Neurociencias, Cronicidad, Envejecimiento y Salud en poblaciones vulnerables

Lineas de Investigación

Esta línea estudia desde aspectos biomédicos básicos de la neurotransmisión y regeneración en el Sistema Nervioso Central hasta aspectos aplicados a clínica y terapéutica. Está formado por diferentes equipos de trabajo que conforman un grupo multidisciplinar que permite el abordaje de enfermedades neuropsiquiatras y neurodegenerativas desde diferentes aproximaciones pero que convergen en el estudio de mecanismos básicos que permitirán el desarrollo de nuevas herramientas diagnósticas y terapéuticas en el tratamiento de estas enfermedades. Este grupo está avalado por años de investigación y docencia

01. Estudiar el papel de los neuropéptidos en el Sistema Nervioso Central (SNC), en áreas clave en la mediación de las funciones de comportamiento asociados con la ansiedad, depresión y el miedo

02. Analizar la interacción funcional de los sistemas opioide y dopaminérgico durante la dependencia a opiáceos en áreas relacionadas con el aprendizaje y consolidación de hábitos de conducta adictiva.

03. Profundizar en las bases moleculares y celulares implicados (como el estrés oxidativo) en la génesis de procesos neurodegenerativos como envejecimiento y Parkinson y estudiar los efectos neuroprotectores de IGF-II.

04. Diagnóstico precoz, monitorización e intervención en enfermedades neurodegenerativas y neuropsiquiátricas y mediante técnicas de evaluación autonómica y cognitiva. Aspectos básicos y aplicados.



Proyectos de Investigación

GALANINA(1-15) Y ANHEDONIA: NUEVA INTERVENCIÓN TERAPÉUTICA ANTIDEPRESIVA

Fondos Feder - Junta de Andalucía
. 2019

COMBINACIÓN GALANINA(1-15)-FLUOXETINA: NUEVA ESTRATEGIA DE POTENCIACIÓN EN EL TRATAMIENTO DE LA DEPRESIÓN

Junta de Andalucía
. 2021

DEPRESION RESISTENTE AL TRATAMIENTO: UNA NUEVA ESTRATEGIA FARMACOLOGICA UTILIZANDO GALANINA(1-15)

Ministerio de Ciencia e Innovación
. 2021

NUEVA TERAPIA DE POTENCIACION: GALANINA(1-15) Y LOS INHIBIDORES DE LA RECAPTACION DE SEROTONINA PARA EL TRATAMIENTO DE LA DEPRESION Y OTROS DESORDENES PSICOTICOS 

Ministerio de Ciencia e Innovación
. 2021

PI-0083-2019. ESTUDIO TRASLACIONAL DE LA PARTICIPACIÓN DEL FRAGMENTO N-TERMINAL 1-15 DE LA GALANINA EN LA DEPENDENCIA ALCOHOLICA: NUEVAS ESTRATEGIAS TERAPÉUTICAS Y EVALUACIÓN DE BIOMARCADORES EN ADICCIÓN.

Consejería de Salud y Familias
. 2019

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020
Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes) 2018

Papel del heteromero GALR2/NPYY1R en la neurogenesis hipocampal: Una posible estrategia terapeutica para la enfermedad de Alzheimer

Programa Operativo FEDER Andalucía 2014-2020 (convocatoria 2018) de generación de conocimiento "frontera" (consolidados y emergentes)
2018 2014


Publicaciones científicas

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Acute Lung Injury Biomarkers in the Prediction of COVID-19 Severity: Total Thiol, Ferritin and Lactate Dehydrogenase

Martinez Mesa A, Cabrera César E, Martín-Montañez E, Sanchez Alvarez E, Lopez PM, et al. Antioxidants (Basel, Switzerland) 2021 Jul 29;10(8):

Alzheimer’s Disease, Mild Cognitive Impairment and Mediterranean Diet. A Systematic Review and Dose-Response Meta-Analysis

García-Casares N, Gallego Fuentes P, Barbancho MÁ, López-Gigosos R, García-Rodríguez A, et al. Journal of clinical medicine 2021 Oct 10;10(20):

Changes in the Objective Structured Clinical Examination (OSCE) of University Schools of Medicine during COVID-19. Experience with a computer-based case simulation OSCE (CCS-OSCE)

