Lineas de Investigación

01. Desarrollar y validar algoritmos de riesgo para predecir el inicio de enfermedades mentales comunes.

02. Diseñar, desarrollar y evaluar programas innovadores de prevención de enfermedades mentales frecuentes.

03. Generar evidencias sobre la efectividad, coste-efectividad y aceptación de los programas de prevención de enfermedades mentales frecuentes.

04. Evaluar la implementación de programas de prevención de enfermedades mentales frecuentes.



Proyectos de Investigación

Prevención primaria de la depresión mediante una APP en población trabajadora con riesgo moderado-alto de depresión: ensayo controlado aleatorio.

Junta de Andalucía
. 2019

JC2018-036577-I AYUDAS JUAN DE LA CIERVA – INCORPORACIÓN 2019.

Agencia Estatal de Investigación
. 2019

Riseup-PPD – Research Innovation and Sustainable Pan-European Network in Peripartum Depression Disorder

Comisión Europea
. 2019

AP-0212-2019 Estudio Cualitativo Sobre el Espacio Colaborativo Atención primaria-Salud Mental

Fundación Pública Andaluza Progreso y Salud
. 2019

RD16/0007/0010 Red de Investigación en Actividades preventivas y promoción de la salud en Atención Primaria

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - CONVOCATORIA DE REDES TEMÁTICAS DE INVESTIGACIÓN COOPERATIVA EN SALUD (RETICS) 2016

AP-0095-2016 Prevención de la depresión a través de una intervención personalizada basada en TICs, algoritmos predictivos de riesgo, y DSS para pacientes y médicos de familia: estudio e-predictD

FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
CONVOCATORIA PARA LA REALIZACIÓN DE PROYECTOS DE INVESTIGACIÓN E INNOVACIÓN EN EL ÁMBITO DE LA ATENCIÓN PRIMARIA DEL SAS 2016

PE-0280-2018. Prevención universal de la depresión y ansiedad en población general mediante una intervención personalizada basada en algoritmos de riesgo, TICs y sistemas de ayuda a las decisiones: ensayo controlado aleatorio. El estudio ?PredictPlusPrevent?

CONSEJERÍA DE SALUD
PROYECTOS ESTRATÉGICOS DE I+D+i CON FORTALECIMIENTO DE CAPITAL HUMANO INVESTIGADOR 2018

PI18-01307 Prevención de la depresión en el medio laboral mediante una intervención personalizada basada en algoritmos de riesgo, TICs y sistemas de ayuda a las decisiones: ensayo controlado aleatorio

INSTITUTO DE SALUD CARLOS III
ACCIÓN ESTRATÉGICA EN SALUD - PROYECTOS DE INVESTIGACIÓN EN SALUD 2018

PI15/00401 Prevención de la depresión a través de una intervención personalizada basada en TICs, algoritmos predictivos de riesgo, y DSS para pacientes y médicos de familia: estudio e-predictD

INSTITUTO DE SALUD CARLOS III
PROYECTOS DE INVESTIGACIÓN EN SALUD (FIS) 2015

EF-0286-2018. Coste-efectividad de las intervenciones preventivas para la depresión y la ansiedad

CONSEJERÍA DE SALUD
ESTANCIAS FORMATIVAS DE INVESTIGACIÓN E INNOVACIÓN 2018

EF-0275-2018. Mediadores de las intervenciones psicológicas en la prevención de la depresión y la ansiedad

CONSEJERÍA DE SALUD
ESTANCIAS FORMATIVAS DE INVESTIGACIÓN E INNOVACIÓN 2018

PS-0330-2016 Impacto de las Habilidades de Comunicación de Los Médicos de Familia en la Prevención de la Depresión en Atención Primaria: Cohorte Prospectiva Anidada en Un Ensayo Clínico Controlado. el Estudio Predictd-Communication.

