Neurociencias, Cronicidad, Envejecimiento y Salud en poblaciones vulnerables

Lineas de Investigación

Esta línea estudia desde aspectos biomédicos básicos de la neurotransmisión y regeneración en el Sistema Nervioso Central hasta aspectos aplicados a clínica y terapéutica. Está formado por diferentes equipos de trabajo que conforman un grupo multidisciplinar que permite el abordaje de enfermedades neuropsiquiatras y neurodegenerativas desde diferentes aproximaciones pero que convergen en el estudio de mecanismos básicos que permitirán el desarrollo de nuevas herramientas diagnósticas y terapéuticas en el tratamiento de estas enfermedades. Este grupo está avalado por años de investigación y docencia

01. Estudiar el papel de los neuropéptidos en el Sistema Nervioso Central (SNC), en áreas clave en la mediación de las funciones de comportamiento asociados con la ansiedad, depresión y el miedo

02. Analizar la interacción funcional de los sistemas opioide y dopaminérgico durante la dependencia a opiáceos en áreas relacionadas con el aprendizaje y consolidación de hábitos de conducta adictiva.

03. Profundizar en las bases moleculares y celulares implicados (como el estrés oxidativo) en la génesis de procesos neurodegenerativos como envejecimiento y Parkinson y estudiar los efectos neuroprotectores de IGF-II.

04. Diagnóstico precoz, monitorización e intervención en enfermedades neurodegenerativas y neuropsiquiátricas y mediante técnicas de evaluación autonómica y cognitiva. Aspectos básicos y aplicados.



Proyectos de Investigación

PI-0083-2019. ESTUDIO TRASLACIONAL DE LA PARTICIPACIÓN DEL FRAGMENTO N-TERMINAL 1-15 DE LA GALANINA EN LA DEPENDENCIA ALCOHOLICA: NUEVAS ESTRATEGIAS TERAPÉUTICAS Y EVALUACIÓN DE BIOMARCADORES EN ADICCIÓN.

Consejería de Salud y Familias
. 2019

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes) 2018

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018 2014


Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro


[18F]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration

Rodríguez-Chinchilla T, Quiroga-Varela A, Molinet-Dronda F, Belloso-Iguerategui A, Merino-Galan L, Jimenez-Urbieta H, Gago B, Rodriguez-Oroz MC
Eur J Nucl Med Mol Imaging 2020 Oct;47(11):2602-2612


Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing

Di Palma M, Sartini S, Lattanzi D, Cuppini R, Pita-Rodriguez M, Diaz-Carmenate Y, Narvaez M, Fuxe K, Borroto-Escuela DO, Ambrogini P
Mech Ageing Dev 2020 Sep;190:111289


Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes

Narváez M, Andrade-Talavera Y, Valladolid-Acebes I, Fredriksson M, Siegele P, Hernandez-Sosa A, Fisahn A, Fuxe K, Borroto-Escuela DO
Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations Neuropharmacology


LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, Pérez-Martín M, Gavito AL, García-Fernández MI, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Sandi C, Pedraza C
Neuropharmacology 2020 Mar 1;164:107896


Relationship Between Mitochondrial Structure and Bioenergetics in Pseudoxanthoma elasticum Dermal Fibroblasts

Lofaro FD, Boraldi F, Garcia-Fernandez M, Estrella L, Valdivielso P, Quaglino D
Front Cell Dev Biol 2020 Dec 17;8:610266


Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum

Gutierrez-Cardo A, Lillo E, Murcia-Casas B, Carrillo-Linares JL, García-Argüello F, Sánchez-Sánchez P, Rodriguez-Morata A, Aranda IB, Sánchez-Chaparro MÁ, García-Fernández M, Valdivielso P
J Clin Med 2020 May 8;9(5):1393


Effects of music therapy as an adjunct to chest physiotherapy in children with cystic fibrosis: A randomized controlled trial

Montero-Ruiz A, Fuentes LA, Pérez Ruiz E, García-Agua Soler N, Rius-Diaz F, Caro Aguilera P, Pérez Frías J, Martín-Montañez E
PLoS One 2020 Oct 30;15(10):e0241334


Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Rodriguez-Losada N, Wendelbob R, Ocaña MC, Casares AD, Guzman de Villoría R, Aguirre Gomez JA, Arraez MA, Gonzalez-Alegre P, Medina MA, Arenas E, Narvaez JA
Front Neurosci 2020 Dec 21;14:570409


Motor impulsivity and delay intolerance are elicited in a dose-dependent manner with a dopaminergic agonist in parkinsonian rats

Jiménez-Urbieta H, Gago B, Quiroga-Varela A, Rodríguez-Chinchilla T, Merino-Galán L, Delgado-Alvarado M, Navalpotro-Gómez I, Belloso-Iguerategui A, Marin C, Rodríguez-Oroz MC
Psychopharmacology (Berl) 2020 Aug;237(8):2419-2431


Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

Borroto-Escuela DO, Ferraro L, Narvaez M, Tanganelli S, Beggiato S, Liu F, Rivera A, Fuxe K
Cells 2020 Apr 27;9(5):1077


Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey

López-González MV, González-García M, Peinado-Aragonés CA, Barbancho MÁ, Díaz-Casares A, Dawid-Milner MS
J Physiol Biochem 2020 Nov;76(4):561-572


Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Browning PGF, Simón AM, López-Téllez JF, Jiménez-Recuerda I, Martín-Montañez E, Pérez-Mediavilla A, Frechilla D, Baxter MG, Khan ZU
Neuroscience 2020 Nov 10;448:287-298


The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease

Romero-Zerbo SY, García-Fernández M, Espinosa-Jiménez V, Pozo-Morales M, Escamilla-Sánchez A, Sánchez-Salido L, Lara E, Cobo-Vuilleumier N, Rafacho A, Olveira G, Rojo-Martínez G, Gauthier BR, González-Mariscal I, Bermúdez-Silva FJ
Front Endocrinol (Lausanne) 2020 Mar 6;11:103


The role of the aqueous extract Polypodium leucotomos in photoprotection

Parrado C, Nicolas J, Juarranz A, Gonzalez S
Photochem Photobiol Sci 2020 May 20


Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, Santin LJ
Brain Sci 2020 Aug 20;10(9):576