García-Seoane JJ, Ramos-Rincón JM, Lara-Muñoz JP, el grupo de trabajo de la ECOE-CCS de la CNDFME., Miembros del grupo de trabajo de la ECOE-CCS de la CNDFME (por orden alfabético de Universidad). Revista clinica espanola 2021 Oct;221(8):456-463

Correlation between retinal nerve fibre layer thickness and white matter lesions in Alzheimer’s disease

Carazo-Barrios L, Archidona-Arranz A, Claros-Ruiz A, García-Basterra I, Garzón-Maldonado FJ, et al. International journal of geriatric psychiatry 2021 Jun;36(6):935-942

Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum

Lillo E, Gutierrez-Cardo A, Murcia-Casas B, Carrillo-Linares JL, Garcia-Argüello F, et al. Journal of clinical medicine 2021 Jun 11;10(12):

Early Occupational Therapy Intervention in the Hospital Discharge after Stroke

García-Pérez P, Rodríguez-Martínez MDC, Lara JP, Cruz-Cosme C International journal of environmental research and public health 2021 Dec 7;18(24):

Evidence of Animal-Assisted Therapy in Neurological Diseases in Adults: A Systematic Review

Rodríguez-Martínez MDC, De la Plana Maestre A, Armenta-Peinado JA, Barbancho MÁ, García-Casares N International journal of environmental research and public health 2021 Dec 7;18(24):

Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus

Borroto-Escuela DO, Pita-Rodriguez M, Fores-Pons R, Barbancho MA, Fuxe K, et al. Journal of cellular physiology 2021 May;236(5):3565-3578

Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression

García-Durán L, Flores-Burgess A, Cantero-García N, Puigcerver A, Narváez JÁ, et al. International journal of molecular sciences 2021 Oct 7;22(19):

Impact of Glucocorticoid on a Cellular Model of Parkinson’s Disease: Oxidative Stress and Mitochondrial Function

Claros S, Gil A, Martinelli M, Valverde N, Lara E, et al. Brain sciences 2021 Aug 22;11(8):

Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson’s disease

Martín-Montañez E, Valverde N, Ladrón de Guevara-Miranda D, Lara E, Romero-Zerbo YS, et al. Redox biology 2021 Oct;46():102095

Neuronal Metabolism and Neuroprotection: Neuroprotective Effect of Fingolimod on Menadione-Induced Mitochondrial Damage

Gil A, Martín-Montañez E, Valverde N, Lara E, Boraldi F, et al. Cells 2020 Dec 29;10(1):

Plasma Concentrations of Lysophosphatidic Acid and Autotaxin in Abstinent Patients with Alcohol Use Disorder and Comorbid Liver Disease

Flores-López M, García-Marchena N, Pavon FJ, Lara E, Porras-Perales O, et al. Biomedicines 2021 Sep 13;9(9):

Psychometric Properties of the Affective Dimension of the Generic Macro-Competence Assessment Scale: Analysis Using Rasch Model

Morales-Rodriguez, FM; Marti-Vilar, M; Pelaez, MAN; Lozano, JMG; Martinez-Ramon, JP; Caracuel, A SUSTAINABILITY 2021

Relationship between parental stress and psychological distress and emotional and behavioural problems in pre-school children with autistic spectrum disorder

Romero-González M, Marín E, Guzmán-Parra J, Navas P, Aguilar JM, et al. Anales de pediatria 2021 Feb;94(2):99-106

Role of patients associations in connective tissue calcifiying diseases: a position statement from EuroSoftCalc.Net group

Valdivielso P, Jacinto M, Devernois G, Laplana J, García-Fernández M, et al. Orphanet journal of rare diseases 2021 Feb 8;16(1):71

Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases

Borroto-Escuela DO, Ambrogini P, Narvaez M, Di Liberto V, Beggiato S, et al. Cells 2021 Jul 27;10(8):

Serum Biomarkers in Differential Diagnosis of Idiopathic Pulmonary Fibrosis and Connective Tissue Disease-Associated Interstitial Lung Disease

Cabrera Cesar E, Lopez-Lopez L, Lara E, Hidalgo-San Juan MV, Parrado Romero C, et al. Journal of clinical medicine 2021 Jul 18;10(14):

The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons

Borroto-Escuela DO, Ferraro L, Beggiato S, Narváez M, Fores-Pons R, et al. Pharmacological reports : PR 2021 Aug;73(4):1096-1108

Usefulness of magnetic resonance spectroscopy in mesial temporal sclerosis: a systematic review

