Neurociencias, Cronicidad, Envejecimiento y Salud en poblaciones vulnerables

Evidence for the existence of A2AR-TrkB heteroreceptor complexes in the dorsal hippocampus of the rat brain: Potential implications of A2AR and TrkB interplay upon ageing

Di Palma M, Sartini S, Lattanzi D, Cuppini R, Pita-Rodriguez M, Diaz-Carmenate Y, Narvaez M, Fuxe K, Borroto-Escuela DO, Ambrogini P
Mech Ageing Dev 2020 Sep;190:111289

Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes

Narváez M, Andrade-Talavera Y, Valladolid-Acebes I, Fredriksson M, Siegele P, Hernandez-Sosa A, Fisahn A, Fuxe K, Borroto-Escuela DO
Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations Neuropharmacology

LPA1 receptor and chronic stress: Effects on behaviour and the genes involved in the hippocampal excitatory/inhibitory balance

Moreno-Fernández RD, Rosell-Valle C, Bacq A, Zanoletti O, Cifuentes M, Pérez-Martín M, Gavito AL, García-Fernández MI, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Sandi C, Pedraza C
Neuropharmacology 2020 Mar 1;164:107896

Relationship Between Mitochondrial Structure and Bioenergetics in Pseudoxanthoma elasticum Dermal Fibroblasts

Lofaro FD, Boraldi F, Garcia-Fernandez M, Estrella L, Valdivielso P, Quaglino D
Front Cell Dev Biol 2020 Dec 17;8:610266

Skin and Arterial Wall Deposits of 18F-NaF and Severity of Disease in Patients with Pseudoxanthoma Elasticum

Gutierrez-Cardo A, Lillo E, Murcia-Casas B, Carrillo-Linares JL, García-Argüello F, Sánchez-Sánchez P, Rodriguez-Morata A, Aranda IB, Sánchez-Chaparro MÁ, García-Fernández M, Valdivielso P
J Clin Med 2020 May 8;9(5):1393

Effects of music therapy as an adjunct to chest physiotherapy in children with cystic fibrosis: A randomized controlled trial

Montero-Ruiz A, Fuentes LA, Pérez Ruiz E, García-Agua Soler N, Rius-Diaz F, Caro Aguilera P, Pérez Frías J, Martín-Montañez E
PLoS One 2020 Oct 30;15(10):e0241334

Graphene Oxide and Reduced Derivatives, as Powder or Film Scaffolds, Differentially Promote Dopaminergic Neuron Differentiation and Survival

Rodriguez-Losada N, Wendelbob R, Ocaña MC, Casares AD, Guzman de Villoría R, Aguirre Gomez JA, Arraez MA, Gonzalez-Alegre P, Medina MA, Arenas E, Narvaez JA
Front Neurosci 2020 Dec 21;14:570409

Motor impulsivity and delay intolerance are elicited in a dose-dependent manner with a dopaminergic agonist in parkinsonian rats

Jiménez-Urbieta H, Gago B, Quiroga-Varela A, Rodríguez-Chinchilla T, Merino-Galán L, Delgado-Alvarado M, Navalpotro-Gómez I, Belloso-Iguerategui A, Marin C, Rodríguez-Oroz MC
Psychopharmacology (Berl) 2020 Aug;237(8):2419-2431

Multiple Adenosine-Dopamine (A2A-D2 Like) Heteroreceptor Complexes in the Brain and Their Role in Schizophrenia

Borroto-Escuela DO, Ferraro L, Narvaez M, Tanganelli S, Beggiato S, Liu F, Rivera A, Fuxe K
Cells 2020 Apr 27;9(5):1077

Pontine A5 region modulation of the cardiorespiratory response evoked from the midbrain dorsolateral periaqueductal grey

López-González MV, González-García M, Peinado-Aragonés CA, Barbancho MÁ, Díaz-Casares A, Dawid-Milner MS
J Physiol Biochem 2020 Nov;76(4):561-572

Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases

Masmudi-Martín M, Navarro-Lobato I, López-Aranda MF, Browning PGF, Simón AM, López-Téllez JF, Jiménez-Recuerda I, Martín-Montañez E, Pérez-Mediavilla A, Frechilla D, Baxter MG, Khan ZU
Neuroscience 2020 Nov 10;448:287-298