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  1. Merchán, A, Sánchez-Kuhn, A, Prados-Pardo, A, Gago, B, Sánchez-Santed, F, Moreno, M et al.. Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93 :149-160. doi: 10.1016/j.pnpbp.2019.03.016. PubMed PMID:30940483 .
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  1. Millón, C, Flores-Burgess, A, Castilla-Ortega, E, Gago, B, García-Fernandez, M, Serrano, A et al.. Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats. Addict Biol. 2019;24 (1):76-87. doi: 10.1111/adb.12582. PubMed PMID:29210146 .
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  1. López-Noriega, L, Capilla-González, V, Cobo-Vuilleumier, N, Martin-Vazquez, E, Lorenzo, PI, Martinez-Force, E et al.. Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. Aging (Albany NY). 2019;11 (18):7746-7779. doi: 10.18632/aging.102285. PubMed PMID:31518338 PubMed Central PMC6781991.
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  1. Torres-Prioris, MJ, López-Barroso, D, Paredes-Pacheco, J, Roé-Vellvé, N, Dawid-Milner, MS, Berthier, ML et al.. Language as a Threat: Multimodal Evaluation and Interventions for Overwhelming Linguistic Anxiety in Severe Aphasia. Front Psychol. 2019;10 :678. doi: 10.3389/fpsyg.2019.00678. PubMed PMID:31133908 PubMed Central PMC6517493.
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  1. García-Alberca, JM, Florido, M, Cáceres, M, Sánchez-Toro, A, Lara, JP, García-Casares, N et al.. Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer's disease. Psychogeriatrics. 2019;19 (1):46-54. doi: 10.1111/psyg.12363. PubMed PMID:30084177 .
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  1. Lara, JP, Compañ, A, Vargas-Núñez, JA, Cardellach, F, Fernández-González, S, López-Muñiz, A et al.. Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition. Rev Clin Esp (Barc). 2019;219 (2):84-89. doi: 10.1016/j.rce.2018.04.015. PubMed PMID:29887248 .
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  1. Masmudi-Martín, M, Navarro-Lobato, I, López-Aranda, MF, Delgado, G, Martín-Montañez, E, Quiros-Ortega, ME et al.. RGS14414 treatment induces memory enhancement and rescues episodic memory deficits. FASEB J. 2019;33 (11):11804-11820. doi: 10.1096/fj.201900429RR. PubMed PMID:31365833 .
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  1. Millón, C, Flores-Burgess, A, Gago, B, Alén, F, Orio, L, García-Durán, L et al.. Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system. J Psychopharmacol. 2019;33 (6):737-747. doi: 10.1177/0269881119844188. PubMed PMID:31081442 .
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  1. Pérez-Belmonte, LM, Florido-Santiago, M, Osuna-Sánchez, J, Barbancho, MA, Millán-Gómez, M, Jímenez-Navarro, MF et al.. Screening Versus Brief Domain-specific Tests to Assess Long-term Postoperative Cognitive Dysfunction After Concomitant Aortic Valve Replacement and Coronary Artery Bypass Grafting. J Cardiovasc Nurs. ;34 (6):511-516. doi: 10.1097/JCN.0000000000000596. PubMed PMID:31365446 .
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  1. Martín-Montañez, E, Pavia, J, Valverde, N, Boraldi, F, Lara, E, Oliver, B et al.. The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells. Free Radic Biol Med. 2019;137 :116-130. doi: 10.1016/j.freeradbiomed.2019.04.022. PubMed PMID:31035004 .
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  1. Carnero-Martín de Soto, P, Tamimi-Mariño, I, Bautista-Enrique, D, Bravo-Zurita, MJ, Cáceres, AG, Tamimi, F et al.. Use of beta-blockers and risk of aseptic loosening in total hip and knee arthroplasty: a nested case - control study. J Musculoskelet Neuronal Interact. 2019;19 (1):104-111. . PubMed PMID:30839308 PubMed Central PMC6454258.
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  1. de la Cruz Cosme, C, Dawid Milner, MS, Ojeda Burgos, G, Gallardo Tur, A, Márquez Martínez, M, Segura, T et al.. Validation of a basic neurosonology laboratory for detecting cervical carotid artery stenosis. Neurologia (Engl Ed). ;34 (6):367-375. doi: 10.1016/j.nrl.2017.01.015. PubMed PMID:28347575 .
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  1. Narváez, M, Borroto-Escuela, DO, Santín, L, Millón, C, Gago, B, Flores-Burgess, A et al.. A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats. Front Cell Neurosci. 2018;12 :119. doi: 10.3389/fncel.2018.00119. PubMed PMID:29765307 PubMed Central PMC5938606.
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  1. Borroto-Escuela, DO, Perez De La Mora, M, Manger, P, Narváez, M, Beggiato, S, Crespo-Ramírez, M et al.. Brain Dopamine Transmission in Health and Parkinson's Disease: Modulation of Synaptic Transmission and Plasticity Through Volume Transmission and Dopamine Heteroreceptors. Front Synaptic Neurosci. 2018;10 :20. doi: 10.3389/fnsyn.2018.00020. PubMed PMID:30042672 PubMed Central PMC6048293.