Fernández-Vega N, Ramos-Rodriguez JR, Alfaro F, Barbancho MÁ, García-Casares N Neuroradiology 2021 Sep;63(9):1395-1405

[F-18]-DPA-714 PET as a specific in vivo marker of early microglial activation in a rat model of progressive dopaminergic degeneration

Rodríguez-Chinchilla T, Quiroga-Varela A, Molinet-Dronda F, Belloso-Iguerategui A, Merino-Galan L, et al. European journal of nuclear medicine and molecular imaging 2020 Oct;47(11):2602-2612

Effect of physical exercise on Alzheimer’s disease. A sistematic review

Agüera Sánchez MÁ, Barbancho Ma MÁ, García-Casares N Atencion primaria 2020 May;52(5):307-318

Effects of music therapy as an adjunct to chest physiotherapy in children with cystic fibrosis: A randomized controlled trial

Montero-Ruiz A, Fuentes LA, Pérez Ruiz E, García-Agua Soler N, Rius-Diaz F, et al. PloS one 2020;15(10):e0241334

Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing

Di Palma M, Sartini S, Lattanzi D, Cuppini R, Pita-Rodriguez M, et al. Mechanisms of ageing and development 2020 Sep;190():111289

Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations

Narváez M, Andrade-Talavera Y, Valladolid-Acebes I, Fredriksson M, Siegele P, et al. Neuropharmacology 2020 Jun 15;170():108070

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Rodriguez-Losada N, Wendelbob R, Ocaña MC, Casares AD, Guzman de Villoría R, et al. Frontiers in neuroscience 2020;14():570409

LPA(1) receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, et al. Neuropharmacology 2020 Mar 1;164():107896

Motor impulsivity and delay intolerance are elicited in a dose-dependent manner with a dopaminergic agonist in parkinsonian rats

Jiménez-Urbieta H, Gago B, Quiroga-Varela A, Rodríguez-Chinchilla T, Merino-Galán L, et al. Psychopharmacology 2020 Aug;237(8):2419-2431

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

Borroto-Escuela DO, Ferraro L, Narvaez M, Tanganelli S, Beggiato S, et al. Cells 2020 Apr 27;9(5):

Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey

López-González MV, González-García M, Peinado-Aragonés CA, Barbancho MÁ, Díaz-Casares A, et al. Journal of physiology and biochemistry 2020 Nov;76(4):561-572

Relationship Between Mitochondrial Structure and Bioenergetics in Pseudoxanthoma elasticum Dermal Fibroblasts

Lofaro FD, Boraldi F, Garcia-Fernandez M, Estrella L, Valdivielso P, et al. Frontiers in cell and developmental biology 2020;8():610266

Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Browning PGF, Simón AM, et al. Neuroscience 2020 Nov 10;448():287-298

Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum

Gutierrez-Cardo A, Lillo E, Murcia-Casas B, Carrillo-Linares JL, García-Argüello F, et al. Journal of clinical medicine 2020 May 8;9(5):

The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease

Romero-Zerbo SY, García-Fernández M, Espinosa-Jiménez V, Pozo-Morales M, Escamilla-Sánchez A, et al. Frontiers in endocrinology 2020;11():103

The role of the aqueous extractPolypodium leucotomosin photoprotection

Parrado C, Nicolas J, Juarranz A, Gonzalez S Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2020 May 20;():

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, et al. Brain sciences 2020 Aug 20;10(9):

Acute Cocaine Enhances Dopamine D2R Recognition and Signaling and Counteracts D2R Internalization in Sigma1R-D2R Heteroreceptor Complexes

Borroto-Escuela DO, Narváez M, Romero-Fernández W, Pinton L, Wydra K, et al. Molecular neurobiology 2019 Oct;56(10):7045-7055

Alcohol-induced cognitive deficits are associated with decreased circulating levels of the neurotrophin BDNF in humans and rats

Silva-Peña D, García-Marchena N, Alén F, Araos P, Rivera P, et al. Addiction biology 2019 Sep;24(5):1019-1033

Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia

Merchán A, Sánchez-Kuhn A, Prados-Pardo A, Gago B, Sánchez-Santed F, et al. Progress in neuro-psychopharmacology & biological psychiatry 2019 Jul 13;93():149-160

Central administration of galanin N-terminal fragment 1-15 decreases the voluntary alcohol intake in rats

Millón C, Flores-Burgess A, Castilla-Ortega E, Gago B, García-Fernandez M, et al. Addiction biology 2019 Jan;24(1):76-87

