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Neuropatología de la Enfermedad de Alzheimer (NEUROAD)

Lineas de Investigación

01. Neuroinflamación y respuesta glial en la enfermedad de Alzheimer.

02. Descifrar nuevos mecanismos (enfoques) patogénicos implicados en la enfermedad de Alzheimer que permitan un mayor éxito traslacional a la clínica humana. Identificación de biomarcadores y dianas terapéuticas.

03. Desarrollo de nuevos modelos animales de la enfermedad de Alzheimer que recapitulen mejor la patología de los pacientes. Estudios preclínicos de nuevas estrategias terapéuticas.

04. Desarrollo de modelos in vitro de la enfermedad de Alzheimer mediante el empleo de células iPSCs derivadas de pacientes. Estudios de mecanismos patogénicos y evaluación de nuevos fármacos.

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Miembros del grupo

  • Todos
  • IR
  • Co-IR
  • Investigador
  • Otro

Proyectos de Investigación

Garcia Leon, Juan Antonio

 IP PREMIOS

001-2019-IBD II PREMIO IBIMA-DIVULGA 2019 A LAS MEJORES PUBLICACIONES DE 2018

FIMABIS
. 2019

Gutierrez Perez, Antonia

 IP PI

Disfunción glial en la enfermedad de Alzheimer: implicaciones patogénicas y potencial clínico Proyecto Colaborativo CIBERNED

Universidad de Málaga
. 2018

Gutierrez Perez, Antonia

 IP PI

PI18/01557. Descifrando la diversidad funcional de la respuesta microglial y astroglial en la enfermedad de Alzheimer: potencial patológico y terapéutico

INSTITUTO DE SALUD CARLOS III
. 2019

Gutierrez Perez, Antonia

 IP PI

Desregulación del Sistema immune innato cerebral y la enfermedad de Alzheimer: nuevas dianas para futuras terapias.

Junta de Andalucía
. 2018

Garcia Leon, Juan Antonio

 IP PI

PI-0276-2018 Inmunidad Innata Cerebral y Periférica en la Enfermedad de Alzheimer: Disección Molecular de Nuevas Vías Patogénicas y Potencial Terapéutico

