Grupo universitario con experiencia en investigaciones sobre el sistema cardiovascular en Vertebrados, utilizando modelos animales de enfermedad de relevancia biomédica

Lineas de Investigación

01. Etiología y fisiopatología de la enfermedad de la válvula aórtica bicúspide.

02. Etiología de las anomalías congénitas de las arterias coronarias

03. Modelos animales de aterosclerosis

04. Crecimiento vascular: angiogénesis y arteriogénesis

05. Desarrollo embrionario del sistema cardiovascular.

06. Anatomía comparada y evolución del sistema cardiovascular.



Proyectos de Investigación

Soto Navarrete, Mª Teresa

IP Acciones Complementarias

Area1_002:Identificación de una variante alélica de Smad2 asociada a la enfermedad de la válvula aórtica bicúspide en una población de pacientes

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
. 2020

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro


Anesthetic-induced Myocardial Conditioning: Molecular Fundamentals and Scope

Guerrero Orriach JL, Escalona Belmonte JJ, Ramirez Aliaga M, Ramirez Fernandez A, Raigón Ponferrada A, Rubio Navarro M, Cruz Mañas J
Curr Med Chem 2020;27(13):2147-2160


Renal and Neurologic Benefit of Levosimendan vs Dobutamine in Patients With Low Cardiac Output Syndrome After Cardiac Surgery: Clinical Trial FIM-BGC-2014-01

Guerrero-Orriach JL, Malo-Manso A, Ramirez-Aliaga M, Florez Vela AI, Galán-Ortega M, Moreno-Cortes I, Gonzalez-Almendros I, Ramirez-Fernandez A, Ariza-Villanueva D, Escalona-Belmonte JJ, Quesada-Muñoz G, Sepúlveda-Haro E, Romero-Molina S, Bellido-Estevez I, Gomez-Luque A, Rubio-Navarro M, Alcaide-Torres J, Santiago-Fernandez C, Garrido-Sanchez L, Cruz-Mañas J
Front Pharmacol 2020 Aug 26;11:1331


Anesthesia in Combination with Propofol Increases Disease-Free Survival in Bladder Cancer Patients Who Undergo Radical Tumor Cystectomy as Compared to Inhalational Anesthetics and Opiate-Based Analgesia

Guerrero Orriach JL, Raigon Ponferrada A, Malo Manso A, Herrera Imbroda B, Escalona Belmonte JJ, Ramirez Aliaga M, Ramirez Fernandez A, Diaz Crespo J, Soriano Perez AM, Fontaneda Heredia A, Dominguez Recio ME, Rubio Navarro M, Cruz Mañas J
Oncology 2020;98(3):161-167


Impacto de la anestesia libre de opioides en cirugía bariátrica [Impact of opioid free anaesthesia in bariatric surgery]

Malo-Manso A, Díaz-Crespo J, Escalona-Belmonte JJ, Romero-Molina S, Cruz-Mañas J, Guerrero-Orriach JL
An Sist Sanit Navar 2020 Apr 20;43(1):51-56


Bicuspid Aortic Valve in 2 Model Species and Review of the Literature

Fernández B, Soto-Navarrete MT, López-García A, López-Unzu MÁ, Durán AC, Fernández MC
Vet Pathol 2020 Mar;57(2):321-331


Development of the ventricular myocardial trabeculae in Scyliorhinus canicula (Chondrichthyes): evolutionary implications

López-Unzu MA, Durán AC, Rodríguez C, Soto-Navarrete MT, Sans-Coma V, Fernández B
Sci Rep 2020 Sep 2;10(1):14434


Embryonic development of bicuspid aortic valves

Soto-Navarrete MT, López-Unzu MÁ, Durán AC, Fernández B
Prog Cardiovasc Dis 2020 Jul-Aug;63(4):407-418


Myosin heavy chain isoforms in the myocardium of the atrioventricular junction of Scyliorhinus canicula (Chondrichthyes, Carcharhiniformes)

López-Unzu MA, Soto-Navarrete MT, Sans-Coma V, Fernández B, Durán AC
J Fish Biol 2020 Sep;97(3):734-739