Environmental Stressors on Skin Aging. Mechanistic Insights

Parrado C, Mercado-Saenz S, Perez-Davo A, Gilaberte Y, Gonzalez S, et al. Frontiers in pharmacology 2019;10():759

Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex

Merchán A, Mora S, Gago B, Rodriguez-Ortega E, Fernández-Teruel A, et al. Genes, brain, and behavior 2019 Mar;18(3):e12489

Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Zamarrón A, Morel E, Lucena SR, Mataix M, Pérez-Davó A, et al. International journal of molecular sciences 2019 Mar 18;20(6):

Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats

Flores-Burgess A, Millón C, Gago B, García-Durán L, Cantero-García N, et al. Neuropharmacology 2019 Sep 1;155():104-112

Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study

Pérez-Belmonte LM, Osuna-Sánchez J, Millán-Gómez M, López-Carmona MD, Gómez-Doblas JJ, et al. Annals of medicine 2019 May – Jun;51(3-4):252-261

Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging

López-Noriega L, Capilla-González V, Cobo-Vuilleumier N, Martin-Vazquez E, Lorenzo PI, et al. Aging 2019 Sep 13;11(18):7746-7779

Language as a Threat: Multimodal Evaluation and Interventions for Overwhelming Linguistic Anxiety in Severe Aphasia

Torres-Prioris MJ, López-Barroso D, Paredes-Pacheco J, Roé-Vellvé N, Dawid-Milner MS, et al. Frontiers in psychology 2019;10():678

Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer’s disease

García-Alberca JM, Florido M, Cáceres M, Sánchez-Toro A, Lara JP, et al. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society 2019 Jan;19(1):46-54

Pharmacological activation of dopamine D-4 receptor modulates morphine-induced changes in the expression of GAD(65/67) and GABA(B) receptors in the basal ganglia

Negrete-Díaz JV, Shumilov K, Real MÁ, Medina-Luque J, Valderrama-Carvajal A, et al. Neuropharmacology 2019 Jul 1;152():22-29

Pramipexole-induced impulsivity in mildparkinsonian rats: a model of impulse control disorders in Parkinson’s disease

Jiménez-Urbieta H, Gago B, Quiroga-Varela A, Rodríguez-Chinchilla T, Merino-Galán L, et al. Neurobiology of aging 2019 Mar;75():126-135

Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition

Lara JP, Compañ A, Vargas-Núñez JA, Cardellach F, Fernández-González S, et al. Revista clinica espanola 2019 Mar;219(2):84-89

RGS14(414) treatment induces memory enhancement and rescues episodic memory deficits

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Delgado G, Martín-Montañez E, et al. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Nov;33(11):11804-11820

Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system

Millón C, Flores-Burgess A, Gago B, Alén F, Orio L, et al. Journal of psychopharmacology (Oxford, England) 2019 Jun;33(6):737-747

Screening Versus Brief Domain-specific Tests to Assess Long-term Postoperative Cognitive Dysfunction After Concomitant Aortic Valve Replacement and Coronary Artery Bypass Grafting.

Pérez-Belmonte LM, Florido-Santiago M, Osuna-Sánchez J, Barbancho MA, Millán-Gómez M, et al. The Journal of cardiovascular nursing 2019 Nov/Dec;34(6):511-516

The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells

Martín-Montañez E, Pavia J, Valverde N, Boraldi F, Lara E, et al. Free radical biology & medicine 2019 Jun;137():116-130

Use of beta-blockers and risk of aseptic loosening in total hip and knee arthroplasty: a nested case – control study

Carnero-Martín de Soto P, Tamimi-Mariño I, Bautista-Enrique D, Bravo-Zurita MJ, Cáceres AG, et al. Journal of musculoskeletal & neuronal interactions 2019 Mar 1;19(1):104-111

Validation of a basic neurosonology laboratory for detecting cervical carotid artery stenosis

de la Cruz Cosme C, Dawid Milner MS, Ojeda Burgos G, Gallardo Tur A, Márquez Martínez M, et al. Neurologia (Barcelona, Spain) 2019 Jul – Aug;34(6):367-375

A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats

Narváez M, Borroto-Escuela DO, Santín L, Millón C, Gago B, et al. Frontiers in cellular neuroscience 2018;12():119

Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke

de la Cruz-Cosme C, Dawid-Milner MS, Ojeda-Burgos G, Gallardo-Tur A, Segura T Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2018 Dec;27(12):3425-3435

Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats

Feltmann K, Borroto-Escuela DO, Rüegg J, Pinton L, de Oliveira Sergio T, et al. Alcoholism, clinical and experimental research 2018 Feb;42(2):338-351

Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area

López-González MV, Díaz-Casares A, González-García M, Peinado-Aragonés CA, Barbancho MA, et al. Journal of physiology and biochemistry 2018 May;74(2):325-334

Immunohistochemical mapping of neurotensin in the alpaca diencephalon

Sánchez ML, Mangas A, Medina LE, Aguilar LA, Díaz-Cabiale Z, et al. Folia histochemica et cytobiologica 2018;56(1):49-58

Oral Photoprotection: Effective Agents and Potential Candidates

Parrado C, Philips N, Gilaberte Y, Juarranz A, González S Frontiers in medicine 2018;5():188

Ratios of proteins in cerebrospinal fluid in Parkinson’s disease cognitive decline: prospective study

Delgado-Alvarado M, Dacosta-Aguayo R, Navalpotro-Gómez I, Gago B, Gorostidi A, et al. Movement disorders : official journal of the Movement Disorder Society 2018 Nov;33(11):1809-1813

Receptor-Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment

Borroto-Escuela DO, Narváez M, Ambrogini P, Ferraro L, Brito I, et al. Molecules (Basel, Switzerland) 2018 Jun 3;23(6):

Selective ablation of striatal striosomes produces the deregulation of dopamine nigrostriatal pathway

Shumilov K, Real MÁ, Valderrama-Carvajal A, Rivera A PloS one 2018;13(8):e0203135

Synthesis and dopaminergic activity of a series of new 1-aryl tetrahydroisoquinolines and 2-substituted 1-aryl-3-tetrahydrobenzazepines

Lucena-Serrano C, Lucena-Serrano A, Rivera A, López-Romero JM, Valpuesta M, et al. Bioorganic chemistry 2018 Oct;80():480-491

Systemic blockade of LPA(1/3) lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior

Sánchez-Marín L, Ladrón de Guevara-Miranda D, Mañas-Padilla MC, Alén F, Moreno-Fernández RD, et al. Neuropharmacology 2018 May 1;133():189-201

The Effects of Parenteral K1 Administration in Pseudoxanthoma Elasticum Patients Versus Controls. A Pilot Study

Carrillo-Linares JL, García-Fernández MI, Morillo MJ, Sánchez P, Rioja J, et al. Frontiers in medicine 2018;5():86

Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis

Sampedro-Piquero P, Moreno-Fernández RD, Mañas-Padilla MC, Gil-Rodríguez S, Gavito AL, et al. Neurobiology of learning and memory 2018 May;151():35-42

Transcriptomic integration of D4R and MOR signaling in the rat caudate putamen

Valderrama-Carvajal A, Irizar H, Gago B, Jiménez-Urbieta H, Fuxe K, et al. Scientific reports 2018 May 9;8(1):7337

Acute polyneuropathies in a hospital in the south of Spain: ten years’ experience

Alonso-Montejo MM, Pradillo MC, Moreno-Medinilla EE, Navas-Sanchez P, Martinez-Anton JL Revista de neurologia 2017 Jun 1;64(11):502-508

Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos

Rodriguez-Losada N, Romero P, Estivill-Torrús G, Guzmán de Villoria R, Aguirre JA PloS one 2017;12(3):e0173978

Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1 R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder

Borroto-Escuela DO, Narváez M, Wydra K, Pintsuk J, Pinton L, et al. Pharmacology, biochemistry, and behavior 2017 Apr;155():24-31

Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells

Alameda MT, Morel E, Parrado C, González S, Juarranz Á International journal of molecular sciences 2017 Feb 21;18(2):

Disturbances in the FGFR1-5-HT1A Heteroreceptor Complexes in the Raphe-Hippocampal 5-HT System Develop in a Genetic Rat Model of Depression

Borroto-Escuela DO, DuPont CM, Li X, Savelli D, Lattanzi D, et al. Frontiers in cellular neuroscience 2017;11():309

Dopamine D-4 receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction

Rivera A, Gago B, Suárez-Boomgaard D, Yoshitake T, Roales-Buján R, et al. Addiction biology 2017 Sep;22(5):1232-1245

Evaluation and treatment of sleep problems in children diagnosed with attention deficit hyperactivity disorder: an update of the evidence

