple gestations in Andalusia, one of the biggest administrative regions in Spain, over the last decade. Assisted reproduction techniques are very often evaluated only in terms of implantation and pregna […]

Maternal-fetal thyroid function at the time of birth and its relation with iodine intake.

Velasco I, Martín J, Gallego M, Gutiérrez-Repiso C, Santiago P, López-Siguero JP, Mesa EG, Peral JH, Pérez V, García-Fuentes E, Soriguer F.
Thyroid. 2013 Dec;23(12):1619-26.

The effects of moderate variations in dietary iodine intake on maternal and fetal thyroid function are poorly understood. Recent studies question the usefulness of neonatal screening of congenital hypothyroidism as a tool for monitoring iodine deficiency. We proposed to test the hypothesis of an association between iodine intake during the last trimester of pregnancy and fetal thyroid function at the time of birth. […]

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