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  1. de la Cruz-Cosme, C, Dawid-Milner, MS, Ojeda-Burgos, G, Gallardo-Tur, A, Segura, T. Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018;27 (12):3425-3435. doi: 10.1016/j.jstrokecerebrovasdis.2018.08.001. PubMed PMID:30185397 .
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  1. Sánchez, ML, Mangas, A, Medina, LE, Aguilar, LA, Díaz-Cabiale, Z, Narváez, JA et al.. Immunohistochemical mapping of neurotensin in the alpaca diencephalon. Folia Histochem Cytobiol. 2018;56 (1):49-58. doi: 10.5603/FHC.a2018.0003. PubMed PMID:29516445 .
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  1. Parrado, C, Philips, N, Gilaberte, Y, Juarranz, A, González, S. Oral Photoprotection: Effective Agents and Potential Candidates. Front Med (Lausanne). 2018;5 :188. doi: 10.3389/fmed.2018.00188. PubMed PMID:29998107 PubMed Central PMC6028556.
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  1. Delgado-Alvarado, M, Dacosta-Aguayo, R, Navalpotro-Gómez, I, Gago, B, Gorostidi, A, Jiménez-Urbieta, H et al.. Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study. Mov Disord. 2018;33 (11):1809-1813. doi: 10.1002/mds.27518. PubMed PMID:30423201 .
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  1. Sánchez-Marín, L, Ladrón de Guevara-Miranda, D, Mañas-Padilla, MC, Alén, F, Moreno-Fernández, RD, Díaz-Navarro, C et al.. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018;133 :189-201. doi: 10.1016/j.neuropharm.2018.01.033. PubMed PMID:29378212 .
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  1. Carrillo-Linares, JL, García-Fernández, MI, Morillo, MJ, Sánchez, P, Rioja, J, Barón, FJ et al.. The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study. Front Med (Lausanne). 2018;5 :86. doi: 10.3389/fmed.2018.00086. PubMed PMID:29713628 PubMed Central PMC5911498.
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  1. Sampedro-Piquero, P, Moreno-Fernández, RD, Mañas-Padilla, MC, Gil-Rodríguez, S, Gavito, AL, Pavón, FJ et al.. Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiol Learn Mem. 2018;151 :35-42. doi: 10.1016/j.nlm.2018.03.023. PubMed PMID:29608953 .
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  1. Valderrama-Carvajal, A, Irizar, H, Gago, B, Jiménez-Urbieta, H, Fuxe, K, Rodríguez-Oroz, MC et al.. Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen. Sci Rep. 2018;8 (1):7337. doi: 10.1038/s41598-018-25604-4. PubMed PMID:29743514 PubMed Central PMC5943359.
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  1. Rodriguez-Losada, N, Romero, P, Estivill-Torrús, G, Guzmán de Villoria, R, Aguirre, JA. Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos. PLoS One. 2017;12 (3):e0173978. doi: 10.1371/journal.pone.0173978. PubMed PMID:28334019 PubMed Central PMC5363826.
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  1. Alameda, MT, Morel, E, Parrado, C, González, S, Juarranz, Á. Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells. Int J Mol Sci. 2017;18 (2):. doi: 10.3390/ijms18020463. PubMed PMID:28230777 PubMed Central PMC5343996.
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  1. Ladrón de Guevara-Miranda, D, Millón, C, Rosell-Valle, C, Pérez-Fernández, M, Missiroli, M, Serrano, A et al.. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10 (3):323-336. doi: 10.1242/dmm.026682. PubMed PMID:28138095 PubMed Central PMC5374316.
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  1. Borroto-Escuela, DO, Carlsson, J, Ambrogini, P, Narváez, M, Wydra, K, Tarakanov, AO et al.. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease. Front Cell Neurosci. 2017;11 :37. doi: 10.3389/fncel.2017.00037. PubMed PMID:28270751 PubMed Central PMC5318393.
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  1. Delgado-Alvarado, M, Gago, B, Navalpotro-Gomez, I, Jiménez-Urbieta, H, Rodriguez-Oroz, MC. Biomarkers for dementia and mild cognitive impairment in Parkinson's disease. Mov Disord. 2016;31 (6):861-81. doi: 10.1002/mds.26662. PubMed PMID:27193487 .
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  1. Millón, C, Flores-Burgess, A, Narváez, M, Borroto-Escuela, DO, Santín, L, Gago, B et al.. Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system. Brain Struct Funct. 2016;221 (9):4491-4504. doi: 10.1007/s00429-015-1180-y. PubMed PMID:26792005 .
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  1. Sánchez, ML, Díaz-Cabiale, Z, Narváez, JA, Manso, B, Salinas, P, Rivada, E et al.. Mapping of methionine-enkephalin-arg6-gly7-leu8 in the human diencephalon. Neuroscience. 2016;334 :245-258. doi: 10.1016/j.neuroscience.2016.08.010. PubMed PMID:27531857 .
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