  1. López-Unzu, MA, Durán, AC, Soto-Navarrete, MT, Sans-Coma, V, Fernández, B. Differential expression of myosin heavy chain isoforms in cardiac segments of gnathostome vertebrates and its evolutionary implications. Front Zool. 2019;16 :18. doi: 10.1186/s12983-019-0318-9. PubMed PMID:31198434 PubMed Central PMC6558913.
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  1. Sánchez-Piña, J, Lorenzale, M, Fernández, MC, Durán, AC, Sans-Coma, V, Fernández, B et al.. Pigmentation of the aortic and pulmonary valves in C57BL/6J x Balb/cByJ hybrid mice of different coat colours. Anat Histol Embryol. 2019;48 (5):429-436. doi: 10.1111/ahe.12463. PubMed PMID:31259435 .
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  1. Lorenzale, M, López-Unzu, MA, Rodríguez, C, Fernández, B, Durán, AC, Sans-Coma, V et al.. The anatomical components of the cardiac outflow tract of chondrichthyans and actinopterygians. Biol Rev Camb Philos Soc. 2018;93 (3):1604-1619. doi: 10.1111/brv.12411. PubMed PMID:29575373 .
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  1. Soto-Navarrete, MT, Arqué, JM, Durán, AC, Fernández, MC, López-Unzu, MA, Lorenzale, M et al.. The arrangement of the coronary artery trunks is subject to inheritance factors: A study in Syrian hamsters. Anat Histol Embryol. 2018;47 (2):140-144. doi: 10.1111/ahe.12333. PubMed PMID:29277933 .
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  1. Fernández, MC, Soto-Navarrete, MT, Durán, AC, Sans-Coma, V, Fernández, B. The Bicuspid Condition of the Aortic Valve Does Not Alter the Incidence of Accessory Coronary Artery Ostia in Syrian Hamsters (Mesocricetus auratus). J Comp Pathol. 2019;166 :9-16. doi: 10.1016/j.jcpa.2018.10.177. PubMed PMID:30691611 .
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  1. Lorenzale, M, Fernández, B, Durán, AC, López-Unzu, MA, Sans-Coma, V. The valves of the cardiac outflow tract of the starry ray, Raja asterias (Chondrichthyes; Rajiformes): Anatomical, histological and evolutionary aspects. Anat Histol Embryol. 2019;48 (1):40-45. doi: 10.1111/ahe.12409. PubMed PMID:30378144 .
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The arrangement of the coronary artery trunks is subject to inheritance factors: A study in Syrian hamsters

Soto-Navarrete, MT; Arque, JM; Duran, AC; Fernandez, MC; Lopez-Unzu, MA; Lorenzale, M; Sans-Coma, V; Fernandez, B
Anatomia Histologia Embryologia 2018


The anatomical components of the cardiac outflow tract of chondrichthyans and actinopterygians

Lorenzale, M; Lopez-Unzu, MA; Rodriguez, C; Fernandez, B; Duran, AC; Sans-Coma, V
Biological Reviews 2018

Cardiac, mandibular and thymic phenotypical association indicates that cranial neural crest underlies bicuspid aortic valve formation in hamsters

Martinez-Vargas, J; Ventura, J; Machuca, A; Munoz-Munoz, F; Fernandez, MC; Soto-Navarrete, MT; Duran, AC; Fernandez, BPlos One. 2017

Dicephalous v. diprosopus sharks: record of a two-headed embryo of Galeus atlanticus and review of the literature

Sans-Coma, V; Rodriguez, C; Lopez-Unzu, MA; Lorenzale, M; Fernandez, B; Vida, L; Duran, ACJournal Of Fish Biology. 2017

Fibrillin 2 is upregulated in the ascending aorta of patients with bicuspid aortic valve

Rueda-Martinez, C; Lamas, O; Mataro, MJ; Robledo-Carmona, J; Sanchez-Espin, G; Moreno-Santos, I; Carrasco-Chinchilla, F; Gallego, P; Such-Martinez, M; de Teresa, E; Jimenez-Navarro, M(autor para petición de copias) ; Fernandez, BEuropean Journal Of Cardio-Thoracic Surgery. 2017

The bulbus arteriosus of the holocephalan heart: gross anatomy, histomorphology, pigmentation, and evolutionary significance

Rodriguez, C; Lorenzale, M; Lopez-Unzu, MA; Fernandez, B; Salmeron, F; Sans-Coma, V; Duran, ACZoology. 2017

Increased blood levels of transforming growth factor beta in patients with aortic dilatation

Rueda-Martinez, Carmen; Lamas, Oscar; Carrasco-Chinchilla, Fernando; Robledo-Carmona, Juan; Porras, Carlos; Sanchez-Espin, Gemma; Navarro, Manuel Jimenez(autor para petición de copias); Fernandez, BorjaInteractive Cardiovascular And Thoracic Surgery. 2017


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