The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease

Romero-Zerbo SY, García-Fernández M, Espinosa-Jiménez V, Pozo-Morales M, Escamilla-Sánchez A, Sánchez-Salido L, Lara E, Cobo-Vuilleumier N, Rafacho A, Olveira G, Rojo-Martínez G, Gauthier BR, González-Mariscal I, Bermúdez-Silva FJ
Front Endocrinol (Lausanne) 2020 Mar 6;11:103

The role of the aqueous extract Polypodium leucotomos in photoprotection

Parrado C, Nicolas J, Juarranz A, Gonzalez S
Photochem Photobiol Sci 2020 May 20

Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice

Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, Santin LJ
Brain Sci 2020 Aug 20;10(9):576

1. Borroto-Escuela, DO, Narváez, M, Romero-Fernández, W, Pinton, L, Wydra, K, Filip, M et al.. Acute Cocaine Enhances Dopamine D₂R Recognition and Signaling and Counteracts D₂R Internalization in Sigma1R-D₂R Heteroreceptor Complexes. Mol Neurobiol. 2019;56 (10):7045-7055. doi: 10.1007/s12035-019-1580-8. PubMed PMID:30972626 PubMed Central PMC6728299.

1. Merchán, A, Sánchez-Kuhn, A, Prados-Pardo, A, Gago, B, Sánchez-Santed, F, Moreno, M et al.. Behavioral and biological markers for predicting compulsive-like drinking in schedule-induced polydipsia. Prog Neuropsychopharmacol Biol Psychiatry. 2019;93 :149-160. doi: 10.1016/j.pnpbp.2019.03.016. PubMed PMID:30940483 .

1. Parrado, C, Mercado-Saenz, S, Perez-Davo, A, Gilaberte, Y, Gonzalez, S, Juarranz, A et al.. Environmental Stressors on Skin Aging. Mechanistic Insights. Front Pharmacol. 2019;10 :759. doi: 10.3389/fphar.2019.00759. PubMed PMID:31354480 PubMed Central PMC6629960.

1. Merchán, A, Mora, S, Gago, B, Rodriguez-Ortega, E, Fernández-Teruel, A, Puga, JL et al.. Excessive habit formation in schedule-induced polydipsia: Microstructural analysis of licking among rat strains and involvement of the orbitofrontal cortex. Genes Brain Behav. 2019;18 (3):e12489. doi: 10.1111/gbb.12489. PubMed PMID:29877027 .

1. Zamarrón, A, Morel, E, Lucena, SR, Mataix, M, Pérez-Davó, A, Parrado, C et al.. Extract of Deschampsia antarctica (EDA) Prevents Dermal Cell Damage Induced by UV Radiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Int J Mol Sci. 2019;20 (6):. doi: 10.3390/ijms20061356. PubMed PMID:30889822 PubMed Central PMC6471785.

1. Flores-Burgess, A, Millón, C, Gago, B, García-Durán, L, Cantero-García, N, Coveñas, R et al.. Galanin (1-15)-fluoxetine interaction in the novel object recognition test. Involvement of 5-HT1A receptors in the prefrontal cortex of the rats. Neuropharmacology. 2019;155 :104-112. doi: 10.1016/j.neuropharm.2019.05.023. PubMed PMID:31128121 .

1. Pérez-Belmonte, LM, Osuna-Sánchez, J, Millán-Gómez, M, López-Carmona, MD, Gómez-Doblas, JJ, Cobos-Palacios, L et al.. Glycaemic efficacy and safety of linagliptin for the management of non-cardiac surgery patients with type 2 diabetes in a real-world setting: Lina-Surg study. Ann Med. ;51 (3-4):252-261. doi: 10.1080/07853890.2019.1613672. PubMed PMID:31037970 PubMed Central PMC7877876.

1. Torres-Prioris, MJ, López-Barroso, D, Paredes-Pacheco, J, Roé-Vellvé, N, Dawid-Milner, MS, Berthier, ML et al.. Language as a Threat: Multimodal Evaluation and Interventions for Overwhelming Linguistic Anxiety in Severe Aphasia. Front Psychol. 2019;10 :678. doi: 10.3389/fpsyg.2019.00678. PubMed PMID:31133908 PubMed Central PMC6517493.

1. García-Alberca, JM, Florido, M, Cáceres, M, Sánchez-Toro, A, Lara, JP, García-Casares, N et al.. Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer's disease. Psychogeriatrics. 2019;19 (1):46-54. doi: 10.1111/psyg.12363. PubMed PMID:30084177 .