CONSEJERÍA DE SALUD
PROYECTOS DE INVESTIGACIÓN EN EL ÁREA ESTRATÉGICA DE SALUD PÚBLICA 2016

Publicaciones científicas

  • Todo
  • D1
  • Q1
  • Q2
  • Otro
  1. Gómez-Gómez, I, Motrico, E, Moreno-Peral, P, Rigabert, A, Conejo-Cerón, S, Ortega-Calvo, M et al.. Effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression: a study protocol for a systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2019;9 (3):e026842. doi: 10.1136/bmjopen-2018-026842. PubMed PMID:30878992 PubMed Central PMC6429884.
Search PubMed
  1. Bellón, JÁ, Conejo-Cerón, S, Cortés-Abela, C, Pena-Andreu, JM, García-Rodríguez, A, Moreno-Peral, P et al.. Effectiveness of psychological and educational interventions for the prevention of depression in the workplace: A systematic review and meta-analysis. Scand J Work Environ Health. 2019;45 (4):324-332. doi: 10.5271/sjweh.3791. PubMed PMID:30500058 .
Search PubMed
  1. Resurrección, DM, Moreno-Peral, P, Gómez-Herranz, M, Rubio-Valera, M, Pastor, L, Caldas de Almeida, JM et al.. Factors associated with non-participation in and dropout from cardiac rehabilitation programmes: a systematic review of prospective cohort studies. Eur J Cardiovasc Nurs. 2019;18 (1):38-47. doi: 10.1177/1474515118783157. PubMed PMID:29909641 .
Search PubMed
  1. Moreno-Peral, P, Conejo-Cerón, S, Fernández, A, Martín-Pérez, C, Fernández-Alonso, C, Rodríguez-Bayón, A et al.. Family physicians' views on participating in prevention of major depression. The predictD-EVAL qualitative study. PLoS ONE. 2019;14 (5):e0217621. doi: 10.1371/journal.pone.0217621. PubMed PMID:31145762 PubMed Central PMC6542521.
Search PubMed
  1. Pons-Vigués, M, Berenguera, A, Coma-Auli, N, March, S, Pombo, H, Masluk, B et al.. Qualitative evaluation of a complex intervention to implement health promotion activities according to healthcare attendees and health professionals: EIRA study (phase II). BMJ Open. 2019;9 (3):e023872. doi: 10.1136/bmjopen-2018-023872. PubMed PMID:30904842 PubMed Central PMC6475230.
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  1. Fernández, A, Mendive, JM, Conejo-Cerón, S, Moreno-Peral, P, King, M, Nazareth, I et al.. A personalized intervention to prevent depression in primary care: cost-effectiveness study nested into a clustered randomized trial. BMC Med. 2018;16 (1):28. doi: 10.1186/s12916-018-1005-y. PubMed PMID:29471877 PubMed Central PMC5824561.
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  1. Zabaleta-Del-Olmo, E, Pombo, H, Pons-Vigués, M, Casajuana-Closas, M, Pujol-Ribera, E, López-Jiménez, T et al.. Correction to: Complex multiple risk intervention to promote healthy behaviours in people between 45 to 75 years attended in primary health care (EIRA study): study protocol for a hybrid trial. BMC Public Health. 2018;18 (1):1004. doi: 10.1186/s12889-018-5905-8. PubMed PMID:30103723 PubMed Central PMC6088411.
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  1. Rodríguez-Morejón, A, Zamanillo, A, Iglesias, G, Moreno-Gámez, A, Navas-Campaña, D, Moreno-Peral, P et al.. Development of the therapeutic language coding system (SICOLENTE): Reliability and construct validity. PLoS ONE. 2018;13 (12):e0209751. doi: 10.1371/journal.pone.0209751. PubMed PMID:30586469 PubMed Central PMC6306244.
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  1. Aznar-Lou, I, Pottegård, A, Fernández, A, Peñarrubia-María, MT, Serrano-Blanco, A, Sabés-Figuera, R et al.. Effect of copayment policies on initial medication non-adherence according to income: a population-based study. BMJ Qual Saf. 2018;27 (11):878-891. doi: 10.1136/bmjqs-2017-007416. PubMed PMID:29545326 .
Search PubMed