Chamorro M, Lara JP, Insa I, Espadas M, Alda-Diez JA Revista de neurologia 2017 May 1;64(9):413-421

Galanin (1-15) enhancement of the behavioral effects of Fluoxetine in the forced swimming test gives a new therapeutic strategy against depression

Flores-Burgess A, Millón C, Gago B, Narváez M, Borroto-Escuela DO, et al. Neuropharmacology 2017 May 15;118():233-241

IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids

Martín-Montañez E, Millon C, Boraldi F, Garcia-Guirado F, Pedraza C, et al. Redox biology 2017 Oct;13():69-81

Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis

Ladrón de Guevara-Miranda D, Millón C, Rosell-Valle C, Pérez-Fernández M, Missiroli M, et al. Disease models & mechanisms 2017 Mar 1;10(3):323-336

maLPA1-null mice as an endophenotype of anxious depression

Moreno-Fernández RD, Pérez-Martín M, Castilla-Ortega E, Rosell Del Valle C, García-Fernández MI, et al. Translational psychiatry 2017 Apr 4;7(4):e1077

Mapping of enkephalins and adrenocorticotropic hormone in the squirrel monkey brainstem

Duque-Díaz E, Díaz-Cabiale Z, Narváez JA, Coveñas R Anatomical science international 2017 Mar;92(2):275-292

Non-linear classifiers applied to EEG analysis for epilepsy seizure detection

Martinez-Del-Rincon, J; Santofimia, MJ; del Toro, X; Barba, J; Romero, F; Navas, P; Lopez, JC EXPERT SYSTEMS WITH APPLICATIONS 2017

The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours

Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Gago B, et al. Neuropeptides 2017 Aug;64():39-45

Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease

Borroto-Escuela DO, Carlsson J, Ambrogini P, Narváez M, Wydra K, et al. Frontiers in cellular neuroscience 2017;11():37

Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy

García-Basterra I, Lahrach I, Morillo Sánchez MJ, Kamal-Salah R, Ríus-Díaz F, et al. The British journal of ophthalmology 2016 Jul;100(7):891-896

Autonomic dysfunction elicited by a medulla oblongata injury after fourth ventricle tumor surgery in a pediatric patient

Martín-Gallego A, Andrade-Andrade I, Dawid-Milner MS, Domínguez-Páez M, Romero-Moreno L, et al. Autonomic neuroscience : basic & clinical 2016 Jan;194():52-7

Biomarkers for Dementia and Mild Cognitive Impairment in Parkinson’s Disease

Delgado-Alvarado M, Gago B, Navalpotro-Gomez I, Jiménez-Urbieta H, Rodriguez-Oroz MC Movement disorders : official journal of the Movement Disorder Society 2016 Jun;31(6):861-81

Fernblock (Polypodium leucotomos Extract): Molecular Mechanisms and Pleiotropic Effects in Light-Related Skin Conditions, Photoaging and Skin Cancers, a Review

Parrado C, Mascaraque M, Gilaberte Y, Juarranz A, Gonzalez S International journal of molecular sciences 2016 Jun 29;17(7):

Galanin (1-15) enhances the antidepressant effects of the 5-HT1A receptor agonist 8-OH-DPAT: involvement of the raphe-hippocampal 5-HT neuron system

Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Santín L, et al. Brain structure & function 2016 Dec;221(9):4491-4504

Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects

Narváez M, Borroto-Escuela DO, Millón C, Gago B, Flores-Burgess A, et al. Brain structure & function 2016 Nov;221(8):4129-4139

MAPPING OF METHIONINE-ENKEPHALIN-Arg(6)-Gly(7)-Leu(8) IN THE HUMAN DIENCEPHALON

Sánchez ML, Díaz-Cabiale Z, Narváez JA, Manso B, Salinas P, et al. Neuroscience 2016 Oct 15;334():245-258

Psychiatric comorbidities in autism spectrum disorder: A comparative study between DSM-IV-TR and DSM-5 diagnosis

Romero, M; Aguilar, JM; Del-Rey-Mejias, A; Mayora, F; Rapado, M; Pecina, M; Barbancho, MA; Ruiz-Veguilla, M; Lara, JP INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY 2016

The importance of sleep deprivation as a mechanism for activating interictal epileptiform paroxysms

Navas P, Rodríguez-Santos L, Bauzano-Poley E, Lara JP, Barbancho MÁ Revista de neurologia 2016 Apr 1;62(7):289-95