1. Negrete-Díaz, JV, Shumilov, K, Real, MÁ, Medina-Luque, J, Valderrama-Carvajal, A, Flores, G et al.. Pharmacological activation of dopamine D₄ receptor modulates morphine-induced changes in the expression of GAD_65/67 and GABA_B receptors in the basal ganglia. Neuropharmacology. 2019;152 :22-29. doi: 10.1016/j.neuropharm.2019.01.024. PubMed PMID:30682345 .

1. Jiménez-Urbieta, H, Gago, B, Quiroga-Varela, A, Rodríguez-Chinchilla, T, Merino-Galán, L, Oregi, A et al.. Pramipexole-induced impulsivity in mildparkinsonian rats: a model of impulse control disorders in Parkinson's disease. Neurobiol Aging. 2019;75 :126-135. doi: 10.1016/j.neurobiolaging.2018.11.021. PubMed PMID:30572183 .

1. Lara, JP, Compañ, A, Vargas-Núñez, JA, Cardellach, F, Fernández-González, S, López-Muñiz, A et al.. Predicted change in the number of permanent medical teachers from 2017 to 2026. The training of future physicians in critical condition. Rev Clin Esp (Barc). 2019;219 (2):84-89. doi: 10.1016/j.rce.2018.04.015. PubMed PMID:29887248 .

1. Millón, C, Flores-Burgess, A, Gago, B, Alén, F, Orio, L, García-Durán, L et al.. Role of the galanin N-terminal fragment (1-15) in anhedonia: Involvement of the dopaminergic mesolimbic system. J Psychopharmacol. 2019;33 (6):737-747. doi: 10.1177/0269881119844188. PubMed PMID:31081442 .

1. Martín-Montañez, E, Pavia, J, Valverde, N, Boraldi, F, Lara, E, Oliver, B et al.. The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells. Free Radic Biol Med. 2019;137 :116-130. doi: 10.1016/j.freeradbiomed.2019.04.022. PubMed PMID:31035004 .

1. Carnero-Martín de Soto, P, Tamimi-Mariño, I, Bautista-Enrique, D, Bravo-Zurita, MJ, Cáceres, AG, Tamimi, F et al.. Use of beta-blockers and risk of aseptic loosening in total hip and knee arthroplasty: a nested case - control study. J Musculoskelet Neuronal Interact. 2019;19 (1):104-111. . PubMed PMID:30839308 PubMed Central PMC6454258.

1. de la Cruz Cosme, C, Dawid Milner, MS, Ojeda Burgos, G, Gallardo Tur, A, Márquez Martínez, M, Segura, T et al.. Validation of a basic neurosonology laboratory for detecting cervical carotid artery stenosis. Neurologia (Engl Ed). ;34 (6):367-375. doi: 10.1016/j.nrl.2017.01.015. PubMed PMID:28347575 .

1. Narváez, M, Borroto-Escuela, DO, Santín, L, Millón, C, Gago, B, Flores-Burgess, A et al.. A Novel Integrative Mechanism in Anxiolytic Behavior Induced by Galanin 2/Neuropeptide Y Y1 Receptor Interactions on Medial Paracapsular Intercalated Amygdala in Rats. Front Cell Neurosci. 2018;12 :119. doi: 10.3389/fncel.2018.00119. PubMed PMID:29765307 PubMed Central PMC5938606.

1. de la Cruz-Cosme, C, Dawid-Milner, MS, Ojeda-Burgos, G, Gallardo-Tur, A, Segura, T. Doppler Resistivity and Cerebral Small Vessel Disease: Hemodynamic Structural Correlation and Usefulness for the Etiological Classification of Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2018;27 (12):3425-3435. doi: 10.1016/j.jstrokecerebrovasdis.2018.08.001. PubMed PMID:30185397 .

1. Feltmann, K, Borroto-Escuela, DO, Rüegg, J, Pinton, L, de Oliveira Sergio, T, Narváez, M et al.. Effects of Long-Term Alcohol Drinking on the Dopamine D2 Receptor: Gene Expression and Heteroreceptor Complexes in the Striatum in Rats. Alcohol Clin Exp Res. 2018;42 (2):338-351. doi: 10.1111/acer.13568. PubMed PMID:29205397 PubMed Central PMC5817245.

1. López-González, MV, Díaz-Casares, A, González-García, M, Peinado-Aragonés, CA, Barbancho, MA, Carrillo de Albornoz, M et al.. Glutamate receptors of the A5 region modulate cardiovascular responses evoked from the dorsomedial hypothalamic nucleus and perifornical area. J Physiol Biochem. 2018;74 (2):325-334. doi: 10.1007/s13105-018-0623-3. PubMed PMID:29577176 .