  1. Rigabert, A, Motrico, E, Moreno-Peral, P, Resurrección, DM, Conejo-Cerón, S, Navas-Campaña, D et al.. Effectiveness of online interventions in preventing depression: a protocol for systematic review and meta-analysis of randomised controlled trials. BMJ Open. 2018;8 (11):e022012. doi: 10.1136/bmjopen-2018-022012. PubMed PMID:30498036 PubMed Central PMC6278812.
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  1. Skröder, H, Pettersson, H, Norlén, F, Gustavsson, P, Rylander, L, Albin, M et al.. Occupational exposure to whole body vibrations and birth outcomes - A nationwide cohort study of Swedish women. Sci. Total Environ. 2020;751 :141476. doi: 10.1016/j.scitotenv.2020.141476. PubMed PMID:32871309 .
  2. Tudi, M, Ruan, HD, Yu, Y, Wang, L, Wei, B, Tong, S et al.. Bioaccumulation and translocation of trace elements in soil-irrigation water-wheat in arid agricultural areas of Xin Jiang, China. Ecotoxicology. 2020; :. doi: 10.1007/s10646-020-02267-4. PubMed PMID:32860622 .
  3. Kim, SJ, Oh, MJ. Potentiality to natural immunization inducement against VHS in olive flounder by live VHSV immersion vaccination at temperature controlled culture condition. Virus Res. 2020;288 :198140. doi: 10.1016/j.virusres.2020.198140. PubMed PMID:32846195 .
  4. Wallentine, S, Bandaranayake, S, Biswas, S, Baker, LR. Plasmon-Resonant Vibrational Sum Frequency Generation of Electrochemical Interfaces: Direct Observation of Carbon Dioxide Electroreduction on Gold. J Phys Chem A. 2020; :. doi: 10.1021/acs.jpca.0c04268. PubMed PMID:32846085 .
  5. Tirloni, E, Nauta, M, Vasconi, M, Di Pietro, V, Bernardi, C, Stella, S et al.. Growth of Listeria monocytogenes in ready-to-eat "shrimp cocktail": Risk assessment and possible preventive interventions. Int. J. Food Microbiol. 2020;334 :108800. doi: 10.1016/j.ijfoodmicro.2020.108800. PubMed PMID:32829187 .
  6. Dey Bhowmik, A, Podder, S, Mondal, P, Shaw, P, Bandyopadhyay, A, Das, A et al.. Chronic exposure to environmentally relevant concentration of fluoride alters Ogg1 and Rad51 expressions in mice: Involvement of epigenetic regulation. Ecotoxicol. Environ. Saf. 2020;202 :110962. doi: 10.1016/j.ecoenv.2020.110962. PubMed PMID:32800233 .
  7. Mahfooz, Y, Yasar, A, Guijian, L, Islam, QU, Akhtar, ABT, Rasheed, R et al.. Critical risk analysis of metals toxicity in wastewater irrigated soil and crops: a study of a semi-arid developing region. Sci Rep. 2020;10 (1):12845. doi: 10.1038/s41598-020-69815-0. PubMed PMID:32733057 PubMed Central PMC7393170.
  8. Han, L, Peng, R, Jiang, W, Xu, T, Zhang, C, Chen, K et al.. Coordination-driven reversible surfaces with site-specifically immobilized nanobody for dynamic cancer cell capture and release. J Mater Chem B. 2020;8 (33):7511-7520. doi: 10.1039/d0tb00574f. PubMed PMID:32677632 .
  9. Zhao, ML, Zeng, WJ, Chai, YQ, Yuan, R, Zhuo, Y. An Affinity-Enhanced DNA Intercalator with Intense ECL Embedded in DNA Hydrogel for Biosensing Applications. Anal. Chem. 2020;92 (16):11044-11052. doi: 10.1021/acs.analchem.0c00152. PubMed PMID:32677426 .
  10. Yu, H, McCuller, L, Tse, M, Kijbunchoo, N, Barsotti, L, Mavalvala, N et al.. Quantum correlations between light and the kilogram-mass mirrors of LIGO. Nature. 2020;583 (7814):43-47. doi: 10.1038/s41586-020-2420-8. PubMed PMID:32612226 .
  11. Souza Neto, HF, Pereira, WVDS, Dias, YN, Souza, ES, Teixeira, RA, Lima, MW et al.. Environmental and human health risks of arsenic in gold mining areas in the eastern Amazon. Environ. Pollut. 2020;265 (Pt B):114969. doi: 10.1016/j.envpol.2020.114969. PubMed PMID:32559696 .
  12. Ge, R, Zhao, H, Wei, JX, Duan, YQ, Bai, Z, Li, C et al.. Improved two-step optimization procedure used for designing an apodizer and Lyot stop in the Lyot coronagraph. Appl Opt. 2020;59 (16):4939-4952. doi: 10.1364/AO.391959. PubMed PMID:32543491 .