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Martini, AC, Gomez-Arboledas, A, Forner, S, Rodriguez-Ortiz, CJ, McQuade, A, Danhash, E et al.. Amyloid-beta impairs TOM1-mediated IL-1R1 signaling. Proc Natl Acad Sci U S A. 2019;116 (42):21198-21206. doi: 10.1073/pnas.1914088116. PubMed PMID:31570577 PubMed Central PMC6800331.
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  1. Trujillo-Estrada, L, Gomez-Arboledas, A, Forner, S, Martini, AC, Gutierrez, A, Baglietto-Vargas, D et al.. Astrocytes: From the Physiology to the Disease. Curr Alzheimer Res. 2019;16 (8):675-698. doi: 10.2174/1567205016666190830110152. PubMed PMID:31470787 .
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  1. Boza-Serrano, A, Ruiz, R, Sanchez-Varo, R, García-Revilla, J, Yang, Y, Jimenez-Ferrer, I et al.. Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease. Acta Neuropathol. 2019;138 (2):251-273. doi: 10.1007/s00401-019-02013-z. PubMed PMID:31006066 PubMed Central PMC6660511.
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  1. Edwards Iii, GA, Gamez, N, Escobedo, G Jr, Calderon, O, Moreno-Gonzalez, I. Modifiable Risk Factors for Alzheimer's Disease. Front Aging Neurosci. 2019;11 :146. doi: 10.3389/fnagi.2019.00146. PubMed PMID:31293412 PubMed Central PMC6601685.
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  1. Jiang, B, Aliyan, A, Cook, NP, Augustine, A, Bhak, G, Maldonado, R et al.. Monitoring the Formation of Amyloid Oligomers Using Photoluminescence Anisotropy. J Am Chem Soc. 2019;141 (39):15605-15610. doi: 10.1021/jacs.9b06966. PubMed PMID:31536338 .
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  1. Cuanalo-Contreras, K, Moreno-Gonzalez, I. Natural Products as Modulators of the Proteostasis Machinery: Implications in Neurodegenerative Diseases. Int J Mol Sci. 2019;20 (19):. doi: 10.3390/ijms20194666. PubMed PMID:31547084 PubMed Central PMC6801507.
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  1. Edwards Iii, G, Gamez, N, Armijo, E, Kramm, C, Morales, R, Taylor-Presse, K et al.. Peripheral Delivery of Neural Precursor Cells Ameliorates Parkinson's Disease-Associated Pathology. Cells. 2019;8 (11):. doi: 10.3390/cells8111359. PubMed PMID:31671704 PubMed Central PMC6912680.
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  1. Garcia-Leon, JA, Vitorica, J, Gutierrez, A. Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. Future Med Chem. 2019;11 (11):1305-1322. doi: 10.4155/fmc-2018-0520. PubMed PMID:31161803 .
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  1. García-Bonilla, M, García-Martín, ML, Muñoz-Hernández, MC, Domínguez-Pinos, D, Martínez-León, MI, Peñalver, A et al.. A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus. J Neuropathol Exp Neurol. 2018;77 (12):1122-1136. doi: 10.1093/jnen/nly097. PubMed PMID:30364991 .
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  1. Romero-Molina, C, Navarro, V, Sanchez-Varo, R, Jimenez, S, Fernandez-Valenzuela, JJ, Sanchez-Mico, MV et al.. Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology. Front Cell Neurosci. 2018;12 :421. doi: 10.3389/fncel.2018.00421. PubMed PMID:30487735 PubMed Central PMC6246744.
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  1. García-León, JA, Cabrera-Socorro, A, Eggermont, K, Swijsen, A, Terryn, J, Fazal, R et al.. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration. Alzheimers Dement. 2018;14 (10):1261-1280. doi: 10.1016/j.jalz.2018.05.007. PubMed PMID:30036493 .
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  1. Baglietto-Vargas, D, Prieto, GA, Limon, A, Forner, S, Rodriguez-Ortiz, CJ, Ikemura, K et al.. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17 (4):e12791. doi: 10.1111/acel.12791. PubMed PMID:29877034 PubMed Central PMC6052400.
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  1. Navarro, V, Sanchez-Mejias, E, Jimenez, S, Muñoz-Castro, C, Sanchez-Varo, R, Davila, JC et al.. Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative. Front Aging Neurosci. 2018;10 :140. doi: 10.3389/fnagi.2018.00140. PubMed PMID:29867449 PubMed Central PMC5958192.
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  1. Gomez-Arboledas, A, Davila, JC, Sanchez-Mejias, E, Navarro, V, Nuñez-Diaz, C, Sanchez-Varo, R et al.. Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease. Glia. 2018;66 (3):637-653. doi: 10.1002/glia.23270. PubMed PMID:29178139 PubMed Central PMC5814816.
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  1. García-León, JA, Kumar, M, Boon, R, Chau, D, One, J, Wolfs, E et al.. SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells. Stem Cell Reports. 2018;10 (2):655-672. doi: 10.1016/j.stemcr.2017.12.014. PubMed PMID:29337119 PubMed Central PMC5830935.
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  1. Gutierrez, A, Vitorica, J. Toward a New Concept of Alzheimer's Disease Models: A Perspective from Neuroinflammation. J Alzheimers Dis. 2018;64 (s1):S329-S338. doi: 10.3233/JAD-179914. PubMed PMID:29562520 .
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  1. Baglietto-Vargas, D, Sánchez-Mejias, E, Navarro, V, Jimenez, S, Trujillo-Estrada, L, Gómez-Arboledas, A et al.. Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer's disease. Sci Rep. 2017;7 (1):10085. doi: 10.1038/s41598-017-10353-7. PubMed PMID:28855626 PubMed Central PMC5577311.
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  1. Peñalver, A, Campos-Sandoval, JA, Blanco, E, Cardona, C, Castilla, L, Martín-Rufián, M et al.. Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity. Front Mol Neurosci. 2017;10 :278. doi: 10.3389/fnmol.2017.00278. PubMed PMID:28928633 PubMed Central PMC5591874.
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  1. García-Sanz, P, Orgaz, L, Bueno-Gil, G, Espadas, I, Rodríguez-Traver, E, Kulisevsky, J et al.. N370S-GBA1 mutation causes lysosomal cholesterol accumulation in Parkinson's disease. Mov Disord. 2017;32 (10):1409-1422. doi: 10.1002/mds.27119. PubMed PMID:28779532 .
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  1. Hernández-Rodríguez, M, Correa-Basurto, J, Gutiérrez, A, Vitorica, J, Rosales-Hernández, MC. Asp32 and Asp228 determine the selective inhibition of BACE1 as shown by docking and molecular dynamics simulations. Eur J Med Chem. 2016;124 :1142-1154. doi: 10.1016/j.ejmech.2016.08.028. PubMed PMID:27639619 .
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  1. Sanchez-Mejias, E, Navarro, V, Jimenez, S, Sanchez-Mico, M, Sanchez-Varo, R, Nuñez-Diaz, C et al.. Soluble phospho-tau from Alzheimer's disease hippocampus drives microglial degeneration. Acta Neuropathol. 2016;132 (6):897-916. doi: 10.1007/s00401-016-1630-5. PubMed PMID:27743026 PubMed Central PMC5106501.
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  1. Carriba, P, Jimenez, S, Navarro, V, Moreno-Gonzalez, I, Barneda-Zahonero, B, Moubarak, RS et al.. Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death. Cell Death Dis. 2015;6 :e1639. doi: 10.1038/cddis.2015.6. PubMed PMID:25675299 PubMed Central PMC4669818.
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  1. Cardona, C, Sánchez-Mejías, E, Dávila, JC, Martín-Rufián, M, Campos-Sandoval, JA, Vitorica, J et al.. Expression of Gls and Gls2 glutaminase isoforms in astrocytes. Glia. 2015;63 (3):365-82. doi: 10.1002/glia.22758. PubMed PMID:25297978 .
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