1. Sánchez, ML, Mangas, A, Medina, LE, Aguilar, LA, Díaz-Cabiale, Z, Narváez, JA et al.. Immunohistochemical mapping of neurotensin in the alpaca diencephalon. Folia Histochem Cytobiol. 2018;56 (1):49-58. doi: 10.5603/FHC.a2018.0003. PubMed PMID:29516445 .

1. Borroto-Escuela, DO, Narváez, M, Ambrogini, P, Ferraro, L, Brito, I, Romero-Fernandez, W et al.. Receptor⁻Receptor Interactions in Multiple 5-HT1A Heteroreceptor Complexes in Raphe-Hippocampal 5-HT Transmission and Their Relevance for Depression and Its Treatment. Molecules. 2018;23 (6):. doi: 10.3390/molecules23061341. PubMed PMID:29865267 PubMed Central PMC6099659.

1. Sánchez-Marín, L, Ladrón de Guevara-Miranda, D, Mañas-Padilla, MC, Alén, F, Moreno-Fernández, RD, Díaz-Navarro, C et al.. Systemic blockade of LPA_1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior. Neuropharmacology. 2018;133 :189-201. doi: 10.1016/j.neuropharm.2018.01.033. PubMed PMID:29378212 .

1. Sampedro-Piquero, P, Moreno-Fernández, RD, Mañas-Padilla, MC, Gil-Rodríguez, S, Gavito, AL, Pavón, FJ et al.. Training memory without aversion: Appetitive hole-board spatial learning increases adult hippocampal neurogenesis. Neurobiol Learn Mem. 2018;151 :35-42. doi: 10.1016/j.nlm.2018.03.023. PubMed PMID:29608953 .

1. Valderrama-Carvajal, A, Irizar, H, Gago, B, Jiménez-Urbieta, H, Fuxe, K, Rodríguez-Oroz, MC et al.. Transcriptomic integration of D₄R and MOR signaling in the rat caudate putamen. Sci Rep. 2018;8 (1):7337. doi: 10.1038/s41598-018-25604-4. PubMed PMID:29743514 PubMed Central PMC5943359.

1. Rodriguez-Losada, N, Romero, P, Estivill-Torrús, G, Guzmán de Villoria, R, Aguirre, JA. Cell survival and differentiation with nanocrystalline glass-like carbon using substantia nigra dopaminergic cells derived from transgenic mouse embryos. PLoS One. 2017;12 (3):e0173978. doi: 10.1371/journal.pone.0173978. PubMed PMID:28334019 PubMed Central PMC5363826.

1. Alameda, MT, Morel, E, Parrado, C, González, S, Juarranz, Á. Cryptomphalus aspersa Mollusc Egg Extract Promotes Regenerative Effects in Human Dermal Papilla Stem Cells. Int J Mol Sci. 2017;18 (2):. doi: 10.3390/ijms18020463. PubMed PMID:28230777 PubMed Central PMC5343996.

1. Rivera, A, Gago, B, Suárez-Boomgaard, D, Yoshitake, T, Roales-Buján, R, Valderrama-Carvajal, A et al.. Dopamine D₄ receptor stimulation prevents nigrostriatal dopamine pathway activation by morphine: relevance for drug addiction. Addict Biol. 2017;22 (5):1232-1245. doi: 10.1111/adb.12407. PubMed PMID:27212105 .

1. Chamorro, M, Lara, JP, Insa, I, Espadas, M, Alda-Diez, JA. [Evaluation and treatment of sleep problems in children diagnosed with attention deficit hyperactivity disorder: an update of the evidence]. Rev Neurol. 2017;64 (9):413-421. . PubMed PMID:28444684 .

1. Ladrón de Guevara-Miranda, D, Millón, C, Rosell-Valle, C, Pérez-Fernández, M, Missiroli, M, Serrano, A et al.. Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis. Dis Model Mech. 2017;10 (3):323-336. doi: 10.1242/dmm.026682. PubMed PMID:28138095 PubMed Central PMC5374316.

1. Millón, C, Flores-Burgess, A, Narváez, M, Borroto-Escuela, DO, Gago, B, Santín, L et al.. The neuropeptides Galanin and Galanin(1-15) in depression-like behaviours. Neuropeptides. 2017;64 :39-45. doi: 10.1016/j.npep.2017.01.004. PubMed PMID:28196617 .