  13. Akshaya, KB, Anitha, V, Nidhin, M, Sudhakar, YN, Louis, G. Electrochemical sensing of vitamin B12 deficiency marker methylmalonic acid using PdAu-PPy tailored carbon fiber paper electrode. Talanta. 2020;217 :121028. doi: 10.1016/j.talanta.2020.121028. PubMed PMID:32498897 .
  14. Tamele, IJ, Vasconcelos, V. Microcystin Incidence in the Drinking Water of Mozambique: Challenges for Public Health Protection. Toxins (Basel). 2020;12 (6):. doi: 10.3390/toxins12060368. PubMed PMID:32498435 PubMed Central PMC7354522.
  15. Bandi, R, Alle, M, Park, CW, Han, SY, Kwon, GJ, Kim, JC et al.. Rapid synchronous synthesis of Ag nanoparticles and Ag nanoparticles/holocellulose nanofibrils: Hg(II) detection and dye discoloration. Carbohydr Polym. 2020;240 :116356. doi: 10.1016/j.carbpol.2020.116356. PubMed PMID:32475600 .
  16. Zhao, X, Yang, Y, Chiribella, G. Quantum Metrology with Indefinite Causal Order. Phys. Rev. Lett. 2020;124 (19):190503. doi: 10.1103/PhysRevLett.124.190503. PubMed PMID:32469602 .
  17. Ayres Cacciatore, F, Dalmás, M, Maders, C, Ataíde Isaía, H, Brandelli, A, da Silva Malheiros, P et al.. Carvacrol encapsulation into nanostructures: Characterization and antimicrobial activity against foodborne pathogens adhered to stainless steel. Food Res. Int. 2020;133 :109143. doi: 10.1016/j.foodres.2020.109143. PubMed PMID:32466924 .
  18. Wang, Y, Yu, J, Mao, YF, Chen, J, Wang, S, Chen, HZ et al.. Stable, high-performance sodium-based plasmonic devices in the near infrared. Nature. 2020;581 (7809):401-405. doi: 10.1038/s41586-020-2306-9. PubMed PMID:32461649 .
  19. Löfgren, L, Forsberg, GB, Davidsson, P, Eketjäll, S, Whatling, C. Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man. Prostaglandins Other Lipid Mediat. 2020;150 :106463. doi: 10.1016/j.prostaglandins.2020.106463. PubMed PMID:32450304 .
  20. Obasi, NA, Aloke, C, Obasi, SE, Famurewa, AC, Ogbu, PN, Onyeji, GN et al.. Elemental Composition and Associated Health Risk of Honey Obtained from Apiary Farms in Southeast Nigeria. J. Food Prot. 2020;83 (10):1745-1756. doi: 10.4315/JFP-20-072. PubMed PMID:32421795 .
Search PubMed
  1. Muñoz Cobos, F, Morales Sutil, ML, Faz García, MC, Ariza González, M, Salazar Agulló, JA, Burgos Varo, ML et al.. [Polio and post-polio syndrome, viewed by patients and health professionals in primary care]. Rev. Esp. Salud Publica. 2018;92 :. . PubMed PMID:29938691 .
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  1. Resurrección, DM, Motrico, E, Rubio-Valera, M, Mora-Pardo, JA, Moreno-Peral, P. Reasons for dropout from cardiac rehabilitation programs in women: A qualitative study. PLoS ONE. 2018;13 (7):e0200636. doi: 10.1371/journal.pone.0200636. PubMed PMID:30011341 PubMed Central PMC6047805.
Search PubMed
  1. Resurrección, DM, Motrico, E, Rigabert, A, Rubio-Valera, M, Conejo-Cerón, S, Pastor, L et al.. Barriers for Nonparticipation and Dropout of Women in Cardiac Rehabilitation Programs: A Systematic Review. J Womens Health (Larchmt). 2017;26 (8):849-859. doi: 10.1089/jwh.2016.6249. PubMed PMID:28388314 .
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  1. Berenguera, A, Pons-Vigués, M, Moreno-Peral, P, March, S, Ripoll, J, Rubio-Valera, M et al.. Beyond the consultation room: Proposals to approach health promotion in primary care according to health-care users, key community informants and primary care centre workers. Health Expect. 2017;20 (5):896-910. doi: 10.1111/hex.12530. PubMed PMID:28116774 PubMed Central PMC5600227.
