TREating Arrhythmogenic cardiomyopathy by TargetIng neuropeptide-Y signaliNG.
Abstract
Arrhythmogenic cardiomyopathy (ACM) is a rare and potentially life-threatening heart disease, often affecting young individuals and athletes. It is characterized by the progressive loss of cardiac muscle cells and their replacement by fibrous and fatty tissue, which can lead to impaired cardiac function and life-threatening arrhythmias. Currently, there are no effective therapies capable of preventing or stopping disease progression.
The TREATYNG project aims to develop new therapeutic strategies for ACM by investigating the role of neuro-cardiac communication, with a particular focus on Neuropeptide Y (NPY), a key co-transmitter of the sympathetic nervous system.
Recent research suggests that sympathetic neurons play an active role in the development and progression of ACM through their interactions with different cardiac cell types. TREATYNG will investigate whether targeting abnormal NPY signalling can prevent or slow disease progression and reduce the risk of cardiac complications.
Through an integrated approach combining in silico, molecular, cellular, in vivo and human cell-based studies, the project will explore the therapeutic potential of NPY-targeting agents, identify new therapeutic targets and develop prognostic biomarkers.
The international consortium brings together researchers with complementary expertise in cardiovascular biology, neuroscience, pharmacology and translational research, as well as patient organisations. This collaborative approach aims to accelerate the development of innovative therapeutic strategies and improve the prognosis and quality of life of people living with arrhythmogenic cardiomyopathy.
Partners
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- Università degli Studi di Padova (Italy), coordinator
- Amsterdam University Medical Center (Netherlands )
- Universitaetsklinikum Freiburg (Germany)
- PhyMedExp, Inserm U1046 CNRS UMR9214 (France)
- University of Twente, Department of BioEngineering Technologies (Netherlands)
- GECA ONLUS, Giovani e Cuore Aritmico Onlus (Italy)
- ARVC-Selbsthilfe e.V. (Germany)
- AICARM APS – Associazione Italiana Cardiomiopatie (Italy)
- Biomedical Research Institute of Málaga and Nanomedicine Platform (IBIMA Plataforma BIONAND)
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Related Links
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- ERDERA JTC 2025 selected projects – erdera.org
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Aknowledgment