1. Borroto-Escuela, DO, Carlsson, J, Ambrogini, P, Narváez, M, Wydra, K, Tarakanov, AO et al.. Understanding the Role of GPCR Heteroreceptor Complexes in Modulating the Brain Networks in Health and Disease. Front Cell Neurosci. 2017;11 :37. doi: 10.3389/fncel.2017.00037. PubMed PMID:28270751 PubMed Central PMC5318393.

1. García-Basterra, I, Lahrach, I, Morillo Sánchez, MJ, Kamal-Salah, R, Ríus-Díaz, F, Dawid Milner, MS et al.. Analysis of peripapillary choroidal thickness in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol. 2016;100 (7):891-896. doi: 10.1136/bjophthalmol-2015-307526. PubMed PMID:26453640 .

1. Sánchez, ML, Díaz-Cabiale, Z, Narváez, JA, Manso, B, Salinas, P, Rivada, E et al.. Mapping of methionine-enkephalin-arg⁶-gly⁷-leu⁸ in the human diencephalon. Neuroscience. 2016;334 :245-258. doi: 10.1016/j.neuroscience.2016.08.010. PubMed PMID:27531857 .

1. Navas, P, Rodríguez-Santos, L, Bauzano-Poley, E, Lara, JP, Barbancho, MÁ. [The importance of sleep deprivation as a mechanism for activating interictal epileptiform paroxysms]. Rev Neurol. 2016;62 (7):289-95. . PubMed PMID:26988166 .

1. Garcia-Martin, G, Chamorro-Muñoz, MI, Martin-Reyes, G, Dawid-Milner, MS, Perez-Errazquin, F, Romero-Acebal, M et al.. Consumption patterns of antiepileptic drugs among epileptic patients in the Western Málaga district. Neurologia. ;30 (1):67-9. doi: 10.1016/j.nrl.2013.02.006. PubMed PMID:23582373 .

1. Fernández Vázquez, R, Martínez Blanco, J, García Vega, Mdel M, Barbancho, MÁ, Alvero-Cruz, JR. EFFECTS OF FOOD AND DRINK INGESTION ON BODY COMPOSITION VARIABLES OF ABDOMINAL BIOELECTRICAL IMPEDANCE. Nutr Hosp. 2015;32 (5):2269-73. doi: 10.3305/nh.2015.32.5.9618. PubMed PMID:26545687 .

1. Borroto-Escuela, DO, Narvaez, M, Pérez-Alea, M, Tarakanov, AO, Jiménez-Beristain, A, Mudó, G et al.. Evidence for the existence of FGFR1-5-HT1A heteroreceptor complexes in the midbrain raphe 5-HT system. Biochem Biophys Res Commun. 2015;456 (1):489-93. doi: 10.1016/j.bbrc.2014.11.112. PubMed PMID:25485703 .

1. De Souza, E, Sánchez, ML, Aguilar, LÁ, Díaz-Cabiale, Z, Narváez, JÁ, Coveñas, R et al.. Mapping of somatostatin-28 (1-12) in the alpaca (Lama pacos) brainstem. Microsc Res Tech. 2015;78 (5):363-74. doi: 10.1002/jemt.22482. PubMed PMID:25754727 .

1. Molinet-Dronda, F, Gago, B, Quiroga-Varela, A, Juri, C, Collantes, M, Delgado, M et al.. Monoaminergic PET imaging and histopathological correlation in unilateral and bilateral 6-hydroxydopamine lesioned rat models of Parkinson's disease: a longitudinal in-vivo study. Neurobiol Dis. 2015;77 :165-72. doi: 10.1016/j.nbd.2015.01.007. PubMed PMID:25681534 .

1. Delgado-Alvarado, M, de la Riva, P, Jiménez-Urbieta, H, Gago, B, Gabilondo, A, Bornstein, B et al.. Parkinsonism, cognitive deficit and behavioural disturbance caused by a novel mutation in the polymerase gamma gene. J Neurol Sci. 2015;350 (1-2):93-7. doi: 10.1016/j.jns.2015.02.011. PubMed PMID:25724872 .

1. Rodriguez-Oroz, MC, Gago, B, Clavero, P, Delgado-Alvarado, M, Garcia-Garcia, D, Jimenez-Urbieta, H et al.. The relationship between atrophy and hypometabolism: is it regionally dependent in dementias?. Curr Neurol Neurosci Rep. 2015;15 (7):44. doi: 10.1007/s11910-015-0562-0. PubMed PMID:26008810 .