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  1. Iglesias-González, M, Aznar-Lou, I, Gil-Girbau, M, Moreno-Peral, P, Peñarrubia-María, MT, Rubio-Valera, M et al.. Comparing watchful waiting with antidepressants for the management of subclinical depression symptoms to mild-moderate depression in primary care: a systematic review. Fam Pract. 2017;34 (6):639-648. doi: 10.1093/fampra/cmx054. PubMed PMID:28985309 .
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  1. Conejo-Cerón, S, Moreno-Peral, P, Rodríguez-Morejón, A, Motrico, E, Navas-Campaña, D, Rigabert, A et al.. Effectiveness of Psychological and Educational Interventions to Prevent Depression in Primary Care: A Systematic Review and Meta-Analysis. Ann Fam Med. 2017;15 (3):262-271. doi: 10.1370/afm.2031. PubMed PMID:28483893 PubMed Central PMC5422089.
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  1. Moreno-Peral, P, Conejo-Cerón, S, Rubio-Valera, M, Fernández, A, Navas-Campaña, D, Rodríguez-Morejón, A et al.. Effectiveness of Psychological and/or Educational Interventions in the Prevention of Anxiety: A Systematic Review, Meta-analysis, and Meta-regression. JAMA Psychiatry. 2017;74 (10):1021-1029. doi: 10.1001/jamapsychiatry.2017.2509. PubMed PMID:28877316 PubMed Central PMC5710546.
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  1. Pons-Vigués, M, Berenguera, A, Coma-Auli, N, Pombo-Ramos, H, March, S, Asensio-Martínez, A et al.. Health-care users, key community informants and primary health care workers' views on health, health promotion, health assets and deficits: qualitative study in seven Spanish regions. Int J Equity Health. 2017;16 (1):99. doi: 10.1186/s12939-017-0590-2. PubMed PMID:28610633 PubMed Central PMC5470288.
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  1. Fontalba-Navas, A, Lucas-Borja, ME, Gil-Aguilar, V, Arrebola, JP, Pena-Andreu, JM, Perez, J et al.. Incidence and risk factors for post-traumatic stress disorder in a population affected by a severe flood. Public Health. 2017;144 :96-102. doi: 10.1016/j.puhe.2016.12.015. PubMed PMID:28274391 .
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  1. Aznar-Lou, I, Fernández, A, Gil-Girbau, M, Fajó-Pascual, M, Moreno-Peral, P, Peñarrubia-María, MT et al.. Initial medication non-adherence: prevalence and predictive factors in a cohort of 1.6 million primary care patients. Br J Clin Pharmacol. 2017;83 (6):1328-1340. doi: 10.1111/bcp.13215. PubMed PMID:28229476 PubMed Central PMC5427227.
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  1. Bellón, JÁ, de Dios Luna, J, King, M, Nazareth, I, Motrico, E, GildeGómez-Barragán, MJ et al.. Predicting the onset of hazardous alcohol drinking in primary care: development and validation of a simple risk algorithm. Br J Gen Pract. 2017;67 (657):e280-e292. doi: 10.3399/bjgp17X690245. PubMed PMID:28360074 PubMed Central PMC5565836.
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  1. Feliu-Soler, A, Reche-Camba, E, Borràs, X, Pérez-Aranda, A, Andrés-Rodríguez, L, Peñarrubia-María, MT et al.. Psychometric Properties of the Cognitive Emotion Regulation Questionnaire (CERQ) in Patients with Fibromyalgia Syndrome. Front Psychol. 2017;8 :2075. doi: 10.3389/fpsyg.2017.02075. PubMed PMID:29321750 PubMed Central PMC5733558.
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  1. Caneo, C, Marston, L, Bellón, JÁ, King, M. Examining the relationship between physical illness and depression: Is there a difference between inflammatory and non inflammatory diseases? A cohort study. Gen Hosp Psychiatry. ;43 :71-77. doi: 10.1016/j.genhosppsych.2016.09.007. PubMed PMID:27796262 .