A Role for Galanin N-Terminal Fragment (1-15) in Anxiety- and Depression-Related Behaviors in Rats

Millón C, Flores-Burgess A, Narváez M, Borroto-Escuela DO, Santín L, et al. The international journal of neuropsychopharmacology 2014 Oct 31;18(3):

ABDOMINAL BIOELECTRICAL IMPEDANCE ANALYSIS AND ANTHROPOMETRY FOR PREDICTING METABOLIC SYNDROME IN MIDDLE AGED MEN

Fernández-Vázquez R, Millán Romero Á, Barbancho MÁ, Alvero-Cruz JR Nutricion hospitalaria 2015 Sep 1;32(3):1122-30

Assessment of Long-Term Cognitive Impairment After Off-Pump Coronary-Artery Bypass Grafting and Related Risk Factors

Pérez-Belmonte LM, San Román-Terán CM, Jiménez-Navarro M, Barbancho MA, García-Alberca JM, et al. Journal of the American Medical Directors Association 2015 Mar;16(3):263.e9-11

Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study

Barbancho MA, Berthier ML, Navas-Sánchez P, Dávila G, Green-Heredia C, et al. Brain and language 2015 Jun-Jul;145-146():1-10

Consumption patterns of antiepileptic drugs among epileptic patients in the Western Malaga district

Garcia-Martin G, Chamorro-Muñoz MI, Martin-Reyes G, Dawid-Milner MS, Perez-Errazquin F, et al. Neurologia (Barcelona, Spain) 2015 Jan-Feb;30(1):67-9

Dunaliella tertiolecta (Chlorophyta) Avoids Cell Death Under Ultraviolet Radiation By Triggering Alternative Photoprotective Mechanisms

Segovia M, Mata T, Palma A, García-Gómez C, Lorenzo R, et al. Photochemistry and photobiology 2015 Nov;91(6):1389-402

Dyskinesias and impulse control disorders in Parkinson’s disease: From pathogenesis to potential therapeutic approaches

Jiménez-Urbieta H, Gago B, de la Riva P, Delgado-Alvarado M, Marin C, et al. Neuroscience and biobehavioral reviews 2015 Sep;56():294-314

Effects of food and drink ingestion on body composition variables of abdominal bioelectrical impedance

Fernández Vázquez R, Martínez Blanco J, García Vega Mdel M, Barbancho MÁ, Alvero-Cruz JR Nutricion hospitalaria 2015 Nov 1;32(5):2269-73

Enhancement of the FGFR1 signaling in the FGFR1-5-HT1A heteroreceptor complex in midbrain raphe 5-HT neuron systems. Relevance for neuroplasticity and depression

Borroto-Escuela DO, Pérez-Alea M, Narvaez M, Tarakanov AO, Mudó G, et al. Biochemical and biophysical research communications 2015 Jul 31;463(3):180-6

Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system

Borroto-Escuela DO, Narvaez M, Pérez-Alea M, Tarakanov AO, Jiménez-Beristain A, et al. Biochemical and biophysical research communications 2015 Jan 2;456(1):489-93

Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions

Narváez M, Millón C, Borroto-Escuela D, Flores-Burgess A, Santín L, et al. Brain structure & function 2015 Jul;220(4):2289-301

Loss of lysophosphatidic acid receptor LPA(1) alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex

García-Díaz B, Riquelme R, Varela-Nieto I, Jiménez AJ, de Diego I, et al. Brain structure & function 2015 Nov;220(6):3701-20

Mapping of Somatostatin-28 (1-12) in the Alpaca (Lama pacos) Brainstem

De Souza E, Sánchez ML, Aguilar LÁ, Díaz-Cabiale Z, Narváez JÁ, et al. Microscopy research and technique 2015 May;78(5):363-74

Parkinsonism, cognitive deficit and behavioural disturbance caused by a novel mutation in the polymerase gamma gene.

Delgado-Alvarado M, de la Riva P, Jiménez-Urbieta H, Gago B, Gabilondo A, et al. Journal of the neurological sciences 2015 Mar 15;350(1-2):93-7

The relationship between atrophy and hypometabolism: is it regionally dependent in dementias?

Rodriguez-Oroz MC, Gago B, Clavero P, Delgado-Alvarado M, Garcia-Garcia D, et al. Current neurology and neuroscience reports 2015 Jul;15(7):44


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