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  1. Bellón, JÁ, Conejo-Cerón, S, Moreno-Peral, P, King, M, Nazareth, I, Martín-Pérez, C et al.. Intervention to Prevent Major Depression in Primary Care: A Cluster Randomized Trial. Ann. Intern. Med. 2016;164 (10):656-65. doi: 10.7326/M14-2653. PubMed PMID:27019334 .
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  1. Moreno-Küstner, B, Mayoral, F, Navas-Campaña, D, García-Herrera, JM, Angona, P, Martín, C et al.. Prevalence of schizophrenia and related disorders in Malaga (Spain): results using multiple clinical databases. Epidemiol Psychiatr Sci. 2016;25 (1):38-48. doi: 10.1017/S2045796014000614. PubMed PMID:25315825 PubMed Central PMC6998667.
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  1. Zabaleta-del-Olmo, E, Bolibar, B, García-Ortíz, L, García-Campayo, J, Llobera, J, Bellón, JÁ et al.. Building interventions in primary health care for long-term effectiveness in health promotion and disease prevention. A focus on complex and multi-risk interventions. Prev Med. 2015;76 Suppl :S1-4. doi: 10.1016/j.ypmed.2015.03.011. PubMed PMID:25778858 .
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  1. García-Mochón, L, Martín, JJ, Aranda-Regules, JM, Rivas-Ruiz, F, Vas, J. Cost effectiveness of using moxibustion to correct non-vertex presentation. Acupunct Med. 2015;33 (2):136-41. doi: 10.1136/acupmed-2014-010696. PubMed PMID:25669428 .
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  1. Bellón, JÁ, Moreno-Peral, P, Motrico, E, Rodríguez-Morejón, A, Fernández, A, Serrano-Blanco, A et al.. Effectiveness of psychological and/or educational interventions to prevent the onset of episodes of depression: A systematic review of systematic reviews and meta-analyses. Prev Med. 2015;76 Suppl :S22-32. doi: 10.1016/j.ypmed.2014.11.003. PubMed PMID:25445331 .
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  1. Fernandez, A, Moreno-Peral, P, Zabaleta-del-Olmo, E, Bellon, JA, Aranda-Regules, JM, Luciano, JV et al.. Is there a case for mental health promotion in the primary care setting? A systematic review. Prev Med. 2015;76 Suppl :S5-11. doi: 10.1016/j.ypmed.2014.11.019. PubMed PMID:25475684 .
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  1. Baladón, L, Fernández, A, Rubio-Valera, M, Cuevas-Esteban, J, Palao, DJ, Bellon, JA et al.. Prevalence of mental disorders in non-demented elderly people in primary care [corrected]. Int Psychogeriatr. 2015;27 (5):757-68. doi: 10.1017/S1041610214002841. PubMed PMID:25643982 .
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  1. Moreno-Peral, P, Conejo-Cerón, S, Fernández, A, Berenguera, A, Martínez-Andrés, M, Pons-Vigués, M et al.. Primary care patients' perspectives of barriers and enablers of primary prevention and health promotion-a meta-ethnographic synthesis. PLoS ONE. 2015;10 (5):e0125004. doi: 10.1371/journal.pone.0125004. PubMed PMID:25938509 PubMed Central PMC4418671.
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  1. García-Rodríguez, A, Gutiérrez-Bedmar, M, Bellón-Saameño, JÁ, Muñoz-Bravo, C, Fernández-Crehuet Navajas, J. [Psychosocial stress environment and health workers in public health: Differences between primary and hospital care]. Aten Primaria. ;47 (6):359-66. doi: 10.1016/j.aprim.2014.09.003. PubMed PMID:25443765 PubMed Central PMC6983690.
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  1. Gutiérrez, B, Bellón, JÁ, Rivera, M, Molina, E, King, M, Marston, L et al.. The risk for major depression conferred by childhood maltreatment is multiplied by BDNF and SERT genetic vulnerability: a replication study. J Psychiatry Neurosci. 2015;40 (3):187-96. doi: 10.1503/jpn.140097. PubMed PMID:25510949 PubMed Central PMC4409436.
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